ES8704905A1 - Un procedimiento para la preparacion de nuevos derivados de ciclopenta (d) pirimidina. - Google Patents
Un procedimiento para la preparacion de nuevos derivados de ciclopenta (d) pirimidina.Info
- Publication number
- ES8704905A1 ES8704905A1 ES552796A ES552796A ES8704905A1 ES 8704905 A1 ES8704905 A1 ES 8704905A1 ES 552796 A ES552796 A ES 552796A ES 552796 A ES552796 A ES 552796A ES 8704905 A1 ES8704905 A1 ES 8704905A1
- Authority
- ES
- Spain
- Prior art keywords
- cyclopenta
- preparation
- pyrimidine derivatives
- hydrogen
- acyloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Dental Preparations (AREA)
- Hydrogenated Pyridines (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Luminescent Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Soil Working Implements (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Eyeglasses (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE UN COMPUESTO DE FORMULA (I) Y DE SUS SALES Y ESTERES. COMPRENDE LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN AGENTE OXIDANTE, TAL COMO UN PERACIDO O PEROXIDO DE HIDROGENO; SEGUIDA DEL TRATAMIENTO DEL DERIVADO N-OXIDO FORMADO CON UN ANHIDRIDO DE FORMULA (R6)2O PARA FORMAR EL COMPUESTO DE FORMULA (I), EN LA QUE X ES HALOGENO Y R2 Y R6 PUEDEN SER VARIOS TIPOS DE RADICALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LA DEPRESION MENTAL.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4362685 | 1985-03-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES552796A0 ES552796A0 (es) | 1987-04-16 |
ES8704905A1 true ES8704905A1 (es) | 1987-04-16 |
Family
ID=12669058
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES552796A Expired ES8704905A1 (es) | 1985-03-07 | 1986-03-07 | Un procedimiento para la preparacion de nuevos derivados de ciclopenta (d) pirimidina. |
ES557198A Expired ES8801221A1 (es) | 1985-03-07 | 1986-11-14 | Un procedimiento para la preparacion de nuevos derivados de ciclopenta(d)pirimidina |
ES557199A Expired ES8801222A1 (es) | 1985-03-07 | 1986-11-14 | Un procedimiento para la preparacion de nuevos derivados de ciclopenta(d)pirimidina |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES557198A Expired ES8801221A1 (es) | 1985-03-07 | 1986-11-14 | Un procedimiento para la preparacion de nuevos derivados de ciclopenta(d)pirimidina |
ES557199A Expired ES8801222A1 (es) | 1985-03-07 | 1986-11-14 | Un procedimiento para la preparacion de nuevos derivados de ciclopenta(d)pirimidina |
Country Status (15)
Country | Link |
---|---|
US (1) | US4749704A (es) |
EP (1) | EP0194161B1 (es) |
JP (1) | JPS6270A (es) |
KR (1) | KR890003839B1 (es) |
AT (1) | ATE106077T1 (es) |
AU (1) | AU580391B2 (es) |
CA (1) | CA1273632A (es) |
DE (1) | DE3689848T2 (es) |
DK (1) | DK165109C (es) |
ES (3) | ES8704905A1 (es) |
FI (1) | FI88717C (es) |
HK (1) | HK1005450A1 (es) |
IE (1) | IE64504B1 (es) |
NO (1) | NO168767C (es) |
ZA (1) | ZA861708B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5037980A (en) * | 1988-04-18 | 1991-08-06 | American Cyanamid Company | Phenyl imidazo[1,2-a]pyrimidines |
US5877178A (en) * | 1991-04-08 | 1999-03-02 | Duquesne University Of The Holy Ghost | Pyrimidine derivatives and methods of making and using these derivatives |
US5234936A (en) * | 1991-10-24 | 1993-08-10 | American Home Products Corporation | Pyrimidocycloalkanes as a ii antagonists |
WO2005014557A1 (en) * | 2003-08-12 | 2005-02-17 | F.Hoffmann-La Roche Ag | Tetrahydroquinazoline derivatives as cfr antagonists |
EP1942069A4 (en) | 2005-10-26 | 2013-01-09 | Mitsubishi Electric Corp | ELEVATOR GROUP MANAGEMENT AND CONTROL APPARATUS |
AU2007269052B2 (en) | 2006-07-06 | 2014-10-23 | Array Biopharma Inc. | Cyclopenta [D] pyrimidines as AKT protein kinase inhibitors |
SI2054418T1 (sl) | 2006-07-06 | 2012-02-29 | Array Biopharma Inc | Dihidrotieno pirimidini kot AKT protein kinazni inhibitorji |
ATE493418T1 (de) | 2006-07-06 | 2011-01-15 | Array Biopharma Inc | Dihydrofuropyrimidine als akt- proteinkinaseinhibitoren |
US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
WO2008021456A2 (en) * | 2006-08-16 | 2008-02-21 | Cytovia, Inc. | N-aryl-5,7-dihydrofuro[3,4-d]pyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
ES2533557T3 (es) | 2007-07-05 | 2015-04-13 | Array Biopharma, Inc. | Pirimidil ciclopentanos como inhibidores de proteína cinasa AKT |
RU2486181C2 (ru) | 2007-07-05 | 2013-06-27 | Эррэй Биофарма Инк. | Пиримидилциклопентаны как ингибиторы акт-протеинкиназ |
US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
WO2009089459A1 (en) | 2008-01-09 | 2009-07-16 | Array Biopharma Inc. | Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors |
MX2010007546A (es) | 2008-01-09 | 2010-09-30 | Array Biopharma Inc | Pirimidil ciclopentanos hidroxilados en forma de inhibidores de akt proteína quinasa. |
DE112009002588B4 (de) | 2008-10-20 | 2019-08-14 | Mitsubishi Electric Corporation | Aufzuggruppenverwaltungssystem |
US9150549B2 (en) | 2011-04-01 | 2015-10-06 | Genentech, Inc. | Combinations of AKT inhibitor compounds and erlotinib, and methods of use |
TR201815685T4 (tr) | 2011-04-01 | 2018-11-21 | Genentech Inc | Kanser tedavisi için akt ve mek inhibe edici bileşiklerin kombinasyonları. |
GB201121127D0 (en) | 2011-12-08 | 2012-01-18 | Dow Corning | Treatment of filler with silane |
CN111303053B (zh) * | 2020-03-16 | 2023-01-17 | 中国海洋大学 | 环戊并[d]嘧啶类化合物及其药学上可接受的盐、溶剂合物或者前药以及应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3470182A (en) * | 1967-02-09 | 1969-09-30 | Sandoz Ag | 4-amino-substituted quinazolines |
US3980650A (en) * | 1972-05-05 | 1976-09-14 | N.V. Koninklijke Pharmaceutische Fabrieken V/H Brocades-Stheeman En Pharmacia | 4-Amino-pyrimidine derivatives |
US3915976A (en) * | 1972-09-01 | 1975-10-28 | Sandoz Ag | Substituted-4-phenyl-5h-cycloalkano(d)pyrimidines |
PH20344A (en) * | 1981-01-29 | 1986-12-04 | Sankyo Co | Aminopyrimidine derivatives, processes for their preparation, and fungicidal, insecticidal and acaricidal compositions containing them |
JPS57203072A (en) * | 1981-06-05 | 1982-12-13 | Sankyo Co Ltd | 4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient |
-
1986
- 1986-03-06 US US06/837,079 patent/US4749704A/en not_active Expired - Lifetime
- 1986-03-06 JP JP61049238A patent/JPS6270A/ja not_active Withdrawn
- 1986-03-07 IE IE59786A patent/IE64504B1/en not_active IP Right Cessation
- 1986-03-07 EP EP86301660A patent/EP0194161B1/en not_active Expired - Lifetime
- 1986-03-07 DK DK106586A patent/DK165109C/da not_active IP Right Cessation
- 1986-03-07 DE DE3689848T patent/DE3689848T2/de not_active Expired - Fee Related
- 1986-03-07 NO NO860852A patent/NO168767C/no unknown
- 1986-03-07 CA CA000503571A patent/CA1273632A/en not_active Expired - Lifetime
- 1986-03-07 AT AT86301660T patent/ATE106077T1/de not_active IP Right Cessation
- 1986-03-07 ZA ZA861708A patent/ZA861708B/xx unknown
- 1986-03-07 ES ES552796A patent/ES8704905A1/es not_active Expired
- 1986-03-07 FI FI860969A patent/FI88717C/fi not_active IP Right Cessation
- 1986-03-07 AU AU54481/86A patent/AU580391B2/en not_active Ceased
- 1986-03-07 KR KR1019860001624A patent/KR890003839B1/ko not_active IP Right Cessation
- 1986-11-14 ES ES557198A patent/ES8801221A1/es not_active Expired
- 1986-11-14 ES ES557199A patent/ES8801222A1/es not_active Expired
-
1998
- 1998-05-27 HK HK98104569A patent/HK1005450A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA1273632A (en) | 1990-09-04 |
ES552796A0 (es) | 1987-04-16 |
DK165109C (da) | 1993-03-01 |
KR860007221A (ko) | 1986-10-08 |
AU5448186A (en) | 1986-09-11 |
ZA861708B (en) | 1986-11-26 |
KR890003839B1 (ko) | 1989-10-05 |
EP0194161A2 (en) | 1986-09-10 |
NO168767B (no) | 1991-12-23 |
DK165109B (da) | 1992-10-12 |
US4749704A (en) | 1988-06-07 |
FI88717C (fi) | 1993-06-28 |
DE3689848T2 (de) | 1995-01-12 |
ES557199A0 (es) | 1988-01-01 |
NO168767C (no) | 1992-04-01 |
NO860852L (no) | 1986-09-08 |
HK1005450A1 (en) | 1999-01-08 |
FI88717B (fi) | 1993-03-15 |
ES557198A0 (es) | 1988-01-01 |
ES8801221A1 (es) | 1988-01-01 |
IE64504B1 (en) | 1995-08-09 |
DK106586A (da) | 1986-09-08 |
DE3689848D1 (de) | 1994-06-30 |
DK106586D0 (da) | 1986-03-07 |
AU580391B2 (en) | 1989-01-12 |
FI860969A0 (fi) | 1986-03-07 |
JPS6270A (ja) | 1987-01-06 |
ATE106077T1 (de) | 1994-06-15 |
ES8801222A1 (es) | 1988-01-01 |
EP0194161B1 (en) | 1994-05-25 |
EP0194161A3 (en) | 1987-09-02 |
IE860597L (en) | 1986-09-07 |
FI860969A (fi) | 1986-09-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20010226 |