DE69912984D1 - Derivate des 6-(4-phenylbutoxy)hexylamins und verfahren zur herstellung von salmeterol - Google Patents

Derivate des 6-(4-phenylbutoxy)hexylamins und verfahren zur herstellung von salmeterol

Info

Publication number
DE69912984D1
DE69912984D1 DE69912984T DE69912984T DE69912984D1 DE 69912984 D1 DE69912984 D1 DE 69912984D1 DE 69912984 T DE69912984 T DE 69912984T DE 69912984 T DE69912984 T DE 69912984T DE 69912984 D1 DE69912984 D1 DE 69912984D1
Authority
DE
Germany
Prior art keywords
general formula
phenylbutoxy
hexylamine
derivatives
aralkyloxycarbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69912984T
Other languages
English (en)
Inventor
Bellmunt Jordi Bessa
Barjoan Pere Dalmases
Olondriz Francisco Marquillas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Vita SA
Original Assignee
Laboratorios Vita SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Vita SA filed Critical Laboratorios Vita SA
Application granted granted Critical
Publication of DE69912984D1 publication Critical patent/DE69912984D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/40—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the same carbon atom of the carbon skeleton, e.g. amino-ketals, ortho esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE69912984T 1998-09-28 1999-09-20 Derivate des 6-(4-phenylbutoxy)hexylamins und verfahren zur herstellung von salmeterol Expired - Lifetime DE69912984D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009802014A ES2142771B1 (es) 1998-09-28 1998-09-28 Nuevos derivados de la 6-(4-fenil-butoxi) hexilamina y procedimiento para la obtencion de salmeterol.
PCT/ES1999/000294 WO2000018722A2 (es) 1998-09-28 1999-09-20 Nuevos derivados de la 6-(4-fenilbutoxi)hexilamina y procedimiento para la obtencion de salmeterol

Publications (1)

Publication Number Publication Date
DE69912984D1 true DE69912984D1 (de) 2003-12-24

Family

ID=8305274

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69912984T Expired - Lifetime DE69912984D1 (de) 1998-09-28 1999-09-20 Derivate des 6-(4-phenylbutoxy)hexylamins und verfahren zur herstellung von salmeterol

Country Status (24)

Country Link
US (1) US6388134B1 (de)
EP (1) EP1132373B1 (de)
JP (1) JP3786834B2 (de)
KR (1) KR100479256B1 (de)
CN (1) CN1189446C (de)
AT (1) ATE254596T1 (de)
AU (1) AU756042B2 (de)
BR (1) BR9913989A (de)
CA (1) CA2344647C (de)
CZ (2) CZ296902B6 (de)
DE (1) DE69912984D1 (de)
EA (1) EA003397B1 (de)
ES (2) ES2142771B1 (de)
HU (1) HUP0103969A3 (de)
IL (1) IL141991A (de)
IS (1) IS2016B (de)
NO (2) NO327780B1 (de)
NZ (1) NZ511157A (de)
OA (1) OA11660A (de)
PL (1) PL196116B1 (de)
PT (1) PT1132373E (de)
SK (1) SK284366B6 (de)
TR (1) TR200100862T2 (de)
WO (1) WO2000018722A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6835857B2 (en) 2002-03-05 2004-12-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Process for the manufacture of 4-(6-bromohexyloxy)-butylbenzene
DE10209583B4 (de) * 2002-03-05 2006-01-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von 4-(6-Bromhexyloxy)-butylbenzol
JP5599974B2 (ja) * 2005-10-17 2014-10-01 ジェネリクス・［ユーケー］・リミテッド 新規な方法
ES2288114B1 (es) * 2006-04-26 2008-12-01 Quimica Sintetica S.A. Nuevo procedimiento de sintesis de (6-(4-fenilbutoxi)hexil)aminas n-sustituidas y su uso en la sintesis de salmeterol xinafoato.
EP2127641A1 (de) 2008-05-26 2009-12-02 Inke, S.A. Mikronisierbare Form von Salmeterolxinafoat
CN101712622B (zh) * 2009-11-10 2012-10-03 浙江万里学院 抗哮喘药物沙美特罗的制备方法
CN103435505A (zh) * 2013-09-05 2013-12-11 南京工业大学 一种合成(r)-沙美特罗的方法
US9447067B2 (en) * 2014-10-03 2016-09-20 Amphastar Pahmaceuticals, Inc. Method of preparing intermediate of salmeterol
KR20230001708U (ko) 2022-02-17 2023-08-24 유기택 재접착식 슬림 평면형 액자

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZW6584A1 (en) * 1983-04-18 1985-04-17 Glaxo Group Ltd Phenethanolamine derivatives
AU581887B2 (en) * 1984-04-17 1989-03-09 Glaxo Group Limited Ethanolamine compounds
ES2065269B1 (es) * 1993-05-11 1995-10-01 S A L V A T Lab Sa 6-(4-(fenilbutoxi) hexilaminometil-4-hidroxi-a1,a3-bencenodimetanol. procedimiento para la obtencion del mismo y nuevos intermedios utilizados en su preparacion.

Also Published As

Publication number Publication date
ES2142771B1 (es) 2001-01-01
CZ296901B6 (cs) 2006-07-12
KR20010079948A (ko) 2001-08-22
EP1132373B1 (de) 2003-11-19
SK284366B6 (sk) 2005-02-04
HUP0103969A2 (hu) 2002-05-29
NO20084343L (no) 2001-03-28
HUP0103969A3 (en) 2003-05-28
CA2344647A1 (en) 2000-04-06
KR100479256B1 (ko) 2005-03-30
NO327780B1 (no) 2009-09-21
JP3786834B2 (ja) 2006-06-14
EP1132373A2 (de) 2001-09-12
NO20011197L (no) 2001-03-28
OA11660A (en) 2004-12-08
TR200100862T2 (tr) 2001-07-23
CZ296902B6 (cs) 2006-07-12
AU5983999A (en) 2000-04-17
IL141991A (en) 2004-03-28
EA200100391A1 (ru) 2001-10-22
CN1320114A (zh) 2001-10-31
IL141991A0 (en) 2002-03-10
AU756042B2 (en) 2003-01-02
CN1189446C (zh) 2005-02-16
US6388134B1 (en) 2002-05-14
IS2016B (is) 2005-06-15
JP2002525349A (ja) 2002-08-13
CZ2001958A3 (cs) 2001-08-15
EA003397B1 (ru) 2003-04-24
NO20011197D0 (no) 2001-03-08
ES2212672T3 (es) 2004-07-16
ES2142771A1 (es) 2000-04-16
BR9913989A (pt) 2001-06-19
ATE254596T1 (de) 2003-12-15
CA2344647C (en) 2005-07-05
PL196116B1 (pl) 2007-12-31
NZ511157A (en) 2002-12-20
WO2000018722A2 (es) 2000-04-06
IS5880A (is) 2001-03-08
PT1132373E (pt) 2004-03-31
WO2000018722A3 (es) 2000-07-06
SK3862001A3 (en) 2002-09-10
PL348572A1 (en) 2002-06-03

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