ES2106698T3 - Procedimiento microbiologico para la preparacion de 3-oxo-4-azaandrostan-3-onas 17beta-carboxi sustituidas. - Google Patents

Procedimiento microbiologico para la preparacion de 3-oxo-4-azaandrostan-3-onas 17beta-carboxi sustituidas.

Info

Publication number
ES2106698T3
ES2106698T3 ES95935926T ES95935926T ES2106698T3 ES 2106698 T3 ES2106698 T3 ES 2106698T3 ES 95935926 T ES95935926 T ES 95935926T ES 95935926 T ES95935926 T ES 95935926T ES 2106698 T3 ES2106698 T3 ES 2106698T3
Authority
ES
Spain
Prior art keywords
azaandrostan
onas
substituted
carboxi
17beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95935926T
Other languages
English (en)
Other versions
ES2106698T1 (es
Inventor
Stefano Poli
Ambrogio Magni
Paride Grisenti
Massimo Leoni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Poli Industria Chimica SpA
Original Assignee
Poli Industria Chimica SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poli Industria Chimica SpA filed Critical Poli Industria Chimica SpA
Publication of ES2106698T1 publication Critical patent/ES2106698T1/es
Application granted granted Critical
Publication of ES2106698T3 publication Critical patent/ES2106698T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/02—Dehydrogenating; Dehydroxylating

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCEDIMIENTO MICROBIOLOGICO PARA LA TRANSFORMACION DE 17-BETA SUSTITUIDA 4-AZAANDROSTAN-3-ONAS Y AL USO DE PRODUCTOS DE BIOTRANSFORMACION COMO INHIBIDORES DE LA ENZIMA 5-ALFA-REDUCTASA.
ES95935926T 1994-10-13 1995-10-10 Procedimiento microbiologico para la preparacion de 3-oxo-4-azaandrostan-3-onas 17beta-carboxi sustituidas. Expired - Lifetime ES2106698T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI942094A IT1270660B (it) 1994-10-13 1994-10-13 Procedimento microbiologico per la preparazione di 3-oxo-4-azasteroidi-17beta-carbossi sostituiti e uso dei prodotti come inibitori dell'enzima 5alfa-riduttasi

Publications (2)

Publication Number Publication Date
ES2106698T1 ES2106698T1 (es) 1997-11-16
ES2106698T3 true ES2106698T3 (es) 2000-06-01

Family

ID=11369703

Family Applications (2)

Application Number Title Priority Date Filing Date
ES95935926T Expired - Lifetime ES2106698T3 (es) 1994-10-13 1995-10-10 Procedimiento microbiologico para la preparacion de 3-oxo-4-azaandrostan-3-onas 17beta-carboxi sustituidas.
ES98124126T Expired - Lifetime ES2184192T3 (es) 1994-10-13 1995-10-10 Procedimiento microbiologico para la transformacion de 3-oxo-4-azaesteroides 17beta-carboxisustituidos y uso de tales productos como inhibidores de la enzima 5alfa-reductasa.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES98124126T Expired - Lifetime ES2184192T3 (es) 1994-10-13 1995-10-10 Procedimiento microbiologico para la transformacion de 3-oxo-4-azaesteroides 17beta-carboxisustituidos y uso de tales productos como inhibidores de la enzima 5alfa-reductasa.

Country Status (10)

Country Link
EP (2) EP0922770B1 (es)
AT (2) ATE224451T1 (es)
AU (1) AU3805095A (es)
DE (2) DE69528296T2 (es)
DK (1) DK0922770T3 (es)
ES (2) ES2106698T3 (es)
IT (1) IT1270660B (es)
PT (2) PT786011E (es)
TR (1) TR199501260A2 (es)
WO (1) WO1996012034A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001004342A1 (en) * 1999-07-07 2001-01-18 Pharmacia & Upjohn Company Process to prepare exemestane
JP4516839B2 (ja) * 2002-04-30 2010-08-04 メルク・シャープ・エンド・ドーム・コーポレイション アンドロゲン受容体修飾因子としての４−アザステロイド誘導体
HU227117B1 (en) 2002-05-10 2010-07-28 Richter Gedeon Nyrt Process for dehydrogenation of aza-androstane compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1070176B (de) * 1959-12-03 American Cyanamid Company, New York, N. Y. (V. St. A.) Verfahren zur Herstellung neuer Steroidverbindungen der 1, 4 - Pregnadienreihe
US2969304A (en) * 1954-07-15 1961-01-24 Ciba Pharm Prod Inc Manufacture of polyoxygenated steroids
US4379842A (en) * 1980-02-13 1983-04-12 Hoffmann-La Roche Inc. Process for the manufacture of 1α-hydroxydehydroepiandrosterone
JP2680870B2 (ja) * 1987-03-12 1997-11-19 ジ・アップジョン・カンパニー エイ・シンプレックスでのステロイド２１‐エステル類の１，２‐脱水素化
US5468860A (en) * 1992-11-19 1995-11-21 Merck & Co., Inc. New finasteride processes

Also Published As

Publication number Publication date
DE69516162T2 (de) 2000-09-14
ITMI942094A0 (it) 1994-10-13
EP0922770A2 (en) 1999-06-16
DE69528296D1 (de) 2002-10-24
ES2184192T3 (es) 2003-04-01
EP0786011B1 (en) 2000-04-05
ITMI942094A1 (it) 1996-04-13
PT786011E (pt) 2000-07-31
EP0922770B1 (en) 2002-09-18
ATE224451T1 (de) 2002-10-15
DE69528296T2 (de) 2003-10-09
DE69516162D1 (de) 2000-05-11
WO1996012034A1 (en) 1996-04-25
PT922770E (pt) 2003-01-31
TR199501260A2 (tr) 1996-06-21
DK0922770T3 (da) 2003-01-27
ES2106698T1 (es) 1997-11-16
ATE191508T1 (de) 2000-04-15
IT1270660B (it) 1997-05-07
AU3805095A (en) 1996-05-06
EP0786011A1 (en) 1997-07-30
EP0922770A3 (en) 1999-06-30

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