DK0474243T3 - 1-methylcarbapenemderivater og fremgangsmåde til fremstilling deraf - Google Patents

1-methylcarbapenemderivater og fremgangsmåde til fremstilling deraf

Info

Publication number
DK0474243T3
DK0474243T3 DK91115083T DK91115083T DK0474243T3 DK 0474243 T3 DK0474243 T3 DK 0474243T3 DK 91115083 T DK91115083 T DK 91115083T DK 91115083 T DK91115083 T DK 91115083T DK 0474243 T3 DK0474243 T3 DK 0474243T3
Authority
DK
Denmark
Prior art keywords
preparation
hydrogen atom
methylcarbapenem derivatives
methylcarbapenem
derivatives
Prior art date
Application number
DK91115083T
Other languages
English (en)
Inventor
Tameo Iwasaki
Kazuhiko Kondo
Hiroshi Horikawa
Totaro Yamaguchi
Tadahiro Matsushita
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Application granted granted Critical
Publication of DK0474243T3 publication Critical patent/DK0474243T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DK91115083T 1990-09-07 1991-09-06 1-methylcarbapenemderivater og fremgangsmåde til fremstilling deraf DK0474243T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP23842090 1990-09-07
JP7028591 1991-01-14

Publications (1)

Publication Number Publication Date
DK0474243T3 true DK0474243T3 (da) 1998-12-07

Family

ID=26411452

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91115083T DK0474243T3 (da) 1990-09-07 1991-09-06 1-methylcarbapenemderivater og fremgangsmåde til fremstilling deraf

Country Status (16)

Country Link
US (1) US5153187A (da)
EP (1) EP0474243B1 (da)
JP (1) JPH0745500B2 (da)
KR (1) KR0148379B1 (da)
CN (1) CN1033455C (da)
AT (1) ATE164582T1 (da)
AU (1) AU630574B2 (da)
CA (1) CA2050255C (da)
DE (1) DE69129175T2 (da)
DK (1) DK0474243T3 (da)
ES (1) ES2115600T3 (da)
FI (2) FI95470C (da)
HU (2) HU211122B (da)
IE (1) IE913065A1 (da)
IL (1) IL99399A0 (da)
SG (1) SG49607A1 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU644008B2 (en) * 1990-08-10 1993-12-02 Sumitomo Pharmaceuticals Company, Limited Beta-lactam compounds, and their production and use
JP2569455B2 (ja) * 1992-03-06 1997-01-08 田辺製薬株式会社 β−ラクタム誘導体の製法
EP0937725A3 (en) 1992-04-28 2004-12-01 Tanabe Seiyaku Co., Ltd. Method for removing the protecting group for hydroxy group
US5587474A (en) * 1992-06-18 1996-12-24 Tanabe Seiyaku Co., Ltd. Method for removing the protecting group for carboxyl group
US5631363A (en) * 1992-11-13 1997-05-20 Tanabe Seiyaku Co., Ltd. Azetidinone compound and process for preparation thereof
US6011150A (en) * 1992-11-13 2000-01-04 Tanabe Seiyaku Co., Ltd. Azetidinone compound and process for preparation thereof
US5442055A (en) * 1992-11-13 1995-08-15 Tanabe Seiyaku Co., Ltd. Azetidinone compound and process for preparation thereof
JP2701685B2 (ja) * 1992-12-28 1998-01-21 田辺製薬株式会社 光学活性４−メルカプト−２−ピロリドン誘導体及びその合成中間体の製法
US5495012A (en) * 1992-12-28 1996-02-27 Tanabe Seiyaku Co., Ltd. Process for preparing optically active 4-mercapto-2-pyrrolidone derivative and intermediate therefor
WO1994029313A1 (en) * 1993-06-16 1994-12-22 Sumitomo Pharmaceuticals Company, Limited NOVEL β-LACTAM COMPOUND AND PROCESS FOR PRODUCING THE SAME
US5550229A (en) * 1993-06-23 1996-08-27 Tanabe Seiyaku Co., Ltd. Alkylation process for preparing azetidinone compound and starting compound therefor
AU4596096A (en) * 1994-09-06 1996-03-27 Banyu Pharmaceutical Co., Ltd. Novel carbapenem derivative
JP2969616B2 (ja) 1994-11-24 1999-11-02 田辺製薬株式会社 ４−メルカプトピロリジン化合物の製法
CA2253860A1 (en) 1996-05-09 1997-11-13 Sankyo Company, Limited Anti-helicobacter pylori compositions containing 1-methylcarbapenem derivatives as the active ingredient
JPH1077285A (ja) 1996-09-04 1998-03-24 Sumitomo Pharmaceut Co Ltd 新規なβ−ラクタム化合物およびその製造法
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
CA2465336C (en) * 2001-11-05 2009-04-28 Sumitomo Pharmaceuticals Co., Ltd. Novel carbapenem compounds
WO2004089954A1 (ja) 2003-04-08 2004-10-21 Sumitomo Pharmaceuticals Co., Ltd. 新規なカルバペネム化合物
US20070265242A1 (en) * 2004-09-03 2007-11-15 Makoto Sunagawa Novel Carbapenem Compound
US20090029964A1 (en) * 2005-03-25 2009-01-29 Makoto Sunagawa Novel carbapenem compound

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60202886A (ja) * 1984-03-27 1985-10-14 Sankyo Co Ltd １―置換カルバペネム―３―カルボン酸誘導体
KR880006244A (ko) * 1986-11-24 1988-07-22 후지사와 도모 기찌 로 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법
DE68919508T2 (de) * 1988-04-01 1995-07-20 Sankyo Co 2-(Heterocyclylthio)carbapenemderivate, deren Herstellung und deren Verwendung als Antibiotika.

Also Published As

Publication number Publication date
JPH04279588A (ja) 1992-10-05
SG49607A1 (en) 1998-06-15
FI914187A (fi) 1992-03-08
IE913065A1 (en) 1992-03-11
FI95470C (fi) 1996-02-12
HUT59410A (en) 1992-05-28
CA2050255C (en) 1997-02-04
EP0474243B1 (en) 1998-04-01
CN1033455C (zh) 1996-12-04
ES2115600T3 (es) 1998-07-01
FI914187A0 (fi) 1991-09-05
US5153187A (en) 1992-10-06
FI952101A0 (fi) 1995-05-03
ATE164582T1 (de) 1998-04-15
AU8347991A (en) 1992-03-12
JPH0745500B2 (ja) 1995-05-17
CA2050255A1 (en) 1992-03-08
DE69129175D1 (de) 1998-05-07
CN1060093A (zh) 1992-04-08
EP0474243A1 (en) 1992-03-11
HU211122B (en) 1995-10-30
HU912884D0 (en) 1992-01-28
AU630574B2 (en) 1992-10-29
FI952101A (fi) 1995-05-03
KR0148379B1 (ko) 1998-11-02
FI95470B (fi) 1995-10-31
IL99399A0 (en) 1992-08-18
KR920006358A (ko) 1992-04-27
FI100399B (fi) 1997-11-28
DE69129175T2 (de) 1998-09-03
HU211892A9 (en) 1995-12-28

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