ATE191508T1 - Mikrobiologisches verfahren zur herstellung von 1-ungesättigten, 17-beta-carboxysubstituierten 3- oxo-4-azaandrostan-3-onen - Google Patents
Mikrobiologisches verfahren zur herstellung von 1-ungesättigten, 17-beta-carboxysubstituierten 3- oxo-4-azaandrostan-3-onenInfo
- Publication number
- ATE191508T1 ATE191508T1 AT95935926T AT95935926T ATE191508T1 AT E191508 T1 ATE191508 T1 AT E191508T1 AT 95935926 T AT95935926 T AT 95935926T AT 95935926 T AT95935926 T AT 95935926T AT E191508 T1 ATE191508 T1 AT E191508T1
- Authority
- AT
- Austria
- Prior art keywords
- azaandrostan
- beta
- onenes
- carboxysubstituted
- oxo
- Prior art date
Links
- 230000002906 microbiologic effect Effects 0.000 title abstract 2
- SPVUYOXSQFMCAO-RIMFYDMWSA-N (3as,3bs,5ar,9ar,9bs,11as)-9a,11a-dimethyl-1,2,3,3a,3b,4,5,5a,6,8,9,9b,10,11-tetradecahydroindeno[5,4-f]quinolin-7-one Chemical class N([C@@H]1CC2)C(=O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CCC[C@@]2(C)CC1 SPVUYOXSQFMCAO-RIMFYDMWSA-N 0.000 abstract 1
- 108010066551 Cholestenone 5 alpha-Reductase Proteins 0.000 abstract 1
- 230000036983 biotransformation Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/02—Dehydrogenating; Dehydroxylating
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI942094A IT1270660B (it) | 1994-10-13 | 1994-10-13 | Procedimento microbiologico per la preparazione di 3-oxo-4-azasteroidi-17beta-carbossi sostituiti e uso dei prodotti come inibitori dell'enzima 5alfa-riduttasi |
| PCT/EP1995/003992 WO1996012034A1 (en) | 1994-10-13 | 1995-10-10 | A microbiological process for the preparation of 17beta-carboxy substituted 3-oxo-4-azasteroids and the use of such products as inhibitors of the enzyme 5alpha-reductase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE191508T1 true ATE191508T1 (de) | 2000-04-15 |
Family
ID=11369703
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98124126T ATE224451T1 (de) | 1994-10-13 | 1995-10-10 | Mikrobiologisches verfahren zur transformation von 17-beta-carboxy-substituierten 3-oxo-4- azasteroiden und die verwendung solcher produkte als inhibitoren des enzyms 5-alpha-reduktase |
| AT95935926T ATE191508T1 (de) | 1994-10-13 | 1995-10-10 | Mikrobiologisches verfahren zur herstellung von 1-ungesättigten, 17-beta-carboxysubstituierten 3- oxo-4-azaandrostan-3-onen |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98124126T ATE224451T1 (de) | 1994-10-13 | 1995-10-10 | Mikrobiologisches verfahren zur transformation von 17-beta-carboxy-substituierten 3-oxo-4- azasteroiden und die verwendung solcher produkte als inhibitoren des enzyms 5-alpha-reduktase |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP0786011B1 (de) |
| AT (2) | ATE224451T1 (de) |
| AU (1) | AU3805095A (de) |
| DE (2) | DE69528296T2 (de) |
| DK (1) | DK0922770T3 (de) |
| ES (2) | ES2184192T3 (de) |
| IT (1) | IT1270660B (de) |
| PT (2) | PT922770E (de) |
| TR (1) | TR199501260A2 (de) |
| WO (1) | WO1996012034A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5873300A (en) * | 1999-07-07 | 2001-01-30 | Pharmacia & Upjohn Company | Process to prepare exemestane |
| JP4516839B2 (ja) * | 2002-04-30 | 2010-08-04 | メルク・シャープ・エンド・ドーム・コーポレイション | アンドロゲン受容体修飾因子としての４−アザステロイド誘導体 |
| HU227117B1 (en) * | 2002-05-10 | 2010-07-28 | Richter Gedeon Nyrt | Process for dehydrogenation of aza-androstane compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1070176B (de) * | 1959-12-03 | American Cyanamid Company, New York, N. Y. (V. St. A.) | Verfahren zur Herstellung neuer Steroidverbindungen der 1, 4 - Pregnadienreihe | |
| US2969304A (en) * | 1954-07-15 | 1961-01-24 | Ciba Pharm Prod Inc | Manufacture of polyoxygenated steroids |
| US4379842A (en) * | 1980-02-13 | 1983-04-12 | Hoffmann-La Roche Inc. | Process for the manufacture of 1α-hydroxydehydroepiandrosterone |
| KR960013094B1 (ko) * | 1987-03-12 | 1996-09-30 | 디 업존 캄파니 | 에이. 심플렉스(A. simplex)에 의한 스테로이드성 21-에스테르의 1,2-탈수소화 |
| US5468860A (en) * | 1992-11-19 | 1995-11-21 | Merck & Co., Inc. | New finasteride processes |
-
1994
- 1994-10-13 IT ITMI942094A patent/IT1270660B/it active IP Right Grant
-
1995
- 1995-10-10 PT PT98124126T patent/PT922770E/pt unknown
- 1995-10-10 AU AU38050/95A patent/AU3805095A/en not_active Abandoned
- 1995-10-10 DK DK98124126T patent/DK0922770T3/da active
- 1995-10-10 AT AT98124126T patent/ATE224451T1/de active
- 1995-10-10 WO PCT/EP1995/003992 patent/WO1996012034A1/en not_active Ceased
- 1995-10-10 ES ES98124126T patent/ES2184192T3/es not_active Expired - Lifetime
- 1995-10-10 EP EP95935926A patent/EP0786011B1/de not_active Expired - Lifetime
- 1995-10-10 DE DE69528296T patent/DE69528296T2/de not_active Expired - Lifetime
- 1995-10-10 ES ES95935926T patent/ES2106698T3/es not_active Expired - Lifetime
- 1995-10-10 AT AT95935926T patent/ATE191508T1/de not_active IP Right Cessation
- 1995-10-10 PT PT95935926T patent/PT786011E/pt unknown
- 1995-10-10 EP EP98124126A patent/EP0922770B1/de not_active Expired - Lifetime
- 1995-10-10 DE DE69516162T patent/DE69516162T2/de not_active Expired - Lifetime
- 1995-10-13 TR TR95/01260A patent/TR199501260A2/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0786011A1 (de) | 1997-07-30 |
| ITMI942094A1 (it) | 1996-04-13 |
| AU3805095A (en) | 1996-05-06 |
| EP0922770A2 (de) | 1999-06-16 |
| DE69516162D1 (de) | 2000-05-11 |
| DK0922770T3 (da) | 2003-01-27 |
| PT922770E (pt) | 2003-01-31 |
| DE69516162T2 (de) | 2000-09-14 |
| EP0922770B1 (de) | 2002-09-18 |
| DE69528296T2 (de) | 2003-10-09 |
| WO1996012034A1 (en) | 1996-04-25 |
| ES2106698T3 (es) | 2000-06-01 |
| DE69528296D1 (de) | 2002-10-24 |
| ATE224451T1 (de) | 2002-10-15 |
| ITMI942094A0 (it) | 1994-10-13 |
| ES2184192T3 (es) | 2003-04-01 |
| IT1270660B (it) | 1997-05-07 |
| PT786011E (pt) | 2000-07-31 |
| EP0786011B1 (de) | 2000-04-05 |
| TR199501260A2 (tr) | 1996-06-21 |
| ES2106698T1 (es) | 1997-11-16 |
| EP0922770A3 (de) | 1999-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |