WO2001012642A3 - Nucleosidderivate und verfahren zu deren herstellung - Google Patents

Nucleosidderivate und verfahren zu deren herstellung Download PDF

Info

Publication number
WO2001012642A3
WO2001012642A3 PCT/DE2000/002755 DE0002755W WO0112642A3 WO 2001012642 A3 WO2001012642 A3 WO 2001012642A3 DE 0002755 W DE0002755 W DE 0002755W WO 0112642 A3 WO0112642 A3 WO 0112642A3
Authority
WO
WIPO (PCT)
Prior art keywords
atom
atoms
nucleoside derivatives
alkyl radical
producing same
Prior art date
Application number
PCT/DE2000/002755
Other languages
English (en)
French (fr)
Other versions
WO2001012642A2 (de
Inventor
Kurt Berlin
Original Assignee
Epigenomics Ag
Kurt Berlin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epigenomics Ag, Kurt Berlin filed Critical Epigenomics Ag
Priority to AU74028/00A priority Critical patent/AU7402800A/en
Priority to EP00962214A priority patent/EP1325016A2/de
Publication of WO2001012642A2 publication Critical patent/WO2001012642A2/de
Publication of WO2001012642A3 publication Critical patent/WO2001012642A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)

Abstract

Beschrieben werden neue Nucleosidderivate der allgemeinen Formel (I), worin R1 eine Nucleobase oder eine mit mindestens einer Schutzgruppe versehene Nucleobase darstellt, R2 ein H-Atom oder eine Diisopropylamino-(2-cyanoethoxy)-phosphinyl-Gruppe bedeutet, R3 ein H-Atom oder ein Alkylrest mit bis zu 4 C-Atomen ist, R4 ein H-Atom, eine Nitrogruppe oder einen Alkylrest mit bis zu 4 C-Atomen darstellt, R5 und R6 unabhängig voneinander ein H-Atom, ein Alkylrest mit bis zu 4 C-Atomen oder ein Alkoxyrest mit bis zu 4 C-Atomen bedeuten oder zusammen eine Methylendioxygruppe darstellen und R7 ein H-Atom oder ein Alkylrest mit bis zu 4 C-Atomen ist. Die neuen Nucleosidderivate lassen sich mittels UV-Licht leicht spalten und werden für die Synthese von Oligonucleotiden verwendet.
PCT/DE2000/002755 1999-08-12 2000-08-10 Nucleosidderivate und verfahren zu deren herstellung WO2001012642A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU74028/00A AU7402800A (en) 1999-08-12 2000-08-10 Nucleoside derivatives and a method for producing same
EP00962214A EP1325016A2 (de) 1999-08-12 2000-08-10 Nucleosidderivate und verfahren zu deren herstellung

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19938092.9 1999-08-12
DE19938092A DE19938092A1 (de) 1999-08-12 1999-08-12 Nucleosidderivate und Verfahren zu deren Herstellung

Publications (2)

Publication Number Publication Date
WO2001012642A2 WO2001012642A2 (de) 2001-02-22
WO2001012642A3 true WO2001012642A3 (de) 2001-06-07

Family

ID=7918075

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2000/002755 WO2001012642A2 (de) 1999-08-12 2000-08-10 Nucleosidderivate und verfahren zu deren herstellung

Country Status (4)

Country Link
EP (1) EP1325016A2 (de)
AU (1) AU7402800A (de)
DE (1) DE19938092A1 (de)
WO (1) WO2001012642A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10133779A1 (de) * 2001-07-16 2003-02-06 Chemogenix Gmbh Multimerpolynukleotidsynthese
DE10209203A1 (de) 2002-03-04 2003-09-25 Ulrich Steiner Verfahren zur Abspaltung von labilen funktionellen Gruppen aus chemischen Verbindungen
DE10247790A1 (de) 2002-10-14 2004-04-22 Chemogenix Gmbh Verfahren zur Herstellung von Oligonukleotidkonjugaten
US7759513B2 (en) * 2003-02-21 2010-07-20 Nigu Chemie Gmbh Photolabile protective groups for improved processes to prepare oligonucleotide arrays

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010128A1 (en) * 1992-11-02 1994-05-11 Affymax Technologies N.V. Novel photoreactive protecting groups

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010128A1 (en) * 1992-11-02 1994-05-11 Affymax Technologies N.V. Novel photoreactive protecting groups

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
H. GIEGRICH ET AL.: "New photolabile protecting groups in nucleoside and nucleotide chemistry - synthesis, cleavage mechanisms and applications", NUCLEOSIDES & NUCLEOTIDES, vol. 17, 1998, pages 1987 - 1996, XP002161670 *

Also Published As

Publication number Publication date
AU7402800A (en) 2001-03-13
EP1325016A2 (de) 2003-07-09
DE19938092A1 (de) 2001-02-22
WO2001012642A2 (de) 2001-02-22

Similar Documents

Publication Publication Date Title
DE68906552D1 (de) Camptothecin-derivate und verfahren zu ihrer herstellung.
HUT65618A (en) Process for producing benzylidene-carbamoyl-2-pyrrolidone, -4-oxazolidinone, -4-thiazolidinone and -3-isothiazolidinone analogues
DK0879236T3 (da) Derivater af camptothecin til anvendelse ved behandling af cancer
IL176075A0 (en) Process for fluorocytidine derivatives
FI905758A0 (fi) Menetelmä anti-tuumoriaineina käyttökelpoisten akryloyylisubstituoitujen pyrrolijohdannaisten valmistamiseksi
NO20021615D0 (no) Nöytralt kationisk lipid for levering av nukleinsyre og medikament
DE59806655D1 (de) Pyranone, verfahren zu ihrer herstellung und verwendung
AP1519A (en) Process for the preparation of thiazolidinedione derivatives.
WO2001012642A3 (de) Nucleosidderivate und verfahren zu deren herstellung
ES2169220T3 (es) Derivados de vitamina d3 con sustituyentes en la posicion 2.
WO2000027337A3 (fr) Procede de photostabilisation de derives de d,3,5-triazine
EP0335979A4 (en) Thienopyrimidine derivatives
CA2355098A1 (en) Chroman derivatives
WO2002044398A3 (en) Universal supports for oligonucleotide synthesis
ATE148128T1 (de) Anthracyclinglycosid-derivate und verfahren zu ihrer herstellung
WO2000064902A3 (en) Process for the preparation of calanolide precursors
HUP0001792A2 (hu) Dibenzo-oxazepin- és -dioxepin-származékok, és felhasználásuk tumorellenes szerként
ATE6500T1 (de) 2-alpha-methyl-dopaminimino-6,7-dihydroxy-1,2,3 4-tetrahydronaphthalin, seine salze, und verfahren zu dessen herstellung.
CA2164152A1 (en) New compounds of the secomacrolide and secoazalide class and a process for the preparation thereof
AU7332996A (en) Therapeutics for thrombocytopenia
ATE258187T1 (de) Herstellung von 2'-substitutierter rns
PT916674E (pt) Derivados de purina com um anel de ciclopropano.
ATE234318T1 (de) D-pentofuranose-derivate und verfahren zu ihrer herstellung
FI20011154A (fi) Välituotteena käyttökelpoiset tiatsolo(3,2-a)atsepiinijohdannaiset ja menetelmä niiden valmistamiseksi
KR840001154A (ko) 1,2-디티올-3-일리덴 암모늄 유도체의 제조방법

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WD Withdrawal of designations after international publication

Free format text: DE

WWE Wipo information: entry into national phase

Ref document number: 2000962214

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWE Wipo information: entry into national phase

Ref document number: 10049177

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 2000962214

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2000962214

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP