AR005797A1 - Trombinmuteinas como antidoto para los inhibidores de las trombinas - Google Patents
Trombinmuteinas como antidoto para los inhibidores de las trombinasInfo
- Publication number
- AR005797A1 AR005797A1 ARP970100548A ARP970100548A AR005797A1 AR 005797 A1 AR005797 A1 AR 005797A1 AR P970100548 A ARP970100548 A AR P970100548A AR P970100548 A ARP970100548 A AR P970100548A AR 005797 A1 AR005797 A1 AR 005797A1
- Authority
- AR
- Argentina
- Prior art keywords
- gly
- seq
- sequential
- antidote
- natural
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Trombinmeteínas, que en comparación con la trombina naatural presentan las siguientes diferencias secuenciales: (a) intercambio de un Gly después de Ala,hallándose el Gly en el entorno secuencial Tyr-Gly-Phe, y teniendo dicho Gly en la protombinahumana natural (SEQ ID NO:14) la posición 558; (b) por lomenos un intercambio o una supresión de los siguientes radicales: (b1) His, que se halla en el entorno secuencial Ala-His-Cys y que en la protombinanatural (SEQ ID NO:14) tiene la posición363; (b2) Asp, que se halla en el entorno sucuencial Arg-Asp-Ile y que en la protombina humana naturalSEQ ID NO:14) tiene la Posición 419; (b3) Ser, que se halla en el entorno secuencial Asp-Ser-Gly, y que en la protombina humana natural(SEQ ID NO:14)tiene la Posición 525; y su utilización como antídoto.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19605126A DE19605126A1 (de) | 1996-02-12 | 1996-02-12 | Thrombinmuteine als Antidot für Thrombininhibitoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR005797A1 true AR005797A1 (es) | 1999-07-14 |
Family
ID=7785198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970100548A AR005797A1 (es) | 1996-02-12 | 1997-02-12 | Trombinmuteinas como antidoto para los inhibidores de las trombinas |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6060300A (es) |
| EP (1) | EP0880591A1 (es) |
| JP (1) | JPH11512621A (es) |
| KR (1) | KR19990082479A (es) |
| CN (1) | CN1211280A (es) |
| AR (1) | AR005797A1 (es) |
| AU (1) | AU1768497A (es) |
| BR (1) | BR9707280A (es) |
| CA (1) | CA2245546A1 (es) |
| CO (1) | CO4600682A1 (es) |
| CZ (1) | CZ247798A3 (es) |
| DE (1) | DE19605126A1 (es) |
| HR (1) | HRP970077A2 (es) |
| HU (1) | HUP9900574A2 (es) |
| IL (1) | IL125077A0 (es) |
| NO (1) | NO983677D0 (es) |
| WO (1) | WO1997029198A1 (es) |
| ZA (1) | ZA971107B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20000018933A (ko) * | 1998-09-07 | 2000-04-06 | 김승수 | 내피세포 성장억제 활성을 가지는 사람 프로트롬빈 크링글단백질 및 이를 암호하는 유전자 |
| GB2355161B (en) * | 1999-10-05 | 2001-09-12 | 3Com Corp | Network device incorporating selective compression of stored data packets |
| KR20020008471A (ko) * | 2000-07-20 | 2002-01-31 | 김승수 | 내피세포 성장 억제활성을 가지는 인간 프로트롬빈크링글, 그것의 재조합벡터 및 이를 발현하는 재조합 숙주 |
| WO2007103447A2 (en) * | 2006-03-06 | 2007-09-13 | Humagene, Inc. | A method for the preparation of recombinant human thrombin |
| DK2193196T3 (en) * | 2007-09-28 | 2016-11-07 | Portola Pharm Inc | Clinical profile of Factor Xa inhibitors, and methods of use thereof |
| US8268783B2 (en) | 2007-09-28 | 2012-09-18 | Portola Pharmaceuticals, Inc. | Antidotes for factor Xa inhibitors and methods of using the same |
| WO2010056765A2 (en) | 2008-11-14 | 2010-05-20 | Portola Pharmaceuticals, Inc. | Antidotes for factor xa inhibitors and methods of using the same in combination with blood coagulating agents |
| CA2767858C (en) | 2009-07-15 | 2019-02-12 | Portola Pharmaceuticals, Inc. | Unit dose formulation of antidotes for factor xa inhibitors and methods of using the same |
| EP2316931B1 (de) * | 2009-10-30 | 2016-12-28 | Senova Gesellschaft für Biowissenschaft und Technik mbH | Polymergekoppelte Peptidasen |
| TWI513466B (zh) | 2010-01-20 | 2015-12-21 | Boehringer Ingelheim Int | 抗凝血劑解毒劑 |
| PE20140964A1 (es) | 2011-03-30 | 2014-08-17 | Boehringer Ingelheim Int | Antidotos anticoagulantes |
| CN106536566A (zh) | 2014-05-26 | 2017-03-22 | 莱顿教学医院 | 用于出血治疗的促止血蛋白 |
| EP3971576A1 (en) | 2020-09-21 | 2022-03-23 | Instrumentation Laboratory Company | Detecting and monitoring oral anticoagulants or intravenous direct thrombin inhibitors in a blood sample |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4203965A1 (de) * | 1992-02-11 | 1993-08-12 | Max Planck Gesellschaft | Antidot fuer hirudin und synthetische thrombininhibitoren |
-
1996
- 1996-02-12 DE DE19605126A patent/DE19605126A1/de not_active Withdrawn
-
1997
- 1997-02-11 US US09/117,708 patent/US6060300A/en not_active Expired - Fee Related
- 1997-02-11 KR KR1019980706212A patent/KR19990082479A/ko not_active Application Discontinuation
- 1997-02-11 ZA ZA971107A patent/ZA971107B/xx unknown
- 1997-02-11 JP JP9528173A patent/JPH11512621A/ja active Pending
- 1997-02-11 CN CN97192210A patent/CN1211280A/zh active Pending
- 1997-02-11 WO PCT/EP1997/000612 patent/WO1997029198A1/de not_active Application Discontinuation
- 1997-02-11 CA CA002245546A patent/CA2245546A1/en not_active Abandoned
- 1997-02-11 CZ CZ982477A patent/CZ247798A3/cs unknown
- 1997-02-11 CO CO97006960A patent/CO4600682A1/es unknown
- 1997-02-11 HU HU9900574A patent/HUP9900574A2/hu unknown
- 1997-02-11 BR BR9707280A patent/BR9707280A/pt not_active Application Discontinuation
- 1997-02-11 AU AU17684/97A patent/AU1768497A/en not_active Abandoned
- 1997-02-11 IL IL12507797A patent/IL125077A0/xx unknown
- 1997-02-11 EP EP97903254A patent/EP0880591A1/de not_active Withdrawn
- 1997-02-11 HR HR19605126.6A patent/HRP970077A2/hr not_active Application Discontinuation
- 1997-02-12 AR ARP970100548A patent/AR005797A1/es unknown
-
1998
- 1998-08-11 NO NO983677A patent/NO983677D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9900574A2 (hu) | 1999-06-28 |
| WO1997029198A1 (de) | 1997-08-14 |
| HRP970077A2 (en) | 1998-04-30 |
| CN1211280A (zh) | 1999-03-17 |
| JPH11512621A (ja) | 1999-11-02 |
| NO983677L (no) | 1998-08-11 |
| NO983677D0 (no) | 1998-08-11 |
| IL125077A0 (en) | 1999-01-26 |
| BR9707280A (pt) | 1999-07-20 |
| CA2245546A1 (en) | 1997-08-14 |
| CZ247798A3 (cs) | 1999-03-17 |
| KR19990082479A (ko) | 1999-11-25 |
| ZA971107B (en) | 1998-08-11 |
| US6060300A (en) | 2000-05-09 |
| AU1768497A (en) | 1997-08-28 |
| DE19605126A1 (de) | 1997-08-14 |
| EP0880591A1 (de) | 1998-12-02 |
| CO4600682A1 (es) | 1998-05-08 |
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