DE69011013D1 - 1-(Pyridinylamino)-2-pyrrolidinone, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel. - Google Patents

1-(Pyridinylamino)-2-pyrrolidinone, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel.

Info

Publication number
DE69011013D1
DE69011013D1 DE69011013T DE69011013T DE69011013D1 DE 69011013 D1 DE69011013 D1 DE 69011013D1 DE 69011013 T DE69011013 T DE 69011013T DE 69011013 T DE69011013 T DE 69011013T DE 69011013 D1 DE69011013 D1 DE 69011013D1
Authority
DE
Germany
Prior art keywords
pyridinylamino
pyrrolidinones
loweralkyl
aryl
medicines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69011013T
Other languages
English (en)
Other versions
DE69011013T2 (de
Inventor
Richard Charles Dr Effland
David Gordon Dr Wettlaufer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69011013D1 publication Critical patent/DE69011013D1/de
Publication of DE69011013T2 publication Critical patent/DE69011013T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
DE69011013T 1989-08-02 1990-07-31 1-(Pyridinylamino)-2-pyrrolidinone, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel. Expired - Lifetime DE69011013T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/388,413 US4994472A (en) 1989-08-02 1989-08-02 1-(pyridinylamino)-2-pyrrolidinones as pain relievers

Publications (2)

Publication Number Publication Date
DE69011013D1 true DE69011013D1 (de) 1994-09-01
DE69011013T2 DE69011013T2 (de) 1994-12-22

Family

ID=23534027

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69011013T Expired - Lifetime DE69011013T2 (de) 1989-08-02 1990-07-31 1-(Pyridinylamino)-2-pyrrolidinone, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel.

Country Status (17)

Country Link
US (1) US4994472A (de)
EP (1) EP0413191B1 (de)
JP (1) JPH0674264B2 (de)
KR (1) KR0164437B1 (de)
AT (1) ATE109142T1 (de)
AU (1) AU635051B2 (de)
CA (1) CA2022484C (de)
DE (1) DE69011013T2 (de)
DK (1) DK0413191T3 (de)
ES (1) ES2059929T3 (de)
FI (1) FI903818A0 (de)
IE (1) IE65117B1 (de)
IL (1) IL95250A (de)
NO (1) NO903388L (de)
NZ (1) NZ234724A (de)
PT (1) PT94878B (de)
ZA (1) ZA906049B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356908A (en) * 1989-04-21 1994-10-18 E. I. Du Pont De Nemours And Company Fungicidal oxazolidinones
OA09338A (fr) * 1989-12-27 1992-09-15 Monsanto Co "Pyridines substituées".
AUPM656594A0 (en) * 1994-06-30 1994-07-21 Orbital Engine Company (Australia) Proprietary Limited A method and apparatus relating to control of the operation of an internal combustion engine
WO1997038993A1 (en) * 1996-04-12 1997-10-23 Hoechst Marion Roussel, Inc. Isatin derivatives as acetylcholinesterase inhibitors and analgesics
US6100276A (en) * 1996-04-12 2000-08-08 Aventis Pharmaceuticals Inc. Isatin derivatives as acetylcholinesterase inhibitors and analgesics
US6825229B2 (en) 2002-03-07 2004-11-30 Blanchette Rockefeller Neurosciences Institute Methods for Alzheimer's Disease treatment and cognitive enhancement
US20050065205A1 (en) 2002-03-07 2005-03-24 Daniel Alkon Methods for Alzheimer's disease treatment and cognitive enhance
KR20050094761A (ko) * 2002-07-02 2005-09-28 블랜체트 록펠러 뉴로사이언시즈 인스티튜트 브리오스타틴형 화합물을 사용한 ｓＡＰＰα 분비의 증진및 인지 개선을 위한 수단으로서의 ＰＫＣ 활성화
TW200538181A (en) 2004-05-18 2005-12-01 Brni Neurosciences Inst Treatment of depressive disorders
GB0412019D0 (en) * 2004-05-28 2004-06-30 Novartis Ag Organic compounds
US20070054890A1 (en) 2005-07-29 2007-03-08 Alkon Daniel L Protein synthesis required for long-term memory is induced by PKC activation on days preceding associative learning
EP2959914A1 (de) 2007-02-09 2015-12-30 Blanchette Rockefeller Neurosciences, Institute Therapeutische wirkungen von bryologen auf durch kopftraumata herbeigeführte gedächtnisstörungen und hirnverletzungen

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670184A1 (de) * 1967-01-20 1971-01-21 Boehringer Sohn Ingelheim Verfahren zur Herstellung heterocyclisch substituierter Hydrazino-imidazoline-(2)
US4260767A (en) * 1979-12-26 1981-04-07 American Cyanamid Company 2-Pyridylhydrazides
US4324884A (en) * 1980-09-25 1982-04-13 General Electric Company Organic amine catalyzed method for making polyetherimide
US4752610A (en) * 1985-12-04 1988-06-21 Hoechst-Roussel Pharmaceuticals Inc. N-(pyrrol-1-yl)pyridinamines having memory enhancing properties
US4792562A (en) * 1985-12-04 1988-12-20 Hoechst-Roussel Pharmaceuticals, Inc. N-(pyrrol-1-yl)pyridinamines having memory enhancing activity
JPH0699307B2 (ja) * 1987-08-20 1994-12-07 キッセイ薬品工業株式会社 抗痴呆剤
US4868190A (en) * 1988-12-27 1989-09-19 Hoechst-Roussel Pharmaceuticals, Inc. N-pyridinyl-9H-carbazol-9-amines

Also Published As

Publication number Publication date
CA2022484A1 (en) 1991-02-03
NO903388L (no) 1991-02-04
KR910004597A (ko) 1991-03-29
JPH0674264B2 (ja) 1994-09-21
EP0413191B1 (de) 1994-07-27
PT94878B (pt) 1997-08-29
DK0413191T3 (da) 1994-10-24
IE65117B1 (en) 1995-10-04
EP0413191A1 (de) 1991-02-20
PT94878A (pt) 1991-04-18
NZ234724A (en) 1992-01-29
FI903818A0 (fi) 1990-07-31
KR0164437B1 (ko) 1999-01-15
DE69011013T2 (de) 1994-12-22
ES2059929T3 (es) 1994-11-16
AU6000290A (en) 1991-02-07
ZA906049B (en) 1991-04-24
CA2022484C (en) 2000-10-17
AU635051B2 (en) 1993-03-11
IL95250A0 (en) 1991-06-10
US4994472A (en) 1991-02-19
IE902786A1 (en) 1991-02-27
NO903388D0 (no) 1990-08-01
ATE109142T1 (de) 1994-08-15
IL95250A (en) 1994-01-25
JPH0368572A (ja) 1991-03-25

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DE69011013T2 (de) 1-(Pyridinylamino)-2-pyrrolidinone, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel.
DE69016531D1 (de) 2,3-Dihydro-1-(pyridinylamino)-indole, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition