ATE505206T1 - Verwendung des melanomdifferenzierungs assoziierten gens (mda-7) zur umwandlung eines krebsphänotyps - Google Patents

Verwendung des melanomdifferenzierungs assoziierten gens (mda-7) zur umwandlung eines krebsphänotyps

Info

Publication number
ATE505206T1
ATE505206T1 AT97940569T AT97940569T ATE505206T1 AT E505206 T1 ATE505206 T1 AT E505206T1 AT 97940569 T AT97940569 T AT 97940569T AT 97940569 T AT97940569 T AT 97940569T AT E505206 T1 ATE505206 T1 AT E505206T1
Authority
AT
Austria
Prior art keywords
mda
melanoma differentiation
gene
differentiation associated
cell
Prior art date
Application number
AT97940569T
Other languages
English (en)
Inventor
Paul Fisher
Original Assignee
Univ Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia filed Critical Univ Columbia
Application granted granted Critical
Publication of ATE505206T1 publication Critical patent/ATE505206T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
AT97940569T 1996-08-16 1997-08-15 Verwendung des melanomdifferenzierungs assoziierten gens (mda-7) zur umwandlung eines krebsphänotyps ATE505206T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/696,573 US5710137A (en) 1996-08-16 1996-08-16 Use of a melanoma differentiation associated gene (mda 7) for reversing a cancerous phenotype
PCT/US1997/014548 WO1998006441A1 (en) 1996-08-16 1997-08-15 USE OF A MELANOMA DIFFERENTIATION ASSOCIATED GENE (mda-7) FOR REVERSING A CANCEROUS PHENOTYPE

Publications (1)

Publication Number Publication Date
ATE505206T1 true ATE505206T1 (de) 2011-04-15

Family

ID=24797643

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97940569T ATE505206T1 (de) 1996-08-16 1997-08-15 Verwendung des melanomdifferenzierungs assoziierten gens (mda-7) zur umwandlung eines krebsphänotyps

Country Status (15)

