HUP0001792A2 - Dibenzo-oxazepin- és -dioxepin-származékok, és felhasználásuk tumorellenes szerként - Google Patents
Dibenzo-oxazepin- és -dioxepin-származékok, és felhasználásuk tumorellenes szerkéntInfo
- Publication number
- HUP0001792A2 HUP0001792A2 HU0001792A HUP0001792A HUP0001792A2 HU P0001792 A2 HUP0001792 A2 HU P0001792A2 HU 0001792 A HU0001792 A HU 0001792A HU P0001792 A HUP0001792 A HU P0001792A HU P0001792 A2 HUP0001792 A2 HU P0001792A2
- Authority
- HU
- Hungary
- Prior art keywords
- lower alkyl
- alkyl group
- substituted
- group
- oxazepine
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 241000228212 Aspergillus Species 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D267/20—[b, f]-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/02—Seven-membered rings
- C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Motorcycle And Bicycle Frame (AREA)
- Rehabilitation Tools (AREA)
Abstract
Az (I) általános képletű vegyületek (mely képletben R1 és R2 jelentéseegymástól függetlenül hidrogénatom, helyettesítetlen kis szénatomszámúalkilcsoport, kis szénatomszámú alkoxi- vagy kis szénatomszámú alkil-tio-csoporttal helyettesített kis szénatomszámú alkilcsoport, vagyacilcsoport, amely helyettesítetlen vagy egy vagy több kisszénatomszámú alkilcsoporttal, halogénatommal helyettesített kisszénatomszámú alkilcsoporttal és/vagy kis szénatomszámúalkoxicsoporttal helyettesítve lehet; X jelentése -CO- vagy -CHOH-; Yjelentése -CO- vagy -CH2-; és Z jelentése -O- vagy -NH-) és epimerjeikés enantiomerjeik, valamint gyógyászatilag alkalmas sóik tumorellenesszerként alkalmazhatók. A fenti vegyületeket valamely Aspergillusnemzetségbe tartozó mikroorganizmus fermentációjával és kívánt esetbenfunkcionális csoportok utólagos módosításával állítják elő. Ó
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96109115 | 1996-06-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0001792A2 true HUP0001792A2 (hu) | 2000-12-28 |
| HUP0001792A3 HUP0001792A3 (en) | 2001-10-29 |
Family
ID=8222857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0001792A HUP0001792A3 (en) | 1996-06-07 | 1997-05-30 | Dibenzo-oxazepine and-dioxepine derivatives and their use as anti-tumor agents |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US5811420A (hu) |
| EP (1) | EP0906295B1 (hu) |
| JP (1) | JP3199752B2 (hu) |
| KR (1) | KR100300152B1 (hu) |
| CN (1) | CN1072650C (hu) |
| AT (1) | ATE207471T1 (hu) |
| AU (1) | AU725649B2 (hu) |
| BR (1) | BR9709773A (hu) |
| CA (1) | CA2257422A1 (hu) |
| CO (1) | CO4940487A1 (hu) |
| CZ (1) | CZ397498A3 (hu) |
| DE (1) | DE69707672T2 (hu) |
| DK (1) | DK0906295T3 (hu) |
| ES (1) | ES2166087T3 (hu) |
| HK (1) | HK1019063A1 (hu) |
| HR (1) | HRP970313A2 (hu) |
| HU (1) | HUP0001792A3 (hu) |
| IL (1) | IL127137A0 (hu) |
| MA (1) | MA24197A1 (hu) |
| NO (1) | NO985685L (hu) |
| NZ (1) | NZ332997A (hu) |
| PE (1) | PE69598A1 (hu) |
| PL (1) | PL330346A1 (hu) |
| PT (1) | PT906295E (hu) |
| RU (1) | RU2167871C2 (hu) |
| TR (1) | TR199802517T2 (hu) |
| UY (1) | UY24578A1 (hu) |
| WO (1) | WO1997047611A1 (hu) |
| YU (1) | YU55898A (hu) |
| ZA (1) | ZA974886B (hu) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ307399A0 (en) * | 1999-09-24 | 1999-10-21 | Luminis Pty Limited | Cell cycle control |
| US20040058310A1 (en) * | 2002-09-20 | 2004-03-25 | Grailhe Regls Christian | Method for measuring a marker indicative of the exposure of a patient to nicotine; a kit for measuring such a marker |
| US20130203715A1 (en) | 2010-07-20 | 2013-08-08 | Pulmatrix, Inc. | Use of trp channel agonists to treat infections |
| CN109722389B (zh) * | 2017-10-31 | 2021-05-14 | 鲁南新时代生物技术有限公司 | 一种烟曲霉菌液体培养基 |
| CN108165590B (zh) * | 2017-12-20 | 2021-11-23 | 河南科技学院 | 一种烟曲霉发酵产烟曲霉素的培养基及培养方法 |
| WO2022187611A1 (en) * | 2021-03-04 | 2022-09-09 | Lifemine Therapeutics | Cdk inhibitor compounds for use in methods of treatment |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9120640D0 (en) * | 1991-09-27 | 1991-11-06 | Ici Plc | Tricyclic heterocycles |
| US5350763A (en) * | 1993-06-11 | 1994-09-27 | Merck & Co., Inc. | Unguinol and analogs are animal growth permittants |
| JPH0769882A (ja) * | 1993-08-27 | 1995-03-14 | Nippon Paint Co Ltd | エプスタイン−バーウィルス活性化抑制剤 |
| AU698960B2 (en) * | 1993-10-15 | 1998-11-12 | Schering Corporation | Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
-
1997
- 1997-05-30 TR TR1998/02517T patent/TR199802517T2/xx unknown
- 1997-05-30 DE DE69707672T patent/DE69707672T2/de not_active Expired - Fee Related
- 1997-05-30 IL IL12713797A patent/IL127137A0/xx not_active IP Right Cessation
- 1997-05-30 CN CN97195242A patent/CN1072650C/zh not_active Expired - Fee Related
- 1997-05-30 DK DK97927080T patent/DK0906295T3/da active
- 1997-05-30 ES ES97927080T patent/ES2166087T3/es not_active Expired - Lifetime
- 1997-05-30 WO PCT/EP1997/002806 patent/WO1997047611A1/en not_active Application Discontinuation
- 1997-05-30 PE PE1997000457A patent/PE69598A1/es not_active Application Discontinuation
- 1997-05-30 RU RU99100107/04A patent/RU2167871C2/ru not_active IP Right Cessation
- 1997-05-30 PL PL97330346A patent/PL330346A1/xx unknown
- 1997-05-30 YU YU55898A patent/YU55898A/sh unknown
- 1997-05-30 CA CA002257422A patent/CA2257422A1/en not_active Abandoned
- 1997-05-30 AU AU31696/97A patent/AU725649B2/en not_active Ceased
- 1997-05-30 JP JP50112498A patent/JP3199752B2/ja not_active Expired - Fee Related
- 1997-05-30 HU HU0001792A patent/HUP0001792A3/hu unknown
- 1997-05-30 CZ CZ983974A patent/CZ397498A3/cs unknown
- 1997-05-30 BR BR9709773A patent/BR9709773A/pt not_active Application Discontinuation
- 1997-05-30 KR KR1019980710016A patent/KR100300152B1/ko not_active IP Right Cessation
- 1997-05-30 AT AT97927080T patent/ATE207471T1/de not_active IP Right Cessation
- 1997-05-30 NZ NZ332997A patent/NZ332997A/xx unknown
- 1997-05-30 PT PT97927080T patent/PT906295E/pt unknown
- 1997-05-30 EP EP97927080A patent/EP0906295B1/en not_active Expired - Lifetime
- 1997-06-03 ZA ZA9704886A patent/ZA974886B/xx unknown
- 1997-06-05 UY UY24578A patent/UY24578A1/es unknown
- 1997-06-05 CO CO97031203A patent/CO4940487A1/es unknown
- 1997-06-05 MA MA24647A patent/MA24197A1/fr unknown
- 1997-06-06 HR HR96109115.4A patent/HRP970313A2/xx not_active Application Discontinuation
- 1997-06-06 US US08/870,798 patent/US5811420A/en not_active Expired - Fee Related
-
1998
- 1998-12-04 NO NO985685A patent/NO985685L/no not_active Application Discontinuation
-
1999
- 1999-09-22 HK HK99104107A patent/HK1019063A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU5114893A (en) | Novel method of esterification of baccatine iii an 10-deacetylbaccatine iii | |
| CA2369099A1 (en) | Anticonvulsant derivatives useful in reducing blood glucose levels | |
| ES8704905A1 (es) | Un procedimiento para la preparacion de nuevos derivados de ciclopenta (d) pirimidina. | |
| CA2291619A1 (en) | Liquid benz-iso-quinoline derivatives | |
| NO304114B1 (no) | Taxanderivater og fremstilling derav | |
| ATE13178T1 (de) | 2-oxoazetidin-derivate, ihre herstellung und verwendung. | |
| HUP0001792A2 (hu) | Dibenzo-oxazepin- és -dioxepin-származékok, és felhasználásuk tumorellenes szerként | |
| DE69719511D1 (de) | Antivirale 2,4-pyrimidindion-derivate und verfahren zu ihrer herstellung | |
| NZ325259A (en) | Phospholipid derivatives of phosphono-carboxylic acids, the production of said derivatives and the use of said derivatives as antiviral medicaments | |
| BG104034A (en) | Method for the preparation of pharmaceutical compounds of antidepressive effect and against the parkinson syndrome effect | |
| ES2056194T3 (es) | Compuestos tetraciclicos antidepresivos. | |
| CA2355098A1 (en) | Chroman derivatives | |
| HUP9903806A2 (hu) | Eljárás kolchicionid vegyületek biológiai átalakítására a megfelelő 3-glikozil-származékokká | |
| DE3566263D1 (de) | Novel cyanoimidazole nucleoside derivatives | |
| HUP9802495A2 (hu) | Eljárás formil-imidazol-származékok előállítására | |
| WO2001012642A3 (de) | Nucleosidderivate und verfahren zu deren herstellung | |
| AU2102600A (en) | Method for producing optically active 1-amino-4-(hydroxymethyl)-cyclopent-2-ene derivatives | |
| HUP0100505A2 (hu) | Eljárás klórbenzoxazolok előállítására | |
| MY102247A (en) | Phosphorylated acylglycosides, their preparation and use |