UY24578A1 - Derivados de dibenzo-oxazepinas y -dioxepinas utiles como agentes antitumorales - Google Patents

Derivados de dibenzo-oxazepinas y -dioxepinas utiles como agentes antitumorales

Info

Publication number
UY24578A1
UY24578A1 UY24578A UY24578A UY24578A1 UY 24578 A1 UY24578 A1 UY 24578A1 UY 24578 A UY24578 A UY 24578A UY 24578 A UY24578 A UY 24578A UY 24578 A1 UY24578 A1 UY 24578A1
Authority
UY
Uruguay
Prior art keywords
oxazepine
dibenzo
derivatives useful
antitumoral agents
dioxepine
Prior art date
Application number
UY24578A
Other languages
English (en)
Inventor
Urvashi Hooda Dhingra
Haroyoshi Shirai
Yuki Takehana
Peter Michael Wovkulich
Nami Yabuki
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of UY24578A1 publication Critical patent/UY24578A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D267/20—[b, f]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/02—Seven-membered rings
    • C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Motorcycle And Bicycle Frame (AREA)
  • Rehabilitation Tools (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Las nuevas fungarrestinas de fórmula general (I), donde r1 y r2 son independientemente, hidrógeno, alquilo-inferior o acilo; x es CO ó CHOH; Y es CO ó CH2; y Z es O ó NH, y las sales de las mismas fisiológicamente utlilizables, pueden ser empleadas como agentes antitumorales. Pueden ser preparadas por fermentación de Aspergillus sp. y, opcionalmente, por modificación subsiguiente de grupos funcionales.
UY24578A 1996-06-07 1997-06-05 Derivados de dibenzo-oxazepinas y -dioxepinas utiles como agentes antitumorales UY24578A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96109115 1996-06-07

Publications (1)

Publication Number Publication Date
UY24578A1 true UY24578A1 (es) 2000-12-29

Family

ID=8222857

Family Applications (1)

Application Number Title Priority Date Filing Date
UY24578A UY24578A1 (es) 1996-06-07 1997-06-05 Derivados de dibenzo-oxazepinas y -dioxepinas utiles como agentes antitumorales

Country Status (30)

Country Link
US (1) US5811420A (es)
EP (1) EP0906295B1 (es)
JP (1) JP3199752B2 (es)
KR (1) KR100300152B1 (es)
CN (1) CN1072650C (es)
AT (1) ATE207471T1 (es)
AU (1) AU725649B2 (es)
BR (1) BR9709773A (es)
CA (1) CA2257422A1 (es)
CO (1) CO4940487A1 (es)
CZ (1) CZ397498A3 (es)
DE (1) DE69707672T2 (es)
DK (1) DK0906295T3 (es)
ES (1) ES2166087T3 (es)
HK (1) HK1019063A1 (es)
HR (1) HRP970313A2 (es)
HU (1) HUP0001792A3 (es)
IL (1) IL127137A0 (es)
MA (1) MA24197A1 (es)
NO (1) NO985685L (es)
NZ (1) NZ332997A (es)
PE (1) PE69598A1 (es)
PL (1) PL330346A1 (es)
PT (1) PT906295E (es)
RU (1) RU2167871C2 (es)
TR (1) TR199802517T2 (es)
UY (1) UY24578A1 (es)
WO (1) WO1997047611A1 (es)
YU (1) YU55898A (es)
ZA (1) ZA974886B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPQ307399A0 (en) * 1999-09-24 1999-10-21 Luminis Pty Limited Cell cycle control
CA2404540A1 (en) * 2002-09-20 2004-03-20 Institut Pasteur A method for measuring a marker indicative of the exposure of a patient to nicotine; a kit for measuring such a marker
US20130203715A1 (en) 2010-07-20 2013-08-08 Pulmatrix, Inc. Use of trp channel agonists to treat infections
CN109722389B (zh) * 2017-10-31 2021-05-14 鲁南新时代生物技术有限公司 一种烟曲霉菌液体培养基
CN108165590B (zh) * 2017-12-20 2021-11-23 河南科技学院 一种烟曲霉发酵产烟曲霉素的培养基及培养方法
WO2022187611A1 (en) * 2021-03-04 2022-09-09 Lifemine Therapeutics Cdk inhibitor compounds for use in methods of treatment

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9120640D0 (en) * 1991-09-27 1991-11-06 Ici Plc Tricyclic heterocycles
US5350763A (en) * 1993-06-11 1994-09-27 Merck & Co., Inc. Unguinol and analogs are animal growth permittants
JPH0769882A (ja) * 1993-08-27 1995-03-14 Nippon Paint Co Ltd エプスタイン−バーウィルス活性化抑制剤
DE69429440T2 (de) * 1993-10-15 2002-08-08 Schering Corp., Kenilworth Tricyclische sulfonamide-derivate zur inhibierung der g-protein funktion und fur die bekandlung von proliferativen erkrantungen

Also Published As

Publication number Publication date
CN1072650C (zh) 2001-10-10
HRP970313A2 (en) 1998-04-30
CA2257422A1 (en) 1997-12-18
MA24197A1 (fr) 1997-12-31
YU55898A (sh) 2001-12-26
KR20000016432A (ko) 2000-03-25
PL330346A1 (en) 1999-05-10
BR9709773A (pt) 1999-08-10
DE69707672T2 (de) 2002-08-08
HUP0001792A2 (hu) 2000-12-28
NO985685D0 (no) 1998-12-04
IL127137A0 (en) 1999-09-22
KR100300152B1 (ko) 2001-09-06
EP0906295A1 (en) 1999-04-07
HK1019063A1 (en) 2000-01-21
RU2167871C2 (ru) 2001-05-27
CZ397498A3 (cs) 1999-03-17
ZA974886B (en) 1997-12-08
AU725649B2 (en) 2000-10-19
ES2166087T3 (es) 2002-04-01
US5811420A (en) 1998-09-22
HUP0001792A3 (en) 2001-10-29
PE69598A1 (es) 1998-11-14
DK0906295T3 (da) 2002-02-11
NZ332997A (en) 2000-05-26
NO985685L (no) 1999-02-04
CO4940487A1 (es) 2000-07-24
DE69707672D1 (de) 2001-11-29
JP3199752B2 (ja) 2001-08-20
TR199802517T2 (xx) 1999-02-22
WO1997047611A1 (en) 1997-12-18
AU3169697A (en) 1998-01-07
ATE207471T1 (de) 2001-11-15
EP0906295B1 (en) 2001-10-24
JPH11511760A (ja) 1999-10-12
CN1221409A (zh) 1999-06-30
PT906295E (pt) 2002-04-29

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