KR910004597A - 1-(피리디닐아미노)-2-피롤리디논, 이의 제조방법 및 약제로서의 이의 용도 - Google Patents

1-(피리디닐아미노)-2-피롤리디논, 이의 제조방법 및 약제로서의 이의 용도 Download PDF

Info

Publication number
KR910004597A
KR910004597A KR1019900011816A KR900011816A KR910004597A KR 910004597 A KR910004597 A KR 910004597A KR 1019900011816 A KR1019900011816 A KR 1019900011816A KR 900011816 A KR900011816 A KR 900011816A KR 910004597 A KR910004597 A KR 910004597A
Authority
KR
South Korea
Prior art keywords
lower alkyl
hydrogen
compound
aryl
pyridinylamino
Prior art date
Application number
KR1019900011816A
Other languages
English (en)
Other versions
KR0164437B1 (ko
Inventor
챨스 애플랜드 리챠드
고든 웨트로퍼 데이비드
Original Assignee
제이. 티. 쉐크
훽스트-러셀 파마슈티칼즈 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 제이. 티. 쉐크, 훽스트-러셀 파마슈티칼즈 인코포레이티드 filed Critical 제이. 티. 쉐크
Publication of KR910004597A publication Critical patent/KR910004597A/ko
Application granted granted Critical
Publication of KR0164437B1 publication Critical patent/KR0164437B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

내용 없음.

Description

1-(피리디닐아미노)-2-피롤리디논, 이의 제조방법 및 약제로서의 이의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (14)

  1. 일반식(I)의 1-(피리디닐아미노)-2-피롤리디논, 약제학적으로 허용되는 이의 산부가염 및 경우에 따라 기하학이성체, 광학이성체 및 입제이성체 및 이의 라세미 혼합물.
  3. 상기식에서, R1, R2및 R3은 독립적으로 수소, 저급알킬, 아릴, 아릴저급알킬, 또는 피리디닐메틸, 피리디닐에틸, 티에닐메틸, 티에닐에틸로 이루어진 그룹중에서 선택된 헤테로아릴 저급알킬이거나, R2와 R3는 함께 탄소수 4 내지 6의 사이클로알킬환, 또는 스피로-용합된 아릴 또는 헤테로아릴 사이클로알칸을 형성하고 ; X는 수소, 할로겐, 하이드록시, 저급알킬, 저급알콕시, 니트로, 아미노 또는 트리플루오로메틸이며; m은 1 내지 3의 정수이다.
  4. 제1항에 있어서, R1이수소 또는 저급알킬이고, R2가 수소, 저급알킬 또는 아릴저급알킬이며 R3이 수소, 저급알킬 또는 아릴저급알킬인 화합물.
  5. 제2항에 있어서, R1이 수소 저급알킬이고, R2가 수소 또는 저급알킬이며, R3가 수소 또는 저급알킬인 화합물.
  6. 제3항에 있어서, R1,R2및 R3가 수소이고, X가 수소이며 m이 1인 화합물.
  7. 제1항에 있어서, 1-(4-피리디닐아미노)-2-피롤리디논 또는 약제학적으로 허용되는 이의 산 부가염인 화합물.
  8. 제1항에 있어서 1-(프로필-4-피리디닐아미노)-2-피롤리디는 또는 약제학적으로 허용되는 이의 산부가염 인 화합물.
  9. 활성성분으로서 제1항에 따른 화합물 및 이를 위한 적절한 담체를 함유하는 약제학적 조성물.
  10. 진총 및/또는 기억증진 활성을 갖는 약제의 제조를 위한 제1항에 따른 화합물의 용도.
  11. 일반식(II)의 화합물을 일반식(III)의 화합물과 반응시킴을 특징으로 하여 제1항에 따른 일반식(I)의 화합물을 제조하는 방법.
  13. 상기식에서, R1,R2,R3,X 및 m은 제1항에서 정의한 바와 같다.
  14. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900011816A 1989-08-02 1990-08-01 1-(피리디닐아미노)-2-피롤리디논, 이의 제조방법 및 이를 포함하는 약제학적 조성물 KR0164437B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/388,413 US4994472A (en) 1989-08-02 1989-08-02 1-(pyridinylamino)-2-pyrrolidinones as pain relievers
US388413 1999-09-01

Publications (2)

Publication Number Publication Date
KR910004597A true KR910004597A (ko) 1991-03-29
KR0164437B1 KR0164437B1 (ko) 1999-01-15

Family

ID=23534027

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900011816A KR0164437B1 (ko) 1989-08-02 1990-08-01 1-(피리디닐아미노)-2-피롤리디논, 이의 제조방법 및 이를 포함하는 약제학적 조성물

Country Status (17)

Country Link
US (1) US4994472A (ko)
EP (1) EP0413191B1 (ko)
JP (1) JPH0674264B2 (ko)
KR (1) KR0164437B1 (ko)
AT (1) ATE109142T1 (ko)
AU (1) AU635051B2 (ko)
CA (1) CA2022484C (ko)
DE (1) DE69011013T2 (ko)
DK (1) DK0413191T3 (ko)
ES (1) ES2059929T3 (ko)
FI (1) FI903818A0 (ko)
IE (1) IE65117B1 (ko)
IL (1) IL95250A (ko)
NO (1) NO903388L (ko)
NZ (1) NZ234724A (ko)
PT (1) PT94878B (ko)
ZA (1) ZA906049B (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356908A (en) * 1989-04-21 1994-10-18 E. I. Du Pont De Nemours And Company Fungicidal oxazolidinones
DE69009962T2 (de) * 1989-12-27 1994-12-15 Monsanto Co Substituierte Pyridin-Verbindungen.
AUPM656594A0 (en) * 1994-06-30 1994-07-21 Orbital Engine Company (Australia) Proprietary Limited A method and apparatus relating to control of the operation of an internal combustion engine
DE69707659T2 (de) * 1996-04-12 2002-05-08 Aventis Pharma Inc Isatinderivate als acetylcholinesterase-inhibitoren und analgetika
US6100276A (en) * 1996-04-12 2000-08-08 Aventis Pharmaceuticals Inc. Isatin derivatives as acetylcholinesterase inhibitors and analgesics
US6825229B2 (en) 2002-03-07 2004-11-30 Blanchette Rockefeller Neurosciences Institute Methods for Alzheimer's Disease treatment and cognitive enhancement
US20050065205A1 (en) 2002-03-07 2005-03-24 Daniel Alkon Methods for Alzheimer's disease treatment and cognitive enhance
CN1678304B (zh) * 2002-07-02 2012-06-27 布朗歇特洛克菲勒神经科学研究所 苔藓抑制素类化合物在制备用于活化PKC而增强sAPPα分泌和改善认知的药物中的应用
TW201206425A (en) 2004-05-18 2012-02-16 Brni Neurosciences Inst Treatment of depressive disorders
GB0412019D0 (en) * 2004-05-28 2004-06-30 Novartis Ag Organic compounds
CA2617003A1 (en) 2005-07-29 2007-02-08 Blanchette Rockefeller Neurosciences Institute Use of a pkc activator, alone or combined with a pkc inhibitor to enhance long term memory
EP2959914A1 (en) 2007-02-09 2015-12-30 Blanchette Rockefeller Neurosciences, Institute Therapeutic effects of bryologs on head trauma-induced memory impairment and brain injury

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670184A1 (de) * 1967-01-20 1971-01-21 Boehringer Sohn Ingelheim Verfahren zur Herstellung heterocyclisch substituierter Hydrazino-imidazoline-(2)
US4260767A (en) * 1979-12-26 1981-04-07 American Cyanamid Company 2-Pyridylhydrazides
US4324884A (en) * 1980-09-25 1982-04-13 General Electric Company Organic amine catalyzed method for making polyetherimide
US4752610A (en) * 1985-12-04 1988-06-21 Hoechst-Roussel Pharmaceuticals Inc. N-(pyrrol-1-yl)pyridinamines having memory enhancing properties
US4792562A (en) * 1985-12-04 1988-12-20 Hoechst-Roussel Pharmaceuticals, Inc. N-(pyrrol-1-yl)pyridinamines having memory enhancing activity
JPH0699307B2 (ja) * 1987-08-20 1994-12-07 キッセイ薬品工業株式会社 抗痴呆剤
US4868190A (en) * 1988-12-27 1989-09-19 Hoechst-Roussel Pharmaceuticals, Inc. N-pyridinyl-9H-carbazol-9-amines

Also Published As

Publication number Publication date
JPH0368572A (ja) 1991-03-25
DK0413191T3 (da) 1994-10-24
DE69011013D1 (de) 1994-09-01
NO903388L (no) 1991-02-04
IE902786A1 (en) 1991-02-27
KR0164437B1 (ko) 1999-01-15
FI903818A0 (fi) 1990-07-31
AU6000290A (en) 1991-02-07
PT94878B (pt) 1997-08-29
AU635051B2 (en) 1993-03-11
EP0413191B1 (en) 1994-07-27
ATE109142T1 (de) 1994-08-15
US4994472A (en) 1991-02-19
PT94878A (pt) 1991-04-18
EP0413191A1 (en) 1991-02-20
IL95250A (en) 1994-01-25
ZA906049B (en) 1991-04-24
IE65117B1 (en) 1995-10-04
CA2022484C (en) 2000-10-17
NZ234724A (en) 1992-01-29
DE69011013T2 (de) 1994-12-22
JPH0674264B2 (ja) 1994-09-21
ES2059929T3 (es) 1994-11-16
NO903388D0 (no) 1990-08-01
IL95250A0 (en) 1991-06-10
CA2022484A1 (en) 1991-02-03

Similar Documents

Publication Publication Date Title
IL95568A0 (en) N-substituted-4-pyrimidinamines and pyrimidinidiamines,process for their preparation and pharmaceutical compositions containing them
KR910004599A (ko) 1,3-디하이드로-1-(피리디닐아미노)-2h-인돌-2-온, 이들의 제조방법 및 이들의 약제로서의 용도
KR910004597A (ko) 1-(피리디닐아미노)-2-피롤리디논, 이의 제조방법 및 약제로서의 이의 용도
KR910004598A (ko) 2,3-디하이드로-1-(피리디닐아미노)-인돌, 이의 제조방법 및 약제로서 이의 용도
HU9200321D0 (en) Process for the production of n-(aryl-oxi-alkyl)-heteroaryl-8-azabicyclo(3.2.1)-octanes and medical preparations containing them
KR920006346A (ko) 3-(1h-인다졸-3-일)-4-피리딘아민, 이의 제조방법, 이의 제조를 위한 중간체 및 약제로서의 이의 용도
KR910018367A (ko) 4-[3-(4-옥소티아졸리디닐)]부티닐아민, 이의 제조방법 및 약물로서 이의 용도
RU95108539A (ru) Производные пенема, их получение и содержащая их фармацевтическая композиция
TH1590A (th) N-(ไบไซคลิค เฮเทอโรไซคลิล)-4-พิเพอริดินามีนชนิดใหม่

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20110811

Year of fee payment: 14

LAPS Lapse due to unpaid annual fee