TR200100862T2 - Yeni 6-(4-fenilbütoksi) heksilamin türevleri ve salmeterolün elde edilme işlemi. - Google Patents

Yeni 6-(4-fenilbütoksi) heksilamin türevleri ve salmeterolün elde edilme işlemi.

Info

Publication number
TR200100862T2
TR200100862T2 TR2001/00862T TR200100862T TR200100862T2 TR 200100862 T2 TR200100862 T2 TR 200100862T2 TR 2001/00862 T TR2001/00862 T TR 2001/00862T TR 200100862 T TR200100862 T TR 200100862T TR 200100862 T2 TR200100862 T2 TR 200100862T2
Authority
TR
Turkey
Prior art keywords
phenylbutoxy
salmeterol
derivatives
general formula
obtaining new
Prior art date
Application number
TR2001/00862T
Other languages
English (en)
Inventor
Bessa Bellmunt Jordi
Dalmases Barjoan Pere
Marquillas Olondriz Francisco
Original Assignee
Vita-Invest, S.A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vita-Invest, S.A filed Critical Vita-Invest, S.A
Publication of TR200100862T2 publication Critical patent/TR200100862T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/40—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the same carbon atom of the carbon skeleton, e.g. amino-ketals, ortho esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Bu bulus genel formülün (I) yeni 6-(4-fenilbütoksi)heksilamin türevleri ve bunun elde edilmesi ile ilgilidir: Burada:(Formül I) -R1'in R3 ve R4'ün bagimsiz olarak C1-C6 alkil, aralkil oldugu veya 5 veya 6 üyeli siklik asetal olusturduklari CHO veya CHOR3OR4'dür ve -R2'in H, benzil veya alkiloksikarbonil,ariloksikarbonil, aralkiloksikarbonil veya bir akil gruptur. Ayni zamanda bu bulus, genel formülün (13) organometalik bilesiminin reaksiyonun R1'in CHO ve R2'in alkiloksikarbonil, ariloksikarbonil, aralkiloksikarbonil veya akil grup oldugu genel formülün (I) sentetik bir ara maddesi ile düsük bir isida atil bir solvent içinde gerçeklestirildigi seklinde karakterize edilen salmeterolün veya farmasötik açidan kabul edilen tuzlarinin elde edilmesi ile ilgilidir.
TR2001/00862T 1998-09-28 1999-09-20 Yeni 6-(4-fenilbütoksi) heksilamin türevleri ve salmeterolün elde edilme işlemi. TR200100862T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009802014A ES2142771B1 (es) 1998-09-28 1998-09-28 Nuevos derivados de la 6-(4-fenil-butoxi) hexilamina y procedimiento para la obtencion de salmeterol.

Publications (1)

Publication Number Publication Date
TR200100862T2 true TR200100862T2 (tr) 2001-07-23

Family

ID=8305274

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/00862T TR200100862T2 (tr) 1998-09-28 1999-09-20 Yeni 6-(4-fenilbütoksi) heksilamin türevleri ve salmeterolün elde edilme işlemi.

Country Status (24)

Country Link
US (1) US6388134B1 (tr)
EP (1) EP1132373B1 (tr)
JP (1) JP3786834B2 (tr)
KR (1) KR100479256B1 (tr)
CN (1) CN1189446C (tr)
AT (1) ATE254596T1 (tr)
AU (1) AU756042B2 (tr)
BR (1) BR9913989A (tr)
CA (1) CA2344647C (tr)
CZ (2) CZ296902B6 (tr)
DE (1) DE69912984D1 (tr)
EA (1) EA003397B1 (tr)
ES (2) ES2142771B1 (tr)
HU (1) HUP0103969A3 (tr)
IL (1) IL141991A (tr)
IS (1) IS2016B (tr)
NO (2) NO327780B1 (tr)
NZ (1) NZ511157A (tr)
OA (1) OA11660A (tr)
PL (1) PL196116B1 (tr)
PT (1) PT1132373E (tr)
SK (1) SK284366B6 (tr)
TR (1) TR200100862T2 (tr)
WO (1) WO2000018722A2 (tr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6835857B2 (en) 2002-03-05 2004-12-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Process for the manufacture of 4-(6-bromohexyloxy)-butylbenzene
DE10209583B4 (de) * 2002-03-05 2006-01-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von 4-(6-Bromhexyloxy)-butylbenzol
JP5599974B2 (ja) * 2005-10-17 2014-10-01 ジェネリクス・［ユーケー］・リミテッド 新規な方法
ES2288114B1 (es) * 2006-04-26 2008-12-01 Quimica Sintetica S.A. Nuevo procedimiento de sintesis de (6-(4-fenilbutoxi)hexil)aminas n-sustituidas y su uso en la sintesis de salmeterol xinafoato.
EP2127641A1 (en) 2008-05-26 2009-12-02 Inke, S.A. Micronisable form of salmeterol xinafoate
CN101712622B (zh) * 2009-11-10 2012-10-03 浙江万里学院 抗哮喘药物沙美特罗的制备方法
CN103435505A (zh) * 2013-09-05 2013-12-11 南京工业大学 一种合成(r)-沙美特罗的方法
US9447067B2 (en) * 2014-10-03 2016-09-20 Amphastar Pahmaceuticals, Inc. Method of preparing intermediate of salmeterol
KR20230001708U (ko) 2022-02-17 2023-08-24 유기택 재접착식 슬림 평면형 액자

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZW6584A1 (en) * 1983-04-18 1985-04-17 Glaxo Group Ltd Phenethanolamine derivatives
AU581887B2 (en) * 1984-04-17 1989-03-09 Glaxo Group Limited Ethanolamine compounds
ES2065269B1 (es) * 1993-05-11 1995-10-01 S A L V A T Lab Sa 6-(4-(fenilbutoxi) hexilaminometil-4-hidroxi-a1,a3-bencenodimetanol. procedimiento para la obtencion del mismo y nuevos intermedios utilizados en su preparacion.

Also Published As

Publication number Publication date
ES2142771B1 (es) 2001-01-01
CZ296901B6 (cs) 2006-07-12
KR20010079948A (ko) 2001-08-22
EP1132373B1 (en) 2003-11-19
SK284366B6 (sk) 2005-02-04
HUP0103969A2 (hu) 2002-05-29
NO20084343L (no) 2001-03-28
HUP0103969A3 (en) 2003-05-28
CA2344647A1 (en) 2000-04-06
KR100479256B1 (ko) 2005-03-30
NO327780B1 (no) 2009-09-21
JP3786834B2 (ja) 2006-06-14
EP1132373A2 (en) 2001-09-12
NO20011197L (no) 2001-03-28
OA11660A (en) 2004-12-08
CZ296902B6 (cs) 2006-07-12
AU5983999A (en) 2000-04-17
IL141991A (en) 2004-03-28
EA200100391A1 (ru) 2001-10-22
CN1320114A (zh) 2001-10-31
IL141991A0 (en) 2002-03-10
AU756042B2 (en) 2003-01-02
CN1189446C (zh) 2005-02-16
US6388134B1 (en) 2002-05-14
IS2016B (is) 2005-06-15
JP2002525349A (ja) 2002-08-13
CZ2001958A3 (cs) 2001-08-15
EA003397B1 (ru) 2003-04-24
NO20011197D0 (no) 2001-03-08
ES2212672T3 (es) 2004-07-16
ES2142771A1 (es) 2000-04-16
BR9913989A (pt) 2001-06-19
ATE254596T1 (de) 2003-12-15
CA2344647C (en) 2005-07-05
PL196116B1 (pl) 2007-12-31
DE69912984D1 (de) 2003-12-24
NZ511157A (en) 2002-12-20
WO2000018722A2 (es) 2000-04-06
IS5880A (is) 2001-03-08
PT1132373E (pt) 2004-03-31
WO2000018722A3 (es) 2000-07-06
SK3862001A3 (en) 2002-09-10
PL348572A1 (en) 2002-06-03

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