ES2059929T3 - 1-(piridinilamino)-2-pirrolidinonas, un procedimiento para su preparacion y su uso como medicamentos. - Google Patents
1-(piridinilamino)-2-pirrolidinonas, un procedimiento para su preparacion y su uso como medicamentos.Info
- Publication number
- ES2059929T3 ES2059929T3 ES90114659T ES90114659T ES2059929T3 ES 2059929 T3 ES2059929 T3 ES 2059929T3 ES 90114659 T ES90114659 T ES 90114659T ES 90114659 T ES90114659 T ES 90114659T ES 2059929 T3 ES2059929 T3 ES 2059929T3
- Authority
- ES
- Spain
- Prior art keywords
- loweralkyl
- pirrolidinonas
- piridinilamino
- medicines
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
ESTA INVENCION ES RELATIVA A 1-(PIRIDINILAMINO)-2-PIRROLIDINONAS DE LA FORMULA EN DONDE R1,R2 Y R3 SON INDEPENDIENTEMENTE HIDROGENO, ALQUILO INFERIOR, ARILO, ARILOALQUILO INFERIOR O HETEROARILO ALQUILO INFERIOR SELECCIONADO DEL GRUPO COMPUESTO DE PIRIDINILMETILO, PIRIDINILETILO, TIENILMETILO, TIENILETILO O R2 Y R3 JUNTOS FORMAN UN ANILLO CICLOALCANO DE 4 A 6 CARBONOS O UN ARILO ESPIRO FUSIONADO O HETEROARILO CICLOALCANO; X ES HIDROGENO, HALOGENO, HIDROXILO, ALQUILO INFERIOR, ALCOXILO INFERIOR, NITROGENO, AMINO O TRIFLUOROMETILO; M ES UN ENTERO DE 1 A 3. TAMBIEN ES RELATIVO A LAS SALES DE ADICION ACIDA FARMACEUTICAMENTE ACEPTABLE DE ELLAS Y DONDE SE INCLUYEN SUS MEZCLAS RACEMICAS Y ESTEREOISOMEROS OPTICOS Y GEOMETRICOS. LOS COMPUESTOS DE ESTA INVENCION MUESTRAN UTILIDAD COMO ANALGESICOS, PARA MEJORAR LA MEMORIA Y PARA EL TRATAMIENTO DEL MAL DE ALZHEIMER.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/388,413 US4994472A (en) | 1989-08-02 | 1989-08-02 | 1-(pyridinylamino)-2-pyrrolidinones as pain relievers |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2059929T3 true ES2059929T3 (es) | 1994-11-16 |
Family
ID=23534027
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90114659T Expired - Lifetime ES2059929T3 (es) | 1989-08-02 | 1990-07-31 | 1-(piridinilamino)-2-pirrolidinonas, un procedimiento para su preparacion y su uso como medicamentos. |
Country Status (17)
Country | Link |
---|---|
US (1) | US4994472A (es) |
EP (1) | EP0413191B1 (es) |
JP (1) | JPH0674264B2 (es) |
KR (1) | KR0164437B1 (es) |
AT (1) | ATE109142T1 (es) |
AU (1) | AU635051B2 (es) |
CA (1) | CA2022484C (es) |
DE (1) | DE69011013T2 (es) |
DK (1) | DK0413191T3 (es) |
ES (1) | ES2059929T3 (es) |
FI (1) | FI903818A0 (es) |
IE (1) | IE65117B1 (es) |
IL (1) | IL95250A (es) |
NO (1) | NO903388L (es) |
NZ (1) | NZ234724A (es) |
PT (1) | PT94878B (es) |
ZA (1) | ZA906049B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5356908A (en) * | 1989-04-21 | 1994-10-18 | E. I. Du Pont De Nemours And Company | Fungicidal oxazolidinones |
NO905555L (no) * | 1989-12-27 | 1991-06-28 | Monsanto Co | Nye 2,6-substituert-pyridincarboxylsyrederivater, herbicide preparater inneholdende samme som aktiv bestanddel og anvendelse av derivatene for ugressbekjempelse. |
AUPM656594A0 (en) * | 1994-06-30 | 1994-07-21 | Orbital Engine Company (Australia) Proprietary Limited | A method and apparatus relating to control of the operation of an internal combustion engine |
US6100276A (en) * | 1996-04-12 | 2000-08-08 | Aventis Pharmaceuticals Inc. | Isatin derivatives as acetylcholinesterase inhibitors and analgesics |
BR9708655A (pt) * | 1996-04-12 | 1999-08-03 | Hoechst Marion Roussel Inc | Derivados de isatina como inibidores de acetilcolinesterase e analgésicos |
US20050065205A1 (en) | 2002-03-07 | 2005-03-24 | Daniel Alkon | Methods for Alzheimer's disease treatment and cognitive enhance |
US6825229B2 (en) | 2002-03-07 | 2004-11-30 | Blanchette Rockefeller Neurosciences Institute | Methods for Alzheimer's Disease treatment and cognitive enhancement |
CN1678304B (zh) * | 2002-07-02 | 2012-06-27 | 布朗歇特洛克菲勒神经科学研究所 | 苔藓抑制素类化合物在制备用于活化PKC而增强sAPPα分泌和改善认知的药物中的应用 |
TW201206425A (en) | 2004-05-18 | 2012-02-16 | Brni Neurosciences Inst | Treatment of depressive disorders |
GB0412019D0 (en) * | 2004-05-28 | 2004-06-30 | Novartis Ag | Organic compounds |
KR20130122630A (ko) | 2005-07-29 | 2013-11-07 | 블랜체트 록펠러 뉴로사이언시즈 인스티튜트 | 단독의 또는 pkc 억제제와 배합된 pkc 활성화제의 장기 기억 향상을 위한 용도 |
ES2548766T3 (es) | 2007-02-09 | 2015-10-20 | Blanchette Rockefeller Neurosciences Institute | Efectos terapéuticos de las briostatinas, briólogos y otras sustancias relacionadas en alteraciones de la memoria inducidas por trauma craneal y por lesiones cerebrales |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1670184A1 (de) * | 1967-01-20 | 1971-01-21 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung heterocyclisch substituierter Hydrazino-imidazoline-(2) |
US4260767A (en) * | 1979-12-26 | 1981-04-07 | American Cyanamid Company | 2-Pyridylhydrazides |
US4324884A (en) * | 1980-09-25 | 1982-04-13 | General Electric Company | Organic amine catalyzed method for making polyetherimide |
US4752610A (en) * | 1985-12-04 | 1988-06-21 | Hoechst-Roussel Pharmaceuticals Inc. | N-(pyrrol-1-yl)pyridinamines having memory enhancing properties |
US4792562A (en) * | 1985-12-04 | 1988-12-20 | Hoechst-Roussel Pharmaceuticals, Inc. | N-(pyrrol-1-yl)pyridinamines having memory enhancing activity |
JPH0699307B2 (ja) * | 1987-08-20 | 1994-12-07 | キッセイ薬品工業株式会社 | 抗痴呆剤 |
US4868190A (en) * | 1988-12-27 | 1989-09-19 | Hoechst-Roussel Pharmaceuticals, Inc. | N-pyridinyl-9H-carbazol-9-amines |
-
1989
- 1989-08-02 US US07/388,413 patent/US4994472A/en not_active Expired - Lifetime
-
1990
- 1990-07-31 EP EP90114659A patent/EP0413191B1/en not_active Expired - Lifetime
- 1990-07-31 IL IL9525090A patent/IL95250A/en active IP Right Revival
- 1990-07-31 DE DE69011013T patent/DE69011013T2/de not_active Expired - Lifetime
- 1990-07-31 NZ NZ234724A patent/NZ234724A/en unknown
- 1990-07-31 ES ES90114659T patent/ES2059929T3/es not_active Expired - Lifetime
- 1990-07-31 AT AT90114659T patent/ATE109142T1/de not_active IP Right Cessation
- 1990-07-31 FI FI903818A patent/FI903818A0/fi not_active Application Discontinuation
- 1990-07-31 DK DK90114659.7T patent/DK0413191T3/da active
- 1990-08-01 KR KR1019900011816A patent/KR0164437B1/ko not_active IP Right Cessation
- 1990-08-01 AU AU60002/90A patent/AU635051B2/en not_active Ceased
- 1990-08-01 PT PT94878A patent/PT94878B/pt not_active IP Right Cessation
- 1990-08-01 ZA ZA906049A patent/ZA906049B/xx unknown
- 1990-08-01 CA CA002022484A patent/CA2022484C/en not_active Expired - Fee Related
- 1990-08-01 IE IE278690A patent/IE65117B1/en not_active IP Right Cessation
- 1990-08-01 NO NO90903388A patent/NO903388L/no unknown
- 1990-08-01 JP JP2202617A patent/JPH0674264B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
KR0164437B1 (ko) | 1999-01-15 |
DE69011013T2 (de) | 1994-12-22 |
PT94878B (pt) | 1997-08-29 |
IL95250A0 (en) | 1991-06-10 |
CA2022484C (en) | 2000-10-17 |
IE65117B1 (en) | 1995-10-04 |
JPH0674264B2 (ja) | 1994-09-21 |
US4994472A (en) | 1991-02-19 |
NZ234724A (en) | 1992-01-29 |
EP0413191B1 (en) | 1994-07-27 |
KR910004597A (ko) | 1991-03-29 |
IL95250A (en) | 1994-01-25 |
NO903388D0 (no) | 1990-08-01 |
JPH0368572A (ja) | 1991-03-25 |
DK0413191T3 (da) | 1994-10-24 |
ZA906049B (en) | 1991-04-24 |
NO903388L (no) | 1991-02-04 |
DE69011013D1 (de) | 1994-09-01 |
PT94878A (pt) | 1991-04-18 |
AU6000290A (en) | 1991-02-07 |
EP0413191A1 (en) | 1991-02-20 |
IE902786A1 (en) | 1991-02-27 |
FI903818A0 (fi) | 1990-07-31 |
CA2022484A1 (en) | 1991-02-03 |
AU635051B2 (en) | 1993-03-11 |
ATE109142T1 (de) | 1994-08-15 |
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ES2059929T3 (es) | 1-(piridinilamino)-2-pirrolidinonas, un procedimiento para su preparacion y su uso como medicamentos. | |
ES2068294T3 (es) | 2,3-dihidro-1-(piridinilamino)-indoles, un procedimiento para su preparacion y su uso como medicamentos. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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