AU2001286768A1 - Novel macrocycles and uses thereof - Google Patents
Novel macrocycles and uses thereofInfo
- Publication number
- AU2001286768A1 AU2001286768A1 AU2001286768A AU8676801A AU2001286768A1 AU 2001286768 A1 AU2001286768 A1 AU 2001286768A1 AU 2001286768 A AU2001286768 A AU 2001286768A AU 8676801 A AU8676801 A AU 8676801A AU 2001286768 A1 AU2001286768 A1 AU 2001286768A1
- Authority
- AU
- Australia
- Prior art keywords
- sub
- novel macrocycles
- compounds
- macrocycles
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Abstract
The present invention relates to compounds having the structure (and pharmaceutically acceptable derivatives thereof) wherein R<SUB>0</SUB>-R<SUB>4</SUB>, Z, X, A-B, D-E, G-J, and K-L are as defined herein, the synthesis thereof and the use of these compounds as therapeutic agents.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22827700P | 2000-08-25 | 2000-08-25 | |
US60/228,277 | 2000-08-25 | ||
US30455301P | 2001-07-11 | 2001-07-11 | |
US60/304,553 | 2001-07-11 | ||
US09/938,754 | 2001-08-24 | ||
PCT/US2001/026577 WO2002016369A2 (en) | 2000-08-25 | 2001-08-24 | Novel macrocycles and uses thereof |
US09/938,754 US7115651B2 (en) | 2000-08-25 | 2001-08-24 | Macrocycles and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001286768A1 true AU2001286768A1 (en) | 2002-03-04 |
Family
ID=27397829
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001286768A Abandoned AU2001286768A1 (en) | 2000-08-25 | 2001-08-24 | Novel macrocycles and uses thereof |
Country Status (6)
Country | Link |
---|---|
US (1) | US7115651B2 (en) |
EP (1) | EP1315732B1 (en) |
AT (1) | ATE328888T1 (en) |
AU (1) | AU2001286768A1 (en) |
DE (1) | DE60120427D1 (en) |
WO (1) | WO2002016369A2 (en) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002322280A1 (en) | 2001-06-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer |
CA2482940A1 (en) * | 2002-04-17 | 2003-10-23 | Taisho Pharmaceuticals Co., Ltd. | Hair growth tonic |
WO2004111077A1 (en) | 2003-06-18 | 2004-12-23 | Tranzyme Pharma Inc. | Macrocyclic antagonists of the motilin receptor |
EP1642880B1 (en) | 2003-06-27 | 2013-09-04 | Kyowa Hakko Kirin Co., Ltd. | Hsp90 family protein inhibitors |
EP1666064A4 (en) * | 2003-08-22 | 2008-12-17 | Kyowa Hakko Kogyo Kk | Remedy for diseases associated with immunoglobulin gene translocation |
US8329683B2 (en) | 2006-06-02 | 2012-12-11 | Nexgenix Pharmaceuticals, Llc | Treatment of neurofibromatosis with radicicol and its derivatives |
WO2008150302A1 (en) * | 2007-06-04 | 2008-12-11 | Nexgenix Pharmaceuticals | Treatment of neurofibromatosis with radicicol and its derivatives |
US8067412B2 (en) * | 2006-08-11 | 2011-11-29 | Universite De Strasbourg | Macrocyclic compounds useful as inhibitors of kinases and HSP90 |
AU2008287542C1 (en) | 2007-06-01 | 2015-01-22 | The Trustees Of Princeton University | Treatment of viral infections by modulation of host cell metabolic pathways |
US8513440B2 (en) | 2007-06-05 | 2013-08-20 | Universite De Strasbourg | Compositions and methods comprising analogues of radicicol A |
CN101854955B (en) * | 2007-09-10 | 2012-07-18 | 马萨诸塞大学 | Mitochondria-targeted anti-tumor agents |
US20110190237A1 (en) * | 2008-01-15 | 2011-08-04 | Nexgenix Pharmaceuticals | Macrocyclic Prodrug Compounds Useful as Therapeutics |
EP2242359B1 (en) * | 2008-01-15 | 2016-06-01 | Universite De Strasbourg | Synthesis of resorcylic acid lactones useful as therapeutic agents |
US20090258869A1 (en) * | 2008-02-08 | 2009-10-15 | The Regents Of The University Of California | Methods and compounds for treatment or prevention of substance-related disorders |
CN102015673B (en) | 2008-02-21 | 2014-10-29 | 昂科协同公司 | Macrocyclic prodrug compounds useful as therapeutics |
US8663210B2 (en) | 2009-05-13 | 2014-03-04 | Novian Health, Inc. | Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy |
WO2016196256A2 (en) | 2015-06-04 | 2016-12-08 | University Of North Carolina At Greensboro | Non-aromatic difluoro analogues of resorcylic acid lactones |
US20230390416A1 (en) * | 2020-10-16 | 2023-12-07 | The Brigham And Women's Hospital, Inc. | Compositions for inducing tumor immunity and reducing drug tolerance |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR96016E (en) | 1966-06-29 | 1972-05-19 | Commercial Solvents Corp | Compound which can be used as a food supplement for animals. |
FR96046E (en) * | 1966-06-29 | 1972-05-19 | Commercial Solvents Corp | Compound which can be used as a food supplement for animals. |
US3621036A (en) * | 1969-02-27 | 1971-11-16 | Merck & Co Inc | Derivatives of zearalane |
BE757082A (en) * | 1970-02-16 | 1971-03-16 | Commercial Solvents Corp | PROCESS FOR PREPARING NEW PRODUCTS WITH ANTIBACTERIAL ACTIVITY |
BE757083A (en) * | 1970-02-16 | 1971-03-16 | Commercial Solvents Corp | NEW PRODUCTS WITH ANTIBACTERIAL ACTIVITY |
US3901921A (en) * | 1972-04-25 | 1975-08-26 | Commercial Solvents Corp | Synthesis of zearalanes and related compounds and intermediates useful in the syntheses thereof |
US4035504A (en) * | 1975-05-12 | 1977-07-12 | Imc Chemical Group, Inc. | Method for treating cholesterolemia by administering resorcylic acid lactone derivatives |
US4088658A (en) * | 1976-11-04 | 1978-05-09 | Imc Chemical Group, Inc. | Synthesis of dideoxyzearalane and related compounds |
US4166764A (en) * | 1978-02-01 | 1979-09-04 | W. R. Grace & Co. | Production of monorden |
US4228079A (en) | 1978-10-30 | 1980-10-14 | W. R. Grace & Co. | Dialkoxy monorden derivatives |
US5650430A (en) * | 1990-06-06 | 1997-07-22 | Sankyo Company, Limited | Radicicol derivatives, their preparation and their anti-tumor activity |
KR920000763A (en) | 1990-06-06 | 1992-01-29 | 가와무라 요시부미 | Radicicol derivatives, preparation method thereof and antitumor activity thereof |
GB9225396D0 (en) | 1992-12-04 | 1993-01-27 | Sandoz Ltd | Improvements in or relating to organic compounds |
US5731343A (en) | 1995-02-24 | 1998-03-24 | The Scripps Research Institute | Method of use of radicicol for treatment of immunopathological disorders |
DE69609325T2 (en) * | 1995-04-26 | 2000-11-23 | Kyowa Hakko Kogyo Kk | DERIVATIVES OF RADICICOLS |
JPH09202781A (en) * | 1996-01-25 | 1997-08-05 | Sankyo Co Ltd | Radicicol derivative |
ATE266017T1 (en) | 1996-10-25 | 2004-05-15 | Kyowa Hakko Kogyo Kk | RADICICOL DERIVATIVES |
WO1999055689A1 (en) | 1998-04-24 | 1999-11-04 | Kyowa Hakko Kogyo Co., Ltd. | Radicicol derivatives |
AU779438B2 (en) * | 1998-12-24 | 2005-01-27 | Novation Pharmaceuticals Inc. | Compounds which affect mRNA stability and uses therefor |
CA2370007A1 (en) | 1999-04-09 | 2000-10-19 | Sloan-Kettering Institute For Cancer Research | Methods and compositions for degradation and/or inhibition of her-family tyrosine kinases |
DK1250155T3 (en) | 1999-12-22 | 2008-08-25 | Scripps Research Inst | Modulators and inhibitors of angiogenesis and vascular permeability |
-
2001
- 2001-08-24 US US09/938,754 patent/US7115651B2/en not_active Expired - Fee Related
- 2001-08-24 AT AT01966236T patent/ATE328888T1/en not_active IP Right Cessation
- 2001-08-24 AU AU2001286768A patent/AU2001286768A1/en not_active Abandoned
- 2001-08-24 DE DE60120427T patent/DE60120427D1/en not_active Expired - Lifetime
- 2001-08-24 EP EP01966236A patent/EP1315732B1/en not_active Expired - Lifetime
- 2001-08-24 WO PCT/US2001/026577 patent/WO2002016369A2/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
US20020091151A1 (en) | 2002-07-11 |
US7115651B2 (en) | 2006-10-03 |
WO2002016369A3 (en) | 2002-08-29 |
ATE328888T1 (en) | 2006-06-15 |
EP1315732B1 (en) | 2006-06-07 |
DE60120427D1 (en) | 2006-07-20 |
EP1315732A2 (en) | 2003-06-04 |
WO2002016369A2 (en) | 2002-02-28 |
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