ES2179932T3 - Nuevos derivados de carbapenem. - Google Patents
Nuevos derivados de carbapenem.Info
- Publication number
- ES2179932T3 ES2179932T3 ES96905036T ES96905036T ES2179932T3 ES 2179932 T3 ES2179932 T3 ES 2179932T3 ES 96905036 T ES96905036 T ES 96905036T ES 96905036 T ES96905036 T ES 96905036T ES 2179932 T3 ES2179932 T3 ES 2179932T3
- Authority
- ES
- Spain
- Prior art keywords
- carbapenem
- new derivatives
- gram
- represented
- powerful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/40—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by an aliphatic carboxylic acid, which is substituted by hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE DESCRIBEN NUEVOS DERIVADOS DEL CARBAPENEM, REPRESENTADOS POR LA SIGUIENTE FORMULA (I), CON UN GRUPO IMIDAZO[5,1-B]TIAZOLIO-6ILMETIL EN LA POSICION 2. LOS COMPUESTOS REPRESENTADOS POR LA FORMULA (I) TIENEN UNA POTENTE ACTIVIDAD ANTIBACTERIANA CONTRA UN AMPLIO ESPECTRO DE BACTERIAS GRAM-POSITIVAS Y GRAM-NEGATIVAS INCLUYENDO PSEUDOMONAS AERUGINOSA Y, ADEMAS, TIENEN UNA POTENTE ACTIVIDAD ANTIBACTERIANA CONTRA VARIAS BACTERIAS PRODUCTORAS DE {BE}-LACTAMASAS Y MRSA Y SON MUY ESTABLES CONTRA DHP-1.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5161695 | 1995-03-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2179932T3 true ES2179932T3 (es) | 2003-02-01 |
Family
ID=12891830
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96905036T Expired - Lifetime ES2179932T3 (es) | 1995-03-10 | 1996-03-08 | Nuevos derivados de carbapenem. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5990101A (es) |
EP (1) | EP0760370B1 (es) |
KR (1) | KR100231496B1 (es) |
CN (1) | CN1057091C (es) |
CA (1) | CA2189995C (es) |
DE (1) | DE69622801T2 (es) |
ES (1) | ES2179932T3 (es) |
TW (1) | TW425396B (es) |
WO (1) | WO1996028455A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW445265B (en) * | 1996-11-25 | 2001-07-11 | Meiji Seika Kaisha | Carbapenem derivatives and antimicrobial agents |
ATE223420T1 (de) * | 1997-01-28 | 2002-09-15 | Meiji Seika Kaisha | Carbapenemderivate |
JP2001515080A (ja) * | 1997-08-13 | 2001-09-18 | メルク エンド カムパニー インコーポレーテッド | メチレンを介して連結されたナフトスルタム誘導体を有するカルバペネム類 |
DE69916287T2 (de) | 1998-06-17 | 2005-03-24 | Merck & Co., Inc. | Verfahren zur synthese von carbapenem-zwischenprodukten |
CA2338816A1 (en) | 1998-07-27 | 2000-02-10 | Yumiko Sambongi | Novel carbapenem derivatives |
JP2005231997A (ja) * | 2000-01-24 | 2005-09-02 | Meiji Seika Kaisha Ltd | カルバペネム誘導体の製造法 |
EP1251134A4 (en) * | 2000-01-26 | 2003-01-29 | Meiji Seika Kaisha | NEW CARBAPENEM DERIVATIVES OF THE QUATERNARY SALT TYPE |
DE60106390T2 (de) * | 2000-01-26 | 2005-02-24 | Meiji Seika Kaisha Ltd. | Neue carbapenem-derivate |
US7482445B2 (en) * | 2003-06-18 | 2009-01-27 | Meiji Seika Kaisha, Ltd. | Crystalline carbapenem intermediate |
CN110997682A (zh) * | 2017-08-17 | 2020-04-10 | 爱杜西亚药品有限公司 | 吲哚胺2,3-二氧酶及/或色氨酸2,3-二氧酶的抑制剂 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4680292A (en) * | 1984-12-13 | 1987-07-14 | Merck & Co., Inc. | Carbapenems and 1-methylcarbapenems having a 2-heteroaryliumaliphatic substituent |
JPS6261985A (ja) * | 1985-09-11 | 1987-03-18 | Sankyo Co Ltd | カルバペネム化合物およびその製法 |
JPH075607B2 (ja) * | 1990-10-12 | 1995-01-25 | 日本レダリー株式会社 | カルバペネム化合物の製造法 |
JPH05230573A (ja) * | 1992-02-25 | 1993-09-07 | Furukawa Alum Co Ltd | 耐食性および強度に優れたアルミニウム合金製ブレージングシート |
JPH06211908A (ja) * | 1992-11-30 | 1994-08-02 | Shin Etsu Chem Co Ltd | 塩化ビニル系重合体の製造方法 |
ATE192927T1 (de) * | 1993-09-16 | 2000-06-15 | Meiji Seika Co | Neue cephem-derivate |
-
1996
- 1996-03-08 CA CA002189995A patent/CA2189995C/en not_active Expired - Fee Related
- 1996-03-08 WO PCT/JP1996/000573 patent/WO1996028455A1/ja active IP Right Grant
- 1996-03-08 KR KR1019960706355A patent/KR100231496B1/ko not_active IP Right Cessation
- 1996-03-08 DE DE69622801T patent/DE69622801T2/de not_active Expired - Fee Related
- 1996-03-08 US US08/737,232 patent/US5990101A/en not_active Expired - Fee Related
- 1996-03-08 EP EP96905036A patent/EP0760370B1/en not_active Expired - Lifetime
- 1996-03-08 ES ES96905036T patent/ES2179932T3/es not_active Expired - Lifetime
- 1996-03-08 CN CN96190177A patent/CN1057091C/zh not_active Expired - Fee Related
- 1996-03-09 TW TW085102872A patent/TW425396B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US5990101A (en) | 1999-11-23 |
KR100231496B1 (ko) | 1999-11-15 |
DE69622801D1 (de) | 2002-09-12 |
EP0760370B1 (en) | 2002-08-07 |
KR970702865A (ko) | 1997-06-10 |
CA2189995C (en) | 2001-01-23 |
EP0760370A1 (en) | 1997-03-05 |
DE69622801T2 (de) | 2003-03-27 |
TW425396B (en) | 2001-03-11 |
CA2189995A1 (en) | 1996-09-19 |
WO1996028455A1 (fr) | 1996-09-19 |
CN1148390A (zh) | 1997-04-23 |
CN1057091C (zh) | 2000-10-04 |
EP0760370A4 (en) | 1997-05-28 |
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