NO20084343L - Fremgangsmate for fremstilling av 6-(4-fenylbutoksy)heksylaminderivater - Google Patents

Fremgangsmate for fremstilling av 6-(4-fenylbutoksy)heksylaminderivater

Info

Publication number
NO20084343L
NO20084343L NO20084343A NO20084343A NO20084343L NO 20084343 L NO20084343 L NO 20084343L NO 20084343 A NO20084343 A NO 20084343A NO 20084343 A NO20084343 A NO 20084343A NO 20084343 L NO20084343 L NO 20084343L
Authority
NO
Norway
Prior art keywords
phenylbutoxy
preparation
hexylamine
derivatives
benzyl
Prior art date
Application number
NO20084343A
Other languages
English (en)
Inventor
Francisco Marquillas Olondriz
Pere Dalmases Barjoan
Jordi Bessa Bellmunt
Original Assignee
Inke Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO20084343L publication Critical patent/NO20084343L/no
Application filed by Inke Sa filed Critical Inke Sa

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/40—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the same carbon atom of the carbon skeleton, e.g. amino-ketals, ortho esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Foreliggende oppfinnelse omhandler en fremgangsmåte for fremskaffelse av derivater av 6-(4-fenylbutoksy)heksylamin med den generelle formelen (I): (I) der: R, er CHO eller CHOR3OR4, der R3 og R4 uavhengig er metyl, etyl, benzyl, eller de danner enten 1,3-dioksolaner eller 1,3-dioksaner; og R2 er H, benzyl eller tert-butoksykarbonyl, benzyloksykarbonyl, etoksykarbonyl, acetyl, benzoyl eller trifluoracetyl.
NO20084343A 1998-09-28 2008-10-16 Fremgangsmate for fremstilling av 6-(4-fenylbutoksy)heksylaminderivater NO20084343L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009802014A ES2142771B1 (es) 1998-09-28 1998-09-28 Nuevos derivados de la 6-(4-fenil-butoxi) hexilamina y procedimiento para la obtencion de salmeterol.
PCT/ES1999/000294 WO2000018722A2 (es) 1998-09-28 1999-09-20 Nuevos derivados de la 6-(4-fenilbutoxi)hexilamina y procedimiento para la obtencion de salmeterol

Publications (1)

Publication Number Publication Date
NO20084343L true NO20084343L (no) 2001-03-28

Family

ID=8305274

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20011197A NO327780B1 (no) 1998-09-28 2001-03-08 Nye 6-(4-fenylbutoksy)heksylamin derivater og fremgangsmate for fremstilling av salmeterol
NO20084343A NO20084343L (no) 1998-09-28 2008-10-16 Fremgangsmate for fremstilling av 6-(4-fenylbutoksy)heksylaminderivater

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20011197A NO327780B1 (no) 1998-09-28 2001-03-08 Nye 6-(4-fenylbutoksy)heksylamin derivater og fremgangsmate for fremstilling av salmeterol

Country Status (24)

Country Link
US (1) US6388134B1 (no)
EP (1) EP1132373B1 (no)
JP (1) JP3786834B2 (no)
KR (1) KR100479256B1 (no)
CN (1) CN1189446C (no)
AT (1) ATE254596T1 (no)
AU (1) AU756042B2 (no)
BR (1) BR9913989A (no)
CA (1) CA2344647C (no)
CZ (2) CZ296902B6 (no)
DE (1) DE69912984D1 (no)
EA (1) EA003397B1 (no)
ES (2) ES2142771B1 (no)
HU (1) HUP0103969A3 (no)
IL (1) IL141991A (no)
IS (1) IS2016B (no)
NO (2) NO327780B1 (no)
NZ (1) NZ511157A (no)
OA (1) OA11660A (no)
PL (1) PL196116B1 (no)
PT (1) PT1132373E (no)
SK (1) SK284366B6 (no)
TR (1) TR200100862T2 (no)
WO (1) WO2000018722A2 (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6835857B2 (en) 2002-03-05 2004-12-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Process for the manufacture of 4-(6-bromohexyloxy)-butylbenzene
DE10209583B4 (de) * 2002-03-05 2006-01-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von 4-(6-Bromhexyloxy)-butylbenzol
JP5599974B2 (ja) * 2005-10-17 2014-10-01 ジェネリクス・［ユーケー］・リミテッド 新規な方法
ES2288114B1 (es) * 2006-04-26 2008-12-01 Quimica Sintetica S.A. Nuevo procedimiento de sintesis de (6-(4-fenilbutoxi)hexil)aminas n-sustituidas y su uso en la sintesis de salmeterol xinafoato.
EP2127641A1 (en) 2008-05-26 2009-12-02 Inke, S.A. Micronisable form of salmeterol xinafoate
CN101712622B (zh) * 2009-11-10 2012-10-03 浙江万里学院 抗哮喘药物沙美特罗的制备方法
CN103435505A (zh) * 2013-09-05 2013-12-11 南京工业大学 一种合成(r)-沙美特罗的方法
US9447067B2 (en) * 2014-10-03 2016-09-20 Amphastar Pahmaceuticals, Inc. Method of preparing intermediate of salmeterol
KR20230001708U (ko) 2022-02-17 2023-08-24 유기택 재접착식 슬림 평면형 액자

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZW6584A1 (en) * 1983-04-18 1985-04-17 Glaxo Group Ltd Phenethanolamine derivatives
AU581887B2 (en) * 1984-04-17 1989-03-09 Glaxo Group Limited Ethanolamine compounds
ES2065269B1 (es) * 1993-05-11 1995-10-01 S A L V A T Lab Sa 6-(4-(fenilbutoxi) hexilaminometil-4-hidroxi-a1,a3-bencenodimetanol. procedimiento para la obtencion del mismo y nuevos intermedios utilizados en su preparacion.

Also Published As

Publication number Publication date
ES2142771B1 (es) 2001-01-01
CZ296901B6 (cs) 2006-07-12
KR20010079948A (ko) 2001-08-22
EP1132373B1 (en) 2003-11-19
SK284366B6 (sk) 2005-02-04
HUP0103969A2 (hu) 2002-05-29
HUP0103969A3 (en) 2003-05-28
CA2344647A1 (en) 2000-04-06
KR100479256B1 (ko) 2005-03-30
NO327780B1 (no) 2009-09-21
JP3786834B2 (ja) 2006-06-14
EP1132373A2 (en) 2001-09-12
NO20011197L (no) 2001-03-28
OA11660A (en) 2004-12-08
TR200100862T2 (tr) 2001-07-23
CZ296902B6 (cs) 2006-07-12
AU5983999A (en) 2000-04-17
IL141991A (en) 2004-03-28
EA200100391A1 (ru) 2001-10-22
CN1320114A (zh) 2001-10-31
IL141991A0 (en) 2002-03-10
AU756042B2 (en) 2003-01-02
CN1189446C (zh) 2005-02-16
US6388134B1 (en) 2002-05-14
IS2016B (is) 2005-06-15
JP2002525349A (ja) 2002-08-13
CZ2001958A3 (cs) 2001-08-15
EA003397B1 (ru) 2003-04-24
NO20011197D0 (no) 2001-03-08
ES2212672T3 (es) 2004-07-16
ES2142771A1 (es) 2000-04-16
BR9913989A (pt) 2001-06-19
ATE254596T1 (de) 2003-12-15
CA2344647C (en) 2005-07-05
PL196116B1 (pl) 2007-12-31
DE69912984D1 (de) 2003-12-24
NZ511157A (en) 2002-12-20
WO2000018722A2 (es) 2000-04-06
IS5880A (is) 2001-03-08
PT1132373E (pt) 2004-03-31
WO2000018722A3 (es) 2000-07-06
SK3862001A3 (en) 2002-09-10
PL348572A1 (en) 2002-06-03

Similar Documents

Publication Publication Date Title
NO20084343L (no) Fremgangsmate for fremstilling av 6-(4-fenylbutoksy)heksylaminderivater
DE69705829D1 (de) Meta-substituierte phenylsulphonamidderivate
DK0594291T3 (da) Fremgangsmåder til fremstilling af 13-etherderivater af milbemyciner og mellemprodukter dertil
ES2158537T3 (es) Derivados de acidos ciclopropilalcanoicos.
DK164903C (da) Substituerede imidazolderivater og fremgangsmaader til fremstilling deraf
NL300202I1 (nl) Nucleotide-analogen.
DE69025529T2 (de) Weitere antivirale Pyrimidin-Nukleosiden
DE69514823T2 (de) Polyanionische benzyl-glykosiden als inhibitoren zur glatten-muskelzellen-proliferation
MY103801A (en) Dideoxydidehydrocarbocyclic nucleosides
ATE277062T1 (de) Neue makrolidderivate
DK283487D0 (da) Thiazolyl-2-yl-imidazo(1,2-a)pyrimidiner, deres fremstilling og brug
FI914015A0 (fi) Menetelmä farmaseuttisesti aktiivisten 7-substituoitu-2-amino-3,5-dihydro-4H-pyrrolo/3,2-d/pyrimidin-4-onien valmistamiseksi
ES8800920A1 (es) Un procedimiento para preparar un derivado de 1,5-benzotiazepina
PL287073A1 (en) Method of obtaining novel derivatives of benzanilide
ATE198746T1 (de) Pyrimidinderivate und pharmazeutische zusammensetzungen
DK0906295T3 (da) Dibenzo-oxazepin- og -dioxepinderivater og deres anvendelse som anti-tumormidler
DE69914880D1 (de) Substituierte 5-(2,2difluor-1,3-benzodioxol-5-yl) cyclopentenopyridinderivate
IL83216A (en) 1((5-(10->9)abeo-6-methylergolin-8beta-yl)methyl)-imidazolidine-(and hexahydropyrimidine)-2,4-dione derivatives,their preparation and pharmaceutical compositions containing them
FR2611713B1 (fr) Nouveaux derives de l'acide (dihydro-2,3 oxo-2 benzofurannyl-3)-2 acetique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
HUT53093A (en) Process for producing substituted 3-amino-sidnonimine derivatives and pharmaceutical compositions them as active components
FI922518A (fi) Menetelmä farmaseuttisesti käyttökelpoisten pilokarpiinijohdannaisten valmistamiseksi

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application