DE69222183D1 - 22-oxacholecalziferol-derivate und ihre herstellung - Google Patents

22-oxacholecalziferol-derivate und ihre herstellung

Info

Publication number
DE69222183D1
DE69222183D1 DE69222183T DE69222183T DE69222183D1 DE 69222183 D1 DE69222183 D1 DE 69222183D1 DE 69222183 T DE69222183 T DE 69222183T DE 69222183 T DE69222183 T DE 69222183T DE 69222183 D1 DE69222183 D1 DE 69222183D1
Authority
DE
Germany
Prior art keywords
oxacholecalziferol
derivatives
production
same
hyperparathyroidism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69222183T
Other languages
English (en)
Other versions
DE69222183T2 (de
Inventor
Masahiro Chugai Seiyaku K Kato
Tetsuhiro Chugai Seiyak Mikami
Kiyoshige Chugai Seiyaku Ochi
Hiroyoshi Chugai Seiy Watanabe
Noboru Chugai Seiyaku Kubodera
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69222183D1 publication Critical patent/DE69222183D1/de
Publication of DE69222183T2 publication Critical patent/DE69222183T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
    • C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
DE69222183T 1991-12-18 1992-12-18 22-oxacholecalziferol-derivate und ihre herstellung Expired - Fee Related DE69222183T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP36105191 1991-12-18
PCT/JP1992/001662 WO1993012083A1 (en) 1991-12-18 1992-12-18 22-oxacholecalciferol derivative and production thereof

Publications (2)

Publication Number Publication Date
DE69222183D1 true DE69222183D1 (de) 1997-10-16
DE69222183T2 DE69222183T2 (de) 1998-01-22

Family

ID=18471985

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69222183T Expired - Fee Related DE69222183T2 (de) 1991-12-18 1992-12-18 22-oxacholecalziferol-derivate und ihre herstellung

Country Status (13)

Country Link
US (1) US5436401A (de)
EP (1) EP0619304B1 (de)
JP (1) JP3493037B2 (de)
KR (1) KR100247214B1 (de)
AT (1) ATE157966T1 (de)
DE (1) DE69222183T2 (de)
DK (1) DK0619304T3 (de)
ES (1) ES2107650T3 (de)
GR (1) GR3025468T3 (de)
HK (1) HK1002729A1 (de)
SG (1) SG78265A1 (de)
TW (1) TW222621B (de)
WO (1) WO1993012083A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3563310D1 (en) * 1985-07-30 1988-07-21 Salzgitter Ind Method and device for the preparation of suspensions with constant indications from basic materials with variable properties
US6121469A (en) 1993-12-23 2000-09-19 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs
US6103709A (en) * 1993-12-23 2000-08-15 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs and methods for treatment of vitamin D diseases
WO1995028162A1 (fr) * 1994-04-19 1995-10-26 Chugai Seiyaku Kabushiki Kaisha Medicament attenuant ou soignant le syndrome paraneoplasique
GB9607034D0 (en) * 1996-04-03 1996-06-05 Leo Pharm Prod Ltd Chemical compounds
KR20060038352A (ko) * 1996-09-03 2006-05-03 더 트러스티스 오브 컬럼비아 유니버시티 인 더 시티 오브 뉴욕 비타민 디 및 스테로이드 유도체들의 합성에 사용되는중간체들
GB9804861D0 (en) * 1998-03-06 1998-04-29 Res Inst Medicine Chem Chemical compounds
KR100560910B1 (ko) * 1998-07-03 2006-03-14 츄가이 세이야꾸 가부시키가이샤 광화학 반응용 자외선 조사장치 및 이를 이용한 비타민 ｄ유도체의 제조방법
DK1219599T3 (da) * 1999-08-27 2010-05-25 Hiroaki Takayama Vitamin-D-derivater som har substituenter i 2-alfa-position
US7074777B2 (en) 2000-04-19 2006-07-11 Chugai Seiyaku Kabushiki Kaisha Vitamin D derivatives
CA2411409C (en) 2000-06-15 2011-05-17 Chugai Seiyaku Kabushiki Kaisha Vitamin d derivatives
CA2425367A1 (en) * 2000-08-30 2003-04-07 Chugai Seiyaku Kabushiki Kaisha Oct formulations
WO2012122451A2 (en) 2011-03-09 2012-09-13 Teva Pharmaceutical Industries Ltd. Polymorphs of maxacalcitol and process for the preparation of maxacalcitol
CN102796134B (zh) * 2012-08-31 2015-07-01 甘肃皓天化学科技有限公司 一种马沙骨化醇中间体的制备方法
CN103508999B (zh) 2013-10-12 2015-05-13 浙江海正药业股份有限公司 马沙骨化醇的合成中间体及其制备方法和用途
CN107286067A (zh) * 2016-04-05 2017-10-24 湖南华腾制药有限公司 一种马沙骨化醇的制备方法
KR102472541B1 (ko) 2019-11-27 2022-11-30 연성정밀화학(주) 막사칼시톨의 제조방법 및 그를 위한 중간체

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61140560A (ja) * 1984-12-12 1986-06-27 Chugai Pharmaceut Co Ltd ２０−オキサ−２１−ノルビタミンｄ３誘導体
JPS61267550A (ja) * 1984-12-28 1986-11-27 Chugai Pharmaceut Co Ltd ９，１０−セコ−５，７，１０（１９）−プレグナトリエン誘導体
JP3050564B2 (ja) * 1989-12-15 2000-06-12 中外製薬株式会社 新規な２２―オキサビタミンｄ誘導体

Also Published As

Publication number Publication date
EP0619304B1 (de) 1997-09-10
SG78265A1 (en) 2001-02-20
ATE157966T1 (de) 1997-09-15
EP0619304A4 (de) 1995-03-29
US5436401A (en) 1995-07-25
DK0619304T3 (da) 1998-02-16
DE69222183T2 (de) 1998-01-22
GR3025468T3 (en) 1998-02-27
JPH0672994A (ja) 1994-03-15
EP0619304A1 (de) 1994-10-12
HK1002729A1 (en) 1998-09-11
WO1993012083A1 (en) 1993-06-24
JP3493037B2 (ja) 2004-02-03
TW222621B (de) 1994-04-21
KR100247214B1 (ko) 2000-03-15
KR940703807A (ko) 1994-12-12
ES2107650T3 (es) 1997-12-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee