US4605661A
(en)
*
|
1984-06-18 |
1986-08-12 |
Eli Lilly And Company |
Aromastase inhibiting α,α-diarylimidazole-4(5)-propionitriles, α,α-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles
|
EP0225292A3
(de)
|
1985-12-06 |
1988-11-30 |
Ciba-Geigy Ag |
Einige N-substituierte Buttersäureamidderivate
|
DE3811574A1
(de)
*
|
1988-03-31 |
1989-10-19 |
Schering Ag |
N-substituierte imidazole, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
|
DE4138042C2
(de)
|
1991-11-19 |
1993-10-14 |
Biotechnolog Forschung Gmbh |
Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel
|
US5716981A
(en)
|
1993-07-19 |
1998-02-10 |
Angiogenesis Technologies, Inc. |
Anti-angiogenic compositions and methods of use
|
US20030203976A1
(en)
|
1993-07-19 |
2003-10-30 |
William L. Hunter |
Anti-angiogenic compositions and methods of use
|
ATE339975T1
(de)
|
1993-07-19 |
2006-10-15 |
Angiotech Pharm Inc |
Anti-angiogener stent und verfahren zu dessen herstellung
|
DE59610712D1
(de)
|
1995-11-17 |
2003-10-16 |
Biotechnolog Forschung Gmbh |
Epothilonderivate, herstellung und verwendung
|
DE19607702A1
(de)
|
1996-02-29 |
1997-09-04 |
Biotechnolog Forschung Gmbh |
Heterozyklische Verbindungen, Herstellungsverfahren und Mittel
|
US6441025B2
(en)
|
1996-03-12 |
2002-08-27 |
Pg-Txl Company, L.P. |
Water soluble paclitaxel derivatives
|
CN101028259A
(zh)
|
1996-03-12 |
2007-09-05 |
Pg-Txl有限公司 |
水溶性紫杉醇产品
|
US20040106985A1
(en)
|
1996-04-26 |
2004-06-03 |
Jang G. David |
Intravascular stent
|
US5917084A
(en)
|
1996-07-03 |
1999-06-29 |
Millennium Pharmaceuticals, Inc. |
Antifungal agents
|
DE19645361A1
(de)
|
1996-08-30 |
1998-04-30 |
Ciba Geigy Ag |
Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B, Teil II
|
US5969145A
(en)
|
1996-08-30 |
1999-10-19 |
Novartis Ag |
Process for the production of epothilones and intermediate products within the process
|
DE19645362A1
(de)
|
1996-10-28 |
1998-04-30 |
Ciba Geigy Ag |
Verfahren zur Herstellung von Epothilon A und B und Derivaten
|
DE19636343C1
(de)
|
1996-08-30 |
1997-10-23 |
Schering Ag |
Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B
|
DE19638870B4
(de)
|
1996-09-23 |
2009-05-14 |
Helmholtz-Zentrum für Infektionsforschung GmbH |
Tubulysine, Verfahren zu ihrer Gewinnung und sie enthaltende Mittel
|
CZ303422B6
(cs)
*
|
1996-11-18 |
2012-09-05 |
GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) |
Epothilon C, zpusob jeho výroby a jeho použití jako cytostatik a prostredku pro ochranu rostlin
|
EP1386922B1
(de)
|
1996-12-03 |
2012-04-11 |
Sloan-Kettering Institute For Cancer Research |
Synthese von Epitholonen, Zwischenprodukte, Analoga und ihre Verwendung
|
US6204388B1
(en)
|
1996-12-03 |
2001-03-20 |
Sloan-Kettering Institute For Cancer Research |
Synthesis of epothilones, intermediates thereto and analogues thereof
|
US6867305B2
(en)
*
|
1996-12-03 |
2005-03-15 |
Sloan-Kettering Institute For Cancer Research |
Synthesis of epothilones, intermediates thereto and analogues thereof
|
US6380394B1
(en)
|
1996-12-13 |
2002-04-30 |
The Scripps Research Institute |
Epothilone analogs
|
US6660758B1
(en)
|
1996-12-13 |
2003-12-09 |
The Scripps Research Institute |
Epothilone analogs
|
DE19701758A1
(de)
|
1997-01-20 |
1998-07-23 |
Wessjohann Ludgar A Dr |
Epothilone-Synthesebausteine
|
WO1998038192A1
(de)
|
1997-02-25 |
1998-09-03 |
GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) |
Seitenkettenmodifizierte epothilone
|
US20020086812A1
(en)
|
1997-03-04 |
2002-07-04 |
Schweinfest Clifford W. |
Methods and compositions for diagnosis and treatment of cancer
|
DE19713970B4
(de)
|
1997-04-04 |
2006-08-31 |
R&D-Biopharmaceuticals Gmbh |
Epothilone-Synthesebausteine II - Prenylderivate
|
DE59805900D1
(de)
|
1997-04-18 |
2002-11-14 |
Studiengesellschaft Kohle Mbh |
Selektive olefinmetathese von bi- oder polyfunktionellen substraten in komprimiertem kohlendioxid als reaktionsmedium
|
US6117659A
(en)
|
1997-04-30 |
2000-09-12 |
Kosan Biosciences, Inc. |
Recombinant narbonolide polyketide synthase
|
DE19849464A1
(de)
|
1997-04-30 |
2000-04-27 |
Schering Ag |
Wirkstofffreisetzende Stents, Verfahren zu ihrer Herstellung und ihre Verwendung zur Restenoseprophylaxe
|
DE19720312A1
(de)
|
1997-05-15 |
1998-11-19 |
Hoechst Ag |
Zubereitung mit erhöhter in vivo Verträglichkeit
|
DE19821954A1
(de)
|
1997-05-15 |
1998-11-19 |
Biotechnolog Forschung Gmbh |
Verfahren zur Herstellung eines Epothilon-Derivats
|
US20030049841A1
(en)
|
1997-06-16 |
2003-03-13 |
Short Jay M. |
High throughput or capillary-based screening for a bioactivity or biomolecule
|
DE19726627A1
(de)
|
1997-06-17 |
1998-12-24 |
Schering Ag |
Zwischenprodukte, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Epothilon
|
US6605599B1
(en)
*
|
1997-07-08 |
2003-08-12 |
Bristol-Myers Squibb Company |
Epothilone derivatives
|
PT1001951E
(pt)
|
1997-07-16 |
2003-02-28 |
Schering Ag |
Derivados de tiazolo, processo para a sua preparacao e utilizacao
|
DE19749717A1
(de)
|
1997-10-31 |
1999-05-06 |
Schering Ag |
Neue C1-C6-Bausteine zur Totalsynthese neuer Epothilon-Derivate sowie Verfahren zur Herstellung dieser Bausteine
|
DE19751200A1
(de)
|
1997-11-13 |
1999-05-20 |
Schering Ag |
Neue Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
|
DE19735574A1
(de)
|
1997-08-09 |
1999-02-11 |
Schering Ag |
Neue [C1(Carboxa)-C6]-Fragmente, Verfahren zu ihrer Herstellung und ihre Verwendung zur Synthese von Epothilon und Epothilonderivaten
|
DE19735578A1
(de)
|
1997-08-09 |
1999-02-11 |
Schering Ag |
Neue (C1-C6)-Fragmente, Verfahren zur Herstellung und ihre Verwendung zur Synthese von Epothilon und Epothilonderivaten
|
DE59814067D1
(de)
|
1997-08-09 |
2007-09-06 |
Bayer Schering Pharma Ag |
Neue epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung
|
DE19813821A1
(de)
|
1998-03-20 |
1999-09-23 |
Schering Ag |
Verfahren zur Herstellung von C1-C6-Bausteinen zur Totalsynthese von Epothilon und Epothilon-Derivaten
|
DE19735575A1
(de)
|
1997-08-09 |
1999-02-11 |
Schering Ag |
Neue (C13-C15)-Fragmente, Verfahren zur Herstellung und ihre Verwendung zur Synthese von Epothilon und Epothilonderivaten
|
DE19744135C1
(de)
|
1997-09-29 |
1999-03-25 |
Schering Ag |
Beschichtete medizinische Implantate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Restenoseprophylaxe
|
US6365749B1
(en)
|
1997-12-04 |
2002-04-02 |
Bristol-Myers Squibb Company |
Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
|
US6320045B1
(en)
|
1997-12-04 |
2001-11-20 |
Bristol-Myers Squibb Company |
Process for the reduction of oxiranyl epothilones to olefinic epothilones
|
US6096757A
(en)
|
1998-12-21 |
2000-08-01 |
Schering Corporation |
Method for treating proliferative diseases
|
US6280999B1
(en)
|
1998-01-23 |
2001-08-28 |
Kosan Bioscience |
Sorangium polyketide synthases and encoding DNA therefor
|
US6090601A
(en)
|
1998-01-23 |
2000-07-18 |
Kosan Bioscience |
Sorangium polyketide synthase
|
KR100669174B1
(ko)
|
1998-02-05 |
2007-01-17 |
노파르티스 아게 |
유기화합물 함유 조성물
|
US6683100B2
(en)
|
1999-01-19 |
2004-01-27 |
Novartis Ag |
Organic compounds
|
DE19804673A1
(de)
|
1998-02-06 |
1999-08-12 |
Studiengesellschaft Kohle Mbh |
Verfahren zur Darstellung makrocyclischer Produkte durch ringschliessende Diin-Metathese
|
US6194181B1
(en)
|
1998-02-19 |
2001-02-27 |
Novartis Ag |
Fermentative preparation process for and crystal forms of cytostatics
|
US6302838B1
(en)
|
1998-02-25 |
2001-10-16 |
Novartis Ag |
Cancer treatment with epothilones
|
MXPA00008365A
(es)
|
1998-02-25 |
2002-11-07 |
Sloan Kettering Inst Cancer |
Sintesis de epotilonas, intermediarios y analogos de las mismas.
|
FR2775187B1
(fr)
|
1998-02-25 |
2003-02-21 |
Novartis Ag |
Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo
|
US6407103B2
(en)
|
1998-04-21 |
2002-06-18 |
Bristol-Myers Squibb Pharma Company |
Indeno [1,2-c] pyrazol-4-ones and their uses
|
US6498257B1
(en)
|
1998-04-21 |
2002-12-24 |
Bristol-Myers Squibb Company |
2,3-olefinic epothilone derivatives
|
US6380395B1
(en)
|
1998-04-21 |
2002-04-30 |
Bristol-Myers Squibb Company |
12, 13-cyclopropane epothilone derivatives
|
JPH11322611A
(ja)
*
|
1998-05-14 |
1999-11-24 |
Sankyo Co Ltd |
抗ウイルス剤
|
GB9810659D0
(en)
|
1998-05-18 |
1998-07-15 |
Ciba Geigy Ag |
Organic compounds
|
US6121029A
(en)
|
1998-06-18 |
2000-09-19 |
Novartis Ag |
Genes for the biosynthesis of epothilones
|
DE19826988A1
(de)
|
1998-06-18 |
1999-12-23 |
Biotechnolog Forschung Gmbh |
Epothilon-Nebenkomponenten
|
DE19830060A1
(de)
|
1998-06-30 |
2000-02-10 |
Schering Ag |
Epothilon-Derivate, Verfahren zu deren Herstellung, Zwischenprodukte und ihre pharmazeutische Verwendung
|
DE19923001A1
(de)
|
1999-05-13 |
2000-11-16 |
Schering Ag |
Epothilon-Derivate, Verfahren zu deren Herstellung, Zwischenprodukte und ihre pharmazeutische Verwendung
|
US6221641B1
(en)
|
1998-07-02 |
2001-04-24 |
Leland Stanford Junior University |
Method for making polyketides
|
US20030199535A1
(en)
|
1998-07-30 |
2003-10-23 |
Claudio Cavazza |
Method for preventing and/or treating peripheral neuropathies induced by the administration of an anticancer agent
|
WO2000020601A2
(en)
|
1998-10-02 |
2000-04-13 |
Kosan Biosciences, Inc. |
Polyketide synthase enzymes and recombinant dna constructs therefor
|
DE19846493A1
(de)
|
1998-10-09 |
2000-04-13 |
Biotechnolog Forschung Gmbh |
DNA-Sequenzen für die enzymatische Synthese von Polyketid- oder Heteropolyketidverbindungen
|
DE19848306A1
(de)
|
1998-10-14 |
2000-04-20 |
Schering Ag |
Verfahren zur Herstellung von Epothilon B und Derivaten sowie Zwischenprodukte für dieses Verfahren
|
JP2003512013A
(ja)
|
1998-10-29 |
2003-04-02 |
コーサン バイオサイエンシーズ, インコーポレイテッド |
組換えオレアンドライドポリケチドシンターゼ
|
US6303767B1
(en)
|
1998-11-05 |
2001-10-16 |
Kosan Biosciences, Inc. |
Nucleic acids encoding narbonolide polyketide synthase enzymes from streptomyces narbonensis
|
US6410301B1
(en)
|
1998-11-20 |
2002-06-25 |
Kosan Biosciences, Inc. |
Myxococcus host cells for the production of epothilones
|
US6303342B1
(en)
|
1998-11-20 |
2001-10-16 |
Kason Biosciences, Inc. |
Recombinant methods and materials for producing epothilones C and D
|
EP1140944B1
(de)
|
1998-12-22 |
2003-08-27 |
Novartis AG |
Epothilonderivate und ihre verwendung als antitumormittel
|
US6780620B1
(en)
|
1998-12-23 |
2004-08-24 |
Bristol-Myers Squibb Company |
Microbial transformation method for the preparation of an epothilone
|
US6419692B1
(en)
|
1999-02-03 |
2002-07-16 |
Scimed Life Systems, Inc. |
Surface protection method for stents and balloon catheters for drug delivery
|
US6596875B2
(en)
|
2000-02-07 |
2003-07-22 |
James David White |
Method for synthesizing epothilones and epothilone analogs
|
EA009206B1
(ru)
|
1999-02-18 |
2007-12-28 |
Шеринг Акциенгезельшафт |
Производные 16-галогенэпотилона и их фармацевтическое использование
|
EP1152764A4
(de)
|
1999-02-18 |
2005-03-23 |
Oxigene Inc |
Zusammenstellungen und methoden zur verwendung in der zielung der vaskularen zerstörung
|
US6406722B1
(en)
|
1999-02-18 |
2002-06-18 |
Robert G. Gallaher |
Method of treating viral infections and lesions with taxane compounds
|
DE19908763A1
(de)
|
1999-02-18 |
2000-08-24 |
Schering Ag |
Neue Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
|
DE19954230A1
(de)
|
1999-11-04 |
2001-11-15 |
Schering Ag |
16-Halogen-Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
|
DE19908767A1
(de)
|
1999-02-18 |
2000-10-19 |
Schering Ag |
Neue Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
|
DE19908760A1
(de)
|
1999-02-18 |
2000-08-24 |
Schering Ag |
Neue Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
|
DE19908765A1
(de)
|
1999-02-18 |
2000-08-24 |
Schering Ag |
16-Halogen-Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
|
DE19907588A1
(de)
|
1999-02-22 |
2000-08-24 |
Biotechnolog Forschung Gmbh |
C-21 Modifizierte Epothilone
|
DE19930111A1
(de)
|
1999-07-01 |
2001-01-04 |
Biotechnolog Forschung Gmbh |
C-21 Modifizierte Epothilone
|
KR100685336B1
(ko)
|
1999-02-22 |
2007-02-23 |
게젤샤프트 퓌어 비오테크놀로기쉐 포르슝 엠베하(게베에프) |
C-21 변형 에포틸론
|
US20020058286A1
(en)
|
1999-02-24 |
2002-05-16 |
Danishefsky Samuel J. |
Synthesis of epothilones, intermediates thereto and analogues thereof
|
US6291684B1
(en)
|
1999-03-29 |
2001-09-18 |
Bristol-Myers Squibb Company |
Process for the preparation of aziridinyl epothilones from oxiranyl epothilones
|
US6211412B1
(en)
|
1999-03-29 |
2001-04-03 |
The University Of Kansas |
Synthesis of epothilones
|
US6603015B2
(en)
|
1999-03-29 |
2003-08-05 |
University Of Kansas |
Synthesis of epothilones
|
EP1043369B1
(de)
|
1999-04-06 |
2004-09-01 |
Seiko Epson Corporation |
Tintenzusammensetzung enthaltend einen Kupferkomplex-Farbstoff
|
CA2369303A1
(en)
|
1999-04-14 |
2000-10-19 |
Arthur B. Pardee |
Method and composition for the treatment of cancer
|
EP2308833A3
(de)
|
1999-04-15 |
2011-09-28 |
Bristol-Myers Squibb Company |
Zyklische Proteintyrosinkinaseinhibitoren
|
US7125875B2
(en)
|
1999-04-15 |
2006-10-24 |
Bristol-Myers Squibb Company |
Cyclic protein tyrosine kinase inhibitors
|
DE10015836A1
(de)
|
2000-03-27 |
2001-10-11 |
Schering Ag |
6-Alkenyl- und 6-Alkinyl-Epothilon-Derivate, Verfahren zu deren Herstellung sowie ihre Verwendung in pharmazeutischen Präparaten
|
DE19954228A1
(de)
|
1999-11-04 |
2001-09-13 |
Schering Ag |
6-Alkenyl-und 6-Alkinyl-Epothilon-Derivate, Verfahren zu deren Herstellung sowie ihre Verwendung in pharmazeutischen Präparaten
|
JP4707240B2
(ja)
*
|
1999-05-05 |
2011-06-22 |
アベンティス・フアーマ・リミテッド |
細胞接着調節剤としての尿素
|
KR100621185B1
(ko)
|
1999-09-09 |
2006-09-06 |
삼성전자주식회사 |
디디씨 모니터의 동작 기록형 마이크로컴퓨터의 제어방법
|
US6569867B2
(en)
|
1999-10-01 |
2003-05-27 |
Kosan Biosciences, Inc. |
Polyketide derivatives
|
US20020147197A1
(en)
|
1999-10-08 |
2002-10-10 |
Newman Michael J. |
Methods and compositions for enhancing pharmaceutical treatments
|
US20030054977A1
(en)
|
1999-10-12 |
2003-03-20 |
Cell Therapeutics, Inc. |
Manufacture of polyglutamate-therapeutic agent conjugates
|
US20020045220A1
(en)
|
1999-10-13 |
2002-04-18 |
Chaitan Khosla |
Biosynthesis of polyketide synthase substrates
|
CN1086389C
(zh)
*
|
1999-11-12 |
2002-06-19 |
中国科学院上海有机化学研究所 |
异埃坡霉素及合成方法
|
US20030036177A1
(en)
|
2002-08-13 |
2003-02-20 |
Joachim Strohhacker |
Single colonies of myxobacteria cells
|
JP2004500388A
(ja)
|
2000-03-01 |
2004-01-08 |
スローン−ケッタリング インスティトュート フォア キャンサー リサーチ |
エポチロン、その中間体およびその類似体の合成
|
US6518421B1
(en)
|
2000-03-20 |
2003-02-11 |
Bristol-Myers Squibb Company |
Process for the preparation of epothilone analogs
|
US6593115B2
(en)
|
2000-03-24 |
2003-07-15 |
Bristol-Myers Squibb Co. |
Preparation of epothilone intermediates
|
TWI310684B
(en)
|
2000-03-27 |
2009-06-11 |
Bristol Myers Squibb Co |
Synergistic pharmaceutical kits for treating cancer
|
DE10020517A1
(de)
|
2000-04-19 |
2001-10-25 |
Schering Ag |
Neue Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
|
DE10020899A1
(de)
|
2000-04-20 |
2001-10-25 |
Schering Ag |
9-Oxa-Epothilon-Derivate, Verfahren zu deren Herstellung sowie ihre Verwendung in pharmazeutischen Präparaten
|
US6998256B2
(en)
|
2000-04-28 |
2006-02-14 |
Kosan Biosciences, Inc. |
Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate
|
US6489314B1
(en)
|
2001-04-03 |
2002-12-03 |
Kosan Biosciences, Inc. |
Epothilone derivatives and methods for making and using the same
|
US6589968B2
(en)
|
2001-02-13 |
2003-07-08 |
Kosan Biosciences, Inc. |
Epothilone compounds and methods for making and using the same
|
US6838265B2
(en)
|
2000-05-02 |
2005-01-04 |
Kosan Biosciences, Inc. |
Overproduction hosts for biosynthesis of polyketides
|
US20020045609A1
(en)
|
2000-05-26 |
2002-04-18 |
Gary Ashley |
Epothilone derivatives and methods for making and using the same
|
WO2002008440A2
(en)
|
2000-07-25 |
2002-01-31 |
Kosan Biosciences, Inc. |
Fermentation process for epothilones
|
WO2002012534A2
(en)
|
2000-08-09 |
2002-02-14 |
Kosan Biosciences, Inc. |
Bio-intermediates for use in the chemical synthesis of polyketides
|
UA75365C2
(en)
|
2000-08-16 |
2006-04-17 |
Bristol Myers Squibb Co |
Epothilone analog polymorph modifications, a method for obtaining thereof (variants), a pharmaceutical composition based thereon
|
EP1309605A1
(de)
*
|
2000-08-18 |
2003-05-14 |
The Board Of Trustees Of The University Of Illinois |
Prodrogen von beulinsauer derivate zur behandlung von krebs und hiv
|
US7766956B2
(en)
|
2000-09-22 |
2010-08-03 |
Boston Scientific Scimed, Inc. |
Intravascular stent and assembly
|
EP1414384A4
(de)
|
2000-10-13 |
2005-07-27 |
Univ Mississippi |
Synthese von epothilonen und verwandteln analoga
|
DE10051136A1
(de)
|
2000-10-16 |
2002-04-18 |
Ludger A Wessjohann |
Epothilone-Synthesebausteine III und Verfahren zur Herstellung von Epothilon B, D und Epothilonderivaten
|
WO2002032844A2
(de)
|
2000-10-16 |
2002-04-25 |
Morphochem Ag |
Epothilone-synthesebausteine iii und iv: unsymmetrisch substituierte acyloine und acyloinderivate, verfahren zu deren herstellung sowie verfahren zur herstellung von epothilon b, d und epothilonderivaten
|
CA2428425A1
(en)
|
2000-11-07 |
2002-08-01 |
Dana-Farber Cancer Institute, Inc. |
Method of treating hematologic tumors and cancers
|
US7070797B2
(en)
|
2000-11-07 |
2006-07-04 |
Dana Farber Cancer Institute, Inc. |
Method of treating hematologic tumors and cancers
|
EP1363996A2
(de)
|
2000-11-22 |
2003-11-26 |
Novartis AG |
Epothilone-resistente zelllinien
|
GB0029895D0
(en)
*
|
2000-12-07 |
2001-01-24 |
Novartis Ag |
Organic compounds
|
IL156580A0
(en)
|
2001-01-25 |
2004-01-04 |
Bristol Myers Squibb Co |
A method for formulating an epothilone analog for parenteral use and pharmaceutical preparations including an epothilone analog
|
ES2304240T3
(es)
|
2001-01-25 |
2008-10-01 |
Bristol-Myers Squibb Company |
Procedimientos para la preparacion de preparaciones farmaceuticas que contienen analogos de epotilona para el tratamiento de cancer.
|
WO2002058699A1
(en)
|
2001-01-25 |
2002-08-01 |
Bristol-Myers Squibb Company |
Pharmaceutical forms of epothilones for oral administration
|
US20030004338A1
(en)
|
2001-02-01 |
2003-01-02 |
Li Wen Sen |
Process for the preparation of epothilone analogs
|
US6893859B2
(en)
|
2001-02-13 |
2005-05-17 |
Kosan Biosciences, Inc. |
Epothilone derivatives and methods for making and using the same
|
BR0207316A
(pt)
|
2001-02-20 |
2004-02-10 |
Bristol Myers Squibb Co |
Derivados de epotilona para o tratamento de tumores refratários
|
BR0207487A
(pt)
|
2001-02-20 |
2004-08-10 |
Brystol Myers Squibb Company |
Método de tratamento de tumores em mamìferos e uso de compostos de epotilona
|
PT1385522E
(pt)
|
2001-02-27 |
2009-09-04 |
Novartis Ag |
Associação contendo um inibidor de transdução de sinais e um derivado da epotilona
|
DE60213884T2
(de)
|
2001-02-27 |
2007-02-22 |
GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) |
Verfahren zur Herstellung von Epothilonen
|
RU2321400C2
(ru)
|
2001-03-14 |
2008-04-10 |
Бристол-Маерс Сквибб Компани |
Композиция аналога эпотилона в сочетании с химиотерапевтическими агентами для лечения рака
|
KR100863089B1
(ko)
|
2001-03-19 |
2008-10-13 |
노파르티스 아게 |
지사제 및 에포틸론 또는 에포틸론 유도체를 포함하는혼합물
|
US20020169125A1
(en)
|
2001-03-21 |
2002-11-14 |
Cell Therapeutics, Inc. |
Recombinant production of polyanionic polymers and uses thereof
|
WO2002076448A1
(en)
|
2001-03-23 |
2002-10-03 |
Napro Biotherapeutics, Inc. |
Molecular conjugates for use in treatment of cancer
|
US7081454B2
(en)
|
2001-03-28 |
2006-07-25 |
Bristol-Myers Squibb Co. |
Tyrosine kinase inhibitors
|
US6900214B2
(en)
|
2001-03-29 |
2005-05-31 |
Bristol-Myers Squibb Company |
Cyano-substituted dihydropyrimidine compounds and their use to treat diseases
|
US20020197261A1
(en)
|
2001-04-26 |
2002-12-26 |
Chun Li |
Therapeutic agent/ligand conjugate compositions, their methods of synthesis and use
|
US6906188B2
(en)
|
2001-04-30 |
2005-06-14 |
State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University |
Method for synthesizing epothilones and epothilone analogs
|
US20030023082A1
(en)
|
2001-05-15 |
2003-01-30 |
Gary Ashley |
Epothilone derivatives and methods for making and using the same
|
JP2004532888A
(ja)
|
2001-06-01 |
2004-10-28 |
ブリストル−マイヤーズ スクイブ カンパニー |
エポチロン誘導体
|
ATE489080T1
(de)
|
2001-06-25 |
2010-12-15 |
Ajinomoto Kk |
Antitumorale mittel
|
US6933385B2
(en)
|
2001-08-03 |
2005-08-23 |
Schering Ag |
Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use
|
DE10138347A1
(de)
|
2001-08-03 |
2003-02-27 |
Schering Ag |
Geschützte 3,5-Dihydroxy-2,2-dimethyl-valeronitrile für die Synthese von Epothilonen- und Derivaten und Verfahren zur Herstellung
|
US6872715B2
(en)
|
2001-08-06 |
2005-03-29 |
Kosan Biosciences, Inc. |
Benzoquinone ansamycins
|
WO2003018002A2
(en)
|
2001-08-23 |
2003-03-06 |
Novartis Ag |
Cyclopropyl and cyclobutyl epothilone analogs
|
CZ2004287A3
(cs)
|
2001-08-31 |
2004-10-13 |
Bristol@Myersásquibbácompany |
Prostředky a způsoby pro léčení rakoviny
|
IL160065A0
(en)
|
2001-09-06 |
2004-06-20 |
Schering Corp |
17beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
|
US20030176368A1
(en)
|
2001-09-06 |
2003-09-18 |
Danishefsky Samuel J. |
Synthesis of epothilones, intermediates thereto and analogues thereof
|
WO2003029195A1
(fr)
|
2001-09-28 |
2003-04-10 |
Sumika Fine Chemicals Co., Ltd. |
Intermediaires pour l'elaboration d'un derive de l'epothilone, et leur procede de production
|
TW200300350A
(en)
|
2001-11-14 |
2003-06-01 |
Bristol Myers Squibb Co |
C-5 modified indazolylpyrrolotriazines
|
US20030134883A1
(en)
|
2001-11-26 |
2003-07-17 |
David Myles |
14-Methyl-epothilones
|
JP2005515201A
(ja)
|
2001-12-03 |
2005-05-26 |
シェーリング コーポレイション |
癌の処置におけるfptインヒビターおよび少なくとも2つの抗腫瘍性剤の使用
|
DE10164592A1
(de)
|
2001-12-21 |
2003-07-03 |
Schering Ag |
C1-C6-Epothilon-Fragmente und Verfahren für die Herstellung von C1-C6-Fragmenten von Epothilonen und deren Derivaten
|
US6884608B2
(en)
|
2001-12-26 |
2005-04-26 |
Bristol-Myers Squibb Company |
Compositions and methods for hydroxylating epothilones
|
TW200303202A
(en)
|
2002-02-15 |
2003-09-01 |
Bristol Myers Squibb Co |
Method of preparation of 21-amino epothilone derivatives
|
US6900331B2
(en)
|
2002-03-01 |
2005-05-31 |
University Of Notre Dame |
Derivatives of epothilone B and D and synthesis thereof
|
EP1340498A1
(de)
|
2002-03-01 |
2003-09-03 |
Schering Aktiengesellschaft |
Verwendung von Epothilonen zur Behandlung von mit proliferativen Prozessen assoziierten Gehirnerkrankungen
|
WO2003076445A2
(en)
|
2002-03-07 |
2003-09-18 |
The Board Of Trustees Of The University Of Illinois |
Microtubule stabilizing compounds
|
AU2003218110A1
(en)
|
2002-03-12 |
2003-09-29 |
Bristol-Myers Squibb Company |
C3-cyano epothilone derivatives
|
WO2003077903A1
(en)
|
2002-03-12 |
2003-09-25 |
Bristol-Myers Squibb Company |
C12-cyano epothilone derivatives
|
US6900208B2
(en)
|
2002-03-28 |
2005-05-31 |
Bristol Myers Squibb Company |
Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders
|
TW200400191A
(en)
|
2002-05-15 |
2004-01-01 |
Bristol Myers Squibb Co |
Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives
|
EP1575556A2
(de)
|
2002-05-20 |
2005-09-21 |
Kosan Biosciences, Inc. |
Verfahren zur verabreichung von epothilon d
|
WO2003105828A1
(en)
|
2002-06-14 |
2003-12-24 |
Bristol-Myers Squibb Company |
Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
|
TW200401638A
(en)
|
2002-06-20 |
2004-02-01 |
Bristol Myers Squibb Co |
Heterocyclic inhibitors of kinases
|
DE10232094A1
(de)
|
2002-07-15 |
2004-02-05 |
GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) |
5-Thiaepothilone und 15-disubstituierte Epothilone
|
TWI329112B
(en)
|
2002-07-19 |
2010-08-21 |
Bristol Myers Squibb Co |
Novel inhibitors of kinases
|
AU2003253365A1
(en)
|
2002-07-31 |
2004-02-23 |
Schering Ag |
New effector conjugates, process for their production and their pharmaceutical use
|
CA2494259A1
(en)
|
2002-08-02 |
2004-02-19 |
Novartis Ag |
Epothilone derivatives
|
WO2004013145A1
(en)
|
2002-08-02 |
2004-02-12 |
Bristol-Myers Squibb Company |
Pyrrolotriazine kinase inhibitors
|
AU2003260723A1
(en)
|
2002-08-17 |
2004-03-03 |
The Queens Universlty Of Belfast |
Use of vinca alkaloyds, taxane, cryptophycine, ephitoline or eleutherobine for treating alzheimer
|
EP1391213A1
(de)
|
2002-08-21 |
2004-02-25 |
Boehringer Ingelheim International GmbH |
Zusammensetzungen und Verfahren zur Behandlung von Krebs mit einem Maytansinoid-CD44-Antikörper Immunokonjugat und chemotherapeutische Mittel
|
US20040126379A1
(en)
|
2002-08-21 |
2004-07-01 |
Boehringer Ingelheim International Gmbh |
Compositions and methods for treating cancer using cytotoxic CD44 antibody immunoconjugates and chemotherapeutic agents
|
AU2003265608A1
(en)
|
2002-08-21 |
2004-03-11 |
Kosan Biosciences, Inc. |
Myxococcus xanthus bacteriophage mx9 transformation and integration system
|
DK1506203T3
(da)
*
|
2002-08-23 |
2007-05-14 |
Sloan Kettering Inst Cancer |
Syntese af epothiloner, mellemprodukter deraf, analoger deraf og anvendelser deraf
|
US7649006B2
(en)
|
2002-08-23 |
2010-01-19 |
Sloan-Kettering Institute For Cancer Research |
Synthesis of epothilones, intermediates thereto and analogues thereof
|
CA2495913A1
(en)
|
2002-08-23 |
2004-03-04 |
Medigene Oncology Gmbh |
Non-vesicular cationic lipid formulations
|
US6921769B2
(en)
|
2002-08-23 |
2005-07-26 |
Sloan-Kettering Institute For Cancer Research |
Synthesis of epothilones, intermediates thereto and analogues thereof
|
US20040043089A1
(en)
|
2002-09-04 |
2004-03-04 |
Rabie A-Bakr M |
Buguzhi agent and composition and methods of preparing and administering the same
|
MY145332A
(en)
|
2002-09-04 |
2012-01-31 |
Schering Corp |
Trisubstituted 4-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
|
JP2006500391A
(ja)
|
2002-09-04 |
2006-01-05 |
シェーリング コーポレイション |
サイクリン依存性キナーゼインヒビターとしてのピラゾロピリミジン
|
CN1701074A
(zh)
|
2002-09-04 |
2005-11-23 |
先灵公司 |
用作依赖细胞周期蛋白激酶抑制剂的吡唑并嘧啶
|
US7078525B2
(en)
|
2002-09-04 |
2006-07-18 |
Schering Corporation |
Pyrazolopyrimidines as cyclin dependent kinase inhibitors
|
GB0221312D0
(en)
|
2002-09-13 |
2002-10-23 |
Novartis Ag |
Organic compounds
|
EP1546365A4
(de)
|
2002-09-16 |
2006-10-11 |
Freshcert Llc |
Durch lebensmittel übertragener krankheitserreger sowie vorrichtung und verfahren zum nachweis des verdorbenseins von lebensmitteln
|
DE60317529T2
(de)
|
2002-09-19 |
2008-09-25 |
Schering Corp. |
Imidazopyridine als hemmstoffe cyclin abhängiger kinasen
|
KR20050072090A
(ko)
|
2002-09-19 |
2005-07-08 |
쉐링 코포레이션 |
사이클린 의존성 키나제 억제제로서의 피라졸로피리딘
|
DE10244847A1
(de)
|
2002-09-20 |
2004-04-01 |
Ulrich Prof. Dr. Speck |
Medizinische Vorrichtung zur Arzneimittelabgabe
|
JP2006503838A
(ja)
|
2002-09-23 |
2006-02-02 |
シェーリング コーポレイション |
サイクリン依存性キナーゼインヒビターとしての新規イミダゾピラジン
|
MXPA05003006A
(es)
|
2002-09-23 |
2005-06-22 |
Squibb Bristol Myers Co |
Metodos para la preparacion, aislamiento y purificacion de epotilona b y estructuras cristalinas de rayos x y de epotilona b.
|
ATE377600T1
(de)
|
2002-09-23 |
2007-11-15 |
Schering Corp |
Imidazopyrazine als cdk-inhibitoren
|
US20040058899A1
(en)
|
2002-09-25 |
2004-03-25 |
Klimko Peter G. |
Use of epothilones and analogs in conjunction with ophthalmic surgery
|
WO2004030620A2
(en)
|
2002-09-30 |
2004-04-15 |
Bristol-Myers Squibb Company |
Novel tyrosine kinase inhibitors
|
TW200501960A
(en)
|
2002-10-02 |
2005-01-16 |
Bristol Myers Squibb Co |
Synergistic kits and compositions for treating cancer
|
AU2003279923A1
(en)
|
2002-10-09 |
2004-05-04 |
Kosan Biosciences, Inc. |
Epo D + 5-FU/GEMCITABINE
|
US7091193B2
(en)
|
2002-10-09 |
2006-08-15 |
Kosan Biosciences Incorporated |
Therapeutic formulations
|
CA2501610C
(en)
|
2002-10-11 |
2012-01-03 |
Dana-Farber Cancer Institute Inc |
Epothilone derivatives for the treatment of multiple myeloma
|
SI1553938T1
(sl)
|
2002-10-15 |
2007-06-30 |
Univ Louisiana State |
Uporaba epotilonskih derivatov za zdravljenje hiperparatiroidizma
|
JP2006508126A
(ja)
|
2002-11-06 |
2006-03-09 |
アザヤ セラピューティクス インコーポレイティッド |
薬学的製剤のタンパク質安定化されたリポソーム製剤
|
AU2003291337B2
(en)
|
2002-11-07 |
2010-09-09 |
Kosan Biosciences Incorporated |
Trans-9,10-dehydroepothilone C and D, analogs thereof and methos of making the same
|
BR0315537A
(pt)
|
2002-11-14 |
2005-09-27 |
Celmed Oncology Usa Inc |
Pró-drogas ativadas por peptìdeo desformilase
|
ES2330517T3
(es)
|
2002-11-28 |
2009-12-11 |
Wolfgang Richter |
Derivados de tia-epotilona para el tratamiento del cancer.
|
AU2003291872A1
(en)
|
2002-12-04 |
2004-06-23 |
Inrs (Institut National De Recherche Scientifique) |
An exopolysaccharides delivery system for active molecules
|
DE10256982A1
(de)
|
2002-12-05 |
2004-06-24 |
Schering Ag |
Neue Effektor-Konjugate, Verfahren zu Ihrer Herstellung und Ihre Pharmazeutische Verwendung
|
JP2006510626A
(ja)
|
2002-12-05 |
2006-03-30 |
シエーリング アクチエンゲゼルシャフト |
増殖疾患の処理における部位特異的供給のためのエポチロン類似体
|
CN1723018A
(zh)
|
2002-12-09 |
2006-01-18 |
诺瓦提斯公司 |
用于治疗支架狭窄的微管稳定剂
|
EP1575454A4
(de)
|
2002-12-09 |
2006-11-29 |
Medtronic Vascular Inc |
Modularer stent mit polymerbrücken an modularen kontaktstellen
|
WO2004052401A2
(en)
|
2002-12-09 |
2004-06-24 |
American Bioscience, Inc. |
Compositions and methods of delivery of pharmacological agents
|
AU2003303058A1
(en)
|
2002-12-12 |
2004-07-09 |
Conforma Therapeutics Corporation |
Cytotoxins and diagnostic imaging agents comprising hsp90 ligands
|
TW200420565A
(en)
|
2002-12-13 |
2004-10-16 |
Bristol Myers Squibb Co |
C-6 modified indazolylpyrrolotriazines
|
AU2003288467A1
(en)
|
2002-12-13 |
2004-07-09 |
Immunomedics, Inc. |
Immunoconjugates with an intracellularly-cleavable linkage
|
GB0230024D0
(en)
|
2002-12-23 |
2003-01-29 |
Novartis Ag |
Organic compounds
|
WO2004063151A2
(en)
|
2003-01-03 |
2004-07-29 |
Bristol-Myers Squibb Company |
Novel tyrosine kinase inhibitors
|
AU2003219947A1
(en)
|
2003-02-26 |
2004-09-28 |
Bristol-Myers Squibb Company |
Compositions and methods for hydroxylating epothilones
|
GB0305928D0
(en)
|
2003-03-14 |
2003-04-23 |
Novartis Ag |
Organic compounds
|
GB0306907D0
(en)
|
2003-03-26 |
2003-04-30 |
Angiogene Pharm Ltd |
Boireductively-activated prodrugs
|
JP2006523235A
(ja)
|
2003-03-28 |
2006-10-12 |
コーザン バイオサイエンシス インコーポレイテッド |
再狭窄を予防するための装置、方法及び組成物
|