DE69528296T2 - Mikrobiologisches Verfahren zur Transformation von 17-beta-Carboxy-substituierten 3-Oxo-4-Azasteroiden und die Verwendung solcher Produkte als Inhibitoren des Enzyms 5-alpha-Reduktase - Google Patents

Mikrobiologisches Verfahren zur Transformation von 17-beta-Carboxy-substituierten 3-Oxo-4-Azasteroiden und die Verwendung solcher Produkte als Inhibitoren des Enzyms 5-alpha-Reduktase

Info

Publication number
DE69528296T2
DE69528296T2 DE69528296T DE69528296T DE69528296T2 DE 69528296 T2 DE69528296 T2 DE 69528296T2 DE 69528296 T DE69528296 T DE 69528296T DE 69528296 T DE69528296 T DE 69528296T DE 69528296 T2 DE69528296 T2 DE 69528296T2
Authority
DE
Germany
Prior art keywords
reductase
inhibitors
beta
enzyme
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69528296T
Other languages
English (en)
Other versions
DE69528296D1 (de
Inventor
Stefano Poli
Paride Grisenti
Ambrogio Magni
Massimo Leoni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Poli Industria Chimica SpA
Original Assignee
Poli Industria Chimica SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poli Industria Chimica SpA filed Critical Poli Industria Chimica SpA
Application granted granted Critical
Publication of DE69528296D1 publication Critical patent/DE69528296D1/de
Publication of DE69528296T2 publication Critical patent/DE69528296T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/02—Dehydrogenating; Dehydroxylating

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
DE69528296T 1994-10-13 1995-10-10 Mikrobiologisches Verfahren zur Transformation von 17-beta-Carboxy-substituierten 3-Oxo-4-Azasteroiden und die Verwendung solcher Produkte als Inhibitoren des Enzyms 5-alpha-Reduktase Expired - Lifetime DE69528296T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI942094A IT1270660B (it) 1994-10-13 1994-10-13 Procedimento microbiologico per la preparazione di 3-oxo-4-azasteroidi-17beta-carbossi sostituiti e uso dei prodotti come inibitori dell'enzima 5alfa-riduttasi

Publications (2)

Publication Number Publication Date
DE69528296D1 DE69528296D1 (de) 2002-10-24
DE69528296T2 true DE69528296T2 (de) 2003-10-09

Family

ID=11369703

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69516162T Expired - Lifetime DE69516162T2 (de) 1994-10-13 1995-10-10 Mikrobiologisches Verfahren zur Herstellung von 1-ungesättigten, 17-beta-carboxysubstituierten 3-Oxo-4-Azaandrostan-3-onen
DE69528296T Expired - Lifetime DE69528296T2 (de) 1994-10-13 1995-10-10 Mikrobiologisches Verfahren zur Transformation von 17-beta-Carboxy-substituierten 3-Oxo-4-Azasteroiden und die Verwendung solcher Produkte als Inhibitoren des Enzyms 5-alpha-Reduktase

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69516162T Expired - Lifetime DE69516162T2 (de) 1994-10-13 1995-10-10 Mikrobiologisches Verfahren zur Herstellung von 1-ungesättigten, 17-beta-carboxysubstituierten 3-Oxo-4-Azaandrostan-3-onen

Country Status (10)

Country Link
EP (2) EP0786011B1 (de)
AT (2) ATE191508T1 (de)
AU (1) AU3805095A (de)
DE (2) DE69516162T2 (de)
DK (1) DK0922770T3 (de)
ES (2) ES2184192T3 (de)
IT (1) IT1270660B (de)
PT (2) PT786011E (de)
TR (1) TR199501260A2 (de)
WO (1) WO1996012034A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001004342A1 (en) * 1999-07-07 2001-01-18 Pharmacia & Upjohn Company Process to prepare exemestane
CA2484173A1 (en) * 2002-04-30 2003-11-13 Merck & Co., Inc. 4-azasteroid derivatives as androgen receptor modulators
HU227117B1 (en) 2002-05-10 2010-07-28 Richter Gedeon Nyrt Process for dehydrogenation of aza-androstane compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1070176B (de) * 1959-12-03 American Cyanamid Company, New York, N. Y. (V. St. A.) Verfahren zur Herstellung neuer Steroidverbindungen der 1, 4 - Pregnadienreihe
US2969304A (en) * 1954-07-15 1961-01-24 Ciba Pharm Prod Inc Manufacture of polyoxygenated steroids
US4379842A (en) * 1980-02-13 1983-04-12 Hoffmann-La Roche Inc. Process for the manufacture of 1α-hydroxydehydroepiandrosterone
JP2680870B2 (ja) * 1987-03-12 1997-11-19 ジ・アップジョン・カンパニー エイ・シンプレックスでのステロイド２１‐エステル類の１，２‐脱水素化
US5468860A (en) * 1992-11-19 1995-11-21 Merck & Co., Inc. New finasteride processes

Also Published As

Publication number Publication date
EP0922770B1 (de) 2002-09-18
EP0922770A3 (de) 1999-06-30
IT1270660B (it) 1997-05-07
TR199501260A2 (tr) 1996-06-21
AU3805095A (en) 1996-05-06
PT922770E (pt) 2003-01-31
DK0922770T3 (da) 2003-01-27
EP0786011A1 (de) 1997-07-30
ATE224451T1 (de) 2002-10-15
ATE191508T1 (de) 2000-04-15
DE69516162D1 (de) 2000-05-11
ES2184192T3 (es) 2003-04-01
EP0922770A2 (de) 1999-06-16
ES2106698T3 (es) 2000-06-01
PT786011E (pt) 2000-07-31
ITMI942094A0 (it) 1994-10-13
WO1996012034A1 (en) 1996-04-25
ES2106698T1 (es) 1997-11-16
DE69516162T2 (de) 2000-09-14
EP0786011B1 (de) 2000-04-05
ITMI942094A1 (it) 1996-04-13
DE69528296D1 (de) 2002-10-24

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