ES2157214T3 - Procedimiento para producir derivados de azetidinona sustituidos en posicion 4. - Google Patents

Procedimiento para producir derivados de azetidinona sustituidos en posicion 4.

Info

Publication number
ES2157214T3
ES2157214T3 ES93900431T ES93900431T ES2157214T3 ES 2157214 T3 ES2157214 T3 ES 2157214T3 ES 93900431 T ES93900431 T ES 93900431T ES 93900431 T ES93900431 T ES 93900431T ES 2157214 T3 ES2157214 T3 ES 2157214T3
Authority
ES
Spain
Prior art keywords
general formula
group
alkyl
defined above
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93900431T
Other languages
English (en)
Inventor
Yuuki Nakagawa
Kiyohito Imai
Tamio Hara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Soda Co Ltd
Original Assignee
Nippon Soda Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Soda Co Ltd filed Critical Nippon Soda Co Ltd
Application granted granted Critical
Publication of ES2157214T3 publication Critical patent/ES2157214T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

UN PROCESO PARA PRODUCIR DERIVADOS ACETIDINONA TUIDOS REPRESENTADOS POR LA FORMULA GENERAL (I) EN DONDE R REPRESENTA HIDROGENO O UN GRUPO DE PROTECCION DE NITROGENO; R1 REPRESENTA UN GRUPO HIDROXILO OPCIONALMENTE PROTEGIDO O UN GRUPO ALQUIL HALOGENADO; R2 REPRESENTA HIDROGENO O ALQUIL; R3 REPRESENTA ALQUIL, FENIL OPCIONALMENTE SUBSTITUIDO, ETC; Y R4 REPRESENTA UN GRUPO DE ATRACCION DE ELECTRONES; O ALTERNATIVAMENTE R3 Y R4 SE COMBINAN JUNTOS PARA FORMAR UN ANILLO, POR LA REACCION DE UN DERIVADO DE ACETIDINONA REPRESENTADO POR LA FORMULA GENERAL (II) EN DONDE R Y R1 SON COMO SE DEFINE ARRIBA, Y Z REPRESENTA UN GRUPO SOBRANTE CON UN COMPUESTO IMIDA REPRESENTADO POR LA FORMULA GENERAL (III) EN DONDE R2, R3 Y R4 SON CADA UNO COMO SE DEFINE ARRIBA, EN PRESENCIA DE UNA BASE Y UN COMPUESTO DE TITANIO REPRESENTADO POR LA FORMULA GENERAL TI(CL)N(OR5)M EN DONDE R5 REPRESENTA UN ALQUIL INFERIOR, 0 MENOR O IGUAL QUE N MENOR O IGUAL QUE 4,0 MENOR O IGUAL QUE M MENOR O IGUAL QUE 4 Y N + M = 4. EL DERIVADO OBTENIDO SE PUEDE CONVERTIR FACILMENTE EN UN ACIDO CARBOXILICO, PARA EMPLEAR COMO UN IMPORTANTE INTERMEDIARIO EN LA PREPARACION DE COMPUESTOS CARBOFENICOS.
ES93900431T 1991-12-26 1992-12-25 Procedimiento para producir derivados de azetidinona sustituidos en posicion 4. Expired - Lifetime ES2157214T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP35683091 1991-12-26
JP16008092 1992-05-28
JP21663192 1992-07-23

Publications (1)

Publication Number Publication Date
ES2157214T3 true ES2157214T3 (es) 2001-08-16

Family

ID=27321631

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93900431T Expired - Lifetime ES2157214T3 (es) 1991-12-26 1992-12-25 Procedimiento para producir derivados de azetidinona sustituidos en posicion 4.

Country Status (6)

Country Link
EP (1) EP0573667B1 (es)
JP (1) JP3220985B2 (es)
AT (1) ATE202087T1 (es)
DE (1) DE69231874T2 (es)
ES (1) ES2157214T3 (es)
WO (1) WO1993013064A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6011150A (en) * 1992-11-13 2000-01-04 Tanabe Seiyaku Co., Ltd. Azetidinone compound and process for preparation thereof
US5631363A (en) * 1992-11-13 1997-05-20 Tanabe Seiyaku Co., Ltd. Azetidinone compound and process for preparation thereof
US5442055A (en) * 1992-11-13 1995-08-15 Tanabe Seiyaku Co., Ltd. Azetidinone compound and process for preparation thereof
US5550229A (en) * 1993-06-23 1996-08-27 Tanabe Seiyaku Co., Ltd. Alkylation process for preparing azetidinone compound and starting compound therefor
EP0632037B1 (en) * 1993-06-30 1997-10-01 Tanabe Seiyaku Co., Ltd. Process for the production of 4-substituted azetidinone derivatives
DE69703164T2 (de) * 1996-10-15 2001-05-17 Procter & Gamble Asymmetrisch imid bleichaktivatoren und zusammensetzungen zu deren verwendung
US6395894B2 (en) 1998-04-16 2002-05-28 Philip J. Pye Process for the synthesis of carbapenem intermidiates, and compounds produced
WO1999052908A1 (en) * 1998-04-16 1999-10-21 Merck & Co., Inc. Titanium catalyzed preparation of carbapenem intermediates
JP3450193B2 (ja) * 1998-07-24 2003-09-22 高砂香料工業株式会社 ４−置換アゼチジノン誘導体の製造方法
KR100335848B1 (ko) * 2000-03-31 2002-05-08 윤재승 아제티디논 유도체, 그 제조방법 및 이를 이용한1-β-알킬아제티디논의 제조방법
US7700603B2 (en) 2003-12-15 2010-04-20 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7592348B2 (en) 2003-12-15 2009-09-22 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7763609B2 (en) 2003-12-15 2010-07-27 Schering Corporation Heterocyclic aspartyl protease inhibitors
JP2008056564A (ja) * 2004-11-12 2008-03-13 Shionogi & Co Ltd アゼチジノン誘導体の製造方法
WO2007013592A1 (ja) * 2005-07-29 2007-02-01 Meiji Seika Kaisha, Ltd. 糖テンプレートを用いたカルバペネム合成中間体の新規合成法
JP5112070B2 (ja) * 2005-09-05 2013-01-09 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 １β−メチルカルバペネム誘導体合成中間体およびその製造法
CN101460494A (zh) * 2006-06-06 2009-06-17 株式会社钟化 4-取代丙内酰胺衍生物的制备方法
JPWO2008020597A1 (ja) * 2006-08-15 2010-01-07 明治製菓株式会社 １−メチルカルバペネム類製造中間体の製造方法
MX2009006228A (es) 2006-12-12 2009-06-22 Schering Corp Inhibidores de aspartil proteasa.
KR100886347B1 (ko) * 2007-04-16 2009-03-03 주식회사 대웅제약 키랄 보조제를 이용한 4-비엠에이의 입체선택적 제조방법
CN101891666B (zh) * 2010-07-20 2012-09-26 深圳市海滨制药有限公司 一种β甲基碳青霉烯类抗生素中间体的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS557251A (en) * 1978-07-03 1980-01-19 Sankyo Co Ltd Preparation 2-azetidinone derivative
JPS56142259A (en) * 1980-03-11 1981-11-06 Sankyo Co Ltd Beta-lactam compound and its preparation
JPS6019764A (ja) * 1983-07-13 1985-01-31 Sankyo Co Ltd アゼチジノン誘導体の製造法
JPS62252785A (ja) * 1986-01-08 1987-11-04 Sankyo Co Ltd ４−置換β−ラクタム化合物

Also Published As

Publication number Publication date
WO1993013064A1 (en) 1993-07-08
ATE202087T1 (de) 2001-06-15
EP0573667A4 (es) 1994-03-30
DE69231874D1 (de) 2001-07-19
EP0573667B1 (en) 2001-06-13
EP0573667A1 (en) 1993-12-15
DE69231874T2 (de) 2001-09-27
JP3220985B2 (ja) 2001-10-22

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