PT92080A - Processo para a preparacao de novos glicosidos antraciclinicos e de antraciclinonas 4-substituidas intermedias com accao anti-tumoral - Google Patents

Processo para a preparacao de novos glicosidos antraciclinicos e de antraciclinonas 4-substituidas intermedias com accao anti-tumoral

Info

Publication number
PT92080A
PT92080A PT92080A PT9208089A PT92080A PT 92080 A PT92080 A PT 92080A PT 92080 A PT92080 A PT 92080A PT 9208089 A PT9208089 A PT 9208089A PT 92080 A PT92080 A PT 92080A
Authority
PT
Portugal
Prior art keywords
group
substituted
preparation
antimacyclinic
ancercyclines
Prior art date
Application number
PT92080A
Other languages
English (en)
Other versions
PT92080B (pt
Inventor
Walter Cabri
Silvia De Bernardinis
Franco Francalanci
Sergio Penco
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of PT92080A publication Critical patent/PT92080A/pt
Publication of PT92080B publication Critical patent/PT92080B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT92080A 1988-10-25 1989-10-23 Processo para a preparacao de novos glicosidos antraciclinicos e de antraciclinonas 4-substituidas intermedias com accao anti-tumoral PT92080B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888824947A GB8824947D0 (en) 1988-10-25 1988-10-25 New 4-substituted anthracyclinones & process for preparing them

Publications (2)

Publication Number Publication Date
PT92080A true PT92080A (pt) 1990-04-30
PT92080B PT92080B (pt) 1995-06-30

Family

ID=10645743

Family Applications (1)

Application Number Title Priority Date Filing Date
PT92080A PT92080B (pt) 1988-10-25 1989-10-23 Processo para a preparacao de novos glicosidos antraciclinicos e de antraciclinonas 4-substituidas intermedias com accao anti-tumoral

Country Status (18)

Country Link
US (1) US5587495A (pt)
EP (1) EP0366973B1 (pt)
JP (1) JPH04501414A (pt)
KR (1) KR900701812A (pt)
AT (1) ATE99318T1 (pt)
AU (1) AU624444B2 (pt)
DE (1) DE68911855T2 (pt)
DK (1) DK168597B1 (pt)
ES (1) ES2061871T3 (pt)
FI (1) FI93364C (pt)
GB (1) GB8824947D0 (pt)
HU (1) HU207733B (pt)
IE (1) IE64161B1 (pt)
IL (1) IL92052A (pt)
NZ (1) NZ231052A (pt)
PT (1) PT92080B (pt)
WO (1) WO1990004601A1 (pt)
ZA (1) ZA898052B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8803301D0 (en) * 1988-02-12 1988-03-09 Erba Carlo Spa Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin
GB8808475D0 (en) * 1988-04-11 1988-05-11 Erba Carlo Spa Process for preparing 4-demethoxydauno-mycinone
NL9001834A (nl) * 1990-08-16 1992-03-16 Pharmachemie Bv Nieuwe antracyclineverbindingen met anti-tumorwerkzaamheid, nieuwe tussenverbindingen voor de bereiding van deze antracyclineverbindingen, alsmede preparaten die de aktieve antracyclineverbindingen bevatten.
US7053191B2 (en) 2003-05-21 2006-05-30 Solux Corporation Method of preparing 4-R-substituted 4-demethoxydaunorubicin
CN100379749C (zh) * 2003-05-21 2008-04-09 獀洛克斯股份有限公司 4-r-取代的4-去甲氧基柔红霉素的制备方法
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US8846882B2 (en) 2011-04-29 2014-09-30 Synbias Pharma Ag Method of producing 4-demethoxydaunorubicin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1500421A (en) * 1975-01-22 1978-02-08 Farmaceutici Italia Optically active anthracyclinones
US4116981A (en) * 1977-05-02 1978-09-26 Yuh-Geng Tsay 5,12-epoxy-naphthacene-6,11-dione derivatives
AU567978B2 (en) * 1983-10-19 1987-12-10 Anti-Cancer Council Of Victoria Carminomycinone precursors and analogues and derivatives thereof.
IT1177014B (it) * 1983-10-19 1987-08-26 Univ Melbourne Composti organici che comprendono antracicline e antraciclinoni

Also Published As

Publication number Publication date
DE68911855D1 (de) 1994-02-10
IL92052A0 (en) 1990-07-12
FI93364B (fi) 1994-12-15
JPH04501414A (ja) 1992-03-12
ZA898052B (en) 1990-08-29
GB8824947D0 (en) 1988-11-30
NZ231052A (en) 1991-04-26
FI93364C (fi) 1995-03-27
AU624444B2 (en) 1992-06-11
PT92080B (pt) 1995-06-30
IE893407L (en) 1990-04-25
HU207733B (en) 1993-05-28
KR900701812A (ko) 1990-12-04
HU896397D0 (en) 1991-07-29
IE64161B1 (en) 1995-07-12
EP0366973B1 (en) 1993-12-29
ATE99318T1 (de) 1994-01-15
DK168597B1 (da) 1994-05-02
US5587495A (en) 1996-12-24
WO1990004601A1 (en) 1990-05-03
IL92052A (en) 1994-06-24
ES2061871T3 (es) 1994-12-16
EP0366973A1 (en) 1990-05-09
DK75291A (da) 1991-06-20
FI911952A0 (fi) 1991-04-22
HUT57228A (en) 1991-11-28
DE68911855T2 (de) 1994-04-21
AU4496289A (en) 1990-05-14
DK75291D0 (da) 1991-04-24

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Legal Events

Date Code Title Description
MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19980630