DE69622801D1 - Neue carbapenemderivate - Google Patents

Neue carbapenemderivate

Info

Publication number
DE69622801D1
DE69622801D1 DE69622801T DE69622801T DE69622801D1 DE 69622801 D1 DE69622801 D1 DE 69622801D1 DE 69622801 T DE69622801 T DE 69622801T DE 69622801 T DE69622801 T DE 69622801T DE 69622801 D1 DE69622801 D1 DE 69622801D1
Authority
DE
Germany
Prior art keywords
carbapen
derivatives
new
new carbapen
carbapen derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69622801T
Other languages
English (en)
Other versions
DE69622801T2 (de
Inventor
Kazuhiro Aihara
Yuko Kano
Sohjiro Shiokawa
Toshiro Sasaki
Fumihito Setsu
Yumiko Toyooka
Miyuki Ishii
Kunio Atsumi
Katsuyoshi Iwamatsu
Atsushi Tamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Application granted granted Critical
Publication of DE69622801D1 publication Critical patent/DE69622801D1/de
Publication of DE69622801T2 publication Critical patent/DE69622801T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/40—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by an aliphatic carboxylic acid, which is substituted by hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69622801T 1995-03-10 1996-03-08 Neue carbapenemderivate Expired - Fee Related DE69622801T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP5161695 1995-03-10
PCT/JP1996/000573 WO1996028455A1 (fr) 1995-03-10 1996-03-08 Nouveaux derives de carbapeneme

Publications (2)

Publication Number Publication Date
DE69622801D1 true DE69622801D1 (de) 2002-09-12
DE69622801T2 DE69622801T2 (de) 2003-03-27

Family

ID=12891830

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69622801T Expired - Fee Related DE69622801T2 (de) 1995-03-10 1996-03-08 Neue carbapenemderivate

Country Status (9)

Country Link
US (1) US5990101A (de)
EP (1) EP0760370B1 (de)
KR (1) KR100231496B1 (de)
CN (1) CN1057091C (de)
CA (1) CA2189995C (de)
DE (1) DE69622801T2 (de)
ES (1) ES2179932T3 (de)
TW (1) TW425396B (de)
WO (1) WO1996028455A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW445265B (en) * 1996-11-25 2001-07-11 Meiji Seika Kaisha Carbapenem derivatives and antimicrobial agents
DE69807722T2 (de) * 1997-01-28 2003-04-30 Meiji Seika Kaisha Carbapenemderivate
EP1003747A4 (de) * 1997-08-13 2002-11-06 Merck & Co Inc Über eine methylengruppe mit einem naphthosultamderivat verbundene carbapeneme
EP1104424B1 (de) 1998-06-17 2004-04-07 Merck & Co., Inc. Verfahren zur synthese von carbapenem-zwischenprodukten
US6458780B1 (en) 1998-07-27 2002-10-01 Meiji Seika Kaisha, Ltd. Carbapenem derivatives
JP2005231997A (ja) * 2000-01-24 2005-09-02 Meiji Seika Kaisha Ltd カルバペネム誘導体の製造法
ES2228896T3 (es) * 2000-01-26 2005-04-16 Meiji Seika Kaisha, Ltd. Nuevos derivados de carbapenem.
WO2001055155A1 (fr) * 2000-01-26 2001-08-02 Meiji Seika Kaisha, Ltd. Nouveaux derives de carbapenem de type sel quaternaire
ATE519771T1 (de) 2003-06-18 2011-08-15 Meiji Seika Pharma Co Ltd Kristallines carbapenemzwischenprodukt
TW201920202A (zh) * 2017-08-17 2019-06-01 瑞士商愛杜西亞製藥有限公司 吲哚胺2,3-二氧酶及/或色胺酸2,3-二氧酶的抑制劑

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4680292A (en) * 1984-12-13 1987-07-14 Merck & Co., Inc. Carbapenems and 1-methylcarbapenems having a 2-heteroaryliumaliphatic substituent
JPS6261985A (ja) * 1985-09-11 1987-03-18 Sankyo Co Ltd カルバペネム化合物およびその製法
JPH075607B2 (ja) * 1990-10-12 1995-01-25 日本レダリー株式会社 カルバペネム化合物の製造法
JPH05230573A (ja) * 1992-02-25 1993-09-07 Furukawa Alum Co Ltd 耐食性および強度に優れたアルミニウム合金製ブレージングシート
JPH06211908A (ja) * 1992-11-30 1994-08-02 Shin Etsu Chem Co Ltd 塩化ビニル系重合体の製造方法
CA2149514C (en) * 1993-09-16 2000-10-31 Kunio Atsumi Novel cephem derivatives

Also Published As

Publication number Publication date
EP0760370A4 (de) 1997-05-28
ES2179932T3 (es) 2003-02-01
KR100231496B1 (ko) 1999-11-15
TW425396B (en) 2001-03-11
KR970702865A (ko) 1997-06-10
DE69622801T2 (de) 2003-03-27
WO1996028455A1 (fr) 1996-09-19
CA2189995C (en) 2001-01-23
CN1148390A (zh) 1997-04-23
CA2189995A1 (en) 1996-09-19
US5990101A (en) 1999-11-23
CN1057091C (zh) 2000-10-04
EP0760370A1 (de) 1997-03-05
EP0760370B1 (de) 2002-08-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee