CO4600682A1 - Protrombinas como antidoto para los inhibidores de la trom- bina - Google Patents

Protrombinas como antidoto para los inhibidores de la trom- bina

Info

Publication number
CO4600682A1
CO4600682A1 CO97006960A CO97006960A CO4600682A1 CO 4600682 A1 CO4600682 A1 CO 4600682A1 CO 97006960 A CO97006960 A CO 97006960A CO 97006960 A CO97006960 A CO 97006960A CO 4600682 A1 CO4600682 A1 CO 4600682A1
Authority
CO
Colombia
Prior art keywords
antidote
protocols
thrombin inhibitors
thrombin
inhibitors
Prior art date
Application number
CO97006960A
Other languages
English (en)
Inventor
Martin Raditsch
Claus Bollschweile
Wolgang Hans
Klaus Rubsamen
Thomas Friedrich
Jurgen Schweden
Martin Schmidt
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of CO4600682A1 publication Critical patent/CO4600682A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A NUEVAS TROMBIN MUTEINAS SU PREPARACION Y UTILIZACION COMO ANTIDOTO PARA LOS INHIBIDORES DE LA TROMBINA.
CO97006960A 1996-02-12 1997-02-11 Protrombinas como antidoto para los inhibidores de la trom- bina CO4600682A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19605126A DE19605126A1 (de) 1996-02-12 1996-02-12 Thrombinmuteine als Antidot für Thrombininhibitoren

Publications (1)

Publication Number Publication Date
CO4600682A1 true CO4600682A1 (es) 1998-05-08

Family

ID=7785198

Family Applications (1)

Application Number Title Priority Date Filing Date
CO97006960A CO4600682A1 (es) 1996-02-12 1997-02-11 Protrombinas como antidoto para los inhibidores de la trom- bina

Country Status (18)

Country Link
US (1) US6060300A (es)
EP (1) EP0880591A1 (es)
JP (1) JPH11512621A (es)
KR (1) KR19990082479A (es)
CN (1) CN1211280A (es)
AR (1) AR005797A1 (es)
AU (1) AU1768497A (es)
BR (1) BR9707280A (es)
CA (1) CA2245546A1 (es)
CO (1) CO4600682A1 (es)
CZ (1) CZ247798A3 (es)
DE (1) DE19605126A1 (es)
HR (1) HRP970077A2 (es)
HU (1) HUP9900574A2 (es)
IL (1) IL125077A0 (es)
NO (1) NO983677D0 (es)
WO (1) WO1997029198A1 (es)
ZA (1) ZA971107B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000018933A (ko) * 1998-09-07 2000-04-06 김승수 내피세포 성장억제 활성을 가지는 사람 프로트롬빈 크링글단백질 및 이를 암호하는 유전자
GB2355161B (en) * 1999-10-05 2001-09-12 3Com Corp Network device incorporating selective compression of stored data packets
KR20020008471A (ko) * 2000-07-20 2002-01-31 김승수 내피세포 성장 억제활성을 가지는 인간 프로트롬빈크링글, 그것의 재조합벡터 및 이를 발현하는 재조합 숙주
WO2007103447A2 (en) * 2006-03-06 2007-09-13 Humagene, Inc. A method for the preparation of recombinant human thrombin
PT2193196T (pt) * 2007-09-28 2016-10-24 Portola Pharm Inc Antídotos para inibidores do fator xa e métodos de utilização dos mesmos
MX2011004907A (es) 2008-11-14 2011-07-29 Portola Pharm Inc Antidotos para inhibidores del factor xa y metodos para el uso de los mismos en combinacion con agentes de coagulacion de sangre.
EP3604510A1 (en) 2009-03-30 2020-02-05 Portola Pharmaceuticals, Inc. Antidotes for factor xa inhibitors and methods of using the same
ES2605801T3 (es) 2009-07-15 2017-03-16 Portola Pharmaceuticals, Inc. Formulación de dosis unitaria de antídoto para inhibidores del factor Xa para su uso en la prevención de la hemorragia
EP2316931B1 (de) 2009-10-30 2016-12-28 Senova Gesellschaft für Biowissenschaft und Technik mbH Polymergekoppelte Peptidasen
TWI513466B (zh) 2010-01-20 2015-12-21 Boehringer Ingelheim Int 抗凝血劑解毒劑
MX2013011092A (es) 2011-03-30 2013-12-06 Boehringer Ingelheim Int Antidotos anticoagulantes.
BR112016027649A2 (pt) 2014-05-26 2017-08-15 Academisch Ziekenhuis Leiden Proteínas prohemostáticas para o tratamento de hemorragia

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4203965A1 (de) * 1992-02-11 1993-08-12 Max Planck Gesellschaft Antidot fuer hirudin und synthetische thrombininhibitoren

Also Published As

Publication number Publication date
DE19605126A1 (de) 1997-08-14
CZ247798A3 (cs) 1999-03-17
US6060300A (en) 2000-05-09
AU1768497A (en) 1997-08-28
NO983677L (no) 1998-08-11
CA2245546A1 (en) 1997-08-14
NO983677D0 (no) 1998-08-11
IL125077A0 (en) 1999-01-26
BR9707280A (pt) 1999-07-20
KR19990082479A (ko) 1999-11-25
HUP9900574A2 (hu) 1999-06-28
JPH11512621A (ja) 1999-11-02
HRP970077A2 (en) 1998-04-30
AR005797A1 (es) 1999-07-14
CN1211280A (zh) 1999-03-17
WO1997029198A1 (de) 1997-08-14
EP0880591A1 (de) 1998-12-02
ZA971107B (en) 1998-08-11

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