ATE99318T1 - 4-substituierte-anthracyclinone und anthracyclin- glycoside und verfahren zu ihrer herstellung. - Google Patents

4-substituierte-anthracyclinone und anthracyclin- glycoside und verfahren zu ihrer herstellung.

Info

Publication number
ATE99318T1
ATE99318T1 AT89118648T AT89118648T ATE99318T1 AT E99318 T1 ATE99318 T1 AT E99318T1 AT 89118648 T AT89118648 T AT 89118648T AT 89118648 T AT89118648 T AT 89118648T AT E99318 T1 ATE99318 T1 AT E99318T1
Authority
AT
Austria
Prior art keywords
group
substituted
production
anthracycline glycosides
anthracyclinones
Prior art date
Application number
AT89118648T
Other languages
English (en)
Inventor
Walter Cabri
Bernardinis Silvia De
Franco Francalanci
Sergio Penco
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Application granted granted Critical
Publication of ATE99318T1 publication Critical patent/ATE99318T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT89118648T 1988-10-25 1989-10-06 4-substituierte-anthracyclinone und anthracyclin- glycoside und verfahren zu ihrer herstellung. ATE99318T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888824947A GB8824947D0 (en) 1988-10-25 1988-10-25 New 4-substituted anthracyclinones & process for preparing them
EP89118648A EP0366973B1 (de) 1988-10-25 1989-10-06 4-Substituierte-Anthracyclinone und Anthracyclin-Glycoside und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
ATE99318T1 true ATE99318T1 (de) 1994-01-15

Family

ID=10645743

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89118648T ATE99318T1 (de) 1988-10-25 1989-10-06 4-substituierte-anthracyclinone und anthracyclin- glycoside und verfahren zu ihrer herstellung.

Country Status (18)

Country Link
US (1) US5587495A (de)
EP (1) EP0366973B1 (de)
JP (1) JPH04501414A (de)
KR (1) KR900701812A (de)
AT (1) ATE99318T1 (de)
AU (1) AU624444B2 (de)
DE (1) DE68911855T2 (de)
DK (1) DK168597B1 (de)
ES (1) ES2061871T3 (de)
FI (1) FI93364C (de)
GB (1) GB8824947D0 (de)
HU (1) HU207733B (de)
IE (1) IE64161B1 (de)
IL (1) IL92052A (de)
NZ (1) NZ231052A (de)
PT (1) PT92080B (de)
WO (1) WO1990004601A1 (de)
ZA (1) ZA898052B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8803301D0 (en) * 1988-02-12 1988-03-09 Erba Carlo Spa Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin
GB8808475D0 (en) * 1988-04-11 1988-05-11 Erba Carlo Spa Process for preparing 4-demethoxydauno-mycinone
NL9001834A (nl) * 1990-08-16 1992-03-16 Pharmachemie Bv Nieuwe antracyclineverbindingen met anti-tumorwerkzaamheid, nieuwe tussenverbindingen voor de bereiding van deze antracyclineverbindingen, alsmede preparaten die de aktieve antracyclineverbindingen bevatten.
CN100379749C (zh) * 2003-05-21 2008-04-09 獀洛克斯股份有限公司 4-r-取代的4-去甲氧基柔红霉素的制备方法
US7053191B2 (en) 2003-05-21 2006-05-30 Solux Corporation Method of preparing 4-R-substituted 4-demethoxydaunorubicin
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US8846882B2 (en) 2011-04-29 2014-09-30 Synbias Pharma Ag Method of producing 4-demethoxydaunorubicin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1500421A (en) * 1975-01-22 1978-02-08 Farmaceutici Italia Optically active anthracyclinones
US4116981A (en) * 1977-05-02 1978-09-26 Yuh-Geng Tsay 5,12-epoxy-naphthacene-6,11-dione derivatives
US4822873A (en) * 1983-10-19 1989-04-18 University Of Melbourne Carminomycinone precurses and analogues
AU567978B2 (en) * 1983-10-19 1987-12-10 Anti-Cancer Council Of Victoria Carminomycinone precursors and analogues and derivatives thereof.

Also Published As

Publication number Publication date
DK75291D0 (da) 1991-04-24
AU624444B2 (en) 1992-06-11
DK168597B1 (da) 1994-05-02
IL92052A0 (en) 1990-07-12
PT92080B (pt) 1995-06-30
GB8824947D0 (en) 1988-11-30
EP0366973A1 (de) 1990-05-09
HU896397D0 (en) 1991-07-29
ES2061871T3 (es) 1994-12-16
ZA898052B (en) 1990-08-29
FI93364C (fi) 1995-03-27
HUT57228A (en) 1991-11-28
WO1990004601A1 (en) 1990-05-03
HU207733B (en) 1993-05-28
DE68911855D1 (de) 1994-02-10
US5587495A (en) 1996-12-24
NZ231052A (en) 1991-04-26
IE893407L (en) 1990-04-25
KR900701812A (ko) 1990-12-04
PT92080A (pt) 1990-04-30
IL92052A (en) 1994-06-24
DK75291A (da) 1991-06-20
DE68911855T2 (de) 1994-04-21
AU4496289A (en) 1990-05-14
FI911952A0 (fi) 1991-04-22
EP0366973B1 (de) 1993-12-29
FI93364B (fi) 1994-12-15
JPH04501414A (ja) 1992-03-12
IE64161B1 (en) 1995-07-12

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee