DE60120427D1 - Radicicol und monocillin und ihre analogen und ihre anwendungen - Google Patents

Radicicol und monocillin und ihre analogen und ihre anwendungen

Info

Publication number
DE60120427D1
DE60120427D1 DE60120427T DE60120427T DE60120427D1 DE 60120427 D1 DE60120427 D1 DE 60120427D1 DE 60120427 T DE60120427 T DE 60120427T DE 60120427 T DE60120427 T DE 60120427T DE 60120427 D1 DE60120427 D1 DE 60120427D1
Authority
DE
Germany
Prior art keywords
monocillin
radicicol
analogs
applications
sub
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60120427T
Other languages
English (en)
Inventor
J Danishefsky
M Garbaccio
K Baeschlin
J Stachel
David Solit
Neil Rosen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sloan Kettering Institute for Cancer Research
Original Assignee
Sloan Kettering Institute for Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sloan Kettering Institute for Cancer Research filed Critical Sloan Kettering Institute for Cancer Research
Application granted granted Critical
Publication of DE60120427D1 publication Critical patent/DE60120427D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
DE60120427T 2000-08-25 2001-08-24 Radicicol und monocillin und ihre analogen und ihre anwendungen Expired - Lifetime DE60120427D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22827700P 2000-08-25 2000-08-25
US30455301P 2001-07-11 2001-07-11
PCT/US2001/026577 WO2002016369A2 (en) 2000-08-25 2001-08-24 Novel macrocycles and uses thereof
US09/938,754 US7115651B2 (en) 2000-08-25 2001-08-24 Macrocycles and uses thereof

Publications (1)

Publication Number Publication Date
DE60120427D1 true DE60120427D1 (de) 2006-07-20

Family

ID=27397829

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60120427T Expired - Lifetime DE60120427D1 (de) 2000-08-25 2001-08-24 Radicicol und monocillin und ihre analogen und ihre anwendungen

Country Status (6)

Country Link
US (1) US7115651B2 (de)
EP (1) EP1315732B1 (de)
AT (1) ATE328888T1 (de)
AU (1) AU2001286768A1 (de)
DE (1) DE60120427D1 (de)
WO (1) WO2002016369A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002322280A1 (en) 2001-06-21 2003-01-21 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
CA2482940A1 (en) * 2002-04-17 2003-10-23 Taisho Pharmaceuticals Co., Ltd. Hair growth tonic
WO2004111077A1 (en) 2003-06-18 2004-12-23 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor
EP1642880B1 (de) 2003-06-27 2013-09-04 Kyowa Hakko Kirin Co., Ltd. Proteininhibitoren der hsp90-familie
EP1666064A4 (de) * 2003-08-22 2008-12-17 Kyowa Hakko Kogyo Kk Mittel zur behandlung von erkrankungen im zusammenhang mit immunoglobulin-gen-translokation
US8329683B2 (en) 2006-06-02 2012-12-11 Nexgenix Pharmaceuticals, Llc Treatment of neurofibromatosis with radicicol and its derivatives
WO2008150302A1 (en) * 2007-06-04 2008-12-11 Nexgenix Pharmaceuticals Treatment of neurofibromatosis with radicicol and its derivatives
US8067412B2 (en) * 2006-08-11 2011-11-29 Universite De Strasbourg Macrocyclic compounds useful as inhibitors of kinases and HSP90
AU2008287542C1 (en) 2007-06-01 2015-01-22 The Trustees Of Princeton University Treatment of viral infections by modulation of host cell metabolic pathways
US8513440B2 (en) 2007-06-05 2013-08-20 Universite De Strasbourg Compositions and methods comprising analogues of radicicol A
CN101854955B (zh) * 2007-09-10 2012-07-18 马萨诸塞大学 靶向线粒体的抗肿瘤剂
US20110190237A1 (en) * 2008-01-15 2011-08-04 Nexgenix Pharmaceuticals Macrocyclic Prodrug Compounds Useful as Therapeutics
EP2242359B1 (de) * 2008-01-15 2016-06-01 Universite De Strasbourg Synthese von resorcylsäurelactonen, die sich als therapeutika eignen
US20090258869A1 (en) * 2008-02-08 2009-10-15 The Regents Of The University Of California Methods and compounds for treatment or prevention of substance-related disorders
CN102015673B (zh) 2008-02-21 2014-10-29 昂科协同公司 用作治疗剂的大环前药化合物
US8663210B2 (en) 2009-05-13 2014-03-04 Novian Health, Inc. Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy
WO2016196256A2 (en) 2015-06-04 2016-12-08 University Of North Carolina At Greensboro Non-aromatic difluoro analogues of resorcylic acid lactones
US20230390416A1 (en) * 2020-10-16 2023-12-07 The Brigham And Women's Hospital, Inc. Compositions for inducing tumor immunity and reducing drug tolerance

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR96016E (fr) 1966-06-29 1972-05-19 Commercial Solvents Corp Composé utilisable comme supplément alimentaire pour les animaux.
FR96046E (fr) * 1966-06-29 1972-05-19 Commercial Solvents Corp Composé utilisable comme supplément alimentaire pour les animaux.
US3621036A (en) * 1969-02-27 1971-11-16 Merck & Co Inc Derivatives of zearalane
BE757082A (fr) * 1970-02-16 1971-03-16 Commercial Solvents Corp Procede de preparation de nouveaux produits a activite antibacterienne
BE757083A (fr) * 1970-02-16 1971-03-16 Commercial Solvents Corp Nouveaux produits a activite antibacterienne
US3901921A (en) * 1972-04-25 1975-08-26 Commercial Solvents Corp Synthesis of zearalanes and related compounds and intermediates useful in the syntheses thereof
US4035504A (en) * 1975-05-12 1977-07-12 Imc Chemical Group, Inc. Method for treating cholesterolemia by administering resorcylic acid lactone derivatives
US4088658A (en) * 1976-11-04 1978-05-09 Imc Chemical Group, Inc. Synthesis of dideoxyzearalane and related compounds
US4166764A (en) * 1978-02-01 1979-09-04 W. R. Grace & Co. Production of monorden
US4228079A (en) 1978-10-30 1980-10-14 W. R. Grace & Co. Dialkoxy monorden derivatives
US5650430A (en) * 1990-06-06 1997-07-22 Sankyo Company, Limited Radicicol derivatives, their preparation and their anti-tumor activity
KR920000763A (ko) 1990-06-06 1992-01-29 가와무라 요시부미 라디시콜 유도체, 그 제조방법 및 그의 항종양 활성
GB9225396D0 (en) 1992-12-04 1993-01-27 Sandoz Ltd Improvements in or relating to organic compounds
US5731343A (en) 1995-02-24 1998-03-24 The Scripps Research Institute Method of use of radicicol for treatment of immunopathological disorders
DE69609325T2 (de) * 1995-04-26 2000-11-23 Kyowa Hakko Kogyo Kk Derivate des radicicols
JPH09202781A (ja) * 1996-01-25 1997-08-05 Sankyo Co Ltd ラディシコール誘導体
ATE266017T1 (de) 1996-10-25 2004-05-15 Kyowa Hakko Kogyo Kk Radicicolderivate
WO1999055689A1 (fr) 1998-04-24 1999-11-04 Kyowa Hakko Kogyo Co., Ltd. Derives de radicicol
AU779438B2 (en) * 1998-12-24 2005-01-27 Novation Pharmaceuticals Inc. Compounds which affect mRNA stability and uses therefor
CA2370007A1 (en) 1999-04-09 2000-10-19 Sloan-Kettering Institute For Cancer Research Methods and compositions for degradation and/or inhibition of her-family tyrosine kinases
DK1250155T3 (da) 1999-12-22 2008-08-25 Scripps Research Inst Modulatorer og inhibitorer af angiogenese og vaskulær permeabilitet

Also Published As

Publication number Publication date
US20020091151A1 (en) 2002-07-11
US7115651B2 (en) 2006-10-03
WO2002016369A3 (en) 2002-08-29
ATE328888T1 (de) 2006-06-15
EP1315732B1 (de) 2006-06-07
AU2001286768A1 (en) 2002-03-04
EP1315732A2 (de) 2003-06-04
WO2002016369A2 (en) 2002-02-28

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Legal Events

Date Code Title Description
8332 No legal effect for de