NO20001871L - Nye 3,6-hemiacetaler fra klassen 9a-azalider - Google Patents

Nye 3,6-hemiacetaler fra klassen 9a-azalider

Info

Publication number
NO20001871L
NO20001871L NO20001871A NO20001871A NO20001871L NO 20001871 L NO20001871 L NO 20001871L NO 20001871 A NO20001871 A NO 20001871A NO 20001871 A NO20001871 A NO 20001871A NO 20001871 L NO20001871 L NO 20001871L
Authority
NO
Norway
Prior art keywords
group
individually
represents hydrogen
carbon atoms
individually represents
Prior art date
Application number
NO20001871A
Other languages
English (en)
Other versions
NO20001871D0 (no
Inventor
Gabrijela Kobrehel
Gorjana Lazarevski
Mladen Vinkovic
Original Assignee
Pliva Pharm & Chem Works
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HR970551A external-priority patent/HRP970551B1/xx
Priority claimed from HR980497A external-priority patent/HRP980497B1/xx
Application filed by Pliva Pharm & Chem Works filed Critical Pliva Pharm & Chem Works
Publication of NO20001871D0 publication Critical patent/NO20001871D0/no
Publication of NO20001871L publication Critical patent/NO20001871L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Abstract

Oppfinnelsen angår forbindelser med den generelle formel (I). -:--y :-" hvori •-;---_ ". R- individuelt står for hydroksyl, en L-cladinosylgruppe med formel (II). hvor. R2 individuelt står for hydrogen eller en silylgruppe,. R3 individuelt står for hydrogen eller sammen med R6 står for en etergruppe, R4 individuelt står for hydrogen, en (d-C)acylgruppe eller -COO-(CH)-Ar-gruppe,. hvor n er 1-7, og Ar individuelt står for en usubstituert eller substituert arylgruppe med opptil 18 karbonatomer,. R5 individuelt står for hydrogen, en metylgruppe eller -COO-(CH)-Ar gruppe, hvor n er 1-7 og Ar individuelt står for en usubstituert eller substituert arylgruppe med opptil 18 karbonatomer,. Rindividuelt står for en hydroksylgruppe eller sammen med R3 står for en. etergruppe,. R7 individuelt står for hydrogen,en (CC)alkylgruppe, en silylgruppe eller sammen. med Rog C-11/C-12-karbonatomene står for et cyklisk karbonat,. Rindividuelt står for hydrogen, en (CC)alkylgruppe, silylgruppe eller sammen med R7 og C-11/C-12-karbonatomene står for et cyklisk karbonat,. bg"dets farmasøytisk akseptable addisjonssalter med uorganiske eller organiske syrer, en fremgangsmåte for fremstillingen derav og anvendelsen derav som antibiotika eller som mellomprodukter for syntese av andre makrolid-antibiotika.
NO20001871A 1997-10-16 2000-04-11 Nye 3,6-hemiacetaler fra klassen 9a-azalider NO20001871L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HR970551A HRP970551B1 (en) 1997-10-16 1997-10-16 Novel o-methyl azythromycin derivatives
HR980497A HRP980497B1 (en) 1998-09-10 1998-09-10 NOVEL 3,6-HEMIKETALS FROM THE CLASS OF 9a-AZALIDES
PCT/HR1998/000005 WO1999020639A2 (en) 1997-10-16 1998-10-13 NOVEL 3,6-HEMIKETALS FROM THE CLASS OF 9a-AZALIDES

Publications (2)

Publication Number Publication Date
NO20001871D0 NO20001871D0 (no) 2000-04-11
NO20001871L true NO20001871L (no) 2000-04-17

Family

ID=26317108

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20001871A NO20001871L (no) 1997-10-16 2000-04-11 Nye 3,6-hemiacetaler fra klassen 9a-azalider

Country Status (26)

Country Link
US (1) US6369035B1 (no)
EP (2) EP1437359B1 (no)
JP (1) JP2001520234A (no)
KR (1) KR100554549B1 (no)
CN (1) CN1281615C (no)
AR (1) AR018014A1 (no)
AT (2) ATE267835T1 (no)
AU (1) AU755315B2 (no)
BG (1) BG64650B1 (no)
BR (1) BR9812808A (no)
CA (1) CA2306963C (no)
DE (2) DE69824201T2 (no)
DK (2) DK1437359T3 (no)
EE (1) EE04681B1 (no)
ES (2) ES2222610T3 (no)
HK (1) HK1032785A1 (no)
HU (1) HUP0004085A3 (no)
IL (2) IL135648A0 (no)
NO (1) NO20001871L (no)
NZ (1) NZ503897A (no)
PL (1) PL191087B1 (no)
PT (2) PT1036083E (no)
RU (1) RU2220148C2 (no)
SI (2) SI1437359T1 (no)
SK (1) SK285914B6 (no)
WO (1) WO1999020639A2 (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20011512A3 (cs) * 1998-11-03 2001-09-12 Pfizer Products Inc. Nová makrolidová antibiotika
KR100361397B1 (ko) * 2000-03-15 2002-11-23 한미약품공업 주식회사 에리스로마이신 에이 9-오-트로필옥심 유도체를 이용한클라리스로마이신의 제조방법
AU2003211113B2 (en) 2002-02-15 2007-08-09 Merckle Gmbh Antibiotic conjugates
AU2003215245A1 (en) 2002-02-15 2003-09-09 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
US7579324B2 (en) 2002-02-15 2009-08-25 C-A-I-R Biosciences Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
HRP20020779A2 (en) 2002-09-27 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. NEW 3-DECLADINOSYL DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICIN A 9a, 11-CYCLIC CARBAMATES
ITMI20022292A1 (it) * 2002-10-29 2004-04-30 Zambon Spa 9a-azalidi ad attivita' antiinfiammatoria.
US7435805B2 (en) * 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
WO2004106353A1 (en) * 2003-05-30 2004-12-09 Pliva - Istrazivacki Institut D.O.O. Process for selective alkylation of macrolide and azalide derivatives
WO2005030227A1 (en) 2003-09-23 2005-04-07 Enanta Pharmaceuticals, Inc. 9a, 11-3C-BICYCLIC 9a-AZALIDE DERIVATIVES
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US7402568B2 (en) 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
WO2008143729A2 (en) * 2007-02-28 2008-11-27 Rib-X Pharmaceuticals, Inc. Macrolide compounds and methods of making and using the same
EP2625185A4 (en) * 2010-10-10 2014-03-26 Synovo Gmbh INFLAMMATORY MAKROLIDE
CA2869461A1 (en) * 2012-03-27 2013-10-03 Michael W. BURNET Anti-inflammatory macrolides
JP7184520B2 (ja) * 2018-01-22 2022-12-06 旭化成株式会社 トランス型脂環式カーボネートの製造方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
UA27040C2 (uk) * 1987-07-09 2000-02-28 Пфайзер Інк. Кристалічhий дигідрат азитроміциhу та спосіб одержаhhя кристалічhого дигідрату азитроміциhу
EP0283055B1 (en) * 1987-09-03 1990-08-29 SOUR PLIVA farmaceutska, Kemijska prehrambena i kozmeticka industrija, n.sol.o. 10-dihydro-10-deoxo-11-azaerythronolide-a-compounds, methods and intermediates for the manufacture thereof and their use in pharmaceuticals and in the manufacture thereof
WO1989002271A1 (en) * 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents
SI9011409A (en) * 1990-07-18 1995-10-31 Pliva Pharm & Chem Works O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
FR2691464B1 (fr) * 1992-05-21 1995-06-02 Roussel Uclaf Nouveaux dérivés de la 1-oxa 6-azacyclopentadécane 13,15-dione, leur procédé de préparation et leur application comme médicaments.
WO1999000124A1 (en) * 1997-06-26 1999-01-07 Merck & Co., Inc. 9a-azalides, compositions containing such compounds and methods of treatment

Also Published As

Publication number Publication date
PT1036083E (pt) 2004-10-29
DE69824201T2 (de) 2005-09-22
DK1437359T3 (da) 2007-04-30
ATE348836T1 (de) 2007-01-15
PL340372A1 (en) 2001-01-29
EP1437359A2 (en) 2004-07-14
WO1999020639A3 (en) 1999-07-08
HK1032785A1 (en) 2001-08-03
DK1036083T3 (da) 2004-09-27
JP2001520234A (ja) 2001-10-30
PT1437359E (pt) 2007-04-30
SK5522000A3 (en) 2000-11-07
SI1036083T1 (en) 2004-10-31
EP1036083B1 (en) 2004-05-26
EP1437359A3 (en) 2005-03-30
WO1999020639A2 (en) 1999-04-29
EE200000226A (et) 2001-06-15
ES2222610T3 (es) 2005-02-01
EP1036083B9 (en) 2005-01-12
DE69836697D1 (de) 2007-02-01
RU2220148C2 (ru) 2003-12-27
HUP0004085A2 (hu) 2001-04-28
BG64650B1 (bg) 2005-10-31
AU9362298A (en) 1999-05-10
SK285914B6 (sk) 2007-11-02
SI1437359T1 (sl) 2007-06-30
CN1281615C (zh) 2006-10-25
EP1437359B1 (en) 2006-12-20
PL191087B1 (pl) 2006-03-31
EE04681B1 (et) 2006-08-15
BR9812808A (pt) 2005-04-12
AU755315B2 (en) 2002-12-12
CA2306963C (en) 2007-05-01
KR20010031160A (ko) 2001-04-16
DK1036083T5 (da) 2005-04-04
DE69824201D1 (de) 2004-07-01
BG104445A (en) 2001-02-28
IL135648A0 (en) 2001-05-20
DE69836697T2 (de) 2007-10-04
IL135648A (en) 2007-03-08
KR100554549B1 (ko) 2006-03-03
EP1036083A2 (en) 2000-09-20
AR018014A1 (es) 2001-10-31
CN1280585A (zh) 2001-01-17
HUP0004085A3 (en) 2003-05-28
CA2306963A1 (en) 1999-04-29
US6369035B1 (en) 2002-04-09
ES2279242T3 (es) 2007-08-16
NZ503897A (en) 2002-10-25
NO20001871D0 (no) 2000-04-11
ATE267835T1 (de) 2004-06-15

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