DE69231874T2 - Verfahren zur herstellung von 4-substituierten azetidinon-derivaten - Google Patents
Verfahren zur herstellung von 4-substituierten azetidinon-derivatenInfo
- Publication number
- DE69231874T2 DE69231874T2 DE69231874T DE69231874T DE69231874T2 DE 69231874 T2 DE69231874 T2 DE 69231874T2 DE 69231874 T DE69231874 T DE 69231874T DE 69231874 T DE69231874 T DE 69231874T DE 69231874 T2 DE69231874 T2 DE 69231874T2
- Authority
- DE
- Germany
- Prior art keywords
- general formula
- group
- alkyl
- producing
- defined above
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- -1 4-SUBSTITUTED AZETIDINONE Chemical class 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical class O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000010936 titanium Substances 0.000 abstract 1
- 150000003609 titanium compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP35683091 | 1991-12-26 | ||
| JP16008092 | 1992-05-28 | ||
| JP21663192 | 1992-07-23 | ||
| PCT/JP1992/001698 WO1993013064A1 (en) | 1991-12-26 | 1992-12-25 | Process for producing 4-substituted azetidinone derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69231874D1 DE69231874D1 (de) | 2001-07-19 |
| DE69231874T2 true DE69231874T2 (de) | 2001-09-27 |
Family
ID=27321631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69231874T Expired - Lifetime DE69231874T2 (de) | 1991-12-26 | 1992-12-25 | Verfahren zur herstellung von 4-substituierten azetidinon-derivaten |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0573667B1 (de) |
| JP (1) | JP3220985B2 (de) |
| AT (1) | ATE202087T1 (de) |
| DE (1) | DE69231874T2 (de) |
| ES (1) | ES2157214T3 (de) |
| WO (1) | WO1993013064A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5442055A (en) * | 1992-11-13 | 1995-08-15 | Tanabe Seiyaku Co., Ltd. | Azetidinone compound and process for preparation thereof |
| US5631363A (en) * | 1992-11-13 | 1997-05-20 | Tanabe Seiyaku Co., Ltd. | Azetidinone compound and process for preparation thereof |
| US6011150A (en) * | 1992-11-13 | 2000-01-04 | Tanabe Seiyaku Co., Ltd. | Azetidinone compound and process for preparation thereof |
| US5550229A (en) * | 1993-06-23 | 1996-08-27 | Tanabe Seiyaku Co., Ltd. | Alkylation process for preparing azetidinone compound and starting compound therefor |
| DE69405922T2 (de) * | 1993-06-30 | 1998-01-29 | Tanabe Seiyaku Co | Verfahren zur Herstellung von 4-substituierten Azetidinon-Derivaten |
| BR9712318A (pt) * | 1996-10-15 | 2002-01-15 | Procter & Gamble | Composto ativador de alvejante, composição de aditivo alvejante, composição de alvejamento e método para alvejar tecidos |
| AU745980B2 (en) * | 1998-04-16 | 2002-04-11 | Merck & Co., Inc. | Titanium catalyzed preparation of carbapenem intermediates |
| US6395894B2 (en) | 1998-04-16 | 2002-05-28 | Philip J. Pye | Process for the synthesis of carbapenem intermidiates, and compounds produced |
| JP3450193B2 (ja) * | 1998-07-24 | 2003-09-22 | 高砂香料工業株式会社 | ４−置換アゼチジノン誘導体の製造方法 |
| KR100335848B1 (ko) * | 2000-03-31 | 2002-05-08 | 윤재승 | 아제티디논 유도체, 그 제조방법 및 이를 이용한1-β-알킬아제티디논의 제조방법 |
| US7700603B2 (en) | 2003-12-15 | 2010-04-20 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| JP2008056564A (ja) * | 2004-11-12 | 2008-03-13 | Shionogi & Co Ltd | アゼチジノン誘導体の製造方法 |
| JP5143556B2 (ja) * | 2005-07-29 | 2013-02-13 | 金一 只野 | 糖テンプレートを用いたカルバペネム合成中間体の新規合成法 |
| WO2007029650A1 (ja) * | 2005-09-05 | 2007-03-15 | Meiji Seika Kaisha, Ltd. | １β－メチルカルバペネム誘導体合成中間体およびその製造法 |
| WO2007142207A1 (ja) * | 2006-06-06 | 2007-12-13 | Kaneka Corporation | ４－置換アゼチジノン誘導体の製造方法 |
| WO2008020597A1 (fr) * | 2006-08-15 | 2008-02-21 | Meiji Seika Kaisha, Ltd. | Procédé de production d'un intermédiaire pour la production de 1-méthylcarbapenem |
| AU2007332754A1 (en) | 2006-12-12 | 2008-06-19 | Schering Corporation | Aspartyl protease inhibitors |
| KR100886347B1 (ko) * | 2007-04-16 | 2009-03-03 | 주식회사 대웅제약 | 키랄 보조제를 이용한 4-비엠에이의 입체선택적 제조방법 |
| CN101891666B (zh) * | 2010-07-20 | 2012-09-26 | 深圳市海滨制药有限公司 | 一种β甲基碳青霉烯类抗生素中间体的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS557251A (en) * | 1978-07-03 | 1980-01-19 | Sankyo Co Ltd | Preparation 2-azetidinone derivative |
| JPS56142259A (en) * | 1980-03-11 | 1981-11-06 | Sankyo Co Ltd | Beta-lactam compound and its preparation |
| JPS6019764A (ja) * | 1983-07-13 | 1985-01-31 | Sankyo Co Ltd | アゼチジノン誘導体の製造法 |
| JPS62252785A (ja) * | 1986-01-08 | 1987-11-04 | Sankyo Co Ltd | ４−置換β−ラクタム化合物 |
-
1992
- 1992-12-25 JP JP51155293A patent/JP3220985B2/ja not_active Expired - Lifetime
- 1992-12-25 WO PCT/JP1992/001698 patent/WO1993013064A1/ja active IP Right Grant
- 1992-12-25 ES ES93900431T patent/ES2157214T3/es not_active Expired - Lifetime
- 1992-12-25 EP EP93900431A patent/EP0573667B1/de not_active Expired - Lifetime
- 1992-12-25 AT AT93900431T patent/ATE202087T1/de active
- 1992-12-25 DE DE69231874T patent/DE69231874T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69231874D1 (de) | 2001-07-19 |
| ATE202087T1 (de) | 2001-06-15 |
| EP0573667A1 (de) | 1993-12-15 |
| ES2157214T3 (es) | 2001-08-16 |
| JP3220985B2 (ja) | 2001-10-22 |
| EP0573667A4 (de) | 1994-03-30 |
| EP0573667B1 (de) | 2001-06-13 |
| WO1993013064A1 (en) | 1993-07-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE202087T1 (de) | Verfahren zur herstellung von 4-substituierten azetidinon-derivaten | |
| ATE254594T1 (de) | Verbindungen verwendbar als zwischenprodukte zur herstellung von piperidinderivate | |
| ATE145891T1 (de) | Verfahren zur herstellung von alkoxyiminoacetamid-derivaten und ein zwischenproduckt dafür | |
| DE69012351D1 (de) | Neue Zwischenprodukte, ihre Herstellung und Verwendung. | |
| ATE201687T1 (de) | Galanthamin-derivat, ein verfahren zu seiner herstellung und seine verwendung als medikament | |
| FI101226B1 (fi) | Menetelmä lääkeaineena käyttökelpoisten 2-[2-(karbonyyli)pyrrolidin-4-yylitio]-6-(1-hydroksietyyli)-1-metyylikarbapen-2-eemi-3-karboksyylihappojohdannaisten valmistamiseksi | |
| DE602004019329D1 (de) | Verfahren zur herstellung substituierter nikotinsäureester | |
| ATE168693T1 (de) | Verfahren zur herstellung von beta- lactamderivaten und zwischenprodukt für ihre synthese | |
| ATE531702T1 (de) | Verfahren zur herstellung von epoxytriazolderivat und zwischenprodukten dafür | |
| ATE82292T1 (de) | Verfahren zur herstellung von 2-alpha-methyl-2beta-(1,2,3-triazol-1-yl)methylpenam-3-alphacarbons|urederivaten. | |
| DE69714749D1 (de) | Verfahren zur herstellung von 3-amino-2-hydroxy-1-propylethern | |
| ATE30718T1 (de) | Herstellung von 1-benzyl azetidin-3-ol und von dem entsprechenden halid acid. | |
| DE69225651T2 (de) | Verwendung von halogenierten beta-lactamen zur herstellung von 3-hydroxycephem-derivaten | |
| ATE122671T1 (de) | Verfahren zur herstellung von 1,3-dioxan-4,6- dionderivaten. | |
| DE69330658D1 (de) | Verfahren zur Herstellung von 4-substituierten Azetidinonderivaten | |
| DE69024114D1 (de) | Verfahren zur Herstellung von Penemen | |
| ATE329917T1 (de) | 1h-pyrrolo 1,2-bö 1,2,4ötriazolederivate, zwischenprodukte und verfahren zur herstellung von 1h-1,2,4,-triazol-5-yl essigsäureesterderivate | |
| ATE51616T1 (de) | Azetidinderivate, verfahren zu ihrer herstellung und ihre verwendung als zwischenprodukte. | |
| DE60008561D1 (de) | Verfahren zur herstellung von oxazol-derivaten | |
| DE69706632T2 (de) | Verfahren zur herstellung von 3-norcephem-verbindungen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| R071 | Expiry of right |
Ref document number: 573667 Country of ref document: EP |