DE69733933D1 - Neue Liganden des Neuropeptide Rezeptors HFGAN72 - Google Patents

Neue Liganden des Neuropeptide Rezeptors HFGAN72

Info

Publication number
DE69733933D1
DE69733933D1 DE69733933T DE69733933T DE69733933D1 DE 69733933 D1 DE69733933 D1 DE 69733933D1 DE 69733933 T DE69733933 T DE 69733933T DE 69733933 T DE69733933 T DE 69733933T DE 69733933 D1 DE69733933 D1 DE 69733933D1
Authority
DE
Germany
Prior art keywords
hfgan72
neuropeptide receptor
new ligands
ligands
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69733933T
Other languages
English (en)
Other versions
DE69733933T2 (de
Inventor
Derk J Bergsma
David P Brooks
Miklos Gellai
Masashi Yanagisawa
Shelagh Wilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
University of Texas System
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Ltd
University of Texas System
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd, University of Texas System, SmithKline Beecham Corp filed Critical SmithKline Beecham Ltd
Application granted granted Critical
Publication of DE69733933D1 publication Critical patent/DE69733933D1/de
Publication of DE69733933T2 publication Critical patent/DE69733933T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69733933T 1996-12-17 1997-12-17 Neue Liganden des Neuropeptid Rezeptors HFGAN72 Expired - Lifetime DE69733933T2 (de)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US3360496P 1996-12-17 1996-12-17
US33604P 1996-12-17
US82051997A 1997-03-19 1997-03-19
US820519 1997-03-19
US88738297A 1997-07-02 1997-07-02
US887382 1997-07-02
US939093 1997-09-26
US08/939,093 US6309854B1 (en) 1996-12-17 1997-09-26 Polynucleotides encoding ligands of the neuropeptide receptor HFGAN72

Publications (2)

Publication Number Publication Date
DE69733933D1 true DE69733933D1 (de) 2005-09-15
DE69733933T2 DE69733933T2 (de) 2006-01-26

Family

ID=27488130

Family Applications (2)

Application Number Title Priority Date Filing Date
DE0849361T Pending DE849361T1 (de) 1996-12-17 1997-12-17 Neue Liganden des Neuropeptide Rezeptors HFGAN72
DE69733933T Expired - Lifetime DE69733933T2 (de) 1996-12-17 1997-12-17 Neue Liganden des Neuropeptid Rezeptors HFGAN72

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE0849361T Pending DE849361T1 (de) 1996-12-17 1997-12-17 Neue Liganden des Neuropeptide Rezeptors HFGAN72

Country Status (5)

Country Link
US (2) US6309854B1 (de)
EP (1) EP0849361B1 (de)
JP (1) JP3946847B2 (de)
CA (1) CA2218452C (de)
DE (2) DE849361T1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69726889T2 (de) * 1996-08-02 2004-10-21 Scripps Research Inst Hypothalamus-spezifische polypeptide
US5935814A (en) * 1997-04-30 1999-08-10 Smithkline Beecham Corporation Polynucleotides encoding HFGAN72Y receptor
US6020157A (en) * 1997-04-30 2000-02-01 Smithkline Beecham Corporation Polynucleotides encoding HFGAN72X receptor
JP2003527302A (ja) * 1997-12-15 2003-09-16 スミスクライン ビーチャム パブリック リミテッド カンパニー 新規な神経ペプチドレセプターｈｆｇａｎ７２のリガンドおよびそのアゴニストまたはアンタゴニストを用いる治療方法
ATE241345T1 (de) * 1999-02-12 2003-06-15 Smithkline Beecham Plc Neue verwendung von orexinrezeptorantagonisten
WO2000047576A1 (en) * 1999-02-12 2000-08-17 Smithkline Beecham Plc Cinnamide derivatives as orexin-1 receptors antagonists
WO2001000787A2 (en) * 1999-06-25 2001-01-04 Smithkline Beecham Corporation Methods of treatment using lig 72a and variants thereof
EP1280827A1 (de) * 2000-05-03 2003-02-05 AstraZeneca AB Verwendung von agonisten/antagonisten des gpr56 rezeptors zur appetitregulierung
AU2001297807A1 (en) * 2000-12-20 2002-11-11 Sri International Modulators of the hypocretin system and methods of screening therefor
US7241579B2 (en) 2000-12-22 2007-07-10 Smithkline Beecham Corporation Method of screening for GPR40 ligands
GB0031527D0 (en) * 2000-12-22 2001-02-07 Smithkline Beecham Plc New use
IL158463A0 (en) 2001-05-05 2004-05-12 Smithkline Beecham Plc N-aroyl cyclic amines
WO2004071395A2 (en) * 2003-02-17 2004-08-26 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor ox1r (ox1r)
US8093255B2 (en) 2008-10-09 2012-01-10 Glaxo Group Limited Imidazo[1,2-A]pyrimidines as orexin receptor antagonists
US8129384B2 (en) 2008-10-09 2012-03-06 Glaxo Group Limited Imidazo[1,2-a]pyrazines as orexin receptor antagonists
GB0823467D0 (en) 2008-12-23 2009-01-28 Glaxo Group Ltd Novel Compounds
EA201171293A1 (ru) 2009-04-24 2012-05-30 Глэксо Груп Лимитед 3-азабицикло[4.1.0]гептаны, применяемые в качестве антагонистов орексина
EP2470525A1 (de) 2009-08-24 2012-07-04 Glaxo Group Limited Piperidinderivate als orexinantagonisten
JP2013502447A (ja) 2009-08-24 2013-01-24 グラクソ グループ リミテッド 睡眠障害の治療のためのオレキシン受容体アンタゴニストとしての５−メチル−ピペリジン誘導体
PE20131162A1 (es) 2010-09-22 2013-10-19 Eisai Randd Man Co Ltd Compuestos de ciclopropano como antagonistas del receptor de orexina
WO2012089607A1 (en) 2010-12-28 2012-07-05 Glaxo Group Limited Novel compounds with a 3a-azabicyclo [4.1.0] heptane core acting on orexin receptors
WO2012089606A1 (en) 2010-12-28 2012-07-05 Glaxo Group Limited Azabicyclo [4.1.0] hept - 4 - yl derivatives as human orexin receptor antagonists
US20150140015A1 (en) * 2013-11-15 2015-05-21 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of pancreatic cancer
ES2843952T3 (es) 2014-10-23 2021-07-21 Eisai R&D Man Co Ltd Composiciones para tratar el insomnio
RU2647771C2 (ru) * 2016-04-26 2018-03-19 Общество с ограниченной ответственностью "Орексал" (ООО "Орексал") Способ получения рекомбинантного орексина а человека, плазмидная днк, штамм-продуцент
US20190151304A1 (en) 2016-05-10 2019-05-23 Inserm (Institut National De La Santé Et De La Rechercjae Médicale Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory
KR20220119065A (ko) 2019-12-20 2022-08-26 에자이 알앤드디 매니지먼트 가부시키가이샤 불면증 치료를 위한 렘보렉산트의 용도
CN115884971A (zh) 2020-07-17 2023-03-31 卫材R&D管理有限公司 取代的哌啶化合物及其用途
TW202334120A (zh) 2022-01-14 2023-09-01 日商衛材R&D企管股份有限公司 經取代之哌啶化合物之結晶以及經取代之哌啶化合物之鹽及其等之結晶

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5508384A (en) * 1992-09-10 1996-04-16 New York University Polypeptide derived from a popamine receptor, and compositions and methods thereof
EP0828751A4 (de) * 1995-05-05 1999-01-20 Human Genome Sciences Inc Humaner neuropeptidrezeptor
DE69726889T2 (de) 1996-08-02 2004-10-21 Scripps Research Inst Hypothalamus-spezifische polypeptide
US6001963A (en) * 1996-12-17 1999-12-14 Smithkline Beecham Corporation Ligands of the neuropeptide receptor HFGAN72

Also Published As

Publication number Publication date
DE69733933T2 (de) 2006-01-26
CA2218452A1 (en) 1998-06-07
JPH10229887A (ja) 1998-09-02
US6309854B1 (en) 2001-10-30
JP3946847B2 (ja) 2007-07-18
US6750026B2 (en) 2004-06-15
US20020082202A1 (en) 2002-06-27
DE849361T1 (de) 2001-01-25
CA2218452C (en) 2001-12-04
EP0849361A2 (de) 1998-06-24
EP0849361A3 (de) 2000-04-19
EP0849361B1 (de) 2005-08-10

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