ES2142771A1 - Nuevos derivados de la 6-(4-penilbutoxi) hexilamina y procedimiento para la obtencion de salmeterol. - Google Patents
Nuevos derivados de la 6-(4-penilbutoxi) hexilamina y procedimiento para la obtencion de salmeterol.Info
- Publication number
- ES2142771A1 ES2142771A1 ES009802014A ES9802014A ES2142771A1 ES 2142771 A1 ES2142771 A1 ES 2142771A1 ES 009802014 A ES009802014 A ES 009802014A ES 9802014 A ES9802014 A ES 9802014A ES 2142771 A1 ES2142771 A1 ES 2142771A1
- Authority
- ES
- Spain
- Prior art keywords
- phenylbutoxy
- hexylamine
- general formula
- new derivatives
- aralkyloxycarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
- C07C217/40—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the same carbon atom of the carbon skeleton, e.g. amino-ketals, ortho esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Nuevos derivados de la 6-(4-fenilbutoxi)hexilamina y procedimiento para la obtención de salmeterol. La presente invención se refiere a nuevos derivados de la 6-(4-fenilbutoxi)hexilamina de fórmula general (I): en la que: R1 , es CHO, o CHOR3 OR4 , donde R3 y R4 son independientemente alquilo C1 - C6 , aralquilo o forman acetales cíclicos de 5 ó 6 miembros; R2 es H, bencilo o un grupo alquiloxicarbonilo, ariloxicarbonilo, aralquiloxicarbonilo o acilo; y a un procedimiento para su obtención. La invención también se refiere a un nuevo procedimiento de obtención de Salmeterol o sus sales farmacéuticamente aceptables que se caracteriza por el hecho de que se lleva a cabo la reacción de un compuesto organometálico con un compuesto de fórmula general (I) en el que R1 es CHO y R2 es un alquiloxicarbonilo, ariloxicarbonilo, aralquiloxicarbonilo, o un grupo acilo.
Priority Applications (27)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009802014A ES2142771B1 (es) | 1998-09-28 | 1998-09-28 | Nuevos derivados de la 6-(4-fenil-butoxi) hexilamina y procedimiento para la obtencion de salmeterol. |
ES99969711T ES2212672T3 (es) | 1998-09-28 | 1999-09-20 | Nuevos derivados de la 6-(4-fenilbutoxi)hexilamina y procedimiento para la obtencion de salmeterol. |
CA002344647A CA2344647C (en) | 1998-09-28 | 1999-09-20 | New derivatives of 6-(4-phenylbutoxy)hexylamine and process for producing salmeterol |
HU0103969A HUP0103969A3 (en) | 1998-09-28 | 1999-09-20 | New derivatives of 6-(4-phenylbutoxy)hexylamine and their use for producing salmeterol |
PT99969711T PT1132373E (pt) | 1998-09-28 | 1999-09-20 | Novos derivados de 6-(4-fenilbutoxi)-hexilamina e processo para a producao de salmeterol |
EP99969711A EP1132373B1 (en) | 1998-09-28 | 1999-09-20 | New derivatives of 6-(4-phenylbutoxy)hexylamine and process for producing salmeterol |
PL348572A PL196116B1 (pl) | 1998-09-28 | 1999-09-20 | Związek pochodnej 6-(4-fenylobutoksy)heksyloaminy, sposób jego otrzymywania oraz sposób wytwarzania Salmeterolu |
NZ511157A NZ511157A (en) | 1998-09-28 | 1999-09-20 | Derivatives of 6-(4-phenylbutoxy)hexylamine and process for producing salmeterol |
EA200100391A EA003397B1 (ru) | 1998-09-28 | 1999-09-20 | Производные 6-(4-фенилбутокси)гексиламина и способ получения сальметерола |
CNB998114324A CN1189446C (zh) | 1998-09-28 | 1999-09-20 | 6-(4-苯基丁氧基)己胺衍生物和获得沙美特罗的方法 |
OA1200100079A OA11660A (en) | 1998-09-28 | 1999-09-20 | New derivatives of 6-(4-phenylbutoxy)hexylamine and process for producing salmeterol. |
IL14199199A IL141991A (en) | 1998-09-28 | 1999-09-20 | History of 6-(4-phenylbutoxy) xylamine, their preparation and use in the process for receiving salamatrol |
PCT/ES1999/000294 WO2000018722A2 (es) | 1998-09-28 | 1999-09-20 | Nuevos derivados de la 6-(4-fenilbutoxi)hexilamina y procedimiento para la obtencion de salmeterol |
KR10-2001-7003977A KR100479256B1 (ko) | 1998-09-28 | 1999-09-20 | 6-(4-페닐부톡시)헥실아민의 신규한 유도체 및 살메테롤의제조방법 |
BR9913989-8A BR9913989A (pt) | 1998-09-28 | 1999-09-20 | Derivados de 6-(4-fenilbutóxi)hexilamina e processo para a obtenção de salmeterol |
US09/806,538 US6388134B1 (en) | 1998-09-28 | 1999-09-20 | Derivatives of 6-(4-phenylbutoxy)hexylamine and process for producing Salmeterol |
AT99969711T ATE254596T1 (de) | 1998-09-28 | 1999-09-20 | Derivate des 6-(4-phenylbutoxy)hexylamins und verfahren zur herstellung von salmeterol |
SK386-2001A SK284366B6 (sk) | 1998-09-28 | 1999-09-20 | Deriváty 6-(4-fenylbutoxy)hexylamínu, spôsob jeho prípravy a spôsob prípravy salmeterolu |
AU59839/99A AU756042B2 (en) | 1998-09-28 | 1999-09-20 | New derivatives of 6-(4-phenylbutoxy)hexylamine and process for producing salmeterol |
JP2000572184A JP3786834B2 (ja) | 1998-09-28 | 1999-09-20 | 新規6−(4−フエニルブトキシ)ヘキシルアミン誘導体およびサルメテロールの製法 |
CZ20033118A CZ296902B6 (cs) | 1998-09-28 | 1999-09-20 | Zpusob prípravy derivátu 6-(4-fenylbutoxy)hexylaminu |
TR2001/00862T TR200100862T2 (tr) | 1998-09-28 | 1999-09-20 | Yeni 6-(4-fenilbütoksi) heksilamin türevleri ve salmeterolün elde edilme işlemi. |
DE69912984T DE69912984D1 (de) | 1998-09-28 | 1999-09-20 | Derivate des 6-(4-phenylbutoxy)hexylamins und verfahren zur herstellung von salmeterol |
CZ20010958A CZ296901B6 (cs) | 1998-09-28 | 1999-09-20 | Zpusob prípravy Salmeterolu a deriváty 6-(4-fenylbutoxy)hexylaminu |
IS5880A IS2016B (is) | 1998-09-28 | 2001-03-08 | Nýjar 6-(4-fenýlbútoxý)hexýlamínafleiður og aðferð til að fá salmeteról |
NO20011197A NO327780B1 (no) | 1998-09-28 | 2001-03-08 | Nye 6-(4-fenylbutoksy)heksylamin derivater og fremgangsmate for fremstilling av salmeterol |
NO20084343A NO20084343L (no) | 1998-09-28 | 2008-10-16 | Fremgangsmate for fremstilling av 6-(4-fenylbutoksy)heksylaminderivater |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009802014A ES2142771B1 (es) | 1998-09-28 | 1998-09-28 | Nuevos derivados de la 6-(4-fenil-butoxi) hexilamina y procedimiento para la obtencion de salmeterol. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2142771A1 true ES2142771A1 (es) | 2000-04-16 |
ES2142771B1 ES2142771B1 (es) | 2001-01-01 |
Family
ID=8305274
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009802014A Expired - Fee Related ES2142771B1 (es) | 1998-09-28 | 1998-09-28 | Nuevos derivados de la 6-(4-fenil-butoxi) hexilamina y procedimiento para la obtencion de salmeterol. |
ES99969711T Expired - Lifetime ES2212672T3 (es) | 1998-09-28 | 1999-09-20 | Nuevos derivados de la 6-(4-fenilbutoxi)hexilamina y procedimiento para la obtencion de salmeterol. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99969711T Expired - Lifetime ES2212672T3 (es) | 1998-09-28 | 1999-09-20 | Nuevos derivados de la 6-(4-fenilbutoxi)hexilamina y procedimiento para la obtencion de salmeterol. |
Country Status (24)
Country | Link |
---|---|
US (1) | US6388134B1 (es) |
EP (1) | EP1132373B1 (es) |
JP (1) | JP3786834B2 (es) |
KR (1) | KR100479256B1 (es) |
CN (1) | CN1189446C (es) |
AT (1) | ATE254596T1 (es) |
AU (1) | AU756042B2 (es) |
BR (1) | BR9913989A (es) |
CA (1) | CA2344647C (es) |
CZ (2) | CZ296902B6 (es) |
DE (1) | DE69912984D1 (es) |
EA (1) | EA003397B1 (es) |
ES (2) | ES2142771B1 (es) |
HU (1) | HUP0103969A3 (es) |
IL (1) | IL141991A (es) |
IS (1) | IS2016B (es) |
NO (2) | NO327780B1 (es) |
NZ (1) | NZ511157A (es) |
OA (1) | OA11660A (es) |
PL (1) | PL196116B1 (es) |
PT (1) | PT1132373E (es) |
SK (1) | SK284366B6 (es) |
TR (1) | TR200100862T2 (es) |
WO (1) | WO2000018722A2 (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2288114A1 (es) * | 2006-04-26 | 2007-12-16 | Quimica Sintetica S.A. | Nuevo procedimiento de sitensis de (6-(4-fenilbutoxi)hexil)aminas n-s ustituidas y su uso en la sintesis de salmeterol xinafoato. |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6835857B2 (en) | 2002-03-05 | 2004-12-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Process for the manufacture of 4-(6-bromohexyloxy)-butylbenzene |
DE10209583B4 (de) * | 2002-03-05 | 2006-01-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung von 4-(6-Bromhexyloxy)-butylbenzol |
AU2006303124B2 (en) | 2005-10-17 | 2013-03-28 | Generics [Uk] Limited | Novel process |
EP2127641A1 (en) | 2008-05-26 | 2009-12-02 | Inke, S.A. | Micronisable form of salmeterol xinafoate |
CN101712622B (zh) * | 2009-11-10 | 2012-10-03 | 浙江万里学院 | 抗哮喘药物沙美特罗的制备方法 |
CN103435505A (zh) * | 2013-09-05 | 2013-12-11 | 南京工业大学 | 一种合成(r)-沙美特罗的方法 |
US9447067B2 (en) * | 2014-10-03 | 2016-09-20 | Amphastar Pahmaceuticals, Inc. | Method of preparing intermediate of salmeterol |
KR20230001708U (ko) | 2022-02-17 | 2023-08-24 | 유기택 | 재접착식 슬림 평면형 액자 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2545482A1 (fr) * | 1983-04-18 | 1984-11-09 | Glaxo Group Ltd | Derives de phenethanolamine |
EP0162576A1 (en) * | 1984-04-17 | 1985-11-27 | Glaxo Group Limited | Ethanolamine compounds |
ES2065269A1 (es) * | 1993-05-11 | 1995-02-01 | S A L V A T Lab Sa | 6-(4-(fenilbutoxi) hexilaminometil-4-hidroxi-a1,a3-bencenodimetanol. procedimiento para la obtencion del mismo y nuevos intermedios utilizados en su preparacion. |
-
1998
- 1998-09-28 ES ES009802014A patent/ES2142771B1/es not_active Expired - Fee Related
-
1999
- 1999-09-20 CN CNB998114324A patent/CN1189446C/zh not_active Expired - Fee Related
- 1999-09-20 ES ES99969711T patent/ES2212672T3/es not_active Expired - Lifetime
- 1999-09-20 NZ NZ511157A patent/NZ511157A/xx not_active IP Right Cessation
- 1999-09-20 CZ CZ20033118A patent/CZ296902B6/cs not_active IP Right Cessation
- 1999-09-20 CZ CZ20010958A patent/CZ296901B6/cs not_active IP Right Cessation
- 1999-09-20 AT AT99969711T patent/ATE254596T1/de not_active IP Right Cessation
- 1999-09-20 HU HU0103969A patent/HUP0103969A3/hu unknown
- 1999-09-20 SK SK386-2001A patent/SK284366B6/sk not_active IP Right Cessation
- 1999-09-20 OA OA1200100079A patent/OA11660A/en unknown
- 1999-09-20 PT PT99969711T patent/PT1132373E/pt unknown
- 1999-09-20 EA EA200100391A patent/EA003397B1/ru not_active IP Right Cessation
- 1999-09-20 US US09/806,538 patent/US6388134B1/en not_active Expired - Lifetime
- 1999-09-20 AU AU59839/99A patent/AU756042B2/en not_active Ceased
- 1999-09-20 PL PL348572A patent/PL196116B1/pl not_active IP Right Cessation
- 1999-09-20 BR BR9913989-8A patent/BR9913989A/pt not_active Application Discontinuation
- 1999-09-20 CA CA002344647A patent/CA2344647C/en not_active Expired - Fee Related
- 1999-09-20 JP JP2000572184A patent/JP3786834B2/ja not_active Expired - Fee Related
- 1999-09-20 WO PCT/ES1999/000294 patent/WO2000018722A2/es active IP Right Grant
- 1999-09-20 KR KR10-2001-7003977A patent/KR100479256B1/ko not_active IP Right Cessation
- 1999-09-20 TR TR2001/00862T patent/TR200100862T2/xx unknown
