ES2186672T3 - Procedimiento para la produccion de derivados 13-eter de milbemicinas, e intermedios de los mismos. - Google Patents

Procedimiento para la produccion de derivados 13-eter de milbemicinas, e intermedios de los mismos.

Info

Publication number
ES2186672T3
ES2186672T3 ES93306899T ES93306899T ES2186672T3 ES 2186672 T3 ES2186672 T3 ES 2186672T3 ES 93306899 T ES93306899 T ES 93306899T ES 93306899 T ES93306899 T ES 93306899T ES 2186672 T3 ES2186672 T3 ES 2186672T3
Authority
ES
Spain
Prior art keywords
intermediates
derivatives
group
milbemicines
eter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93306899T
Other languages
English (en)
Inventor
Mitsugi Shibano
Mutsuo Suzuki
Shunshi Kojima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of ES2186672T3 publication Critical patent/ES2186672T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UN INTERMEDIARIO UTIL EN LA SINTESIS DE DERIVADOS DE MILBEMICINA TIENEN UN ENLACE ETER EN LA POSICION-13 Y LA CUAL SE REPRESENTA POR LA FORMULA GENERAL (IIID); DONDE R ES UN GRUPO METILO, UNO ETILO, UNO ISOPROPILO O UNO SEC-BUTILO, Y R5 Y R6 SON INDIVIDUALMENTE UN ATOMO DE H O UN GRUPO PROTECTOR, Y PRECURSORES RELACIONADOS Y PROCESO PARA PRODUCIR LOS INTERMEDIARIOS.
ES93306899T 1992-09-01 1993-09-01 Procedimiento para la produccion de derivados 13-eter de milbemicinas, e intermedios de los mismos. Expired - Lifetime ES2186672T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP23344492 1992-09-01
JP26366092 1992-10-01
JP32284792 1992-12-02

Publications (1)

Publication Number Publication Date
ES2186672T3 true ES2186672T3 (es) 2003-05-16

Family

ID=27331997

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93306899T Expired - Lifetime ES2186672T3 (es) 1992-09-01 1993-09-01 Procedimiento para la produccion de derivados 13-eter de milbemicinas, e intermedios de los mismos.

Country Status (14)

Country Link
US (2) US5461168A (es)
EP (1) EP0594291B1 (es)
JP (1) JP2654337B2 (es)
KR (1) KR0161541B1 (es)
AT (1) ATE229960T1 (es)
AU (1) AU666750B2 (es)
CA (1) CA2105251C (es)
DE (1) DE69332577T2 (es)
DK (1) DK0594291T3 (es)
ES (1) ES2186672T3 (es)
HK (1) HK1010371A1 (es)
NZ (1) NZ248559A (es)
PT (1) PT594291E (es)
TW (1) TW262474B (es)

Families Citing this family (152)

* Cited by examiner, † Cited by third party
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US6136838A (en) * 1998-03-19 2000-10-24 Merck & Co., Inc. Sulfurpentafluorophenylpyrazoles for controlling ectoparasitic infestations
JP4499847B2 (ja) * 1998-05-25 2010-07-07 三井化学アグロ株式会社 ミルベマイシン類の１３−エステル誘導体の製造法
KR100612634B1 (ko) * 1998-05-25 2006-08-14 상꾜 아그로 가부시키가이샤 밀베마이신류의 13-에스테르 유도체의 제조법
JP2002121195A (ja) * 2000-10-12 2002-04-23 Sankyo Co Ltd １３位置換ミルベマイシン誘導体の製造法
AU2005223483B2 (en) 2004-03-18 2009-04-23 Zoetis Llc N-(1-arylpyrazol-4l)sulfonamides and their use as parasiticides
US7919522B2 (en) 2007-05-03 2011-04-05 Merial Limited Compositions comprising C-13 alkoxyether macrolide compounds and phenylpyrazole compounds
TWI487486B (zh) 2009-12-01 2015-06-11 Syngenta Participations Ag 以異唑啉衍生物為主之殺蟲化合物
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US8957058B2 (en) 2010-10-05 2015-02-17 Syngenta Participations Ag Insecticidal pyrrolidin-yl-aryl-carboxamides
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MX2013013211A (es) 2011-05-18 2014-02-20 Syngenta Participations Ag Compuestos insecticidas a base de derivados de ariltioacetamida.
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US9339505B2 (en) 2011-05-31 2016-05-17 Syngenta Participations Ag Pesticidal mixtures including isoxazoline derivatives
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US5461168A (en) 1995-10-24
DE69332577T2 (de) 2003-11-20
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NZ248559A (en) 1995-05-26
EP0594291A1 (en) 1994-04-27
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AU4497993A (en) 1994-03-10
ATE229960T1 (de) 2003-01-15
EP0594291B1 (en) 2002-12-18
HK1010371A1 (en) 1999-06-17
KR940007038A (ko) 1994-04-26
TW262474B (es) 1995-11-11
PT594291E (pt) 2003-03-31
US5625078A (en) 1997-04-29
DE69332577D1 (de) 2003-01-30
JP2654337B2 (ja) 1997-09-17

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