DE69836697D1 - Neue 3,6-Hemiketale der 9a-Azalidklasse - Google Patents

Neue 3,6-Hemiketale der 9a-Azalidklasse

Info

Publication number
DE69836697D1
DE69836697D1 DE69836697T DE69836697T DE69836697D1 DE 69836697 D1 DE69836697 D1 DE 69836697D1 DE 69836697 T DE69836697 T DE 69836697T DE 69836697 T DE69836697 T DE 69836697T DE 69836697 D1 DE69836697 D1 DE 69836697D1
Authority
DE
Germany
Prior art keywords
azalid
hemiketals
class
new
azalid class
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69836697T
Other languages
English (en)
Other versions
DE69836697T2 (de
Inventor
Gabrijela Kobrehel
Gorjana Lazarevski
Mladen Vinkovic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fidelta doo
Original Assignee
GlaxoSmithKline Istrazivacki Centar Zagreb doo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HR970551A external-priority patent/HRP970551B1/xx
Priority claimed from HR980497A external-priority patent/HRP980497B1/xx
Application filed by GlaxoSmithKline Istrazivacki Centar Zagreb doo filed Critical GlaxoSmithKline Istrazivacki Centar Zagreb doo
Application granted granted Critical
Publication of DE69836697D1 publication Critical patent/DE69836697D1/de
Publication of DE69836697T2 publication Critical patent/DE69836697T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69836697T 1997-10-16 1998-10-13 Neue 3,6-Hemiketale der 9a-Azalidklasse Expired - Fee Related DE69836697T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HR970551 1997-10-16
HR970551A HRP970551B1 (en) 1997-10-16 1997-10-16 Novel o-methyl azythromycin derivatives
HR980497 1998-09-10
HR980497A HRP980497B1 (en) 1998-09-10 1998-09-10 NOVEL 3,6-HEMIKETALS FROM THE CLASS OF 9a-AZALIDES

Publications (2)

Publication Number Publication Date
DE69836697D1 true DE69836697D1 (de) 2007-02-01
DE69836697T2 DE69836697T2 (de) 2007-10-04

Family

ID=26317108

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69824201T Expired - Fee Related DE69824201T2 (de) 1997-10-16 1998-10-13 Neue 9a-azalide
DE69836697T Expired - Fee Related DE69836697T2 (de) 1997-10-16 1998-10-13 Neue 3,6-Hemiketale der 9a-Azalidklasse

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69824201T Expired - Fee Related DE69824201T2 (de) 1997-10-16 1998-10-13 Neue 9a-azalide

Country Status (26)

Country Link
US (1) US6369035B1 (de)
EP (2) EP1036083B9 (de)
JP (1) JP2001520234A (de)
KR (1) KR100554549B1 (de)
CN (1) CN1281615C (de)
AR (1) AR018014A1 (de)
AT (2) ATE267835T1 (de)
AU (1) AU755315B2 (de)
BG (1) BG64650B1 (de)
BR (1) BR9812808A (de)
CA (1) CA2306963C (de)
DE (2) DE69824201T2 (de)
DK (2) DK1437359T3 (de)
EE (1) EE04681B1 (de)
ES (2) ES2222610T3 (de)
HK (1) HK1032785A1 (de)
HU (1) HUP0004085A3 (de)
IL (2) IL135648A0 (de)
NO (1) NO20001871L (de)
NZ (1) NZ503897A (de)
PL (1) PL191087B1 (de)
PT (2) PT1437359E (de)
RU (1) RU2220148C2 (de)
SI (2) SI1036083T1 (de)
SK (1) SK285914B6 (de)
WO (1) WO1999020639A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2349338C (en) 1998-11-03 2005-12-06 Pfizer Products Inc. Novel macrolide antibiotics
KR100361397B1 (ko) * 2000-03-15 2002-11-23 한미약품공업 주식회사 에리스로마이신 에이 9-오-트로필옥심 유도체를 이용한클라리스로마이신의 제조방법
US20040005641A1 (en) 2002-02-15 2004-01-08 Michael Burnet Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
EP1482957A4 (de) 2002-02-15 2006-07-19 Merckle Gmbh Antibiotische konjugate
CA2476423A1 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
HRP20020779A2 (en) 2002-09-27 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. NEW 3-DECLADINOSYL DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICIN A 9a, 11-CYCLIC CARBAMATES
ITMI20022292A1 (it) * 2002-10-29 2004-04-30 Zambon Spa 9a-azalidi ad attivita' antiinfiammatoria.
WO2004106353A1 (en) * 2003-05-30 2004-12-09 Pliva - Istrazivacki Institut D.O.O. Process for selective alkylation of macrolide and azalide derivatives
US7435805B2 (en) 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
WO2005030227A1 (en) 2003-09-23 2005-04-07 Enanta Pharmaceuticals, Inc. 9a, 11-3C-BICYCLIC 9a-AZALIDE DERIVATIVES
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US7402568B2 (en) 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
WO2008106226A2 (en) * 2007-02-28 2008-09-04 Rib-X Pharmaceuticals, Inc. Macrolide compounds and methods of making and using the same
EP2625185A4 (de) * 2010-10-10 2014-03-26 Synovo Gmbh Entzündungshemmende makrolide
AU2013239679A1 (en) * 2012-03-27 2014-10-30 Michael W. BURNET Anti-inflammatory macrolides
JP7184520B2 (ja) * 2018-01-22 2022-12-06 旭化成株式会社 トランス型脂環式カーボネートの製造方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
UA27040C2 (uk) * 1987-07-09 2000-02-28 Пфайзер Інк. Кристалічhий дигідрат азитроміциhу та спосіб одержаhhя кристалічhого дигідрату азитроміциhу
DE3860503D1 (de) * 1987-09-03 1990-10-04 Pliva Pharm & Chem Works 10-dihydro-10-deoxo-11-azaerythronolid-a-verbindungen,verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung in arzneimitteln und in deren herstellung.
WO1989002271A1 (en) * 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents
SI9011409A (en) * 1990-07-18 1995-10-31 Pliva Pharm & Chem Works O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
FR2691464B1 (fr) * 1992-05-21 1995-06-02 Roussel Uclaf Nouveaux dérivés de la 1-oxa 6-azacyclopentadécane 13,15-dione, leur procédé de préparation et leur application comme médicaments.
AU7961498A (en) * 1997-06-26 1999-01-19 Merck & Co., Inc. 9a-azalides, compositions containing such compounds and methods of treatment

Also Published As

Publication number Publication date
NO20001871L (no) 2000-04-17
EP1036083B9 (de) 2005-01-12
HK1032785A1 (en) 2001-08-03
ES2279242T3 (es) 2007-08-16
PT1036083E (pt) 2004-10-29
AU9362298A (en) 1999-05-10
SK285914B6 (sk) 2007-11-02
SK5522000A3 (en) 2000-11-07
DE69836697T2 (de) 2007-10-04
IL135648A0 (en) 2001-05-20
US6369035B1 (en) 2002-04-09
CN1281615C (zh) 2006-10-25
PL191087B1 (pl) 2006-03-31
WO1999020639A3 (en) 1999-07-08
BG104445A (en) 2001-02-28
DE69824201D1 (de) 2004-07-01
CA2306963A1 (en) 1999-04-29
DE69824201T2 (de) 2005-09-22
AR018014A1 (es) 2001-10-31
PL340372A1 (en) 2001-01-29
BG64650B1 (bg) 2005-10-31
BR9812808A (pt) 2005-04-12
WO1999020639A2 (en) 1999-04-29
EP1036083B1 (de) 2004-05-26
JP2001520234A (ja) 2001-10-30
EP1437359B1 (de) 2006-12-20
ES2222610T3 (es) 2005-02-01
EP1437359A3 (de) 2005-03-30
DK1036083T3 (da) 2004-09-27
AU755315B2 (en) 2002-12-12
IL135648A (en) 2007-03-08
CA2306963C (en) 2007-05-01
EE04681B1 (et) 2006-08-15
SI1437359T1 (sl) 2007-06-30
DK1437359T3 (da) 2007-04-30
SI1036083T1 (en) 2004-10-31
NO20001871D0 (no) 2000-04-11
KR20010031160A (ko) 2001-04-16
CN1280585A (zh) 2001-01-17
DK1036083T5 (da) 2005-04-04
KR100554549B1 (ko) 2006-03-03
ATE267835T1 (de) 2004-06-15
EP1437359A2 (de) 2004-07-14
EP1036083A2 (de) 2000-09-20
PT1437359E (pt) 2007-04-30
NZ503897A (en) 2002-10-25
EE200000226A (et) 2001-06-15
HUP0004085A2 (hu) 2001-04-28
RU2220148C2 (ru) 2003-12-27
HUP0004085A3 (en) 2003-05-28
ATE348836T1 (de) 2007-01-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee