ATE157966T1 - 22-oxacholecalziferol-derivate und ihre herstellung - Google Patents

22-oxacholecalziferol-derivate und ihre herstellung

Info

Publication number
ATE157966T1
ATE157966T1 AT93900419T AT93900419T ATE157966T1 AT E157966 T1 ATE157966 T1 AT E157966T1 AT 93900419 T AT93900419 T AT 93900419T AT 93900419 T AT93900419 T AT 93900419T AT E157966 T1 ATE157966 T1 AT E157966T1
Authority
AT
Austria
Prior art keywords
oxacholecalziferol
derivatives
preparation
same
hyperparathyroidism
Prior art date
Application number
AT93900419T
Other languages
English (en)
Inventor
Masahiro Kato
Tetsuhiro Mikami
Kiyoshige Ochi
Hiroyoshi Watanabe
Noboru Kubodera
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE157966T1 publication Critical patent/ATE157966T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
    • C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
AT93900419T 1991-12-18 1992-12-18 22-oxacholecalziferol-derivate und ihre herstellung ATE157966T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP36105191 1991-12-18

Publications (1)

Publication Number Publication Date
ATE157966T1 true ATE157966T1 (de) 1997-09-15

Family

ID=18471985

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93900419T ATE157966T1 (de) 1991-12-18 1992-12-18 22-oxacholecalziferol-derivate und ihre herstellung

Country Status (13)

Country Link
US (1) US5436401A (de)
EP (1) EP0619304B1 (de)
JP (1) JP3493037B2 (de)
KR (1) KR100247214B1 (de)
AT (1) ATE157966T1 (de)
DE (1) DE69222183T2 (de)
DK (1) DK0619304T3 (de)
ES (1) ES2107650T3 (de)
GR (1) GR3025468T3 (de)
HK (1) HK1002729A1 (de)
SG (1) SG78265A1 (de)
TW (1) TW222621B (de)
WO (1) WO1993012083A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3563310D1 (en) * 1985-07-30 1988-07-21 Salzgitter Ind Method and device for the preparation of suspensions with constant indications from basic materials with variable properties
US6103709A (en) * 1993-12-23 2000-08-15 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs and methods for treatment of vitamin D diseases
US6121469A (en) 1993-12-23 2000-09-19 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs
DE69527789T2 (de) * 1994-04-19 2003-04-10 Chugai Pharmaceutical Co Ltd Mittel zur behandlung von kachexie die im zusammenhang mit tumoren steht
GB9607034D0 (en) * 1996-04-03 1996-06-05 Leo Pharm Prod Ltd Chemical compounds
KR100503919B1 (ko) * 1996-09-03 2005-07-27 더 트러스티스 오브 컬럼비아 유니버시티 인 더 시티 오브 뉴욕 비타민 디 및 스테로이드 유도체들의 합성에 사용되는 중간체들의 제조방법
GB9804861D0 (en) 1998-03-06 1998-04-29 Res Inst Medicine Chem Chemical compounds
AU4291299A (en) * 1998-07-03 2000-01-24 Chugai Seiyaku Kabushiki Kaisha Ultraviolet irradiation apparatus for photochemical reaction and method for preparing vitamin d derivative using the same
ATE462689T1 (de) * 1999-08-27 2010-04-15 Hiroaki Takayama Vitamin-d-derivate mit substituenten an der 2- alpha-position
WO2001079166A1 (fr) 2000-04-19 2001-10-25 Chugai Seiyaku Kabushiki Kaisha Derives de la vitamine d
IL153395A0 (en) * 2000-06-15 2003-07-06 Chugai Pharmaceutical Co Ltd Vitamin d derivatives
CN1781487A (zh) * 2000-08-30 2006-06-07 中外制药株式会社 Oct制剂
JP2014514274A (ja) 2011-03-09 2014-06-19 テバ ファーマシューティカル インダストリーズ リミティド マキサカルシトールの多形およびマキサカルシトールの調製方法
CN102796134B (zh) * 2012-08-31 2015-07-01 甘肃皓天化学科技有限公司 一种马沙骨化醇中间体的制备方法
CN103508999B (zh) 2013-10-12 2015-05-13 浙江海正药业股份有限公司 马沙骨化醇的合成中间体及其制备方法和用途
CN107286067A (zh) * 2016-04-05 2017-10-24 湖南华腾制药有限公司 一种马沙骨化醇的制备方法
US20230065886A1 (en) 2019-11-27 2023-03-02 Yonsung Fine Chemical Co., Ltd. Method for producing maxacalcitol, and intermediate therefor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61140560A (ja) * 1984-12-12 1986-06-27 Chugai Pharmaceut Co Ltd ２０−オキサ−２１−ノルビタミンｄ３誘導体
JPS61267550A (ja) * 1984-12-28 1986-11-27 Chugai Pharmaceut Co Ltd ９，１０−セコ−５，７，１０（１９）−プレグナトリエン誘導体
JP3050564B2 (ja) * 1989-12-15 2000-06-12 中外製薬株式会社 新規な２２―オキサビタミンｄ誘導体

Also Published As

Publication number Publication date
DE69222183T2 (de) 1998-01-22
TW222621B (de) 1994-04-21
KR100247214B1 (ko) 2000-03-15
SG78265A1 (en) 2001-02-20
GR3025468T3 (en) 1998-02-27
EP0619304A4 (de) 1995-03-29
ES2107650T3 (es) 1997-12-01
WO1993012083A1 (en) 1993-06-24
EP0619304A1 (de) 1994-10-12
KR940703807A (ko) 1994-12-12
HK1002729A1 (en) 1998-09-11
JP3493037B2 (ja) 2004-02-03
JPH0672994A (ja) 1994-03-15
DK0619304T3 (da) 1998-02-16
US5436401A (en) 1995-07-25
EP0619304B1 (de) 1997-09-10
DE69222183D1 (de) 1997-10-16

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee