IT1270660B - Procedimento microbiologico per la preparazione di 3-oxo-4-azasteroidi-17beta-carbossi sostituiti e uso dei prodotti come inibitori dell'enzima 5alfa-riduttasi - Google Patents

Procedimento microbiologico per la preparazione di 3-oxo-4-azasteroidi-17beta-carbossi sostituiti e uso dei prodotti come inibitori dell'enzima 5alfa-riduttasi

Info

Publication number
IT1270660B
IT1270660B ITMI942094A ITMI942094A IT1270660B IT 1270660 B IT1270660 B IT 1270660B IT MI942094 A ITMI942094 A IT MI942094A IT MI942094 A ITMI942094 A IT MI942094A IT 1270660 B IT1270660 B IT 1270660B
Authority
IT
Italy
Prior art keywords
enzyme
inhibitors
replaced
products
carboss
Prior art date
Application number
ITMI942094A
Other languages
English (en)
Inventor
Stefano Poli
Ambrogio Magni
Paride Grisenti
Massimo Leoni
Original Assignee
Poli Ind Chimica Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poli Ind Chimica Spa filed Critical Poli Ind Chimica Spa
Publication of ITMI942094A0 publication Critical patent/ITMI942094A0/it
Priority to ITMI942094A priority Critical patent/IT1270660B/it
Priority to DE69516162T priority patent/DE69516162T2/de
Priority to EP98124126A priority patent/EP0922770B1/en
Priority to EP95935926A priority patent/EP0786011B1/en
Priority to PCT/EP1995/003992 priority patent/WO1996012034A1/en
Priority to DK98124126T priority patent/DK0922770T3/da
Priority to ES98124126T priority patent/ES2184192T3/es
Priority to AT98124126T priority patent/ATE224451T1/de
Priority to AT95935926T priority patent/ATE191508T1/de
Priority to AU38050/95A priority patent/AU3805095A/en
Priority to PT98124126T priority patent/PT922770E/pt
Priority to DE69528296T priority patent/DE69528296T2/de
Priority to ES95935926T priority patent/ES2106698T3/es
Priority to PT95935926T priority patent/PT786011E/pt
Priority to TR95/01260A priority patent/TR199501260A2/xx
Publication of ITMI942094A1 publication Critical patent/ITMI942094A1/it
Application granted granted Critical
Publication of IT1270660B publication Critical patent/IT1270660B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/02—Dehydrogenating; Dehydroxylating

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

La presente invenzione riguarda un procedimento microbiologico per la trasformazione di 4-azaandrostan-3-oni-17? - sostituiti e l'uso del prodotti di biotrasformazione come inibitori dell'enzima 5? - riduttasi.
ITMI942094A 1994-10-13 1994-10-13 Procedimento microbiologico per la preparazione di 3-oxo-4-azasteroidi-17beta-carbossi sostituiti e uso dei prodotti come inibitori dell'enzima 5alfa-riduttasi IT1270660B (it)

Priority Applications (15)

Application Number Priority Date Filing Date Title
ITMI942094A IT1270660B (it) 1994-10-13 1994-10-13 Procedimento microbiologico per la preparazione di 3-oxo-4-azasteroidi-17beta-carbossi sostituiti e uso dei prodotti come inibitori dell'enzima 5alfa-riduttasi
AT95935926T ATE191508T1 (de) 1994-10-13 1995-10-10 Mikrobiologisches verfahren zur herstellung von 1-ungesättigten, 17-beta-carboxysubstituierten 3- oxo-4-azaandrostan-3-onen
PT98124126T PT922770E (pt) 1994-10-13 1995-10-10 Processo microbiologico para a transformacao de 3-oxo-4-azaesteroides 17-beta-carboxi-substituidos e utilizacao de tais prodtos inibidores da enzima 5-alfa-reductase
EP95935926A EP0786011B1 (en) 1994-10-13 1995-10-10 Microbiological process for the preparation of 1-unsaturated 17-beta-carboxysubstituted 3-oxo-4-azaandrostan-3-ones
PCT/EP1995/003992 WO1996012034A1 (en) 1994-10-13 1995-10-10 A microbiological process for the preparation of 17beta-carboxy substituted 3-oxo-4-azasteroids and the use of such products as inhibitors of the enzyme 5alpha-reductase
DK98124126T DK0922770T3 (da) 1994-10-13 1995-10-10 Mikrobiologisk fremgangsmåde til omdannelsen af 17-beta-carboxysubstituerede 3-oxo-4-azasteroider og anvendelsen af sådanne produkter som hæmmere af enzymet 5-alfa-reduktase
ES98124126T ES2184192T3 (es) 1994-10-13 1995-10-10 Procedimiento microbiologico para la transformacion de 3-oxo-4-azaesteroides 17beta-carboxisustituidos y uso de tales productos como inhibidores de la enzima 5alfa-reductasa.
AT98124126T ATE224451T1 (de) 1994-10-13 1995-10-10 Mikrobiologisches verfahren zur transformation von 17-beta-carboxy-substituierten 3-oxo-4- azasteroiden und die verwendung solcher produkte als inhibitoren des enzyms 5-alpha-reduktase
DE69516162T DE69516162T2 (de) 1994-10-13 1995-10-10 Mikrobiologisches Verfahren zur Herstellung von 1-ungesättigten, 17-beta-carboxysubstituierten 3-Oxo-4-Azaandrostan-3-onen
AU38050/95A AU3805095A (en) 1994-10-13 1995-10-10 A microbiological process for the preparation of 17beta-carboxy substituted 3-oxo-4-azasteroids and the use of such products as inhibitors of the enzyme 5alpha-reductase
EP98124126A EP0922770B1 (en) 1994-10-13 1995-10-10 A microbiological process for the transformation of 17beta-carboxy substituted 3-oxo-4-azasteroids and the use of such products as inhibitors of the enzyme 5alpha-reductase
DE69528296T DE69528296T2 (de) 1994-10-13 1995-10-10 Mikrobiologisches Verfahren zur Transformation von 17-beta-Carboxy-substituierten 3-Oxo-4-Azasteroiden und die Verwendung solcher Produkte als Inhibitoren des Enzyms 5-alpha-Reduktase
ES95935926T ES2106698T3 (es) 1994-10-13 1995-10-10 Procedimiento microbiologico para la preparacion de 3-oxo-4-azaandrostan-3-onas 17beta-carboxi sustituidas.
PT95935926T PT786011E (pt) 1994-10-13 1995-10-10 Processo microbiologico para a preparacao de 3-oxo-4-aza-androstan-3-onas carboxi-substituidas em posicao 17 e comportando uma ligacao dupla em posicao 1
TR95/01260A TR199501260A2 (tr) 1994-10-13 1995-10-13 17-betakarboksi ikameli 3-okso-4-azasteroidlerin hazirlanmasi icin mikrobiyolojik bir islem ve bu tür ürünlerin 5alfa-redüktaz enzimi inhibitörleri olarak kullanimi.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI942094A IT1270660B (it) 1994-10-13 1994-10-13 Procedimento microbiologico per la preparazione di 3-oxo-4-azasteroidi-17beta-carbossi sostituiti e uso dei prodotti come inibitori dell'enzima 5alfa-riduttasi

Publications (3)

Publication Number Publication Date
ITMI942094A0 ITMI942094A0 (it) 1994-10-13
ITMI942094A1 ITMI942094A1 (it) 1996-04-13
IT1270660B true IT1270660B (it) 1997-05-07

Family

ID=11369703

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI942094A IT1270660B (it) 1994-10-13 1994-10-13 Procedimento microbiologico per la preparazione di 3-oxo-4-azasteroidi-17beta-carbossi sostituiti e uso dei prodotti come inibitori dell'enzima 5alfa-riduttasi

Country Status (10)

Country Link
EP (2) EP0922770B1 (it)
AT (2) ATE191508T1 (it)
AU (1) AU3805095A (it)
DE (2) DE69516162T2 (it)
DK (1) DK0922770T3 (it)
ES (2) ES2106698T3 (it)
IT (1) IT1270660B (it)
PT (2) PT922770E (it)
TR (1) TR199501260A2 (it)
WO (1) WO1996012034A1 (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5873300A (en) * 1999-07-07 2001-01-30 Pharmacia & Upjohn Company Process to prepare exemestane
JP4516839B2 (ja) * 2002-04-30 2010-08-04 メルク・シャープ・エンド・ドーム・コーポレイション アンドロゲン受容体修飾因子としての４−アザステロイド誘導体
HU227117B1 (en) 2002-05-10 2010-07-28 Richter Gedeon Nyrt Process for dehydrogenation of aza-androstane compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1070176B (de) * 1959-12-03 American Cyanamid Company, New York, N. Y. (V. St. A.) Verfahren zur Herstellung neuer Steroidverbindungen der 1, 4 - Pregnadienreihe
US2969304A (en) * 1954-07-15 1961-01-24 Ciba Pharm Prod Inc Manufacture of polyoxygenated steroids
US4379842A (en) * 1980-02-13 1983-04-12 Hoffmann-La Roche Inc. Process for the manufacture of 1α-hydroxydehydroepiandrosterone
KR960013094B1 (ko) * 1987-03-12 1996-09-30 디 업존 캄파니 에이. 심플렉스(A. simplex)에 의한 스테로이드성 21-에스테르의 1,2-탈수소화
US5468860A (en) * 1992-11-19 1995-11-21 Merck & Co., Inc. New finasteride processes

Also Published As

Publication number Publication date
PT922770E (pt) 2003-01-31
DE69516162T2 (de) 2000-09-14
PT786011E (pt) 2000-07-31
DE69528296D1 (de) 2002-10-24
ATE224451T1 (de) 2002-10-15
ATE191508T1 (de) 2000-04-15
ITMI942094A0 (it) 1994-10-13
DE69528296T2 (de) 2003-10-09
ITMI942094A1 (it) 1996-04-13
DK0922770T3 (da) 2003-01-27
EP0922770A3 (en) 1999-06-30
ES2106698T1 (es) 1997-11-16
EP0922770B1 (en) 2002-09-18
TR199501260A2 (tr) 1996-06-21
ES2106698T3 (es) 2000-06-01
EP0922770A2 (en) 1999-06-16
AU3805095A (en) 1996-05-06
EP0786011B1 (en) 2000-04-05
WO1996012034A1 (en) 1996-04-25
ES2184192T3 (es) 2003-04-01
DE69516162D1 (de) 2000-05-11
EP0786011A1 (en) 1997-07-30

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19971029