HK1028048A1 - 4"-Substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives. - Google Patents

4"-Substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives.

Info

Publication number
HK1028048A1
HK1028048A1 HK00107338A HK00107338A HK1028048A1 HK 1028048 A1 HK1028048 A1 HK 1028048A1 HK 00107338 A HK00107338 A HK 00107338A HK 00107338 A HK00107338 A HK 00107338A HK 1028048 A1 HK1028048 A1 HK 1028048A1
Authority
HK
Hong Kong
Prior art keywords
homoerythromycin
deoxo
aza
derivatives
substituted
Prior art date
Application number
HK00107338A
Other languages
English (en)
Inventor
Brian Scott Bronk
Michael Anthony Letavic
Takushi Kaneko
Bingwei Vera Yang
Edward Alan Glazer
Engmiao Cheng
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21959336&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1028048(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of HK1028048A1 publication Critical patent/HK1028048A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK00107338A 1997-06-11 2000-11-17 4"-Substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives. HK1028048A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4934897P 1997-06-11 1997-06-11
PCT/IB1998/000839 WO1998056802A1 (en) 1997-06-11 1998-05-29 4'-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives

Publications (1)

Publication Number Publication Date
HK1028048A1 true HK1028048A1 (en) 2001-02-02

Family

ID=21959336

Family Applications (3)

Application Number Title Priority Date Filing Date
HK00107338A HK1028048A1 (en) 1997-06-11 2000-11-17 4"-Substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives.
HK05101261A HK1068893A1 (en) 1997-06-11 2005-02-16 4"-Substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives
HK06108418.1A HK1088014A1 (en) 1997-06-11 2006-07-28 4"-substituted-9-deoxo-9a-aza-9a-homoerythromy a derivatives

Family Applications After (2)

Application Number Title Priority Date Filing Date
HK05101261A HK1068893A1 (en) 1997-06-11 2005-02-16 4"-Substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives
HK06108418.1A HK1088014A1 (en) 1997-06-11 2006-07-28 4"-substituted-9-deoxo-9a-aza-9a-homoerythromy a derivatives

Country Status (50)

Country Link
US (4) US6420536B1 (sr)
EP (1) EP0988310B9 (sr)
JP (2) JP3315704B2 (sr)
KR (1) KR100396168B1 (sr)
CN (4) CN101691390A (sr)
AP (1) AP1231A (sr)
AR (1) AR013086A1 (sr)
AT (1) ATE251173T1 (sr)
AU (1) AU749816B2 (sr)
BG (1) BG64391B1 (sr)
BR (1) BRPI9810519B8 (sr)
CA (1) CA2293823C (sr)
CO (1) CO4950611A1 (sr)
CZ (1) CZ298556B6 (sr)
DE (2) DE122004000018I2 (sr)
DK (1) DK0988310T3 (sr)
DZ (1) DZ2514A1 (sr)
EA (1) EA002441B1 (sr)
EG (1) EG24081A (sr)
ES (1) ES2205487T3 (sr)
FR (1) FR04C0013I2 (sr)
GT (1) GT199800077A (sr)
HK (3) HK1028048A1 (sr)
HN (1) HN1998000086A (sr)
HR (1) HRP980314B1 (sr)
HU (2) HU228005B1 (sr)
ID (1) ID22992A (sr)
IL (1) IL132809A0 (sr)
IS (1) IS1998B (sr)
LU (1) LU91076I9 (sr)
MA (1) MA24564A1 (sr)
ME (1) ME00876B (sr)
MY (1) MY123354A (sr)
NL (1) NL300150I2 (sr)
NO (1) NO316911B1 (sr)
NZ (2) NZ514871A (sr)
OA (1) OA11224A (sr)
PA (1) PA8452201A1 (sr)
PE (1) PE79699A1 (sr)
PL (1) PL191601B1 (sr)
PT (1) PT988310E (sr)
RS (1) RS49675B (sr)
SI (1) SI0988310T1 (sr)
SK (1) SK284171B6 (sr)
TN (1) TNSN98082A1 (sr)
TW (1) TW472060B (sr)
UA (1) UA67744C2 (sr)
UY (1) UY25040A1 (sr)
WO (1) WO1998056802A1 (sr)
ZA (1) ZA985017B (sr)

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EP1779853A3 (en) * 1997-09-10 2010-01-27 Merial Ltd. 9a-azalides as veterinary antimicrobial agents
CA2302010C (en) * 1997-09-10 2010-11-23 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
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US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
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US6100240A (en) * 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
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ES2552682T3 (es) 2003-03-10 2015-12-01 Merck Sharp & Dohme Corp. Agentes antibacterianos novedosos
WO2005030227A1 (en) 2003-09-23 2005-04-07 Enanta Pharmaceuticals, Inc. 9a, 11-3C-BICYCLIC 9a-AZALIDE DERIVATIVES
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US7767797B1 (en) * 2004-09-30 2010-08-03 Synovo Gmbh Macrocyclic compounds and methods of use thereof
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EP1841437B1 (en) * 2005-01-14 2009-04-29 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. 9a-carbamoyl and thiocarbamoyl azalides with antimalarial activity
CN101917850B (zh) 2007-10-25 2016-01-13 森普拉制药公司 大环内酯类抗菌剂的制备方法
US8791080B2 (en) * 2008-10-24 2014-07-29 Cempra Pharmaceuticals, Inc. Methods for treating gastrointestinal diseases
US9937194B1 (en) * 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
ES2608285T3 (es) 2009-09-10 2017-04-07 Cempra Pharmaceuticals, Inc. Procedimientos para el tratamiento de paludismo, tuberculosis y enfermedades por MAC
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CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
WO2013013834A1 (en) 2011-07-27 2013-01-31 Farma Grs, D.O.O. New crystalline forms of tulathromycin
AU2013239696C1 (en) 2012-03-27 2018-11-29 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
CN102786569B (zh) * 2012-09-07 2016-12-07 安徽中升药业有限公司 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法
CA2905975A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
EP2968384A4 (en) 2013-03-15 2017-02-15 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
EP3027634B1 (en) * 2013-07-31 2018-03-21 Farma GRS, d.o.o. Process for preparation of tulathromycin
CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
CN104725446B (zh) * 2015-03-26 2017-10-27 宁夏泰瑞制药股份有限公司 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法
CN104861018A (zh) * 2015-06-17 2015-08-26 瑞普（天津）生物药业有限公司 一种泰拉菌素的制备方法
CN105646617A (zh) * 2016-01-21 2016-06-08 杭州海尔希畜牧科技有限公司 一种制备泰拉霉素的方法
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CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN108003207B (zh) * 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法
CN111087433B (zh) * 2018-10-23 2023-03-21 湖北美天生物科技股份有限公司 一种泰拉霉素中间体的制备方法

