IL139141A0 - 1,2,6,7,8, 12b-HEXAHYDRO-6-OXOPYRIDO[2,1-a] [2] AZEPINE INTERMEDIATES FOR PREPARING TRI-AND TETRACYCLIC INHIBITORS OF ENKEPHALINASE AND ANGIOTENSION CONVERTING ENZYME - Google Patents
1,2,6,7,8, 12b-HEXAHYDRO-6-OXOPYRIDO[2,1-a] [2] AZEPINE INTERMEDIATES FOR PREPARING TRI-AND TETRACYCLIC INHIBITORS OF ENKEPHALINASE AND ANGIOTENSION CONVERTING ENZYMEInfo
- Publication number
- IL139141A0 IL139141A0 IL13914100A IL13914100A IL139141A0 IL 139141 A0 IL139141 A0 IL 139141A0 IL 13914100 A IL13914100 A IL 13914100A IL 13914100 A IL13914100 A IL 13914100A IL 139141 A0 IL139141 A0 IL 139141A0
- Authority
- IL
- Israel
- Prior art keywords
- oxopyrido
- enkephalinase
- hexahydro
- converting enzyme
- angiotension converting
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 102000003729 Neprilysin Human genes 0.000 title 1
- 108090000028 Neprilysin Proteins 0.000 title 1
- XYOVOXDWRFGKEX-UHFFFAOYSA-N azepine Chemical compound N1C=CC=CC=C1 XYOVOXDWRFGKEX-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL13914100A IL139141A0 (en) | 1994-12-21 | 2000-10-19 | 1,2,6,7,8, 12b-HEXAHYDRO-6-OXOPYRIDO[2,1-a] [2] AZEPINE INTERMEDIATES FOR PREPARING TRI-AND TETRACYCLIC INHIBITORS OF ENKEPHALINASE AND ANGIOTENSION CONVERTING ENZYME |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36091594A | 1994-12-21 | 1994-12-21 | |
US08/535,403 US5641880A (en) | 1994-12-21 | 1995-10-24 | Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof |
IL11642895A IL116428A (en) | 1994-12-21 | 1995-12-18 | Process for preparing intermediates of tri- and tetracyclic inhibitors of enkephalinase and angiotensin converting enzyme and 1-(3-aryl-2-phthalimidopropanoyl)-1, 4 dihydropyridine intermediates thereof |
IL13914100A IL139141A0 (en) | 1994-12-21 | 2000-10-19 | 1,2,6,7,8, 12b-HEXAHYDRO-6-OXOPYRIDO[2,1-a] [2] AZEPINE INTERMEDIATES FOR PREPARING TRI-AND TETRACYCLIC INHIBITORS OF ENKEPHALINASE AND ANGIOTENSION CONVERTING ENZYME |
Publications (1)
Publication Number | Publication Date |
---|---|
IL139141A0 true IL139141A0 (en) | 2001-11-25 |
Family
ID=27001069
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13914195A IL139141A (en) | 1994-12-21 | 1995-12-18 | 7-Phthalimido-1,2,6,7,8,12b hexahydro-pyrido Ä2,1-aÜbenzazepin-6-one and analogs thereof intermediates for preparing tri-and tetracyclic inhibitors ofenkephalinase and angiotensin converting enzyme |
IL11642895A IL116428A (en) | 1994-12-21 | 1995-12-18 | Process for preparing intermediates of tri- and tetracyclic inhibitors of enkephalinase and angiotensin converting enzyme and 1-(3-aryl-2-phthalimidopropanoyl)-1, 4 dihydropyridine intermediates thereof |
IL13914295A IL139142A (en) | 1994-12-21 | 1995-12-18 | 4-CYANO-1,2,3,4,6,7,8,12b-OCTAHYDRO-6- OXOPYRIDO [2,1-A] [2] BENZAZEPINE AND ANALOGS THEREOF INTERMEDIATES FOR PREPARING TRI- AND TETRACYCLIC INHIBITORS OF ENKEPHALINASE AND ANGIOTENSIN CONVERTING ENZYME |
IL12899699A IL128996A0 (en) | 1994-12-21 | 1999-03-15 | A novel process for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof |
IL13914100A IL139141A0 (en) | 1994-12-21 | 2000-10-19 | 1,2,6,7,8, 12b-HEXAHYDRO-6-OXOPYRIDO[2,1-a] [2] AZEPINE INTERMEDIATES FOR PREPARING TRI-AND TETRACYCLIC INHIBITORS OF ENKEPHALINASE AND ANGIOTENSION CONVERTING ENZYME |
IL13914200A IL139142A0 (en) | 1994-12-21 | 2000-10-19 | 4-CYANO-1,2,3,4,6,7,8,12B-OCTAHYDRO-6- OXOPYRIDO[2,1-a] [2] BENZAZEPINE INTERMEDIATES FOR PREPARING TRI-AND TETRACYCLIC INHIBITORS OF ENKEPHALINASE AND ANGIOTENSIN CONVERTING ENZYME |
Family Applications Before (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13914195A IL139141A (en) | 1994-12-21 | 1995-12-18 | 7-Phthalimido-1,2,6,7,8,12b hexahydro-pyrido Ä2,1-aÜbenzazepin-6-one and analogs thereof intermediates for preparing tri-and tetracyclic inhibitors ofenkephalinase and angiotensin converting enzyme |
IL11642895A IL116428A (en) | 1994-12-21 | 1995-12-18 | Process for preparing intermediates of tri- and tetracyclic inhibitors of enkephalinase and angiotensin converting enzyme and 1-(3-aryl-2-phthalimidopropanoyl)-1, 4 dihydropyridine intermediates thereof |
IL13914295A IL139142A (en) | 1994-12-21 | 1995-12-18 | 4-CYANO-1,2,3,4,6,7,8,12b-OCTAHYDRO-6- OXOPYRIDO [2,1-A] [2] BENZAZEPINE AND ANALOGS THEREOF INTERMEDIATES FOR PREPARING TRI- AND TETRACYCLIC INHIBITORS OF ENKEPHALINASE AND ANGIOTENSIN CONVERTING ENZYME |
IL12899699A IL128996A0 (en) | 1994-12-21 | 1999-03-15 | A novel process for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13914200A IL139142A0 (en) | 1994-12-21 | 2000-10-19 | 4-CYANO-1,2,3,4,6,7,8,12B-OCTAHYDRO-6- OXOPYRIDO[2,1-a] [2] BENZAZEPINE INTERMEDIATES FOR PREPARING TRI-AND TETRACYCLIC INHIBITORS OF ENKEPHALINASE AND ANGIOTENSIN CONVERTING ENZYME |
Country Status (23)
Country | Link |
---|---|
US (1) | US5734049A (xx) |
EP (1) | EP0800527B1 (xx) |
JP (1) | JP3658408B2 (xx) |
CN (2) | CN1113894C (xx) |
AR (1) | AR000378A1 (xx) |
AT (2) | ATE190315T1 (xx) |
AU (1) | AU689362B2 (xx) |
CA (2) | CA2208569C (xx) |
DE (2) | DE69533002T2 (xx) |
DK (2) | DK0957109T3 (xx) |
ES (2) | ES2216386T3 (xx) |
FI (1) | FI121599B (xx) |
GR (1) | GR3033329T3 (xx) |
HK (1) | HK1066009A1 (xx) |
HU (1) | HU227675B1 (xx) |
IL (6) | IL139141A (xx) |
MX (1) | MX9704677A (xx) |
NO (2) | NO308900B1 (xx) |
NZ (2) | NZ298245A (xx) |
PT (2) | PT957109E (xx) |
SI (2) | SI0800527T1 (xx) |
TW (1) | TW401413B (xx) |
WO (1) | WO1996019492A1 (xx) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6683075B1 (en) | 1996-12-23 | 2004-01-27 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use |
US6635632B1 (en) | 1996-12-23 | 2003-10-21 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
US9695121B2 (en) * | 2013-01-30 | 2017-07-04 | Basf Se | 2,6-bis-(aminomethyl)piperidine derivatives |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA874107B (xx) * | 1986-06-13 | 1987-12-09 | ||
US4973585A (en) * | 1986-06-13 | 1990-11-27 | Merrell Dow Pharmaceuticals | Tricyclic lactams active as antihypertensive agents |
US4824832A (en) * | 1987-12-30 | 1989-04-25 | Merrell Dow Pharmaceuticals Inc. | Sulfhydryl containing tricyclic lactams and their pharmacological methods of use |
CA2053340C (en) * | 1990-10-18 | 2002-04-02 | Timothy P. Burkholder | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
US5430145A (en) * | 1990-10-18 | 1995-07-04 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
NZ241023A (en) * | 1990-12-21 | 1994-10-26 | Merrell Dow Pharma | Condensed benzazepine derivatives and pharmaceutical compositions |
AU657793B2 (en) * | 1991-09-27 | 1995-03-23 | Merrell Pharmaceuticals Inc. | Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
US5457196A (en) * | 1991-09-27 | 1995-10-10 | Merrell Dow Pharmaceuticals Inc. | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
