KR910006277A - N-치환된-4-피리미딘아민 및 피리미딘디아민, 이의 제조방법 및 약제로서의 이의 용도 - Google Patents
N-치환된-4-피리미딘아민 및 피리미딘디아민, 이의 제조방법 및 약제로서의 이의 용도 Download PDFInfo
- Publication number
- KR910006277A KR910006277A KR1019900013896A KR900013896A KR910006277A KR 910006277 A KR910006277 A KR 910006277A KR 1019900013896 A KR1019900013896 A KR 1019900013896A KR 900013896 A KR900013896 A KR 900013896A KR 910006277 A KR910006277 A KR 910006277A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- hydrogen
- pharmaceutically acceptable
- acid addition
- acceptable acid
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (13)
- 일반식(Ⅰ)의 화합물과 약제학적으로 허용가능한 이의 산부가염 및 적당하게는 이의 기하학 및 광학 이성체와 라세믹 혼합물.상기식에서 R1은 수소, 저급알킬, 알릴 또는 아릴저급알킬이고; R2및 R3는 독립적으로 수소 또는 저급알킬이거나 R2및 R3는 함께 아릴이며; R4및 R5는 독립적으로 수소 또는 저급알킬이거나 R4및 R5가 함께 아릴이고; X는 수소, 할로겐, 시아노, 니트로, 아미노, 저급알킬, 저급알콕시, 트리플루오로메틸 또는이며, Y는 수소, 할로겐 또느 저급알킬이고; m은 1 내지 3의 정수이다.
- 제1항에 있어서, R1이 수소 또는 저급알킬인 화합물.
- 제2항에 있어서, R4및 R5가 함께 페닐인 화합물.
- 제1항에 있어서, N-(1H-인돌-1-일)-N-프로필-4-피리미딘아민 또는 이의 약제학적으로 허용 가능한 산부가염인 화합물.
- 제1항에 있어서, N-(3-메틸-1H-인돌-1-일)-N-프로필-4-피리미딘아민 또는 이의 약제학적으로 허용 가능한 산부가염인 화합물.
- 제1항에 있어서, N-(피리미딘-4-일)-9H-카바졸-9-아민 또는 이의 약제학적으로 허용 가능한 산부가염인 화합물.
- 제1항에 있어서, 5-시아노-N-(1H-인돌-1-일)-N-프로필-4-피리미딘아민 또는 이의 약제학적으로 허용 가능한 산부가염인 화합물.
- 제1항에 있어서, 6-클로로-N-(1H-인돌-1-일)-N-프로필-4-피리미딘아민 또는 이의 약제학적으로 허용 가능한 산부가염인 화합물.
- 제1항에 있어서, 6-클로로-N-(3-메틸-1H-인돌-1-일)-4-피리미딘아민 또는 이의 약제학적으로 허용 가능한 산부가염인 화합물.
- 제1항에 있어서, 5-시아노-N-(1H-인돌-1-일)-4-피리미딘아민 또는 이의 약제학적으로 허용 가능한 산부가염인 화합물.
- 활성 성분으로서의 제1항에 따른 화합물 및 이를 위해 적절한 담체를 함유하는 약제학적 조성물.
- 진통 및/또는 기억 증진활성을 가진 약제의 제조를 위한 제1항에 따른 화합물의 용도.
- a) 일반식(Ⅱ)의 화합물과 일반식(Ⅲ)의 화합물을 반응시키고, b) X가 클로로인 일반식(Ⅰ)의 화합물을 임의로 촉매적 수소화시켜 X가 수소인 일반식(Ⅰ)의 합물을 제조하거나, c) X가 할로겐이고 m이 1인 일반식(Ⅱ)의 화합물을 R1이 수소이고 R2및 R3이 함께 페닐이며, R4가 수소이고, R5가 수소 또는 저급알킬인 일반식(Ⅱ)의 화합물 2몰 이상과 임의로 반응시켜 R1이 수소이고, R2및 R3가 함께 페닐이며, R4및 R5가 상기에서 정의한 바와 같고, X가 그룹이며, Y가 수소 또는 저급알킬인 일반식(Ⅰ)의 화합물을 제조함을 특징으로 하여, 제1항에 따른 일반식(Ⅰ)의 화합물을 제조하는 방법.상기식에서 R1내지 R5, X 및 m은 제1항에서 정의한 바와 같고, Hal은 할로겐이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/402,415 US4983608A (en) | 1989-09-05 | 1989-09-05 | N-substituted-4-pyrimidinamines and pyrimidinediamines |
US402,415 | 1989-09-05 | ||
US402415 | 1989-09-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR910006277A true KR910006277A (ko) | 1991-04-29 |
KR0162641B1 KR0162641B1 (ko) | 1998-12-01 |
Family
ID=23591798
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019900013896A KR0162641B1 (ko) | 1989-09-05 | 1990-09-04 | N-치환된-4-피리미딘 아민 및-피리미딘 디아민 및 이를 포함하는 약제학적 조성물 |
Country Status (18)
Country | Link |
---|---|
US (1) | US4983608A (ko) |
EP (1) | EP0417584B1 (ko) |
JP (1) | JPH07116181B2 (ko) |
KR (1) | KR0162641B1 (ko) |
AT (1) | ATE163012T1 (ko) |
AU (1) | AU626450B2 (ko) |
CA (1) | CA2024572C (ko) |
DE (1) | DE69032020T2 (ko) |
DK (1) | DK0417584T3 (ko) |
ES (1) | ES2112830T3 (ko) |
FI (1) | FI904327A0 (ko) |
GR (1) | GR3026318T3 (ko) |
IE (1) | IE903213A1 (ko) |
IL (1) | IL95568A (ko) |
NO (1) | NO903851L (ko) |
NZ (1) | NZ235145A (ko) |
PT (1) | PT95202B (ko) |
ZA (1) | ZA907033B (ko) |
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US5155098A (en) * | 1989-06-09 | 1992-10-13 | Hoechst-Roussel Pharmaceuticals Inc. | N-heteroaryl-purin-6-amines, and pharmaceutical compositions and methods employing them |
US5214038A (en) * | 1991-04-15 | 1993-05-25 | Hoechst-Roussel Pharmaceuticals Inc. | 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof |
US5319096A (en) * | 1992-04-03 | 1994-06-07 | Hoechst-Roussel Pharmaceuticals Inc. | (1H-indol-1-yl)-2-(amino) acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use |
US5459274A (en) * | 1994-05-13 | 1995-10-17 | Hoechst-Roussel Pharmaceuticals Inc. | Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines |
US5852028A (en) * | 1995-12-18 | 1998-12-22 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
AU726058B2 (en) * | 1995-09-01 | 2000-10-26 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
US5935966A (en) * | 1995-09-01 | 1999-08-10 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
ZA989365B (en) | 1997-10-15 | 1999-04-15 | Boehringer Mannheim Pharm Corp | Preparation for treating alzheimer's disease |
CN1297447A (zh) | 1998-02-17 | 2001-05-30 | 图拉列克股份有限公司 | 抗病毒嘧啶衍生物 |
AU5438499A (en) | 1998-08-29 | 2000-03-21 | Astrazeneca Ab | Pyrimidine compounds |
JP2002523497A (ja) * | 1998-08-29 | 2002-07-30 | アストラゼネカ・アクチエボラーグ | ピリミジン化合物 |
GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
GB9905075D0 (en) | 1999-03-06 | 1999-04-28 | Zeneca Ltd | Chemical compounds |
GB9907658D0 (en) | 1999-04-06 | 1999-05-26 | Zeneca Ltd | Chemical compounds |
GB9919778D0 (en) | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
ES2306671T3 (es) * | 1999-10-07 | 2008-11-16 | Amgen Inc. | Inhibidores de triazina quinasa. |
US6410726B1 (en) | 2000-01-12 | 2002-06-25 | Tularik Inc. | Arylsulfonic acid salts of pyrimidine-based antiviral |
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GB0004890D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
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GB0004888D0 (en) * | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0004887D0 (en) * | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0007371D0 (en) | 2000-03-28 | 2000-05-17 | Astrazeneca Uk Ltd | Chemical compounds |
GB0016877D0 (en) | 2000-07-11 | 2000-08-30 | Astrazeneca Ab | Chemical compounds |
GB0021726D0 (en) * | 2000-09-05 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
GB0103926D0 (en) * | 2001-02-17 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
GB0113041D0 (en) | 2001-05-30 | 2001-07-18 | Astrazeneca Ab | Chemical compounds |
US7115617B2 (en) * | 2001-08-22 | 2006-10-03 | Amgen Inc. | Amino-substituted pyrimidinyl derivatives and methods of use |
US6939874B2 (en) | 2001-08-22 | 2005-09-06 | Amgen Inc. | Substituted pyrimidinyl derivatives and methods of use |
TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
GB0205690D0 (en) * | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
GB0205693D0 (en) * | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
EP1490354A1 (en) * | 2002-03-09 | 2004-12-29 | Astrazeneca AB | 4-imidazolyl substituted pyrimidine derivatives with cdk inhibitory activity |
GB0205688D0 (en) * | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
CN1678321A (zh) * | 2002-07-29 | 2005-10-05 | 里格尔药品股份有限公司 | 用2,4-嘧啶二胺化合物治疗或者预防自体免疫性疾病的方法 |
EP2130541A3 (en) | 2002-07-29 | 2013-12-18 | Rigel Pharmaceuticals, Inc. | Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds |
US7109337B2 (en) * | 2002-12-20 | 2006-09-19 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
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UA80767C2 (en) * | 2002-12-20 | 2007-10-25 | Pfizer Prod Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
GB0311276D0 (en) * | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
GB0311274D0 (en) * | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
EP1656372B1 (en) * | 2003-07-30 | 2013-04-10 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases |
TW200528101A (en) * | 2004-02-03 | 2005-09-01 | Astrazeneca Ab | Chemical compounds |
BRPI0510980A (pt) * | 2004-05-14 | 2007-11-27 | Pfizer Prod Inc | derivados de pirimidina para o tratamento do crescimento anormal de células |
BRPI0510963A (pt) * | 2004-05-14 | 2007-11-20 | Pfizer Prod Inc | derivados pirimidina para o tratamento do crescimento anormal de células |
CA2566477A1 (en) * | 2004-05-14 | 2005-11-24 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
US20060205945A1 (en) * | 2004-05-14 | 2006-09-14 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
CA2578349A1 (en) * | 2004-09-01 | 2006-03-16 | Rigel Pharmaceuticals, Inc. | Synthesis of 2,4-pyrimidinediamine compounds |
ATE540035T1 (de) * | 2004-11-24 | 2012-01-15 | Rigel Pharmaceuticals Inc | Spiro-2,4-pyrimidindiamin-verbindungen und ihre verwendungen |
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MX2008001428A (es) * | 2005-07-30 | 2008-04-04 | Astrazeneca Ab | Compuestos de imidazolil-pirimidina para uso en el tratamiento de trastornos proliferativos. |
