IL92052A - 4-Hydrocarbyl 4-Demethoxy-deanomycinins and the process for their preparation - Google Patents

4-Hydrocarbyl 4-Demethoxy-deanomycinins and the process for their preparation

Info

Publication number
IL92052A
IL92052A IL9205289A IL9205289A IL92052A IL 92052 A IL92052 A IL 92052A IL 9205289 A IL9205289 A IL 9205289A IL 9205289 A IL9205289 A IL 9205289A IL 92052 A IL92052 A IL 92052A
Authority
IL
Israel
Prior art keywords
group
formula
daunomycinone
demethoxy
compound
Prior art date
Application number
IL9205289A
Other languages
English (en)
Hebrew (he)
Other versions
IL92052A0 (en
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Priority to IL10497489A priority Critical patent/IL104974A/en
Publication of IL92052A0 publication Critical patent/IL92052A0/xx
Priority to IL104974A priority patent/IL104974A0/xx
Publication of IL92052A publication Critical patent/IL92052A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL9205289A 1988-10-25 1989-10-19 4-Hydrocarbyl 4-Demethoxy-deanomycinins and the process for their preparation IL92052A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL10497489A IL104974A (en) 1988-10-25 1989-10-19 4-Demethoxy-4-Transformed-anthracycline glycosides and their preparation
IL104974A IL104974A0 (en) 1988-10-25 1993-03-08 Anthracycline glycosides,their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888824947A GB8824947D0 (en) 1988-10-25 1988-10-25 New 4-substituted anthracyclinones & process for preparing them

Publications (2)

Publication Number Publication Date
IL92052A0 IL92052A0 (en) 1990-07-12
IL92052A true IL92052A (en) 1994-06-24

Family

ID=10645743

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9205289A IL92052A (en) 1988-10-25 1989-10-19 4-Hydrocarbyl 4-Demethoxy-deanomycinins and the process for their preparation

Country Status (18)

Country Link
US (1) US5587495A (de)
EP (1) EP0366973B1 (de)
JP (1) JPH04501414A (de)
KR (1) KR900701812A (de)
AT (1) ATE99318T1 (de)
AU (1) AU624444B2 (de)
DE (1) DE68911855T2 (de)
DK (1) DK168597B1 (de)
ES (1) ES2061871T3 (de)
FI (1) FI93364C (de)
GB (1) GB8824947D0 (de)
HU (1) HU207733B (de)
IE (1) IE64161B1 (de)
IL (1) IL92052A (de)
NZ (1) NZ231052A (de)
PT (1) PT92080B (de)
WO (1) WO1990004601A1 (de)
ZA (1) ZA898052B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8803301D0 (en) * 1988-02-12 1988-03-09 Erba Carlo Spa Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin
GB8808475D0 (en) * 1988-04-11 1988-05-11 Erba Carlo Spa Process for preparing 4-demethoxydauno-mycinone
NL9001834A (nl) * 1990-08-16 1992-03-16 Pharmachemie Bv Nieuwe antracyclineverbindingen met anti-tumorwerkzaamheid, nieuwe tussenverbindingen voor de bereiding van deze antracyclineverbindingen, alsmede preparaten die de aktieve antracyclineverbindingen bevatten.
US7053191B2 (en) 2003-05-21 2006-05-30 Solux Corporation Method of preparing 4-R-substituted 4-demethoxydaunorubicin
CN100379749C (zh) * 2003-05-21 2008-04-09 獀洛克斯股份有限公司 4-r-取代的4-去甲氧基柔红霉素的制备方法
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US8846882B2 (en) 2011-04-29 2014-09-30 Synbias Pharma Ag Method of producing 4-demethoxydaunorubicin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1500421A (en) * 1975-01-22 1978-02-08 Farmaceutici Italia Optically active anthracyclinones
US4116981A (en) * 1977-05-02 1978-09-26 Yuh-Geng Tsay 5,12-epoxy-naphthacene-6,11-dione derivatives
AU567978B2 (en) * 1983-10-19 1987-12-10 Anti-Cancer Council Of Victoria Carminomycinone precursors and analogues and derivatives thereof.
IT1177014B (it) * 1983-10-19 1987-08-26 Univ Melbourne Composti organici che comprendono antracicline e antraciclinoni

Also Published As

Publication number Publication date
DE68911855D1 (de) 1994-02-10
IL92052A0 (en) 1990-07-12
FI93364B (fi) 1994-12-15
JPH04501414A (ja) 1992-03-12
ZA898052B (en) 1990-08-29
PT92080A (pt) 1990-04-30
GB8824947D0 (en) 1988-11-30
NZ231052A (en) 1991-04-26
FI93364C (fi) 1995-03-27
AU624444B2 (en) 1992-06-11
PT92080B (pt) 1995-06-30
IE893407L (en) 1990-04-25
HU207733B (en) 1993-05-28
KR900701812A (ko) 1990-12-04
HU896397D0 (en) 1991-07-29
IE64161B1 (en) 1995-07-12
EP0366973B1 (de) 1993-12-29
ATE99318T1 (de) 1994-01-15
DK168597B1 (da) 1994-05-02
US5587495A (en) 1996-12-24
WO1990004601A1 (en) 1990-05-03
ES2061871T3 (es) 1994-12-16
EP0366973A1 (de) 1990-05-09
DK75291A (da) 1991-06-20
FI911952A0 (fi) 1991-04-22
HUT57228A (en) 1991-11-28
DE68911855T2 (de) 1994-04-21
AU4496289A (en) 1990-05-14
DK75291D0 (da) 1991-04-24

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