IL127137A0 - Dibenzo-oxazepine and-dioxepine derivatives and their use as anti-tumor agents - Google Patents

Dibenzo-oxazepine and-dioxepine derivatives and their use as anti-tumor agents

Info

Publication number
IL127137A0
IL127137A0 IL12713797A IL12713797A IL127137A0 IL 127137 A0 IL127137 A0 IL 127137A0 IL 12713797 A IL12713797 A IL 12713797A IL 12713797 A IL12713797 A IL 12713797A IL 127137 A0 IL127137 A0 IL 127137A0
Authority
IL
Israel
Prior art keywords
lower alkyl
tumor agents
oxazepine
dibenzo
substituted
Prior art date
Application number
IL12713797A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL127137A0 publication Critical patent/IL127137A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D267/00Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02Seven-membered rings
    • C07D267/08Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/16Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D267/20[b, f]-condensed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D321/00Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/02Seven-membered rings
    • C07D321/10Seven-membered rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/08Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/14Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Motorcycle And Bicycle Frame (AREA)
  • Rehabilitation Tools (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL12713797A 1996-06-07 1997-05-30 Dibenzo-oxazepine and-dioxepine derivatives and their use as anti-tumor agents IL127137A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96109115 1996-06-07
PCT/EP1997/002806 WO1997047611A1 (en) 1996-06-07 1997-05-30 Dibenzo-oxazepine and -dioxepine derivatives and their use as anti-tumor agents

Publications (1)

Publication Number Publication Date
IL127137A0 true IL127137A0 (en) 1999-09-22

Family

ID=8222857

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12713797A IL127137A0 (en) 1996-06-07 1997-05-30 Dibenzo-oxazepine and-dioxepine derivatives and their use as anti-tumor agents

Country Status (30)

Country Link
US (1) US5811420A (hu)
EP (1) EP0906295B1 (hu)
JP (1) JP3199752B2 (hu)
KR (1) KR100300152B1 (hu)
CN (1) CN1072650C (hu)
AT (1) ATE207471T1 (hu)
AU (1) AU725649B2 (hu)
BR (1) BR9709773A (hu)
CA (1) CA2257422A1 (hu)
CO (1) CO4940487A1 (hu)
CZ (1) CZ397498A3 (hu)
DE (1) DE69707672T2 (hu)
DK (1) DK0906295T3 (hu)
ES (1) ES2166087T3 (hu)
HK (1) HK1019063A1 (hu)
HR (1) HRP970313A2 (hu)
HU (1) HUP0001792A3 (hu)
IL (1) IL127137A0 (hu)
MA (1) MA24197A1 (hu)
NO (1) NO985685L (hu)
NZ (1) NZ332997A (hu)
PE (1) PE69598A1 (hu)
PL (1) PL330346A1 (hu)
PT (1) PT906295E (hu)
RU (1) RU2167871C2 (hu)
TR (1) TR199802517T2 (hu)
UY (1) UY24578A1 (hu)
WO (1) WO1997047611A1 (hu)
YU (1) YU55898A (hu)
ZA (1) ZA974886B (hu)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPQ307399A0 (en) * 1999-09-24 1999-10-21 Luminis Pty Limited Cell cycle control
CA2404540A1 (en) * 2002-09-20 2004-03-20 Institut Pasteur A method for measuring a marker indicative of the exposure of a patient to nicotine; a kit for measuring such a marker
US20130203715A1 (en) 2010-07-20 2013-08-08 Pulmatrix, Inc. Use of trp channel agonists to treat infections
CN109722389B (zh) * 2017-10-31 2021-05-14 鲁南新时代生物技术有限公司 一种烟曲霉菌液体培养基
CN108165590B (zh) * 2017-12-20 2021-11-23 河南科技学院 一种烟曲霉发酵产烟曲霉素的培养基及培养方法
US20240299344A1 (en) * 2021-03-04 2024-09-12 Lifemine Therapeutics Compounds, compositions, and methods of treatment thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9120640D0 (en) * 1991-09-27 1991-11-06 Ici Plc Tricyclic heterocycles
US5350763A (en) * 1993-06-11 1994-09-27 Merck & Co., Inc. Unguinol and analogs are animal growth permittants
JPH0769882A (ja) * 1993-08-27 1995-03-14 Nippon Paint Co Ltd エプスタイン−バーウィルス活性化抑制剤
ZA947969B (en) * 1993-10-15 1996-07-12 Schering Corp Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases

Also Published As

Publication number Publication date
KR100300152B1 (ko) 2001-09-06
DE69707672D1 (de) 2001-11-29
BR9709773A (pt) 1999-08-10
ATE207471T1 (de) 2001-11-15
MA24197A1 (fr) 1997-12-31
CA2257422A1 (en) 1997-12-18
NO985685L (no) 1999-02-04
DE69707672T2 (de) 2002-08-08
KR20000016432A (ko) 2000-03-25
UY24578A1 (es) 2000-12-29
AU725649B2 (en) 2000-10-19
TR199802517T2 (xx) 1999-02-22
ES2166087T3 (es) 2002-04-01
DK0906295T3 (da) 2002-02-11
PE69598A1 (es) 1998-11-14
YU55898A (sh) 2001-12-26
CN1072650C (zh) 2001-10-10
PL330346A1 (en) 1999-05-10
JP3199752B2 (ja) 2001-08-20
HUP0001792A2 (hu) 2000-12-28
EP0906295B1 (en) 2001-10-24
CN1221409A (zh) 1999-06-30
US5811420A (en) 1998-09-22
RU2167871C2 (ru) 2001-05-27
NZ332997A (en) 2000-05-26
EP0906295A1 (en) 1999-04-07
CZ397498A3 (cs) 1999-03-17
ZA974886B (en) 1997-12-08
WO1997047611A1 (en) 1997-12-18
HUP0001792A3 (en) 2001-10-29
PT906295E (pt) 2002-04-29
HK1019063A1 (en) 2000-01-21
JPH11511760A (ja) 1999-10-12
NO985685D0 (no) 1998-12-04
AU3169697A (en) 1998-01-07
HRP970313A2 (en) 1998-04-30
CO4940487A1 (es) 2000-07-24

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
RH1 Patent not in force