MX9704677A - Procedimientos novedosos para preparar intermediarios de inhibidores de encefalinasa y enzima de conversion a angiotensina y sus intermediarios. - Google Patents

Procedimientos novedosos para preparar intermediarios de inhibidores de encefalinasa y enzima de conversion a angiotensina y sus intermediarios.

Info

Publication number
MX9704677A
MX9704677A MX9704677A MX9704677A MX9704677A MX 9704677 A MX9704677 A MX 9704677A MX 9704677 A MX9704677 A MX 9704677A MX 9704677 A MX9704677 A MX 9704677A MX 9704677 A MX9704677 A MX 9704677A
Authority
MX
Mexico
Prior art keywords
intermediates
enkephalinase
inhibitors
converting enzyme
angiotensin converting
Prior art date
Application number
MX9704677A
Other languages
English (en)
Inventor
Gary A Flynn
Thomas D Bannister
Michael J Genin
Douglas W Beight
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/535,403 external-priority patent/US5641880A/en
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of MX9704677A publication Critical patent/MX9704677A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

La presente invencion se refiere a procedimientos novedosos para preparar intermediarios de la formula (I) y a intermediarios novedosos de los mismos, los cuales son utiles en la preparacion de inhibidores de encefalinasa y enzima de conversion de angiotensina.
MX9704677A 1994-12-21 1995-11-20 Procedimientos novedosos para preparar intermediarios de inhibidores de encefalinasa y enzima de conversion a angiotensina y sus intermediarios. MX9704677A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36091594A 1994-12-21 1994-12-21
US08/535,403 US5641880A (en) 1994-12-21 1995-10-24 Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
PCT/US1995/015225 WO1996019492A1 (en) 1994-12-21 1995-11-20 Novel processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof

Publications (1)

Publication Number Publication Date
MX9704677A true MX9704677A (es) 1997-09-30

Family

ID=27001069

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9704677A MX9704677A (es) 1994-12-21 1995-11-20 Procedimientos novedosos para preparar intermediarios de inhibidores de encefalinasa y enzima de conversion a angiotensina y sus intermediarios.

Country Status (23)

Country Link
US (1) US5734049A (es)
EP (1) EP0800527B1 (es)
JP (1) JP3658408B2 (es)
CN (2) CN1113894C (es)
AR (1) AR000378A1 (es)
AT (2) ATE266040T1 (es)
AU (1) AU689362B2 (es)
CA (2) CA2297134C (es)
DE (2) DE69533002T2 (es)
DK (2) DK0957109T3 (es)
ES (2) ES2216386T3 (es)
FI (1) FI121599B (es)
GR (1) GR3033329T3 (es)
HK (1) HK1066009A1 (es)
HU (1) HU227675B1 (es)
IL (6) IL139141A (es)
MX (1) MX9704677A (es)
NO (2) NO308900B1 (es)
NZ (2) NZ298245A (es)
PT (2) PT800527E (es)
SI (2) SI0957109T1 (es)
TW (1) TW401413B (es)
WO (1) WO1996019492A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6683075B1 (en) 1996-12-23 2004-01-27 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
EP2951154B1 (de) * 2013-01-30 2017-04-19 Basf Se 2,6-bis-(aminomethyl)piperidin- (2,6-bamp-), 2,6-bis-(isocyanomethyl)piperidin- (diisocyanat-) und 2,6-dicyanopiperidin-derivate (2,6-dcp-derivate) und ihre verwendung in der herstellung von epoxyharzen, polyurethanen, polyetherolen und polyamiden

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4973585A (en) * 1986-06-13 1990-11-27 Merrell Dow Pharmaceuticals Tricyclic lactams active as antihypertensive agents
ZA874107B (es) * 1986-06-13 1987-12-09
US4824832A (en) * 1987-12-30 1989-04-25 Merrell Dow Pharmaceuticals Inc. Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
CA2053340C (en) * 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
ATE158303T1 (de) * 1990-12-21 1997-10-15 Merrell Pharma Inc Neue trizyklische amino- und nitro verbindungen mit ace-hemmenden eigenschaften
AU657793B2 (en) * 1991-09-27 1995-03-23 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
CA2078758C (en) * 1991-09-27 2003-12-09 Alan M. Warshawsky 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
RU2124503C1 (ru) * 1992-05-18 1999-01-10 И.Р.Сквибб энд Санз, Инк. Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
US5525723A (en) * 1993-11-18 1996-06-11 Bristol-Myers Squibb Co. Compounds containing a fused multiple ring lactam

Also Published As

Publication number Publication date
IL116428A (en) 2001-03-19
DE69515517D1 (de) 2000-04-13
PT800527E (pt) 2000-06-30
AU4368596A (en) 1996-07-10
CN1495186A (zh) 2004-05-12
NO20001822L (no) 1997-08-20
DK0957109T3 (da) 2004-06-01
IL116428A0 (en) 1996-03-31
IL128996A0 (en) 2000-02-17
DE69533002T2 (de) 2005-05-04
IL139141A0 (en) 2001-11-25
CA2208569A1 (en) 1996-06-27
CA2297134A1 (en) 1996-06-27
IL139141A (en) 2005-11-20
NO20001822D0 (no) 2000-04-07
GR3033329T3 (en) 2000-09-29
IL139142A0 (en) 2001-11-25
NO972875L (no) 1997-08-20
PT957109E (pt) 2004-09-30
HK1066009A1 (en) 2005-03-11
NO308900B1 (no) 2000-11-13
WO1996019492A1 (en) 1996-06-27
CA2297134C (en) 2004-02-10
CN1170413A (zh) 1998-01-14
ES2216386T3 (es) 2004-10-16
ATE190315T1 (de) 2000-03-15
NO972875D0 (no) 1997-06-20
HUT78073A (hu) 1999-08-30
DE69515517T2 (de) 2000-07-06
SI0800527T1 (en) 2000-08-31
AR000378A1 (es) 1997-06-18
NZ334608A (en) 1999-07-29
IL139142A (en) 2004-07-25
TW401413B (en) 2000-08-11
JP3658408B2 (ja) 2005-06-08
EP0800527A1 (en) 1997-10-15
EP0800527B1 (en) 2000-03-08
FI972620A (fi) 1997-06-18
DK0800527T3 (da) 2000-06-05
NO310025B1 (no) 2001-05-07
CN1241924C (zh) 2006-02-15
HU227675B1 (en) 2011-11-28
CA2208569C (en) 2000-07-11
DE69533002D1 (de) 2004-06-09
SI0957109T1 (en) 2004-10-31
AU689362B2 (en) 1998-03-26
FI972620A0 (fi) 1997-06-18
JPH10511348A (ja) 1998-11-04
NZ298245A (en) 1999-04-29
FI121599B (fi) 2011-01-31
CN1113894C (zh) 2003-07-09
ES2147863T3 (es) 2000-10-01
US5734049A (en) 1998-03-31
ATE266040T1 (de) 2004-05-15

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Legal Events

Date Code Title Description
FG Grant or registration
HC Change of company name or juridical status

Owner name: CERALOC INNOVATION AB

GB Transfer or rights
PD Change of proprietorship

Owner name: AVENTISUB II INC.

MM Annulment or lapse due to non-payment of fees