DK0906295T3 - Dibenzo-oxazepin- og -dioxepinderivater og deres anvendelse som anti-tumormidler - Google Patents

Dibenzo-oxazepin- og -dioxepinderivater og deres anvendelse som anti-tumormidler

Info

Publication number
DK0906295T3
DK0906295T3 DK97927080T DK97927080T DK0906295T3 DK 0906295 T3 DK0906295 T3 DK 0906295T3 DK 97927080 T DK97927080 T DK 97927080T DK 97927080 T DK97927080 T DK 97927080T DK 0906295 T3 DK0906295 T3 DK 0906295T3
Authority
DK
Denmark
Prior art keywords
lower alkyl
tumor agents
oxazepine
dibenzo
substituted
Prior art date
Application number
DK97927080T
Other languages
English (en)
Inventor
Urvashi Hooda Dhingra
Haruyoshi Shirai
Yuki Takehana
Peter Michael Wovkulich
Nami Yabuki
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK0906295T3 publication Critical patent/DK0906295T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D267/00Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02Seven-membered rings
    • C07D267/08Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/16Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D267/20[b, f]-condensed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D321/00Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/02Seven-membered rings
    • C07D321/10Seven-membered rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/08Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/14Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Motorcycle And Bicycle Frame (AREA)
  • Rehabilitation Tools (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK97927080T 1996-06-07 1997-05-30 Dibenzo-oxazepin- og -dioxepinderivater og deres anvendelse som anti-tumormidler DK0906295T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96109115 1996-06-07
PCT/EP1997/002806 WO1997047611A1 (en) 1996-06-07 1997-05-30 Dibenzo-oxazepine and -dioxepine derivatives and their use as anti-tumor agents

Publications (1)

Publication Number Publication Date
DK0906295T3 true DK0906295T3 (da) 2002-02-11

Family

ID=8222857

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97927080T DK0906295T3 (da) 1996-06-07 1997-05-30 Dibenzo-oxazepin- og -dioxepinderivater og deres anvendelse som anti-tumormidler

Country Status (30)

Country Link
US (1) US5811420A (da)
EP (1) EP0906295B1 (da)
JP (1) JP3199752B2 (da)
KR (1) KR100300152B1 (da)
CN (1) CN1072650C (da)
AT (1) ATE207471T1 (da)
AU (1) AU725649B2 (da)
BR (1) BR9709773A (da)
CA (1) CA2257422A1 (da)
CO (1) CO4940487A1 (da)
CZ (1) CZ397498A3 (da)
DE (1) DE69707672T2 (da)
DK (1) DK0906295T3 (da)
ES (1) ES2166087T3 (da)
HK (1) HK1019063A1 (da)
HR (1) HRP970313A2 (da)
HU (1) HUP0001792A3 (da)
IL (1) IL127137A0 (da)
MA (1) MA24197A1 (da)
NO (1) NO985685L (da)
NZ (1) NZ332997A (da)
PE (1) PE69598A1 (da)
PL (1) PL330346A1 (da)
PT (1) PT906295E (da)
RU (1) RU2167871C2 (da)
TR (1) TR199802517T2 (da)
UY (1) UY24578A1 (da)
WO (1) WO1997047611A1 (da)
YU (1) YU55898A (da)
ZA (1) ZA974886B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPQ307399A0 (en) * 1999-09-24 1999-10-21 Luminis Pty Limited Cell cycle control
CA2404540A1 (en) * 2002-09-20 2004-03-20 Institut Pasteur A method for measuring a marker indicative of the exposure of a patient to nicotine; a kit for measuring such a marker
US20130203715A1 (en) 2010-07-20 2013-08-08 Pulmatrix, Inc. Use of trp channel agonists to treat infections
CN109722389B (zh) * 2017-10-31 2021-05-14 鲁南新时代生物技术有限公司 一种烟曲霉菌液体培养基
CN108165590B (zh) * 2017-12-20 2021-11-23 河南科技学院 一种烟曲霉发酵产烟曲霉素的培养基及培养方法
WO2022187611A1 (en) * 2021-03-04 2022-09-09 Lifemine Therapeutics Cdk inhibitor compounds for use in methods of treatment

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9120640D0 (en) * 1991-09-27 1991-11-06 Ici Plc Tricyclic heterocycles
US5350763A (en) * 1993-06-11 1994-09-27 Merck & Co., Inc. Unguinol and analogs are animal growth permittants
JPH0769882A (ja) * 1993-08-27 1995-03-14 Nippon Paint Co Ltd エプスタイン−バーウィルス活性化抑制剤
DE69429440T2 (de) * 1993-10-15 2002-08-08 Schering Corp., Kenilworth Tricyclische sulfonamide-derivate zur inhibierung der g-protein funktion und fur die bekandlung von proliferativen erkrantungen

Also Published As

Publication number Publication date
CN1072650C (zh) 2001-10-10
HRP970313A2 (en) 1998-04-30
CA2257422A1 (en) 1997-12-18
MA24197A1 (fr) 1997-12-31
YU55898A (sh) 2001-12-26
KR20000016432A (ko) 2000-03-25
PL330346A1 (en) 1999-05-10
BR9709773A (pt) 1999-08-10
DE69707672T2 (de) 2002-08-08
HUP0001792A2 (hu) 2000-12-28
NO985685D0 (no) 1998-12-04
IL127137A0 (en) 1999-09-22
KR100300152B1 (ko) 2001-09-06
EP0906295A1 (en) 1999-04-07
HK1019063A1 (en) 2000-01-21
RU2167871C2 (ru) 2001-05-27
CZ397498A3 (cs) 1999-03-17
ZA974886B (en) 1997-12-08
AU725649B2 (en) 2000-10-19
ES2166087T3 (es) 2002-04-01
US5811420A (en) 1998-09-22
HUP0001792A3 (en) 2001-10-29
PE69598A1 (es) 1998-11-14
NZ332997A (en) 2000-05-26
NO985685L (no) 1999-02-04
CO4940487A1 (es) 2000-07-24
UY24578A1 (es) 2000-12-29
DE69707672D1 (de) 2001-11-29
JP3199752B2 (ja) 2001-08-20
TR199802517T2 (xx) 1999-02-22
WO1997047611A1 (en) 1997-12-18
AU3169697A (en) 1998-01-07
ATE207471T1 (de) 2001-11-15
EP0906295B1 (en) 2001-10-24
JPH11511760A (ja) 1999-10-12
CN1221409A (zh) 1999-06-30
PT906295E (pt) 2002-04-29

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