Country Link
US (6) US5710137A (de)
EP (2) EP2251040A1 (de)
JP (2) JP4890666B2 (de)
KR (2) KR100528047B1 (de)
CN (2) CN100363057C (de)
AT (1) ATE505206T1 (de)
AU (1) AU727735B2 (de)
BR (1) BRPI9711137B8 (de)
CA (1) CA2263750C (de)
DE (1) DE69740175D1 (de)
DK (1) DK0957941T3 (de)
ES (1) ES2364513T3 (de)
NZ (1) NZ334034A (de)
SI (1) SI0957941T1 (de)
WO (1) WO1998006441A1 (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69435103D1 (de) * 1993-10-27 2008-07-10 Univ Columbia Methode zur Bildung einer subtrahierten cDNA Bank und ihre Verwendung
US5633161A (en) * 1995-03-29 1997-05-27 Millennium Pharmaceuticals, Inc. Murine gene fomy030 coding for tumor progression inhibitor
US6825320B1 (en) 1995-03-29 2004-11-30 Millenium Pharmaceuticals, Inc. FOHY03 polypeptides
US6794185B1 (en) 1995-03-29 2004-09-21 Millennium Pharmaceuticals, Inc. fohy030 nucleic acid molecules
US6251597B1 (en) 1996-03-29 2001-06-26 Millennium Pharmaceuticals, Inc. Methods for detecting fohy030
US6312909B1 (en) 1996-03-29 2001-11-06 Millennium Pharmaceuticals, Inc. Compositions and methods for the diagnosis prevention and treatment of tumor progression
US5710137A (en) * 1996-08-16 1998-01-20 The Trustees Of Columbia University In The City Of New York Use of a melanoma differentiation associated gene (mda 7) for reversing a cancerous phenotype
AU2469799A (en) * 1998-01-26 1999-08-09 Genquest Inc. Differentiation-associated sequences and methods of use therefor
US6413717B1 (en) 1998-03-18 2002-07-02 Corixa Corporation Methods for indentifying anti-cancer agents
WO1999060124A2 (en) * 1998-05-15 1999-11-25 Fei Huang Differentiation-associated sequences and methods of use therefor
WO2000046391A2 (en) * 1999-02-02 2000-08-10 The Trustees Of Columbia University In The City Of New York Genes displaying enhanced expression during cellular senescence and terminal cell differentiation and uses thereof
US6841362B1 (en) 2000-02-29 2005-01-11 The Trustees Of Columbia University In The City Of New York Melanoma differentiation associated gene-7 promoter and uses thereof
WO2002033975A2 (en) * 2000-10-15 2002-04-25 Sonicblue Incorporated Method and system for dynamic ad placement
CA2429769C (en) * 2000-12-07 2016-04-26 Board Of Regents, The University Of Texas System Methods of treatment involving human mda-7
GB0109515D0 (en) * 2001-04-17 2001-06-06 Neg Micon As A method for transporting a set of large longitudinal items, a package system to be used by the method and use of such a package system
EP1281767A3 (de) 2001-07-31 2003-05-28 Aladar A. Szalay Lichtausstrahlende Mikroorganismen und Zellen für die Diagnose und Therapie von Tumoren
US20030082140A1 (en) * 2001-08-20 2003-05-01 Fisher Paul B. Combinatorial methods for inducing cancer cell death
AU2003228267A1 (en) * 2002-03-05 2003-09-22 Board Of Regents, The University Of Texas System Methods of enhancing immune induction involving mda-7
EP1578196A4 (de) * 2002-12-23 2006-04-12 Univ Columbia Mda-7 und freie radikale bei der krebsbehandlung
AU2004218407A1 (en) * 2003-03-03 2004-09-16 Board Of Regents, The University Of Texas System Methods and compositions involving MDA-7
US20040229335A1 (en) * 2003-05-15 2004-11-18 Introgen Therapeutics, Inc. Methods and compositions for the production of adenoviral vectors
ATE420160T1 (de) 2003-06-18 2009-01-15 Genelux Corp Modifizierte rekombinante vacciniaviren, verwendungen davon
CA2548220A1 (en) * 2003-12-01 2005-09-09 Introgen Therapeutics, Inc. Use of mda-7 to inhibit infection by pathogenic organisms
US20070281041A1 (en) * 2004-03-02 2007-12-06 Introgen Therapeutics, Inc. Compositions and Methods Involving MDA-7 for the Treatment of Cancer
US20080026410A1 (en) * 2004-12-02 2008-01-31 Antonia Vlahou Biomarkers for Bladder Cancer
CN101166539B (zh) * 2005-02-08 2012-01-04 得克萨斯大学体系董事会 用于治疗癌症的涉及mda-7的组合物和方法
WO2007092944A2 (en) * 2006-02-08 2007-08-16 Introgen Therapeutics, Inc. Compositions and methods involving gene therapy and proteasome modulation
TW200819540A (en) 2006-07-11 2008-05-01 Genelux Corp Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders
EP2426142A3 (de) 2006-10-16 2012-06-13 Genelux Corporation Modifizierte Impfstoffvirusstämme zur Verwendung in einem Diagnose- und Therapieverfahren
WO2008156655A2 (en) * 2007-06-15 2008-12-24 Genelux Corporation Vaccinia virus vectors encoding a sodium-dependent transporter protein for imaging and/or treatment of tumors
KR200449370Y1 (ko) 2010-04-26 2010-07-06 범진아이엔디(주) 두께가 두꺼운 제품을 수축 및 기포없이 사출하는 금형
US10189773B2 (en) 2010-05-07 2019-01-29 Medicus Biosciences, Llc In-vivo gelling pharmaceutical pre-formulation
CN101935347B (zh) * 2010-07-27 2014-11-05 郑骏年 mda-7/IL-24去泛素化突变体
US10111985B2 (en) 2011-08-10 2018-10-30 Medicus Biosciences, Llc Biocompatible hydrogel polymer formulations for the controlled delivery of biomolecules
US11083821B2 (en) 2011-08-10 2021-08-10 C.P. Medical Corporation Biocompatible hydrogel polymer formulations for the controlled delivery of biomolecules
US10117885B2 (en) 2011-08-11 2018-11-06 Allergy Research Group, Llc Chewable lipid supplements for treating pain and fibromyalgia
AU2013259166B2 (en) 2012-05-11 2016-03-10 Theragenics Corporation Biocompatible hydrogel treatments for retinal detachment
AU2014236385B2 (en) 2013-03-14 2019-01-24 Theragenics Corporation Biocompatible hydrogel polymer matrix for delivery of cells
CA3004530A1 (en) * 2015-11-07 2017-05-11 Multivir Inc. Methods and compositions comprising tumor suppressor gene therapy and immune checkpoint blockade for the treatment of cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5183884A (en) * 1989-12-01 1993-02-02 United States Of America Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor
DE69435103D1 (de) * 1993-10-27 2008-07-10 Univ Columbia Methode zur Bildung einer subtrahierten cDNA Bank und ihre Verwendung
US5643761A (en) * 1993-10-27 1997-07-01 The Trustees Of Columbia University In The City Of New York Method for generating a subtracted cDNA library and uses of the generated library
US5710137A (en) * 1996-08-16 1998-01-20 The Trustees Of Columbia University In The City Of New York Use of a melanoma differentiation associated gene (mda 7) for reversing a cancerous phenotype
US6190909B1 (en) * 1997-04-17 2001-02-20 Millennium Pharmaceuticals, Inc. TH2-specific gene
US6440741B2 (en) 1999-03-15 2002-08-27 The Trustees Of Columbia University In The City Of New York Expression vector for consistent cellular expression of the tet on repressor in multiple cell types
WO2001005437A2 (en) 1999-07-15 2001-01-25 Introgen Therapeutics, Inc. Methods for treatment of hyperproliferative diseases using human mda-7
US6511676B1 (en) 1999-11-05 2003-01-28 Teni Boulikas Therapy for human cancers using cisplatin and other drugs or genes encapsulated into liposomes

Also Published As

Publication number Publication date
BRPI9711137B8 (pt) 2021-05-25
JP4890666B2 (ja) 2012-03-07
NZ334034A (en) 2000-10-27
WO1998006441A1 (en) 1998-02-19
JP2000516618A (ja) 2000-12-12
CA2263750A1 (en) 1998-02-19
KR100528047B1 (ko) 2005-11-15
SI0957941T1 (sl) 2011-09-30
DE69740175D1 (de) 2011-05-26
EP2251040A1 (de) 2010-11-17
JP2012051909A (ja) 2012-03-15
US20100189680A1 (en) 2010-07-29
US6855686B2 (en) 2005-02-15
CN1575819A (zh) 2005-02-09
BRPI9711137B1 (pt) 2016-01-26
ES2364513T3 (es) 2011-09-05
US7291605B2 (en) 2007-11-06
EP0957941A4 (de) 2001-09-05
US20020091098A1 (en) 2002-07-11
US5710137A (en) 1998-01-20
US20050191277A1 (en) 2005-09-01
DK0957941T3 (da) 2011-06-27
CN100363057C (zh) 2008-01-23
KR20000030021A (ko) 2000-05-25
US20080057035A1 (en) 2008-03-06
AU4231997A (en) 1998-03-06
US7579330B2 (en) 2009-08-25
CN1166409C (zh) 2004-09-15
KR20050054946A (ko) 2005-06-10
EP0957941B1 (de) 2011-04-13
CN1238697A (zh) 1999-12-15
US6355622B1 (en) 2002-03-12
AU727735B2 (en) 2000-12-21
BR9711137A (pt) 1999-08-17
CA2263750C (en) 2009-01-13
EP0957941A1 (de) 1999-11-24
KR100574049B1 (ko) 2006-04-27

Similar Documents

Publication Publication Date Title
ATE505206T1 (de) Verwendung des melanomdifferenzierungs assoziierten gens (mda-7) zur umwandlung eines krebsphänotyps
ES8307263A1 (es) Un procedimiento para la preparacion de fosfonamidas sustituidas.
TW289020B (de)
AP0202540A0 (en) Inhibitors of interleukin -1B converting enyme.
PH31271A (en) 9-Deoxotaxane compounds.
HUT65689A (en) Process for producing sulfonamides and pharmaceutical preparations containing them
MY133647A (en) Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates
WO1992017152A3 (en) Method for detecting and treating alzheimer's disease
MX9704030A (es) 1,1-dioxidos de 2-heterocicliloxi y tiometil-1,2,5-tiadiazolidin-3-ona y composiciones y metodo de uso de los mismos.
HU9204029D0 (en) Proteolytic enzym inhibitors
MA23395A1 (fr) Procede de preparation de nouvelles formulations
MY106202A (en) Saccharin derivatives useful as proteolytic enzyme inhibitors and preparation thereof.
BG103286A (en) Compositions and methods for ore dressing
EP0522709A3 (en) Polymerization inhibitors for acrylic acids and esters
ES8305700A1 (es) Un procedimiento para la preparacion de derivados dipeptidicos.
MY131384A (en) Novel 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
WO1988003927A3 (en) Renin inhibitors
NZ307444A (en) Polyphenol oxidase genes from lettuce and banana
DE69402201T2 (de) Phosphorhaltiges, metallurgisches silizium zur herstellung von organohalosilanen
IT1270660B (it) Procedimento microbiologico per la preparazione di 3-oxo-4-azasteroidi-17beta-carbossi sostituiti e uso dei prodotti come inibitori dell'enzima 5alfa-riduttasi
GR3031236T3 (en) Process for the preparation of pilocarpine.
FR2720406B1 (fr) Composition de microorganismes et procédé pour la production de xylitol.
MX9704677A (es) Procedimientos novedosos para preparar intermediarios de inhibidores de encefalinasa y enzima de conversion a angiotensina y sus intermediarios.
ES8502162A1 (es) Procedimiento para preparar un hidrolizado proteinico
NZ505085A (en) Pharmaceutical compositions comprising bipapcitide monocarboxylate and/or bipapcitide dicarboxylate for imaging and treating thrombi

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0957941

Country of ref document: EP