ES2061077T3 - Metodo para producir un producto intermedio para la preparacion de promedicamentos. - Google Patents

Metodo para producir un producto intermedio para la preparacion de promedicamentos.

Info

Publication number
ES2061077T3
ES2061077T3 ES90917427T ES90917427T ES2061077T3 ES 2061077 T3 ES2061077 T3 ES 2061077T3 ES 90917427 T ES90917427 T ES 90917427T ES 90917427 T ES90917427 T ES 90917427T ES 2061077 T3 ES2061077 T3 ES 2061077T3
Authority
ES
Spain
Prior art keywords
drugs
producing
preparation
intermediate product
oetos
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90917427T
Other languages
English (en)
Inventor
Frantz Johannes Lund
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharmaceutical Products Ltd AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharmaceutical Products Ltd AS filed Critical Leo Pharmaceutical Products Ltd AS
Application granted granted Critical
Publication of ES2061077T3 publication Critical patent/ES2061077T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
    • C07C329/02—Monothiocarbonic acids; Derivatives thereof
    • C07C329/04—Esters of monothiocarbonic acids
    • C07C329/06—Esters of monothiocarbonic acids having sulfur atoms of thiocarbonic groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/96—Esters of carbonic or haloformic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

LA PRESENTE INVENCION SE REFIERE A LOS INTERMEDIOS HASTA LA FECHA DESCONOCIDOS DE LA FORMULA (I), EN LA QUE R1 REPRESENTA HIDROGENO O CADENAS DE CARBONO C1-C20 ALIFATICAS RAMIFICADAS O NO, O UN GRUPO ARILO O ARALQUILO, DONDE ARILO Y "AR" SIGNIFICAN UN COMPUESTO AROMATICO O HETEROCICLICO, ANILLOS SUSTITUYENTES DE 5 O 6 MIEMBROS CONTENIENDO 10 2 HETEROATOMOS SELECCIONADOS ENTRE O, S Y N, SIENDO OPCIONALMENTE R1 MAS SUSTITUIDO, Y SU CADENA PUEDE ESTAR INTERRUMPIDA POR HETEROATOMOS COMO OXIGENO, O POR GRUPOS CARBONILOS; Y R3 REPRESENTA H O ALQUILOS C1-C3. ESTOS INTERMEDIOS PUEDEN USARSE EN METODOS DE UNA ETAPA PARA PRODUCIR FARMACOS DE LA FORMULA (II), DONDE D-H = FARMACO EN SI MISMO.
ES90917427T 1990-01-22 1990-11-28 Metodo para producir un producto intermedio para la preparacion de promedicamentos. Expired - Lifetime ES2061077T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909001405A GB9001405D0 (en) 1990-01-22 1990-01-22 New intermediates,their production and use

Publications (1)

Publication Number Publication Date
ES2061077T3 true ES2061077T3 (es) 1994-12-01

Family

ID=10669692

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90917427T Expired - Lifetime ES2061077T3 (es) 1990-01-22 1990-11-28 Metodo para producir un producto intermedio para la preparacion de promedicamentos.

Country Status (13)

Country Link
US (1) US5401868A (es)
EP (1) EP0541550B1 (es)
JP (1) JP3025532B2 (es)
AT (1) ATE111073T1 (es)
AU (1) AU6883191A (es)
CA (1) CA2064872C (es)
DE (1) DE69012351T2 (es)
DK (1) DK0541550T3 (es)
ES (1) ES2061077T3 (es)
GB (1) GB9001405D0 (es)
HU (1) HUT60459A (es)
IE (1) IE64470B1 (es)
WO (1) WO1991010639A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2375909A1 (en) 1999-07-19 2001-01-25 Shionogi & Co., Ltd. Tricyclic compounds bearing acyloxymethoxycarbonyl pendants
CN1441790A (zh) * 2000-01-28 2003-09-10 罗姆和哈斯公司 增强性质的药物
US6376548B1 (en) 2000-01-28 2002-04-23 Rohm And Haas Company Enhanced propertied pesticides
US7186855B2 (en) * 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) * 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) * 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
MXPA03011566A (es) * 2001-06-11 2004-10-28 Xenoport Inc Formas de dosificacion de profarmacos de analogos de gaba administrados oralmente que tienen toxicidad reducida.
US6927036B2 (en) * 2002-02-19 2005-08-09 Xero Port, Inc. Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
PA8579701A1 (es) * 2002-08-23 2005-05-24 Pfizer Prod Inc Profarmaco inhibidor de beta-lactamasa
EP1636240A1 (en) * 2003-06-05 2006-03-22 Pfizer Products Inc. Beta-lactamase inhibitor prodrug
US7662987B2 (en) * 2003-07-15 2010-02-16 Xenoport, Inc. Methods for synthesis of acyloxyalkyl compounds
KR101140559B1 (ko) * 2003-08-20 2012-07-05 제노포트 인코포레이티드 아실옥시알킬 카르바메이트 프로드러그, 합성 및 사용 방법
EP1716115B1 (en) 2003-12-30 2013-02-27 XenoPort, Inc. Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
CN101486668B (zh) * 2003-12-30 2014-07-02 什诺波特有限公司 酰氧基烃基氨基甲酸酯前药及其中间体的合成
JP4938771B2 (ja) 2005-06-20 2012-05-23 ゼノポート，インコーポレーテッド トラネキサム酸のカルバミン酸アシルオキシアルキルプロドラッグ、合成法、および使用
US7531572B2 (en) * 2006-07-28 2009-05-12 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of α-amino acids, methods of synthesis and use
TW201014818A (en) * 2008-06-24 2010-04-16 Teva Pharma Processes for preparing prodrugs of gabapentin and intermediates thereof
US20110060040A1 (en) * 2009-09-04 2011-03-10 Xenoport, Inc. Uses of acyloxyalkyl carbamate prodrugs of tranexamic acid
JP6105207B2 (ja) * 2012-03-30 2017-03-29 美津濃株式会社 ラケットフレーム
US20140024621A1 (en) 2012-07-23 2014-01-23 Ms Therapeutics Limited Aminopyridine compounds and their uses
US20230000812A1 (en) * 2020-08-13 2023-01-05 Nanjing Heron Pharmaceutical Science And Technology Co., Ltd. Ibuprofen ester prodrug, pharmaceutical composition, preparation method and application

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3479328A (en) * 1966-11-18 1969-11-18 Ashland Oil Inc Novel monomers and polymers
US3769271A (en) * 1971-04-15 1973-10-30 Lilly Co Eli N-protected amino acids and peptides
FR2363546A1 (fr) * 1976-09-07 1978-03-31 Poudres & Explosifs Ste Nale Monomeres mixtes allyliques-acryliques, leur preparation et polymeres en derivant
DE2939660A1 (de) * 1979-09-29 1981-04-16 Basf Ag, 6700 Ludwigshafen Neue carbamate, ihre herstellung und diese enthaltende pharmazeutische zubereitungen
JPS58189186A (ja) * 1982-04-30 1983-11-04 Takeda Chem Ind Ltd セフアロスポリン誘導体
IL67445A (en) * 1982-12-09 1985-11-29 Teva Pharma Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids
DE3301670A1 (de) * 1983-01-20 1984-07-26 Bayer Ag, 5090 Leverkusen Leimungsmittel
US5221754A (en) * 1989-06-09 1993-06-22 Research Corporation Technologies, Inc. Reagents for rapid peptide synthesis

Also Published As

Publication number Publication date
CA2064872A1 (en) 1991-07-23
DK0541550T3 (da) 1994-10-17
HU9200477D0 (en) 1992-08-28
WO1991010639A1 (en) 1991-07-25
CA2064872C (en) 2002-01-22
EP0541550A1 (en) 1993-05-19
US5401868A (en) 1995-03-28
ATE111073T1 (de) 1994-09-15
JPH05503925A (ja) 1993-06-24
DE69012351T2 (de) 1995-02-09
HUT60459A (en) 1992-09-28
GB9001405D0 (en) 1990-03-21
DE69012351D1 (de) 1994-10-13
EP0541550B1 (en) 1994-09-07
AU6883191A (en) 1991-08-05
JP3025532B2 (ja) 2000-03-27
IE904309A1 (en) 1991-07-31
IE64470B1 (en) 1995-08-09

Similar Documents

Publication Publication Date Title
ES2061077T3 (es) Metodo para producir un producto intermedio para la preparacion de promedicamentos.
ES2013801A6 (es) Procedimiento de preparacion de derivados de 4h-1-benzopiran-4-ona o sus sales.
PT76450B (de) Spiro/4.(3+n)-2-aza-3-carbonsaeure-derivate verfahren zu ihrer herstellung diese enthaltende mittel und ihre verwendung
DK290779A (da) Fremgangsmaade til fremstilling af 1-desoxynojirmycin og n-substituerede derivater deraf
SE8703169D0 (sv) 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5h-2,3-benzodiazepine, acid addition salts thereof and process for preparing same
NO924028D0 (no) Forbedret fremgangsmaate for fremstilling av substituerte indolonderivater
ES544417A0 (es) Procedimiento para preparar 8-alquiltio-2-piperazino-pirimido(5,4-d)pirimidinas.
ES2128554T3 (es) Nuevos derivados del acido glutamico, procedimiento para su preparacion y su utilizacion como medicamentos para el aumento de la memoria y aprendizaje.
DK379281A (da) Azolylalkyl-derivater fremgangsmaade til deres fremstilling og deres anvendelse som fungicider
GB1347467A (en) Process for the preparation of crystal biolet lactone
MX9400165A (es) Derivados de ter-butilergolina, proceso para su produccion y composiciones farmaceuticas que los contienen.
DK0500443T3 (da) Phenylethanolamino- og phenylethanolaminomethyltetraliner, fremgangsmåde til deres fremstilling, mellemprodukter til denne fremgangsmåde og farmaceutiske præparater der indeholder dem
NO873564D0 (no) Nye tyroninderivater.
SE8501988L (sv) Iminotiazolidinderivat
ES2139934T3 (es) Procedimiento mejorado para preparar derivados de cadena lateral de ciclohexapeptidil lipopeptidos.
DK0422751T3 (es)
EP0490224A3 (de) Salicylaldehyd- und Salicylsäurederivate sowie deren Schwefelanaloge, Verfahren und Zwischenprodukte zu ihrer Herstellung
DE69011677D1 (de) Verfahren zur herstellung von substituierten ethenen.
DK469285A (da) Thiadiazolderivater, der indvirker paa centralnervesystemet, fremgangsmaade til fremstilling deraf og midler indeholdende derivaterne
ES550781A0 (es) Un procedimiento para preparar un derivado de 1-benzhidril--4-cinamilpiperazina
SE7611953L (sv) Forfarande for framstellning av aroyl-fenyl-naftalenderivat anvendbara sasom antifertilitets- och antitumormedel
ATE254100T1 (de) Verfahren zur herstellung von guanidinderivaten
ES2036219T3 (es) 2,2; 6,6-dietilen-3-oxo-17alfa-pren-4-en-21,17alfa-carbolactonas, procedimiento para su preparacion y preparados farmaceuticos que las contienen.
PT99378A (pt) Processo para a preparacao de intermediarios uteis para a preparacao de acido 4,5-difluoroantranilico
JPS5618958A (en) Preparation of n- d-alpha-methyl-beta-mercaptopropionyl -l- proline derivative

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 541550

Country of ref document: ES