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BRPI0810199A2 (pt) | 2007-04-13 | 2014-10-14 | Sanofi Aventis | Síntese catalisada por metal de transição de n-aminoindóis |
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Family Cites Families (5)
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US4752610A (en) * | 1985-12-04 | 1988-06-21 | Hoechst-Roussel Pharmaceuticals Inc. | N-(pyrrol-1-yl)pyridinamines having memory enhancing properties |
US4792562A (en) * | 1985-12-04 | 1988-12-20 | Hoechst-Roussel Pharmaceuticals, Inc. | N-(pyrrol-1-yl)pyridinamines having memory enhancing activity |
ES2065324T3 (es) * | 1987-04-24 | 1995-02-16 | Hoechst Roussel Pharma | N-(piridinil)-1h-indol-1-aminas, un procedimiento para su preparacion y su uso como medicamentos. |
US4806554A (en) * | 1988-01-11 | 1989-02-21 | Hoechst-Roussel Pharmaceuticals, Inc. | Pyrazol and indazolpyridinamines |
US4868190A (en) * | 1988-12-27 | 1989-09-19 | Hoechst-Roussel Pharmaceuticals, Inc. | N-pyridinyl-9H-carbazol-9-amines |
-
1989
- 1989-09-05 US US07/402,415 patent/US4983608A/en not_active Expired - Lifetime
-
1990
- 1990-09-01 DK DK90116826T patent/DK0417584T3/da active
- 1990-09-01 DE DE69032020T patent/DE69032020T2/de not_active Expired - Lifetime
- 1990-09-01 ES ES90116826T patent/ES2112830T3/es not_active Expired - Lifetime
- 1990-09-01 AT AT90116826T patent/ATE163012T1/de not_active IP Right Cessation
- 1990-09-01 EP EP90116826A patent/EP0417584B1/en not_active Expired - Lifetime
- 1990-09-03 IL IL9556890A patent/IL95568A/en unknown
- 1990-09-03 NZ NZ235145A patent/NZ235145A/en unknown
- 1990-09-03 FI FI904327A patent/FI904327A0/fi not_active IP Right Cessation
- 1990-09-04 IE IE321390A patent/IE903213A1/en not_active IP Right Cessation
- 1990-09-04 KR KR1019900013896A patent/KR0162641B1/ko not_active IP Right Cessation
- 1990-09-04 AU AU62089/90A patent/AU626450B2/en not_active Ceased
- 1990-09-04 JP JP2232639A patent/JPH07116181B2/ja not_active Expired - Lifetime
- 1990-09-04 NO NO90903851A patent/NO903851L/no unknown
- 1990-09-04 PT PT95202A patent/PT95202B/pt not_active IP Right Cessation
- 1990-09-04 CA CA002024572A patent/CA2024572C/en not_active Expired - Lifetime
- 1990-09-04 ZA ZA907033A patent/ZA907033B/xx unknown
-
1998
- 1998-03-11 GR GR980400509T patent/GR3026318T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE163012T1 (de) | 1998-02-15 |
EP0417584B1 (en) | 1998-02-04 |
IE903213A1 (en) | 1991-03-13 |
US4983608A (en) | 1991-01-08 |
AU6208990A (en) | 1991-03-14 |
EP0417584A3 (en) | 1992-02-26 |
ZA907033B (en) | 1991-06-26 |
KR0162641B1 (ko) | 1998-12-01 |
EP0417584A2 (en) | 1991-03-20 |
DE69032020D1 (de) | 1998-03-12 |
NO903851D0 (no) | 1990-09-04 |
NO903851L (no) | 1991-03-06 |
DE69032020T2 (de) | 1998-07-09 |
JPH0393784A (ja) | 1991-04-18 |
CA2024572A1 (en) | 1991-03-06 |
NZ235145A (en) | 1992-12-23 |
AU626450B2 (en) | 1992-07-30 |
PT95202B (pt) | 1997-06-30 |
IL95568A (en) | 1995-01-24 |
CA2024572C (en) | 2000-09-26 |
ES2112830T3 (es) | 1998-04-16 |
DK0417584T3 (da) | 1998-09-23 |
PT95202A (pt) | 1991-05-22 |
IL95568A0 (en) | 1991-06-30 |
GR3026318T3 (en) | 1998-06-30 |
JPH07116181B2 (ja) | 1995-12-13 |
FI904327A0 (fi) | 1990-09-03 |
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