DE69828390D1 - Diaminotrifluoromethylpyrimidinderivate enthaltende antikrebs-zusammensetzung - Google Patents
Diaminotrifluoromethylpyrimidinderivate enthaltende antikrebs-zusammensetzungInfo
- Publication number
- DE69828390D1 DE69828390D1 DE69828390T DE69828390T DE69828390D1 DE 69828390 D1 DE69828390 D1 DE 69828390D1 DE 69828390 T DE69828390 T DE 69828390T DE 69828390 T DE69828390 T DE 69828390T DE 69828390 D1 DE69828390 D1 DE 69828390D1
- Authority
- DE
- Germany
- Prior art keywords
- composition
- diaminotrifluoromethylpyrimidin
- anticreasic
- derivatives
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- MEHAREFZRGNRJP-UHFFFAOYSA-N 2-(trifluoromethyl)pyrimidine-4,6-diamine Chemical class NC1=CC(N)=NC(C(F)(F)F)=N1 MEHAREFZRGNRJP-UHFFFAOYSA-N 0.000 title 1
- UVPXDGMMAFWHMJ-UHFFFAOYSA-N 2-(trifluoromethyl)pyridine-3,4-diamine Chemical class NC1=CC=NC(C(F)(F)F)=C1N UVPXDGMMAFWHMJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000006254 cycloalkyl carbonyl group Chemical group 0.000 abstract 1
- -1 furancarbonyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6008397 | 1997-02-28 | ||
| JP6008397 | 1997-02-28 | ||
| PCT/JP1998/000776 WO1998037887A1 (en) | 1997-02-28 | 1998-02-26 | Anticancer composition comprising a diaminotrifluoromethylpyridine derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69828390D1 true DE69828390D1 (de) | 2005-02-03 |
| DE69828390T2 DE69828390T2 (de) | 2005-06-02 |
Family
ID=13131845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69828390T Expired - Lifetime DE69828390T2 (de) | 1997-02-28 | 1998-02-26 | Antikrebs-zusammensetzung |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6197796B1 (de) |
| EP (1) | EP0971711B1 (de) |
| KR (1) | KR20000075769A (de) |
| CN (1) | CN1111407C (de) |
| AT (1) | ATE285771T1 (de) |
| AU (1) | AU731274B2 (de) |
| CA (1) | CA2280744A1 (de) |
| DE (1) | DE69828390T2 (de) |
| TW (1) | TW415843B (de) |
| WO (1) | WO1998037887A1 (de) |
| ZA (1) | ZA981430B (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60134626D1 (de) | 2000-01-31 | 2008-08-14 | Ishihara Sangyo Kaisha | Heilmittel und vorbeugende mittel für verdauungserkrankungen die diaminotrifluoromethylpyridinverbindungen enthalten |
| EP1252891B1 (de) * | 2000-02-01 | 2005-10-05 | Ishihara Sangyo Kaisha, Ltd. | Verwendung von DIAMINOTRIFLUOROMETHYLPYRIDINDERIVATEn für die Prevention und Behandlung von Lebererkrankungen |
| JP4848092B2 (ja) | 2000-02-01 | 2011-12-28 | 石原産業株式会社 | ジアミノトリフルオロメチルピリジン誘導体を含有する肺不全の治療剤又は予防剤 |
| WO2004040302A1 (ja) * | 2002-10-30 | 2004-05-13 | Ishihara Sangyo Kaisha, Ltd. | ＲＡＰＬ・Ｒａｐ１相互作用制御 |
| CN103183812B (zh) | 2005-04-22 | 2016-03-02 | 三菱化学株式会社 | 来自生物质资源的聚酯及其制造方法 |
| DE102008015424A1 (de) * | 2008-03-20 | 2009-09-24 | Beiersdorf Ag | Kühlende kosmetische oder dermatologische Zubereitungen mit einem Gehalt an (1R,2S,5R)-2-Isopropyl-5-methyl-N-(2-(pyridyn-2-yl)ethyl-cyclohexancarboxamid und/oder (1R,2S,5R)-N-(4-(Cyanomethyl)-phenyl)-2-isopropyl-5- methylcyclohexancarboxamid mit Menthoxypropandiol |
| JP5584518B2 (ja) | 2009-05-28 | 2014-09-03 | 石原産業株式会社 | ジアミノトリフルオロメチルピリジン誘導体を含有する抗ショック剤 |
| TWI858061B (zh) | 2019-05-15 | 2024-10-11 | 日商石原產業股份有限公司 | Ｎ－（２－乙基磺醯基胺基－５－三氟甲基－３－吡啶基）環己烷羧醯胺．一鈉鹽之無水合物結晶體 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE157969T1 (de) * | 1990-07-10 | 1997-09-15 | Ishihara Sangyo Kaisha | Diaminotrifluoromethylpyrimidinderivate, verfahren zu ihrer herstellung und diese enthaltende phospholipase-a2-inhibitoren |
| US5229403A (en) * | 1990-07-10 | 1993-07-20 | Ishihara Sangyo Kaisha Ltd. | Diaminotrifluoromethylpyridine derivatives and phospholipase A2 inhibitor containing them |
-
1998
- 1998-02-20 ZA ZA981430A patent/ZA981430B/xx unknown
- 1998-02-20 TW TW087102406A patent/TW415843B/zh not_active IP Right Cessation
- 1998-02-26 AU AU61163/98A patent/AU731274B2/en not_active Ceased
- 1998-02-26 DE DE69828390T patent/DE69828390T2/de not_active Expired - Lifetime
- 1998-02-26 WO PCT/JP1998/000776 patent/WO1998037887A1/en not_active Ceased
- 1998-02-26 US US09/355,957 patent/US6197796B1/en not_active Expired - Lifetime
- 1998-02-26 AT AT98905653T patent/ATE285771T1/de not_active IP Right Cessation
- 1998-02-26 EP EP98905653A patent/EP0971711B1/de not_active Expired - Lifetime
- 1998-02-26 KR KR1019997007841A patent/KR20000075769A/ko not_active Ceased
- 1998-02-26 CN CN98802776A patent/CN1111407C/zh not_active Expired - Fee Related
- 1998-02-26 CA CA002280744A patent/CA2280744A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2280744A1 (en) | 1998-09-03 |
| US6197796B1 (en) | 2001-03-06 |
| TW415843B (en) | 2000-12-21 |
| WO1998037887A1 (en) | 1998-09-03 |
| DE69828390T2 (de) | 2005-06-02 |
| EP0971711A1 (de) | 2000-01-19 |
| CN1248166A (zh) | 2000-03-22 |
| EP0971711B1 (de) | 2004-12-29 |
| KR20000075769A (ko) | 2000-12-26 |
| ATE285771T1 (de) | 2005-01-15 |
| AU6116398A (en) | 1998-09-18 |
| AU731274B2 (en) | 2001-03-29 |
| ZA981430B (en) | 1998-08-24 |
| CN1111407C (zh) | 2003-06-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |