NO982606L - Naftylsubstituerte benzimidazolderivater som antikoagulanter - Google Patents

Naftylsubstituerte benzimidazolderivater som antikoagulanter

Info

Publication number
NO982606L
NO982606L NO982606A NO982606A NO982606L NO 982606 L NO982606 L NO 982606L NO 982606 A NO982606 A NO 982606A NO 982606 A NO982606 A NO 982606A NO 982606 L NO982606 L NO 982606L
Authority
NO
Norway
Prior art keywords
anticoagulants
benzimidazole derivatives
naphthyl substituted
substituted benzimidazole
naphthyl
Prior art date
Application number
NO982606A
Other languages
English (en)
Other versions
NO312673B1 (no
NO982606D0 (no
Inventor
Damian O Arnaiz
Brian D Griedel
Stephen T Sakata
Kenneth J Shaw
Zunchan Zhao
Original Assignee
Berlex Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berlex Lab filed Critical Berlex Lab
Publication of NO982606D0 publication Critical patent/NO982606D0/no
Publication of NO982606L publication Critical patent/NO982606L/no
Publication of NO312673B1 publication Critical patent/NO312673B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
NO19982606A 1995-12-08 1998-06-05 Naftylsubstituerte benzimidazolderivater som antikoagulanter, farmasöytisk preparat inneholdende disse, og anvendelse avforbindelsene for fremstilling av et medikament NO312673B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/570,057 US5849759A (en) 1995-12-08 1995-12-08 Naphthyl-substituted benzimidazole derivatives as anti-coagulants
PCT/IB1996/001496 WO1997021437A1 (en) 1995-12-08 1996-12-05 Naphthyl-substituted benzimidazole derivatives as anticoagulants

Publications (3)

Publication Number Publication Date
NO982606D0 NO982606D0 (no) 1998-06-05
NO982606L true NO982606L (no) 1998-08-10
NO312673B1 NO312673B1 (no) 2002-06-17

Family

ID=24278023

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19982606A NO312673B1 (no) 1995-12-08 1998-06-05 Naftylsubstituerte benzimidazolderivater som antikoagulanter, farmasöytisk preparat inneholdende disse, og anvendelse avforbindelsene for fremstilling av et medikament

Country Status (23)

Country Link
US (1) US5849759A (no)
EP (1) EP0865281B1 (no)
JP (1) JP2000502082A (no)
KR (1) KR19990071974A (no)
CN (1) CN1110305C (no)
AT (1) ATE215371T1 (no)
CZ (1) CZ177698A3 (no)
DE (1) DE69620443T2 (no)
DK (1) DK0865281T3 (no)
ES (1) ES2175179T3 (no)
HK (1) HK1018208A1 (no)
HU (1) HUP9904066A3 (no)
IL (1) IL124537A (no)
MX (1) MX9804597A (no)
NO (1) NO312673B1 (no)
NZ (1) NZ325449A (no)
PL (1) PL327169A1 (no)
PT (1) PT865281E (no)
RU (1) RU98112597A (no)
SK (1) SK282767B6 (no)
UA (1) UA49869C2 (no)
WO (1) WO1997021437A1 (no)
ZA (1) ZA9610315B (no)

Families Citing this family (80)

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AU707323B2 (en) 1995-03-10 1999-07-08 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
US5994375A (en) * 1996-02-12 1999-11-30 Berlex Laboratories, Inc. Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants
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US6372759B1 (en) * 1997-06-26 2002-04-16 Eli Lilly And Company Antithrombotic agents
US6150379A (en) * 1997-11-26 2000-11-21 Axys Pharmaceuticals, Inc. Compounds and compositions as anticoagulants
DE19753522A1 (de) * 1997-12-03 1999-06-10 Boehringer Ingelheim Pharma Substituierte Indole, ihre Herstellung und ihre Verwendung als Arzneimittel
US6686364B2 (en) 1997-12-08 2004-02-03 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
US6140351A (en) * 1997-12-19 2000-10-31 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
JP3811006B2 (ja) 1997-12-19 2006-08-16 シエーリング アクチエンゲゼルシャフト 抗凝血物質類としてのオルト−アントラニルアミド誘導体類
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Also Published As

Publication number Publication date
EP0865281A1 (en) 1998-09-23
KR19990071974A (ko) 1999-09-27
US5849759A (en) 1998-12-15
ZA9610315B (en) 1997-06-17
RU98112597A (ru) 2000-10-20
EP0865281B1 (en) 2002-04-03
HK1018208A1 (en) 1999-12-17
SK74698A3 (en) 1998-12-02
NO312673B1 (no) 2002-06-17
IL124537A0 (en) 1998-12-06
NZ325449A (en) 2000-01-28
DE69620443T2 (de) 2002-11-28
WO1997021437A1 (en) 1997-06-19
AU1395697A (en) 1997-07-03
HUP9904066A3 (en) 2001-11-28
PT865281E (pt) 2002-09-30
ATE215371T1 (de) 2002-04-15
SK282767B6 (sk) 2002-12-03
JP2000502082A (ja) 2000-02-22
DK0865281T3 (da) 2002-07-29
EP0865281A4 (en) 1999-07-28
NO982606D0 (no) 1998-06-05
PL327169A1 (en) 1998-11-23
DE69620443D1 (de) 2002-05-08
MX9804597A (es) 1998-10-31
AU700894B2 (en) 1999-01-14
HUP9904066A2 (hu) 2000-03-28
ES2175179T3 (es) 2002-11-16
CZ177698A3 (cs) 1998-09-16
CN1110305C (zh) 2003-06-04
IL124537A (en) 2002-04-21
CN1209062A (zh) 1999-02-24
UA49869C2 (uk) 2002-10-15

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