DK168597B1 - 4-substituerede demethoxy-daunomydinoner og anthracyclinglycosider deraf samt fremgangsmåde til fremstilling af glycosiderne - Google Patents
4-substituerede demethoxy-daunomydinoner og anthracyclinglycosider deraf samt fremgangsmåde til fremstilling af glycosiderne Download PDFInfo
- Publication number
- DK168597B1 DK168597B1 DK075291A DK75291A DK168597B1 DK 168597 B1 DK168597 B1 DK 168597B1 DK 075291 A DK075291 A DK 075291A DK 75291 A DK75291 A DK 75291A DK 168597 B1 DK168597 B1 DK 168597B1
- Authority
- DK
- Denmark
- Prior art keywords
- formula
- demethoxy
- glycoside
- group
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8824947 | 1988-10-25 | ||
| GB888824947A GB8824947D0 (en) | 1988-10-25 | 1988-10-25 | New 4-substituted anthracyclinones & process for preparing them |
| PCT/EP1989/001266 WO1990004601A1 (en) | 1988-10-25 | 1989-10-24 | New 4-substituted anthracyclinones and anthracycline glycosides and the process for preparing them |
| EP8901266 | 1989-10-24 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK75291D0 DK75291D0 (da) | 1991-04-24 |
| DK75291A DK75291A (da) | 1991-06-20 |
| DK168597B1 true DK168597B1 (da) | 1994-05-02 |
Family
ID=10645743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK075291A DK168597B1 (da) | 1988-10-25 | 1991-04-24 | 4-substituerede demethoxy-daunomydinoner og anthracyclinglycosider deraf samt fremgangsmåde til fremstilling af glycosiderne |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5587495A (pt) |
| EP (1) | EP0366973B1 (pt) |
| JP (1) | JPH04501414A (pt) |
| KR (1) | KR900701812A (pt) |
| AT (1) | ATE99318T1 (pt) |
| AU (1) | AU624444B2 (pt) |
| DE (1) | DE68911855T2 (pt) |
| DK (1) | DK168597B1 (pt) |
| ES (1) | ES2061871T3 (pt) |
| FI (1) | FI93364C (pt) |
| GB (1) | GB8824947D0 (pt) |
| HU (1) | HU207733B (pt) |
| IE (1) | IE64161B1 (pt) |
| IL (1) | IL92052A (pt) |
| NZ (1) | NZ231052A (pt) |
| PT (1) | PT92080B (pt) |
| WO (1) | WO1990004601A1 (pt) |
| ZA (1) | ZA898052B (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8803301D0 (en) * | 1988-02-12 | 1988-03-09 | Erba Carlo Spa | Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin |
| GB8808475D0 (en) * | 1988-04-11 | 1988-05-11 | Erba Carlo Spa | Process for preparing 4-demethoxydauno-mycinone |
| NL9001834A (nl) * | 1990-08-16 | 1992-03-16 | Pharmachemie Bv | Nieuwe antracyclineverbindingen met anti-tumorwerkzaamheid, nieuwe tussenverbindingen voor de bereiding van deze antracyclineverbindingen, alsmede preparaten die de aktieve antracyclineverbindingen bevatten. |
| US7053191B2 (en) | 2003-05-21 | 2006-05-30 | Solux Corporation | Method of preparing 4-R-substituted 4-demethoxydaunorubicin |
| CN100379749C (zh) * | 2003-05-21 | 2008-04-09 | 獀洛克斯股份有限公司 | 4-r-取代的4-去甲氧基柔红霉素的制备方法 |
| US8802830B2 (en) * | 2005-12-20 | 2014-08-12 | Solux Corporation | Synthesis of epirubicin from 13-dihydrodaunorubicine |
| US8357785B2 (en) * | 2008-01-08 | 2013-01-22 | Solux Corporation | Method of aralkylation of 4′-hydroxyl group of anthracylins |
| US8846882B2 (en) | 2011-04-29 | 2014-09-30 | Synbias Pharma Ag | Method of producing 4-demethoxydaunorubicin |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1500421A (en) * | 1975-01-22 | 1978-02-08 | Farmaceutici Italia | Optically active anthracyclinones |
| US4116981A (en) * | 1977-05-02 | 1978-09-26 | Yuh-Geng Tsay | 5,12-epoxy-naphthacene-6,11-dione derivatives |
| AU567978B2 (en) * | 1983-10-19 | 1987-12-10 | Anti-Cancer Council Of Victoria | Carminomycinone precursors and analogues and derivatives thereof. |
| IT1177014B (it) * | 1983-10-19 | 1987-08-26 | Univ Melbourne | Composti organici che comprendono antracicline e antraciclinoni |
-
1988
- 1988-10-25 GB GB888824947A patent/GB8824947D0/en active Pending
-
1989
- 1989-10-06 EP EP89118648A patent/EP0366973B1/en not_active Expired - Lifetime
- 1989-10-06 ES ES89118648T patent/ES2061871T3/es not_active Expired - Lifetime
- 1989-10-06 DE DE89118648T patent/DE68911855T2/de not_active Expired - Fee Related
- 1989-10-06 AT AT89118648T patent/ATE99318T1/de not_active IP Right Cessation
- 1989-10-18 NZ NZ231052A patent/NZ231052A/xx unknown
- 1989-10-19 IL IL9205289A patent/IL92052A/en not_active IP Right Cessation
- 1989-10-23 PT PT92080A patent/PT92080B/pt not_active IP Right Cessation
- 1989-10-23 IE IE340789A patent/IE64161B1/en not_active IP Right Cessation
- 1989-10-24 JP JP1511359A patent/JPH04501414A/ja active Pending
- 1989-10-24 AU AU44962/89A patent/AU624444B2/en not_active Ceased
- 1989-10-24 ZA ZA898052A patent/ZA898052B/xx unknown
- 1989-10-24 HU HU896397A patent/HU207733B/hu not_active IP Right Cessation
- 1989-10-24 KR KR1019900701338A patent/KR900701812A/ko active IP Right Grant
- 1989-10-24 WO PCT/EP1989/001266 patent/WO1990004601A1/en active IP Right Grant
- 1989-10-24 US US07/678,352 patent/US5587495A/en not_active Expired - Fee Related
-
1991
- 1991-04-22 FI FI911952A patent/FI93364C/fi not_active IP Right Cessation
- 1991-04-24 DK DK075291A patent/DK168597B1/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE68911855D1 (de) | 1994-02-10 |
| IL92052A0 (en) | 1990-07-12 |
| FI93364B (fi) | 1994-12-15 |
| JPH04501414A (ja) | 1992-03-12 |
| ZA898052B (en) | 1990-08-29 |
| PT92080A (pt) | 1990-04-30 |
| GB8824947D0 (en) | 1988-11-30 |
| NZ231052A (en) | 1991-04-26 |
| FI93364C (fi) | 1995-03-27 |
| AU624444B2 (en) | 1992-06-11 |
| PT92080B (pt) | 1995-06-30 |
| IE893407L (en) | 1990-04-25 |
| HU207733B (en) | 1993-05-28 |
| KR900701812A (ko) | 1990-12-04 |
| HU896397D0 (en) | 1991-07-29 |
| IE64161B1 (en) | 1995-07-12 |
| EP0366973B1 (en) | 1993-12-29 |
| ATE99318T1 (de) | 1994-01-15 |
| US5587495A (en) | 1996-12-24 |
| WO1990004601A1 (en) | 1990-05-03 |
| IL92052A (en) | 1994-06-24 |
| ES2061871T3 (es) | 1994-12-16 |
| EP0366973A1 (en) | 1990-05-09 |
| DK75291A (da) | 1991-06-20 |
| FI911952A0 (fi) | 1991-04-22 |
| HUT57228A (en) | 1991-11-28 |
| DE68911855T2 (de) | 1994-04-21 |
| AU4496289A (en) | 1990-05-14 |
| DK75291D0 (da) | 1991-04-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |