KR950032160A - 1-[2-1h-인덴-3-일)에틸]-4-(나프트-1- 일) 피페라진 유도체, 그의 제법 및 치료학적 이용 - Google Patents

1-[2-1h-인덴-3-일)에틸]-4-(나프트-1- 일) 피페라진 유도체, 그의 제법 및 치료학적 이용 Download PDF

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Publication number
KR950032160A
KR950032160A KR1019950002800A KR19950002800A KR950032160A KR 950032160 A KR950032160 A KR 950032160A KR 1019950002800 A KR1019950002800 A KR 1019950002800A KR 19950002800 A KR19950002800 A KR 19950002800A KR 950032160 A KR950032160 A KR 950032160A
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South Korea
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formula
compound according
general formula
compound
therapeutic use
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KR1019950002800A
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English (en)
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마누리 필립
오비츠 다니엘
뻬이노 미셸
스브랭 미레이유
죠르쥬 빠스깔
Original Assignee
에. 뚜레 레메뜨르
신떼라보 소시에떼 아노님
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Application filed by 에. 뚜레 레메뜨르, 신떼라보 소시에떼 아노님 filed Critical 에. 뚜레 레메뜨르
Publication of KR950032160A publication Critical patent/KR950032160A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 일반식(I)의 화합물;
(상기 식에서 X는 수소원자, C1-C3알콕시기 또는 시클로프로필메톡시를 나타내며, Y는 수소원자 또는 메톡시기를 나타낸다)과 치료학적 이용에 관한 것이다.

Description

1-[2-1H-인덴-3-일)에틸]-4-(나프트-1-일) 피페라진 유도체, 그의 제법 및 치료학적 이용
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 염기 또는 부가염의 형태로 일반식(I)에 해당하는 화합물
    상기 식에서, X는 수소원자, C1-C3알콕시기 또는 시클로프로필메톡시기를 나타내며, Y는 수소원자 또는 메톡시기를 나타낸다.
  2. 제1항에 있어서, X는 C1-C3알콕시기를 나타내며, Y는 메톡시기를 나타내는 것을 특징으로 하는 화합물.
  3. 제2항에 있어서, X가 메톡시기를 나타내는 것을 특징으로 하는 화합물.
  4. a) Y가 특허청구의 범위 제1항에 정의된 바와 같은 일반식(Ⅱ)
    의 1H-인덴-3-아세트산 유도체를 환원제로 처리하여 일반식(Ⅲ)
    의 알코올을 형성하고, 그 다음 알코올을 4-메틸벤젠술포닐 클로라이드로 처리하여 일반식(Ⅳ)
    의 유도체를 얻고, 최종적으로 X가 특허청구의 범위 제1항에 정의된 바와 같은 일반식(Ⅴ)
    의 피페라진 유도체와 반응시키거나 또는, b) 상기 일반식(Ⅱ)의 1H-인덴-3-아세트산 유도체를 먼저, N,N′-카르보닐이미다졸과 반응시켜서 원 위치에서 해당 이미다졸리드를 얻고, 그 다음 상기 일반식(Ⅴ)의 피페라진 유도체로 처리하여 일반식(Ⅵ)
    의 아미드를 얻고, 최종적으로 환원제를 사용하여 환원시키는 것을 특징으로 하는 특허청구의 범위 제1항에 따른 화합물의 제조방법.
  5. 특허청구의 범위 제1항에 따른 화합물로 구성되는 것을 특징으로 하는 약제.
  6. 특허청구의 범위 제1항에 따른 화합물을 부형제와 조합하여 함유하는 것을 특징으로 하는 약학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950002800A 1994-02-16 1995-02-15 1-[2-1h-인덴-3-일)에틸]-4-(나프트-1- 일) 피페라진 유도체, 그의 제법 및 치료학적 이용 KR950032160A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9401736A FR2716193B1 (fr) 1994-02-16 1994-02-16 Dérivés de 1[2-(1h-inden-3-yl)ethyl]-4-(naphtalen-1-yl)piperazine, leur préparation et leur application en thérapeutique.
FR94.01736 1994-02-16

Publications (1)

Publication Number Publication Date
KR950032160A true KR950032160A (ko) 1995-12-20

Family

ID=9460124

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950002800A KR950032160A (ko) 1994-02-16 1995-02-15 1-[2-1h-인덴-3-일)에틸]-4-(나프트-1- 일) 피페라진 유도체, 그의 제법 및 치료학적 이용

Country Status (18)

Country Link
US (1) US5530002A (ko)
EP (1) EP0668273A1 (ko)
JP (1) JPH07252243A (ko)
KR (1) KR950032160A (ko)
CN (1) CN1112554A (ko)
AU (1) AU680327B2 (ko)
CA (1) CA2142535A1 (ko)
CZ (1) CZ39395A3 (ko)
FI (1) FI950670A (ko)
FR (1) FR2716193B1 (ko)
HU (1) HUT71898A (ko)
IL (1) IL112661A0 (ko)
NO (1) NO304230B1 (ko)
NZ (1) NZ270500A (ko)
PL (1) PL307286A1 (ko)
RU (1) RU95102147A (ko)
SK (1) SK20795A3 (ko)
ZA (1) ZA951235B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2737724B1 (fr) * 1995-08-09 1997-09-05 Synthelabo Derives de 1-[2-(2,3-dihydro-1h-inden-1-yl)ethyl]-4- (naphtalen-1-yl) piperazine, leur preparation et leur application en therapeutique
FR2737723B1 (fr) * 1995-08-09 1997-09-05 Synthelabo Derives de 1-(2-(1h-inden-3-yl)ethyl)-4-(naphtalen-1-yl)- piperazine, leur preparation et leur application en therapeutique
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
DE602005019098D1 (de) * 2004-12-21 2010-03-11 Hoffmann La Roche Tetralin- und indanderivate und deren anwendungen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4130646A (en) * 1975-07-25 1978-12-19 E. R. Squibb & Sons, Inc. 1,2,3,4-Tetrahydro-2-((4-(phenyl)-1-piperazinyl)methyl)-1-naphthalenols and derivatives and analogs thereof
US4845221A (en) * 1988-04-15 1989-07-04 American Home Products Corporation Serotonergic substituted piperazinyl tetralins
FR2670491B1 (fr) * 1990-12-14 1993-02-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant.
IT1255178B (it) * 1992-06-26 1995-10-20 Pierrel Spa N(eter0)-aril-n(etero)-tetralinalchil piperazine aventi attivita' serotoninergica,dopaminergica e adrenergica

Also Published As

Publication number Publication date
CA2142535A1 (en) 1995-08-17
HUT71898A (en) 1996-02-28
RU95102147A (ru) 1996-12-10
AU1224495A (en) 1995-08-24
NZ270500A (en) 1996-02-27
FI950670A (fi) 1995-08-17
CZ39395A3 (en) 1995-10-18
PL307286A1 (en) 1995-08-21
NO950560L (no) 1995-08-17
US5530002A (en) 1996-06-25
FR2716193A1 (fr) 1995-08-18
SK20795A3 (en) 1995-09-13
JPH07252243A (ja) 1995-10-03
AU680327B2 (en) 1997-07-24
CN1112554A (zh) 1995-11-29
NO304230B1 (no) 1998-11-16
EP0668273A1 (fr) 1995-08-23
FI950670A0 (fi) 1995-02-15
NO950560D0 (no) 1995-02-15
IL112661A0 (en) 1995-05-26
HU9500453D0 (en) 1995-03-28
ZA951235B (en) 1996-01-18
FR2716193B1 (fr) 1996-04-05

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