DE69012351D1 - Neue Zwischenprodukte, ihre Herstellung und Verwendung. - Google Patents

Neue Zwischenprodukte, ihre Herstellung und Verwendung.

Info

Publication number
DE69012351D1
DE69012351D1 DE69012351T DE69012351T DE69012351D1 DE 69012351 D1 DE69012351 D1 DE 69012351D1 DE 69012351 T DE69012351 T DE 69012351T DE 69012351 T DE69012351 T DE 69012351T DE 69012351 D1 DE69012351 D1 DE 69012351D1
Authority
DE
Germany
Prior art keywords
pct
stands
sec
aryl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69012351T
Other languages
English (en)
Other versions
DE69012351T2 (de
Inventor
Frantz Lund
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharmaceutical Products Ltd AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharmaceutical Products Ltd AS filed Critical Leo Pharmaceutical Products Ltd AS
Application granted granted Critical
Publication of DE69012351D1 publication Critical patent/DE69012351D1/de
Publication of DE69012351T2 publication Critical patent/DE69012351T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
    • C07C329/02—Monothiocarbonic acids; Derivatives thereof
    • C07C329/04—Esters of monothiocarbonic acids
    • C07C329/06—Esters of monothiocarbonic acids having sulfur atoms of thiocarbonic groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/96—Esters of carbonic or haloformic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69012351T 1990-01-22 1990-11-28 Neue Zwischenprodukte, ihre Herstellung und Verwendung. Expired - Fee Related DE69012351T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909001405A GB9001405D0 (en) 1990-01-22 1990-01-22 New intermediates,their production and use
PCT/DK1990/000308 WO1991010639A1 (en) 1990-01-22 1990-11-28 New intermediates, their production and use

Publications (2)

Publication Number Publication Date
DE69012351D1 true DE69012351D1 (de) 1994-10-13
DE69012351T2 DE69012351T2 (de) 1995-02-09

Family

ID=10669692

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69012351T Expired - Fee Related DE69012351T2 (de) 1990-01-22 1990-11-28 Neue Zwischenprodukte, ihre Herstellung und Verwendung.

Country Status (13)

Country Link
US (1) US5401868A (de)
EP (1) EP0541550B1 (de)
JP (1) JP3025532B2 (de)
AT (1) ATE111073T1 (de)
AU (1) AU6883191A (de)
CA (1) CA2064872C (de)
DE (1) DE69012351T2 (de)
DK (1) DK0541550T3 (de)
ES (1) ES2061077T3 (de)
GB (1) GB9001405D0 (de)
HU (1) HUT60459A (de)
IE (1) IE64470B1 (de)
WO (1) WO1991010639A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001005768A1 (fr) 1999-07-19 2001-01-25 Shionogi & Co., Ltd. Composes tricycliques porteurs de pendants acyloxymethoxycarbonyle
US6376548B1 (en) 2000-01-28 2002-04-23 Rohm And Haas Company Enhanced propertied pesticides
CA2397831A1 (en) * 2000-01-28 2001-08-02 Rohm And Haas Company Enhanced propertied pharmaceuticals
US7186855B2 (en) * 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
WO2002100347A2 (en) * 2001-06-11 2002-12-19 Xenoport, Inc. Prodrugs of gaba analogs, compositions and uses thereof
US7232924B2 (en) * 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
EP1485082A4 (de) 2002-02-19 2009-12-30 Xenoport Inc Syntheseverfahren für prodrugs von 1-acyl-alkyl derivaten und ihre zusammensetzungen
PA8579701A1 (es) * 2002-08-23 2005-05-24 Pfizer Prod Inc Profarmaco inhibidor de beta-lactamasa
WO2004108733A1 (en) * 2003-06-05 2004-12-16 Pfizer Products Inc. Beta-lactamase inhibitor prodrug
WO2005010011A2 (en) * 2003-07-15 2005-02-03 Xenoport, Inc. Methods of synthesis of acyloxyalkyl compounds
PT1660440E (pt) * 2003-08-20 2012-05-15 Xenoport Inc Pró-fármacos de aciloxialquilcarbamato, métodos de síntese e utilização
CA2551859C (en) 2003-12-30 2011-10-04 Xenoport, Inc. Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
CN1902175B (zh) * 2003-12-30 2012-08-22 什诺波特有限公司 酰氧基烃基氨基甲酸酯前药及其中间体的合成
NZ564468A (en) 2005-06-20 2011-05-27 Xenoport Inc Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use
TW200820963A (en) * 2006-07-28 2008-05-16 Xenoport Inc Acyloxyalkyl carbamate prodrugs of α-amino acids, methods of synthesis and use
US20090318728A1 (en) * 2008-06-24 2009-12-24 Teva Pharmaceutical Industries Ltd. Processes for preparing prodrugs of gabapentin and intermediates thereof
WO2011028234A1 (en) * 2009-09-04 2011-03-10 Xenoport, Inc. Uses of acyloxyalkyl carbamate prodrugs of tranexamic acid
JP6105207B2 (ja) * 2012-03-30 2017-03-29 美津濃株式会社 ラケットフレーム
US20140024621A1 (en) 2012-07-23 2014-01-23 Ms Therapeutics Limited Aminopyridine compounds and their uses
CN114728883A (zh) * 2020-08-13 2022-07-08 南京海融医药科技股份有限公司 布洛芬酯类前药、药物组合物以及制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3479328A (en) * 1966-11-18 1969-11-18 Ashland Oil Inc Novel monomers and polymers
US3769271A (en) * 1971-04-15 1973-10-30 Lilly Co Eli N-protected amino acids and peptides
FR2363546A1 (fr) * 1976-09-07 1978-03-31 Poudres & Explosifs Ste Nale Monomeres mixtes allyliques-acryliques, leur preparation et polymeres en derivant
DE2939660A1 (de) * 1979-09-29 1981-04-16 Basf Ag, 6700 Ludwigshafen Neue carbamate, ihre herstellung und diese enthaltende pharmazeutische zubereitungen
JPS58189186A (ja) * 1982-04-30 1983-11-04 Takeda Chem Ind Ltd セフアロスポリン誘導体
IL67445A (en) * 1982-12-09 1985-11-29 Teva Pharma Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids
DE3301670A1 (de) * 1983-01-20 1984-07-26 Bayer Ag, 5090 Leverkusen Leimungsmittel
US5221754A (en) * 1989-06-09 1993-06-22 Research Corporation Technologies, Inc. Reagents for rapid peptide synthesis

Also Published As

Publication number Publication date
EP0541550A1 (de) 1993-05-19
DK0541550T3 (da) 1994-10-17
IE64470B1 (en) 1995-08-09
GB9001405D0 (en) 1990-03-21
IE904309A1 (en) 1991-07-31
AU6883191A (en) 1991-08-05
DE69012351T2 (de) 1995-02-09
EP0541550B1 (de) 1994-09-07
CA2064872C (en) 2002-01-22
ATE111073T1 (de) 1994-09-15
CA2064872A1 (en) 1991-07-23
US5401868A (en) 1995-03-28
ES2061077T3 (es) 1994-12-01
HUT60459A (en) 1992-09-28
HU9200477D0 (en) 1992-08-28
WO1991010639A1 (en) 1991-07-25
JP3025532B2 (ja) 2000-03-27
JPH05503925A (ja) 1993-06-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: LEO PHARMA A/S ZWEITNAME: LEO PHARMACEUTICAL PRODU

8339 Ceased/non-payment of the annual fee