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Also Published As

Publication number Publication date
PE79699A1 (es) 1999-08-25
NO996106D0 (no) 1999-12-10
CN1793155A (zh) 2006-06-28
KR100396168B1 (ko) 2003-08-27
SK284171B6 (sk) 2004-10-05
UA67744C2 (uk) 2004-07-15
NZ514871A (en) 2003-08-29
PL191601B1 (pl) 2006-06-30
ATE251173T1 (de) 2003-10-15
ME00876B (me) 2012-06-20
DZ2514A1 (fr) 2003-02-01
IL132809A0 (en) 2001-03-19
CN1243766C (zh) 2006-03-01
AU7347598A (en) 1998-12-30
CZ298556B6 (cs) 2007-11-07
FR04C0013I2 (sr) 2005-10-21
DE69818665D1 (de) 2003-11-06
AU749816B2 (en) 2002-07-04
NZ500660A (en) 2002-03-01
CA2293823C (en) 2004-02-17
NL300150I2 (nl) 2004-09-01
CN1172947C (zh) 2004-10-27
CA2293823A1 (en) 1998-12-17
EP0988310A1 (en) 2000-03-29
US6936592B2 (en) 2005-08-30
TW472060B (en) 2002-01-11
AR013086A1 (es) 2000-12-13
EP0988310B9 (en) 2006-03-08
SK168399A3 (en) 2000-11-07
HUS1200028I1 (hu) 2016-08-29
FR04C0013I1 (sr) 2004-06-11
UY25040A1 (es) 2000-09-29
OA11224A (en) 2003-07-16
BRPI9810519A (pt) 2000-09-19
CZ442199A3 (cs) 2000-07-12
ES2205487T3 (es) 2004-05-01
HUP0002209A3 (en) 2003-05-28
HRP980314B1 (en) 2004-04-30
HK1068893A1 (en) 2005-07-29
NO316911B1 (no) 2004-06-21
US20020061858A1 (en) 2002-05-23
DK0988310T3 (da) 2003-12-15
HRP980314A2 (en) 1999-04-30
CN1566129A (zh) 2005-01-19
SI0988310T1 (en) 2004-02-29
PL337505A1 (en) 2000-08-28
NL300150I1 (nl) 2004-08-02
HUP0002209A2 (hu) 2000-12-28
TNSN98082A1 (fr) 2005-03-15
GT199800077A (es) 1999-12-02
DE122004000018I2 (de) 2011-01-13
KR20010013632A (ko) 2001-02-26
LU91076I9 (en) 2018-07-02
US20040023896A1 (en) 2004-02-05
MY123354A (en) 2006-05-31
CN1259136A (zh) 2000-07-05
DE122004000018I1 (de) 2004-09-30
IS1998B (is) 2005-03-15
ZA985017B (en) 1999-12-17
RS49675B (sr) 2007-11-15
WO1998056802A1 (en) 1998-12-17
CO4950611A1 (es) 2000-09-01
BRPI9810519B8 (pt) 2022-11-16
AP9801255A0 (en) 1998-06-30
US20040180842A1 (en) 2004-09-16
IS5252A (is) 1999-11-16
HK1088014A1 (en) 2006-10-27
ID22992A (id) 1999-12-23
BG64391B1 (bg) 2004-12-30
US6420536B1 (en) 2002-07-16
BRPI9810519B1 (pt) 2012-02-22
PT988310E (pt) 2003-12-31
JP2000514098A (ja) 2000-10-24
YU58699A (sr) 2002-08-12
US6777393B2 (en) 2004-08-17
LU91076I2 (fr) 2004-07-05
JP2002316933A (ja) 2002-10-31
JP3315704B2 (ja) 2002-08-19
EG24081A (en) 2008-05-11
AP1231A (en) 2003-12-11
MA24564A1 (fr) 1998-12-31
BG103945A (en) 2000-07-31
HN1998000086A (es) 1999-03-08
PA8452201A1 (es) 2000-05-24
NO996106L (no) 2000-02-10
HU228005B1 (en) 2012-08-28
EA199901015A1 (ru) 2000-06-26
DE69818665T2 (de) 2004-04-29
EA002441B1 (ru) 2002-04-25
CN1793155B (zh) 2010-05-12
EP0988310B1 (en) 2003-10-01
CN101691390A (zh) 2010-04-07

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Effective date: 20180528