DK1251846T3 - C4-Carbonattaxaner - Google Patents
C4-CarbonattaxanerInfo
- Publication number
- DK1251846T3 DK1251846T3 DK00980427T DK00980427T DK1251846T3 DK 1251846 T3 DK1251846 T3 DK 1251846T3 DK 00980427 T DK00980427 T DK 00980427T DK 00980427 T DK00980427 T DK 00980427T DK 1251846 T3 DK1251846 T3 DK 1251846T3
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- formula
- carbonattaxaner
- 3cch2
- ch3c
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- -1 cyclobutyl- Chemical group 0.000 abstract 1
- 125000002933 cyclohexyloxy group Chemical group C1(CCCCC1)O* 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 229940126701 oral medication Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17996500P | 2000-02-03 | 2000-02-03 | |
| PCT/US2000/031484 WO2001056565A1 (en) | 2000-02-03 | 2000-11-16 | C-4 carbonate taxanes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1251846T3 true DK1251846T3 (da) | 2004-11-29 |
Family
ID=22658728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00980427T DK1251846T3 (da) | 2000-02-03 | 2000-11-16 | C4-Carbonattaxaner |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6750246B1 (da) |
| EP (1) | EP1251846B1 (da) |
| JP (1) | JP2003523971A (da) |
| AT (1) | ATE273005T1 (da) |
| AU (1) | AU778284B2 (da) |
| CA (1) | CA2399116A1 (da) |
| CZ (1) | CZ20022956A3 (da) |
| DE (1) | DE60012988T2 (da) |
| DK (1) | DK1251846T3 (da) |
| ES (1) | ES2226954T3 (da) |
| HK (1) | HK1047891B (da) |
| MY (1) | MY129310A (da) |
| NZ (1) | NZ521136A (da) |
| PE (1) | PE20020747A1 (da) |
| PT (1) | PT1251846E (da) |
| RU (1) | RU2243223C2 (da) |
| TR (1) | TR200402454T4 (da) |
| TW (2) | TWI245041B (da) |
| WO (1) | WO2001056565A1 (da) |
| ZA (1) | ZA200207037B (da) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6750246B1 (en) | 2000-02-03 | 2004-06-15 | Bristol-Myers Squibb Company | C-4 carbonate taxanes |
| US6916942B2 (en) * | 2000-02-03 | 2005-07-12 | Bristol-Myers Squibb Company | Process for the preparation of C-4 carbonate taxanes |
| UY27185A1 (es) * | 2001-02-28 | 2002-09-30 | Bristol Myers Squibb Co | Dosificación metronómica de taxanos |
| EP1623706A3 (en) * | 2001-02-28 | 2006-02-22 | Bristol-Myers Squibb Company | Metronomic dosing of taxanes for inhibiting tumor growth |
| US7063977B2 (en) * | 2001-08-21 | 2006-06-20 | Bristol-Myers Squibb Company | Enzymatic resolution of t-butyl taxane derivatives |
| CA2470826A1 (en) * | 2001-12-20 | 2003-07-03 | Bristol-Myers Squibb Company | Pharmaceutical compositions of orally active taxane derivatives having enhanced bioavailability |
| US20070105944A1 (en) * | 2002-10-25 | 2007-05-10 | Comezoglu S N | Taxane metabolites |
| US7371759B2 (en) * | 2003-09-25 | 2008-05-13 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
| TW200533339A (en) * | 2004-03-16 | 2005-10-16 | Bristol Myers Squibb Co | Therapeutic synergy of anti-cancer compounds |
| US7459562B2 (en) * | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
| TW200538453A (en) * | 2004-04-26 | 2005-12-01 | Bristol Myers Squibb Co | Bicyclic heterocycles as kinase inhibitors |
| US20050288290A1 (en) | 2004-06-28 | 2005-12-29 | Borzilleri Robert M | Fused heterocyclic kinase inhibitors |
| US7432373B2 (en) * | 2004-06-28 | 2008-10-07 | Bristol-Meyers Squibb Company | Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors |
| US7439246B2 (en) * | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
| WO2006058121A1 (en) * | 2004-11-23 | 2006-06-01 | Bristol-Myers Squibb Company | Crystalline forms of 3'-tert-butyl-3'-n-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-n-debenzoyl-4-o-methoxycarbonyl-paclitaxel |
| US20060258736A1 (en) * | 2005-05-12 | 2006-11-16 | Bristol-Myers Squibb Company | Dosing regimen |
| US20080221135A1 (en) * | 2005-05-13 | 2008-09-11 | Bristol-Myers Squibb Company | Combination therapy |
| US7348325B2 (en) | 2005-11-30 | 2008-03-25 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| PL217731B1 (pl) | 2006-06-01 | 2014-08-29 | Tomasz Byrski | Sposób wykrywania genetycznie uwarunkowanej obniżonej odpowiedzi na chemioterapię cytostatykiem taksanowym, zastosowanie mutacji założycielskiej oraz zestawu do wykrywania takiej odpowiedzi |
| KR101821768B1 (ko) | 2009-11-05 | 2018-01-24 | 리젠 파마슈티컬스 소시에떼 아노님 | 신규한 벤조피란 키나제 조절제 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY110249A (en) | 1989-05-31 | 1998-03-31 | Univ Florida State | Method for preparation of taxol using beta lactam |
| US5399726A (en) | 1993-01-29 | 1995-03-21 | Florida State University | Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups |
| US6521660B2 (en) | 1991-09-23 | 2003-02-18 | Florida State University | 3′-alkyl substituted taxanes and pharmaceutical compositions containing them |
| US5284864A (en) | 1991-09-23 | 1994-02-08 | Florida State University | Butenyl substituted taxanes and pharmaceutical compositions containing them |
| US6335362B1 (en) | 1991-09-23 | 2002-01-01 | Florida State University | Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them |
| US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
| JP3492690B2 (ja) | 1992-12-23 | 2004-02-03 | ブリストル‐マイアーズ スクイブ カンパニー | 新規な側鎖をもつタキサン類およびその中間体類 |
| US5973160A (en) | 1992-12-23 | 1999-10-26 | Poss; Michael A. | Methods for the preparation of novel sidechain-bearing taxanes |
| US5567592A (en) | 1994-02-02 | 1996-10-22 | Regents Of The University Of California | Screening method for the identification of bioenhancers through the inhibition of P-glycoprotein transport in the gut of a mammal |
| US5767296A (en) | 1994-06-09 | 1998-06-16 | Daiichi Pharmaceutical Co., Ltd. | Deacetoxytaxol derivatives |
| FR2726272B1 (fr) * | 1994-10-26 | 1996-12-06 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US5840929A (en) | 1995-04-14 | 1998-11-24 | Bristol-Myers Squibb Company | C4 methoxy ether derivatives of paclitaxel |
| TW354293B (en) | 1995-06-06 | 1999-03-11 | Bristol Myers Squibb Co | Prodrugs of paclitaxel derivatives |
| US6964946B1 (en) | 1995-10-26 | 2005-11-15 | Baker Norton Pharmaceuticals, Inc. | Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same |
| US6245805B1 (en) | 1995-10-26 | 2001-06-12 | Baker Norton Pharmaceuticals, Inc. | Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
| US5739359A (en) * | 1997-01-24 | 1998-04-14 | Virginia Tech Intellectual Properties, Inc. | Methods for preparing 1-deoxy paclitaxels |
| AU759030B2 (en) | 1997-12-31 | 2003-04-03 | Bristol-Myers Squibb Company | 2-aroyl-4-acyl paclitaxel (taxol) analogs |
| WO2000069840A1 (en) | 1999-05-17 | 2000-11-23 | Bristol-Myers Squibb Company | Novel reaction conditions for the cleavage of silyl ethers in the preparation of paclitaxel (taxol®) and paclitaxel analogues |
| KR100634249B1 (ko) | 1999-08-11 | 2006-10-17 | 브리스톨-마이어스스퀴브컴파니 | 파클리탁셀 ｃ-4 메틸 카르보네이트 동족체의 제조 방법 |
| PL354777A1 (en) | 1999-10-27 | 2004-02-23 | Baker Norton Pharmaceuticals, Inc. | Method and compositions for administering taxanes orally to human patients |
| US6750246B1 (en) | 2000-02-03 | 2004-06-15 | Bristol-Myers Squibb Company | C-4 carbonate taxanes |
| CA2434641A1 (en) | 2001-01-18 | 2002-08-22 | Pharmacia And Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
| UY27185A1 (es) | 2001-02-28 | 2002-09-30 | Bristol Myers Squibb Co | Dosificación metronómica de taxanos |
| DE10154464B4 (de) | 2001-11-08 | 2005-10-20 | Max Delbrueck Centrum | Oral verabreichbare pharmazeutische Zubereitung umfassend liposomal verkapseltes Taxol |
| US20040092428A1 (en) | 2001-11-27 | 2004-05-13 | Hongming Chen | Oral pharmaceuticals formulation comprising paclitaxel, derivatives and methods of administration thereof |
-
2000
- 2000-11-14 US US09/712,352 patent/US6750246B1/en not_active Expired - Lifetime
- 2000-11-16 DK DK00980427T patent/DK1251846T3/da active
- 2000-11-16 AU AU17692/01A patent/AU778284B2/en not_active Ceased
- 2000-11-16 DE DE60012988T patent/DE60012988T2/de not_active Expired - Lifetime
- 2000-11-16 JP JP2001556256A patent/JP2003523971A/ja active Pending
- 2000-11-16 PT PT00980427T patent/PT1251846E/pt unknown
- 2000-11-16 RU RU2002123641/04A patent/RU2243223C2/ru not_active IP Right Cessation
- 2000-11-16 CZ CZ20022956A patent/CZ20022956A3/cs unknown
- 2000-11-16 CA CA002399116A patent/CA2399116A1/en not_active Abandoned
- 2000-11-16 WO PCT/US2000/031484 patent/WO2001056565A1/en active IP Right Grant
- 2000-11-16 ES ES00980427T patent/ES2226954T3/es not_active Expired - Lifetime
- 2000-11-16 TR TR2004/02454T patent/TR200402454T4/xx unknown
- 2000-11-16 EP EP00980427A patent/EP1251846B1/en not_active Expired - Lifetime
- 2000-11-16 NZ NZ521136A patent/NZ521136A/en unknown
- 2000-11-16 AT AT00980427T patent/ATE273005T1/de active
-
2001
- 2001-01-29 MY MYPI20010372A patent/MY129310A/en unknown
- 2001-01-29 TW TW090101690A patent/TWI245041B/zh not_active IP Right Cessation
- 2001-01-29 TW TW094114392A patent/TWI245042B/zh not_active IP Right Cessation
- 2001-02-02 PE PE2001000117A patent/PE20020747A1/es not_active Application Discontinuation
-
2002
- 2002-09-02 ZA ZA200207037A patent/ZA200207037B/en unknown
-
2003
- 2003-01-02 HK HK03100017.6A patent/HK1047891B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1047891B (zh) | 2005-01-28 |
| PT1251846E (pt) | 2004-11-30 |
| DE60012988T2 (de) | 2005-08-25 |
| ZA200207037B (en) | 2003-12-02 |
| ATE273005T1 (de) | 2004-08-15 |
| MY129310A (en) | 2007-03-30 |
| TR200402454T4 (tr) | 2004-12-21 |
| EP1251846A1 (en) | 2002-10-30 |
| TWI245042B (en) | 2005-12-11 |
| AU778284B2 (en) | 2004-11-25 |
| DE60012988D1 (en) | 2004-09-16 |
| RU2002123641A (ru) | 2004-01-10 |
| NZ521136A (en) | 2004-05-28 |
| RU2243223C2 (ru) | 2004-12-27 |
| HK1047891A1 (en) | 2003-03-14 |
| EP1251846B1 (en) | 2004-08-11 |
| US6750246B1 (en) | 2004-06-15 |
| WO2001056565A1 (en) | 2001-08-09 |
| JP2003523971A (ja) | 2003-08-12 |
| EP1251846A4 (en) | 2003-03-12 |
| AU1769201A (en) | 2001-08-14 |
| TWI245041B (en) | 2005-12-11 |
| TW200526613A (en) | 2005-08-16 |
| CA2399116A1 (en) | 2001-08-09 |
| CZ20022956A3 (cs) | 2003-02-12 |
| ES2226954T3 (es) | 2005-04-01 |
| PE20020747A1 (es) | 2002-08-17 |
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