TR200402454T4 - C-4 karbonat taksanlar. - Google Patents

C-4 karbonat taksanlar.

Info

Publication number
TR200402454T4
TR200402454T4 TR2004/02454T TR200402454T TR200402454T4 TR 200402454 T4 TR200402454 T4 TR 200402454T4 TR 2004/02454 T TR2004/02454 T TR 2004/02454T TR 200402454 T TR200402454 T TR 200402454T TR 200402454 T4 TR200402454 T4 TR 200402454T4
Authority
TR
Turkey
Prior art keywords
formula
compounds
taxanes
carbonate
zopropyl
Prior art date
Application number
TR2004/02454T
Other languages
English (en)
Inventor
F. Kadow John
Mastalerz Harold
May Xue Qiufen
Hansel Steven
Edson Zoeckler Mary
C. Rose William
G. Tarrant James
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of TR200402454T4 publication Critical patent/TR200402454T4/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Carbon And Carbon Compounds (AREA)

Abstract

(Formül(I)); Mevcut bulus yeni taksan türevleri ile, bunlarin antitümör maddeleri olarak kullanimi ve farmasötik bilesimleri ile ilgilidir. Bulus formül (I) bilesiklerini ve formül (I) bilesiklerinin veya bunlarin farmasötik tuzlarinin insan veya veteriner hastaliklarinin tedavisinde oral ilaçlar olarak kullanimini talep etmektedir, ki burada: R fenil, zopropil veya tert bütildir; R1-C(O)Rz'dir, ki burada Rz(CH3)3CO-,(CH3)3CCH2-,CH3(CH2)3O-,siklobütil-, sikloheksiloksi veya (2-furil)'dir; R2 CH3C(O)O-'dir.
TR2004/02454T 2000-02-03 2000-11-16 C-4 karbonat taksanlar. TR200402454T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17996500P 2000-02-03 2000-02-03

Publications (1)

Publication Number Publication Date
TR200402454T4 true TR200402454T4 (tr) 2004-12-21

Family

ID=22658728

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2004/02454T TR200402454T4 (tr) 2000-02-03 2000-11-16 C-4 karbonat taksanlar.

Country Status (20)

Country Link
US (1) US6750246B1 (tr)
EP (1) EP1251846B1 (tr)
JP (1) JP2003523971A (tr)
AT (1) ATE273005T1 (tr)
AU (1) AU778284B2 (tr)
CA (1) CA2399116A1 (tr)
CZ (1) CZ20022956A3 (tr)
DE (1) DE60012988T2 (tr)
DK (1) DK1251846T3 (tr)
ES (1) ES2226954T3 (tr)
HK (1) HK1047891B (tr)
MY (1) MY129310A (tr)
NZ (1) NZ521136A (tr)
PE (1) PE20020747A1 (tr)
PT (1) PT1251846E (tr)
RU (1) RU2243223C2 (tr)
TR (1) TR200402454T4 (tr)
TW (2) TWI245041B (tr)
WO (1) WO2001056565A1 (tr)
ZA (1) ZA200207037B (tr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750246B1 (en) 2000-02-03 2004-06-15 Bristol-Myers Squibb Company C-4 carbonate taxanes
US6916942B2 (en) * 2000-02-03 2005-07-12 Bristol-Myers Squibb Company Process for the preparation of C-4 carbonate taxanes
UY27185A1 (es) * 2001-02-28 2002-09-30 Bristol Myers Squibb Co Dosificación metronómica de taxanos
EP1623706A3 (en) * 2001-02-28 2006-02-22 Bristol-Myers Squibb Company Metronomic dosing of taxanes for inhibiting tumor growth
US7063977B2 (en) * 2001-08-21 2006-06-20 Bristol-Myers Squibb Company Enzymatic resolution of t-butyl taxane derivatives
BR0215184A (pt) * 2001-12-20 2006-06-06 Bristol Myers Squibb Co composições farmacêuticas de derivados de taxano oralmente ativos tendo biodisponibilidade aumentada
US20070105944A1 (en) * 2002-10-25 2007-05-10 Comezoglu S N Taxane metabolites
US7371759B2 (en) * 2003-09-25 2008-05-13 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
TW200533339A (en) * 2004-03-16 2005-10-16 Bristol Myers Squibb Co Therapeutic synergy of anti-cancer compounds
US7459562B2 (en) * 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
TW200538453A (en) * 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
US7439246B2 (en) * 2004-06-28 2008-10-21 Bristol-Myers Squibb Company Fused heterocyclic kinase inhibitors
US7432373B2 (en) * 2004-06-28 2008-10-07 Bristol-Meyers Squibb Company Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
US7173031B2 (en) 2004-06-28 2007-02-06 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US20060116420A1 (en) * 2004-11-23 2006-06-01 Ramakrishnan Chidambaram Crystalline forms of 3'-tert-Butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4-O-methoxycarbonyl-paclitaxel
US20060258736A1 (en) * 2005-05-12 2006-11-16 Bristol-Myers Squibb Company Dosing regimen
US20080221135A1 (en) * 2005-05-13 2008-09-11 Bristol-Myers Squibb Company Combination therapy
US7348325B2 (en) 2005-11-30 2008-03-25 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
PL217731B1 (pl) 2006-06-01 2014-08-29 Tomasz Byrski Sposób wykrywania genetycznie uwarunkowanej obniżonej odpowiedzi na chemioterapię cytostatykiem taksanowym, zastosowanie mutacji założycielskiej oraz zestawu do wykrywania takiej odpowiedzi
CN105801550B (zh) 2009-11-05 2019-06-14 理森制药股份公司 新型苯并吡喃激酶调节剂

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY110249A (en) 1989-05-31 1998-03-31 Univ Florida State Method for preparation of taxol using beta lactam
US5284864A (en) 1991-09-23 1994-02-08 Florida State University Butenyl substituted taxanes and pharmaceutical compositions containing them
US5283253A (en) 1991-09-23 1994-02-01 Florida State University Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them
US5399726A (en) 1993-01-29 1995-03-21 Florida State University Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
US6521660B2 (en) 1991-09-23 2003-02-18 Florida State University 3′-alkyl substituted taxanes and pharmaceutical compositions containing them
US6335362B1 (en) 1991-09-23 2002-01-01 Florida State University Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
US5973160A (en) 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
KR100378612B1 (ko) 1992-12-23 2003-04-03 브리스톨-마이어스스퀴브컴파니 신규 측쇄-함유 탁산 및 그의 중간체 화합물
US5567592A (en) 1994-02-02 1996-10-22 Regents Of The University Of California Screening method for the identification of bioenhancers through the inhibition of P-glycoprotein transport in the gut of a mammal
EP0764643A1 (en) 1994-06-09 1997-03-26 Daiichi Pharmaceutical Co., Ltd. Deacetoxytaxol derivative
FR2726272B1 (fr) * 1994-10-26 1996-12-06 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US5840929A (en) 1995-04-14 1998-11-24 Bristol-Myers Squibb Company C4 methoxy ether derivatives of paclitaxel
TW354293B (en) 1995-06-06 1999-03-11 Bristol Myers Squibb Co Prodrugs of paclitaxel derivatives
US6245805B1 (en) 1995-10-26 2001-06-12 Baker Norton Pharmaceuticals, Inc. Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents
US6964946B1 (en) 1995-10-26 2005-11-15 Baker Norton Pharmaceuticals, Inc. Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same
US5739359A (en) * 1997-01-24 1998-04-14 Virginia Tech Intellectual Properties, Inc. Methods for preparing 1-deoxy paclitaxels
HUP0101457A3 (en) 1997-12-31 2003-01-28 Bristol Myers Squibb Co Antitumor 2-aroyl-4-acyl paclitaxel analogs and medicaments containing them , their intermediates and method for producing them
PT1178979E (pt) 1999-05-17 2004-04-30 Bristol Myers Squibb Co Novas condicoes de reaccao para a clivagem de eteres de sililo na preparacao de paclitaxel (taxol(r)) e analogos de paclitaxel
DE60010476T2 (de) 1999-08-11 2005-04-14 Bristol-Myers Squibb Co. Verfahren zur Herstellung eines C-4-Methylcarbonat-Analogons von Paclitaxel
JP2003512443A (ja) 1999-10-27 2003-04-02 ベーカー ノートン ファーマシューティカルズ インコーポレイテッド タキサンをヒト患者に経口投与するための方法及び組成物
US6750246B1 (en) 2000-02-03 2004-06-15 Bristol-Myers Squibb Company C-4 carbonate taxanes
EP1365759A2 (en) 2001-01-18 2003-12-03 PHARMACIA & UPJOHN COMPANY Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
UY27185A1 (es) 2001-02-28 2002-09-30 Bristol Myers Squibb Co Dosificación metronómica de taxanos
DE10154464B4 (de) 2001-11-08 2005-10-20 Max Delbrueck Centrum Oral verabreichbare pharmazeutische Zubereitung umfassend liposomal verkapseltes Taxol
US20040092428A1 (en) 2001-11-27 2004-05-13 Hongming Chen Oral pharmaceuticals formulation comprising paclitaxel, derivatives and methods of administration thereof

Also Published As

Publication number Publication date
ES2226954T3 (es) 2005-04-01
TWI245042B (en) 2005-12-11
ATE273005T1 (de) 2004-08-15
JP2003523971A (ja) 2003-08-12
MY129310A (en) 2007-03-30
RU2002123641A (ru) 2004-01-10
DE60012988T2 (de) 2005-08-25
NZ521136A (en) 2004-05-28
WO2001056565A1 (en) 2001-08-09
HK1047891B (zh) 2005-01-28
EP1251846B1 (en) 2004-08-11
EP1251846A4 (en) 2003-03-12
HK1047891A1 (en) 2003-03-14
PT1251846E (pt) 2004-11-30
AU778284B2 (en) 2004-11-25
CA2399116A1 (en) 2001-08-09
US6750246B1 (en) 2004-06-15
TW200526613A (en) 2005-08-16
TWI245041B (en) 2005-12-11
AU1769201A (en) 2001-08-14
EP1251846A1 (en) 2002-10-30
CZ20022956A3 (cs) 2003-02-12
DK1251846T3 (da) 2004-11-29
ZA200207037B (en) 2003-12-02
PE20020747A1 (es) 2002-08-17
DE60012988D1 (en) 2004-09-16
RU2243223C2 (ru) 2004-12-27

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