KR850001213A - 이미다조[1,5-a] 피리미딘 유도체의 제조방법 - Google Patents

이미다조[1,5-a] 피리미딘 유도체의 제조방법 Download PDF

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Publication number
KR850001213A
KR850001213A KR1019840004075A KR840004075A KR850001213A KR 850001213 A KR850001213 A KR 850001213A KR 1019840004075 A KR1019840004075 A KR 1019840004075A KR 840004075 A KR840004075 A KR 840004075A KR 850001213 A KR850001213 A KR 850001213A
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South Korea
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groups
group
formula
converted
alkylthio
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KR1019840004075A
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KR910005850B1 (ko
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이리쿠라 추토무 (외 5)
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오기하라 히데오
교린 세이야꾸 가부시끼 가이샤
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Publication of KR850001213A publication Critical patent/KR850001213A/ko
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Publication of KR910005850B1 publication Critical patent/KR910005850B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

이미다조[1,5-a] 피리미딘 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 다음 일반식(II)의 화합물을 포스포릴클로라이드, 티오닐클로라이드와 같은 축합제로 전환시켜 다음 일반식(III)의 화합물을 생성하고, 일반식(III)의 화합물중의 한개 또는 두 개의 X를 수소원자로 환원시키거나, 알카리, 암모니아, 아민 알코올 및 알킬티올레이트로 처리하여 하이드록시그룹, 아미노 또는 치환된 아미노그룹, 알콕시그룹 및 알킬티오그룹으로 전환시켜 다음 일반식(I)의 유리염기 및 그의 산부가염을 제조하는 방법.
    상기 식에서, X는 할로겐원자이고, X1및 X2는 수소원자, 할로겐원자, 하이드록시그룹, 아미노 또는 치환된 아미노그룹, 알콕시그룹, 알킬티오그룹, 알킬설피닐그룹 및 알킬설포닐그룹으로 이루어진 그룹으로부터 선택되고, R1,R2및 R3는 수소원자, 알킬그룹, 알케닐그룹, 알키닐그룹, 아릴그룹 및 아르알킬 그룹으로 이루어진 그룹으로부터 선택된다.
  2. 제1항에 있어서, 알킬티오그룹을 알킬설피닐그룹 또는 알킬설포닐그룹으로 전환시키는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840004075A 1983-07-12 1984-07-12 이미다조[1,5-a]피리미딘 유도체의 제조방법 KR910005850B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP58-126697 1983-07-12
JP58126697A JPS6019789A (ja) 1983-07-12 1983-07-12 イミダゾ〔１，５−ａ〕ピリミジン誘導体

Publications (2)

Publication Number Publication Date
KR850001213A true KR850001213A (ko) 1985-03-16
KR910005850B1 KR910005850B1 (ko) 1991-08-05

Family

ID=14941605

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840004075A KR910005850B1 (ko) 1983-07-12 1984-07-12 이미다조[1,5-a]피리미딘 유도체의 제조방법

Country Status (9)

Country Link
US (1) US4649198A (ko)
EP (1) EP0134928B1 (ko)
JP (1) JPS6019789A (ko)
KR (1) KR910005850B1 (ko)
AU (1) AU563849B2 (ko)
CA (1) CA1238045A (ko)
DE (1) DE3469177D1 (ko)
DK (1) DK339584A (ko)
ES (1) ES8604589A1 (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6143191A (ja) * 1984-08-07 1986-03-01 Kyorin Pharmaceut Co Ltd イミダゾ〔１，５−ａ〕ピリミジン誘導体
WO1987006576A1 (en) * 1986-04-29 1987-11-05 Pfizer Inc. Calcium independent camp phosphodiesterase inhibitor antidepressant
US5395935A (en) * 1992-05-08 1995-03-07 Pfizer Inc. Endo-bicyclo[2.2.1]heptan-2-ol and derived pharmaceutical agents
BR0309892A2 (pt) * 2002-05-09 2011-04-05 Cytokinetics Inc composto, composição, métodos para modular a atividade da cinesina de ksp, para inibir a ksp, e para o tratamento de uma doença proliferativa celular, e, uso de um composto
CA2483627A1 (en) * 2002-05-23 2003-12-04 Merck & Co., Inc. Mitotic kinesin inhibitors
RU2341296C2 (ru) * 2002-05-24 2008-12-20 Энджиотек Интернэшнл Аг Композиции и способы покрытия медицинских имплантатов
US8313760B2 (en) 2002-05-24 2012-11-20 Angiotech International Ag Compositions and methods for coating medical implants
WO2004114655A1 (en) * 2003-06-18 2004-12-29 Thomson Licensing S.A. Apparatus for recording data on motion picture film
JP2007518711A (ja) 2003-12-19 2007-07-12 メルク　エンド　カムパニー　インコーポレーテッド 有糸分裂キネシン阻害剤
WO2022002243A1 (zh) * 2020-07-02 2022-01-06 江苏恒瑞医药股份有限公司 咪唑并嘧啶类衍生物、其制备方法及其在医药上的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2160020A1 (de) * 1971-12-03 1973-06-07 Bayer Ag Perchlor-imidazo-pyrimidin, verfahren zu seiner herstellung, sowie seine verwendung als fungizid
US3923808A (en) * 1972-12-08 1975-12-02 Janssen Pharmaceutica Nv Bicyclic imidazoles and pyrimidines
US4178449A (en) * 1978-04-17 1979-12-11 American Cyanamid Company Pyrazolo[1,5-a]pyrimidines and imidazo-[1,5-a]pyrimidines
US4236005A (en) * 1979-07-02 1980-11-25 American Cyanamid Company Imidazo[1,5-a]pyrimidines
US4408047A (en) * 1980-03-28 1983-10-04 Merck & Co., Inc. Imidazodiazines

Also Published As

Publication number Publication date
KR910005850B1 (ko) 1991-08-05
EP0134928B1 (en) 1988-02-03
DK339584D0 (da) 1984-07-11
ES8604589A1 (es) 1986-02-01
JPH0450315B2 (ko) 1992-08-13
CA1238045A (en) 1988-06-14
DE3469177D1 (en) 1988-03-10
AU563849B2 (en) 1987-07-23
US4649198A (en) 1987-03-10
EP0134928A1 (en) 1985-03-27
JPS6019789A (ja) 1985-01-31
DK339584A (da) 1985-01-13
ES534259A0 (es) 1986-02-01
AU2937184A (en) 1985-01-17

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