- 1999-09-20 IL IL14199199A patent/IL141991A/en not_active IP Right Cessation
- 1999-09-20 DE DE69912984T patent/DE69912984D1/de not_active Expired - Lifetime
- 1999-09-20 EP EP99969711A patent/EP1132373B1/en not_active Expired - Lifetime
-
2001
- 2001-03-08 IS IS5880A patent/IS2016B/is unknown
- 2001-03-08 NO NO20011197A patent/NO327780B1/no not_active IP Right Cessation
-
2008
- 2008-10-16 NO NO20084343A patent/NO20084343L/no not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2545482A1 (fr) * | 1983-04-18 | 1984-11-09 | Glaxo Group Ltd | Derives de phenethanolamine |
EP0162576A1 (en) * | 1984-04-17 | 1985-11-27 | Glaxo Group Limited | Ethanolamine compounds |
ES2065269A1 (es) * | 1993-05-11 | 1995-02-01 | S A L V A T Lab Sa | 6-(4-(fenilbutoxi) hexilaminometil-4-hidroxi-a1,a3-bencenodimetanol. procedimiento para la obtencion del mismo y nuevos intermedios utilizados en su preparacion. |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2288114A1 (es) * | 2006-04-26 | 2007-12-16 | Quimica Sintetica S.A. | Nuevo procedimiento de sitensis de (6-(4-fenilbutoxi)hexil)aminas n-s ustituidas y su uso en la sintesis de salmeterol xinafoato. |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2186672T3 (es) | Procedimiento para la produccion de derivados 13-eter de milbemicinas, e intermedios de los mismos. | |
FI956270A0 (fi) | Piperdiinijohdannaisia ja menetelmä niiden valmistamiseksi | |
HU9401943D0 (en) | Process for producing amide and urea derivatives and compositions containing them | |
ES2157214T3 (es) | Procedimiento para producir derivados de azetidinona sustituidos en posicion 4. | |
ATE161262T1 (de) | Optisch aktives zwischenprodukt und dessen herstellung | |
ES2142771A1 (es) | Nuevos derivados de la 6-(4-penilbutoxi) hexilamina y procedimiento para la obtencion de salmeterol. | |
NO20001871L (no) | Nye 3,6-hemiacetaler fra klassen 9a-azalider | |
PL309874A1 (en) | Novel derivatives of pyrrolocarbasol, method of obtaining them and pharmaceutical composition containing such derivatives | |
ATE148128T1 (de) | Anthracyclinglycosid-derivate und verfahren zu ihrer herstellung | |
HUP0203364A2 (hu) | Eljárás 3-helyettesített-4-arilkinolin-2-on származékok előállítására | |
IS6728A (is) | Aðferð við að framleiða útskipt imídasópýridínefnasamband | |
HUT57039A (en) | Process for producing pharmaceutical compositions | |
HUT60992A (en) | Process for producing optically active norbornyl amine derivatives | |
DK0492350T3 (da) | Fremgangsmåde til fremstilling af (S)-vinyl- og (S)-allenyl-GABA | |
HU0001727D0 (en) | Novel 1-aza-2-alkyl-6-aryl-cycloalkane compounds, process for producing them and medicaments containing the same | |
HUT47938A (en) | Process for producing indoloquinoxaline derivatives with substituent in 6-position containing cyclic group, as well as pharmaceuticals comprising these compounds as active ingredient | |
IE34441L (en) | Dibenzazepine derivatives | |
EP1219608A4 (en) | PYRIMID DERIVATIVES, METHOD FOR PRODUCING THE DERIVATIVES AND MEDICINES CONTAINING IT AS THE ACTIVE COMPONENT | |
EP1148059A4 (en) | THIAZOLPYRIMIDINE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE | |
EP1219610A4 (en) | PROCESS FOR THE PREPARATION OF OXAZOLE DERIVATIVES | |
MX9601953A (es) | Nuevo compesto derivados de 5h-tiazolo [3,2-a] pirimidin-5-ona. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EC2A | Search report published |
Date of ref document: 20000416 Kind code of ref document: A1 Effective date: 20000416 |
|
FD1A | Patent lapsed |
Effective date: 20100312 |