ES2106112T3 (es) * | 1991-09-27 | 1997-11-01 | Merrell Pharma Inc | Derivados de indano-2-mercaptoacetilamida con una actividad inhibidora de encefalinasa y de ace. |
RU2124503C1 (ru) * | 1992-05-18 | 1999-01-10 | И.Р.Сквибб энд Санз, Инк. | Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция |
US5238932A (en) * | 1992-05-20 | 1993-08-24 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
US5525723A (en) * | 1993-11-18 | 1996-06-11 | Bristol-Myers Squibb Co. | Compounds containing a fused multiple ring lactam |
-
1995
- 1995-11-20 ES ES99114227T patent/ES2216386T3/es not_active Expired - Lifetime
- 1995-11-20 DE DE69533002T patent/DE69533002T2/de not_active Expired - Lifetime
- 1995-11-20 DE DE69515517T patent/DE69515517T2/de not_active Expired - Lifetime
- 1995-11-20 CA CA002208569A patent/CA2208569C/en not_active Expired - Fee Related
- 1995-11-20 SI SI9530326T patent/SI0800527T1/xx unknown
- 1995-11-20 JP JP51980096A patent/JP3658408B2/ja not_active Expired - Lifetime
- 1995-11-20 WO PCT/US1995/015225 patent/WO1996019492A1/en active IP Right Grant
- 1995-11-20 MX MX9704677A patent/MX9704677A/es not_active IP Right Cessation
- 1995-11-20 HU HU9901108A patent/HU227675B1/hu not_active IP Right Cessation
- 1995-11-20 DK DK99114227T patent/DK0957109T3/da active
- 1995-11-20 AT AT95942465T patent/ATE190315T1/de active
- 1995-11-20 DK DK95942465T patent/DK0800527T3/da active
- 1995-11-20 EP EP95942465A patent/EP0800527B1/en not_active Expired - Lifetime
- 1995-11-20 SI SI9530707T patent/SI0957109T1/xx unknown
- 1995-11-20 AT AT99114227T patent/ATE266040T1/de active
- 1995-11-20 PT PT99114227T patent/PT957109E/pt unknown
- 1995-11-20 ES ES95942465T patent/ES2147863T3/es not_active Expired - Lifetime
- 1995-11-20 CN CN95196905A patent/CN1113894C/zh not_active Expired - Fee Related
- 1995-11-20 AU AU43685/96A patent/AU689362B2/en not_active Ceased
- 1995-11-20 PT PT95942465T patent/PT800527E/pt unknown
- 1995-11-20 CN CN02155715.2A patent/CN1241924C/zh not_active Expired - Fee Related
- 1995-11-20 NZ NZ298245A patent/NZ298245A/en not_active IP Right Cessation
- 1995-11-20 CA CA002297134A patent/CA2297134C/en not_active Expired - Fee Related
- 1995-12-16 TW TW084113469A patent/TW401413B/zh not_active IP Right Cessation
- 1995-12-18 IL IL13914195A patent/IL139141A/xx not_active IP Right Cessation
- 1995-12-18 IL IL11642895A patent/IL116428A/xx not_active IP Right Cessation
- 1995-12-18 IL IL13914295A patent/IL139142A/en not_active IP Right Cessation
- 1995-12-19 AR AR33467595A patent/AR000378A1/es unknown
-
1996
- 1996-11-04 US US08/743,481 patent/US5734049A/en not_active Expired - Lifetime
-
1997
- 1997-06-18 FI FI972620A patent/FI121599B/fi not_active IP Right Cessation
- 1997-06-20 NO NO972875A patent/NO308900B1/no not_active IP Right Cessation
-
1999
- 1999-03-11 NZ NZ334608A patent/NZ334608A/xx not_active IP Right Cessation
- 1999-03-15 IL IL12899699A patent/IL128996A0/xx unknown
-
2000
- 2000-04-07 NO NO20001822A patent/NO310025B1/no not_active IP Right Cessation
- 2000-04-26 GR GR20000401013T patent/GR3033329T3/el unknown
- 2000-10-19 IL IL13914100A patent/IL139141A0/xx unknown
- 2000-10-19 IL IL13914200A patent/IL139142A0/xx active IP Right Grant
-
2004
- 2004-11-12 HK HK04108970A patent/HK1066009A1/xx not_active IP Right Cessation
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